The Hedgehog signaling pathway in cancer

Clinical Cancer Research

Volumn 12, Issue 20 PART 1, 2006, Pages 5924-5928

  Evangelista, Marie ^a   Tian, Hua ^a   De Sauvage, Frederic J ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CYCLOPAMINE; FIBROBLAST GROWTH FACTOR; NOTCH RECEPTOR; PLATELET DERIVED GROWTH FACTOR; PROTEIN P53; PROTEIN PATCHED 1; SOMATOMEDIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; WNT PROTEIN;

BASAL CELL CARCINOMA; BASAL CELL NEVUS SYNDROME; CANCER GROWTH; CANCER MODEL; CELL DIFFERENTIATION; CELL PROLIFERATION; EMBRYO DEVELOPMENT; EXPERIMENTAL MODEL; GENE MUTATION; GENE OVEREXPRESSION; GENE TARGETING; HUMAN; MEDULLOBLASTOMA; NONHUMAN; PRIORITY JOURNAL; REVIEW; RHABDOMYOSARCOMA;

CARRIER PROTEINS; HEDGEHOG PROTEINS; HUMANS; MEMBRANE GLYCOPROTEINS; NEOPLASMS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

EID: 33750686955     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-06-1736     Document Type: Review

References (66)

1. Huangfu D, Anderson KV. Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates. Development 2006;133:3-14.
2. Jia J, Jiang J. Decoding the Hedgehog signal in animal development. Cell Mol Life Sci 2006;63:1249-65.
3. Nybakken K, Perrimon N. Hedgehog signal transduction: recent findings. Curr Opin Genet Dev 2002;12:503-11.
4. Mann RK, Beachy PA. Novel lipid modifications of secreted protein signals. Annu Rev Biochem 2004;73:891-923.
5. Burke R, Nellen D, Bellotto M, et al. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. Cell 1999;99:803-15.
6. Bellaiche Y, The I, Perrimon N. Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion. Nature 1998;394:85-8.
7. Taipale J, Cooper MK, Maiti T, Beachy PA. Patched acts catalytically to suppress the activity of Smoothened. Nature 2002;418:892-7.
8. Denef N, Neubuser D, Perez L, Cohen SM. Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell 2000;102:521-31.
9. Stone DM, Hynes M, Armanini M, et al. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 1996;384:129-34.
10. Chuang PT, McMahon AP. Vertebrate Hedgehog signaling modulated by induction of a Hedgehog-binding protein. Nature 1999;397:617-21.
11. Lee CS, Buttitta L, Fan CM. Evidence that the WNT-inducible growth arrest-specific gene 1 encodes an antagonists of sonic hedgehog signaling in the somite. Proc Natl Acad Sci U S A 2001;98:11347-52.
12. Tenzen T, Allen BL, Cole F, Kang JS, Krauss RS, McMahon AP. The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev Cell 2006;10:647-56.
13. Yao S, Lum L, Beachy P. The ihog cell-surface proteins bind hedgehog and mediate pathway activation. Cell 2006;125:343-57.
14. Zhang W, Kang JS, Cole F, Yi MJ, Krauss RS. Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly. Dev Cell 2006;10:657-65.
15. Ruiz i Altaba A. Catching a Gli-mpse of Hedgehog. Cell 1997;90:193-6.
16. Chen Y, Gallaher N, Goodman RH, Smolik SM. Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus. Proc Natl Acad Sci U S A 1998;95:2349-54.
17. Price MA, Kalderon D. Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by glycogen synthase kinase 3 and casein kinase 1. Cell 2002;108:823-35.
18. Price MA, Kalderon D. Proteolysis of cubitus interruptus in Drosophila requires phosphorylation by protein kinase A. Development 1999;126:4331-9.
19. Jia J, Amanai K, Wang G, Tang J, Wang B, Jiang J. Shaggy/GSK3 antagonizes Hedgehog signaling by regulating Cubitus interruptus. Nature 2002;416:548-52.
20. Cheng SY, Bishop JM. Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex. Proc Natl Acad Sci U S A 2002;99:5442-7.
21. Kogerman P, Grimm T, Kogerman L, et al. Mammalian suppressor-of-fused modulates nuclear-cytoplastic shuttling of Gli-1. Nat Cell Biol 1999;1:312-9.
22. Ding Q, Fukami S, Meng X, et al. Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the sucellular distribution of Gli1. Curr Biol 1999;9:1119-22.
23. Pearse RV II, Collier LS, Scott MP, Tabin CJ. Vertebrate homologs of Drosophila suppressor of fused interact with the gli family of transcriptional regulators. Dev Biol 1999;212:323-36.
24. Lum L, Zhang C, Oh S, et al. Hedgehog signal transduction via Smooothened association with a cytoplasmic complex scaffolded by the atypical kinesin Costal-2. Mol Cell 2003;12:1261-74.
25. Jia J, Tong C, Jiang J. Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail. Genes Dev 2003;17:2709-20.
26. Ruel L, Rodriguez R, Gallet A, Lavenant-Staccini L, Therond PP. Stability and association of Smoothened Costal2, and Fused with Cubitus interruptus are regulated by Hedgehog. Nat Cell Biol 2003;5:907-13.
27. Ogden SK, Ascano M, Jr., Stegman MA, Suber LM, Hooper JE, Robbins DJ. Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2. Curr Biol 2003;13:1998-2003.
28. Merchant M, Evangelista M, Luoh SM, et al. Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus. Mol Cell Biol 2005;25:7054-68.
29. Chen MH, Gao N, Kawakami T, Chuang PT. Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development. Mol Cell Biol 2005;25:7042-53.
30. Huangfu D, Liu A, Rakeman AS, Murcia NS, Niswander L, Anderson KV. Hedgehog signaling in the mouse requires intraflagellar transport proteins. Nature 2003;426:83-7.
31. Huangfu D, Anderson KV. Cilia and Hedgehog responsiveness in the mouse. Proc Natl Acad Sci U S A 2005;102:11325-30.
32. May SR, Ashique AM, Karlen M, et al. Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and rep ressor functions of Gli. Dev Biol 2005;287:378-89.
33. Hahn H, Wicking C, Zaphiropoulous PG, et al. Mutation of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 1996;85:841-51.
34. Johnson RL, Rothman AL, Xie J, et al. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 1996;272:1668-71.
35. Reifenberger J, Wolter M, Weber RG, et al. Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Cancer Res 1998;58:1798-803.
36. Xie J, Murone M, Luoh SM, et al. Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature 1998;391:90-2.
37. Dahmane N, Lee J, Robins P, Heller P, Ruiz i Altaba A. Activation of the transcription factor Gli1 and hedgehog signaling pathway in skin tumours. Nature 1997;389:876-81.
38. Taylor MD, Liu L, Raffel C, et al. Mutations in SUFU predispose to medulloblastoma. Nat Genet 2002;31:306-10.
39. Raffel C, Jenkins RB, Frederick L, et al. Sporadic medulloblastomas contain PTCH mutations. Cancer Res 1997;57:842-5.
40. Watkins DN, Berman DM, Burkholder SG, Wang B, Beachy PA, Baylin SB. Hedgehog signaling within airway epithelial progenitors and in small-cell lung cancer. Nature 2003;422:313-7.
41. Berman DM, Karhadkar SS, Maitra A, et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 2003;425:846-51.
42. Thayer SP, di Magliano MP, Heiser PW, et al. Hedgehog is and early and late mediator of pancreatic cancer tumorigenesis. Nature 2003;425:851-6.
43. Karhadkar SS, Bova GS, Abdallah N, et al. Hedgehog signaling in prostate regeneration, neoplasia, and metastasis. Nature 2004;431:707-12.
44. Sanchez P, Hernandez AM, Stecca B, et al. Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling. Proc Natl Acad Sci U S A 2004;101:12561-6.
45. Palma V, Lim DA, Dahmane N, et al. Sonic hedgehog controls stem cell behavior in the postnatal and adult brain. Development 2005;132:335-44.
46. Ahn S, Joyner AL. In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog. Nature 2005;437:894-7.
47. Machold R, Hayashi S, Rutlin M, et al. Sonic hedgehog is required for progenerator cell maintenance in telencephalic stem cell niches. Neuron 2003;39:937-50.
48. Liu S, Dontu G, Wicha MS. Mammary stem cells, self renewal pathways, and carcinogenesis. Breast Cancer Res 2005;7:86-95.
49. Bhardwaj G, Murdoch B, Wu D, et al. Sonic hedgehog induces the proliferation of premative human hematopoietic cells via BMP regulation. Nat Immunol 2001;2:172-80.
50. Palma V, Ruiz i Altaba A. Hedgehog-GLI signaling regulates the behavior of the cells with stem cell properties in the developing neocortex. Development 2004;131:337-45.
51. Liu S, Dontu G, Mantle ID, et al. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res 2006;66:6063-71.
52. Lipinski RJ, Cook CH, Barnett DH, Gipp JJ, Peterson RE, Bushman W. Sonic hedgehog signaling regulates the expression of insulin-like growth factor binding protein-6 during fetal prostate development. Dev Dyn 2005;233:829-36.
53. Xie J, Aszterbaum M, Zhang X, et al. A role of PDGFRα in basal cell carcinoma proliferation. Proc Natl Acad Sci U S A 2001;98:9255-9.
54. Sun X, Lewandoski M, Meyers EN, Liu YH, Maxson RE, Jr., Martin GR. Conditional inactivation of Fgf4 reveals complexity of signaling during limb bud development. Nat Genet 2000;25:83-6.
55. Yu J, Carroll TJ, McMahon AP. Sonic hedgehog regulates proliferation and differentation of mesenchymal cells in the mouse metanephric kidney. Development 2002;129:5301-12.
56. Hallahan AR, Pritchard JI, Hansen S, et al. The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas. Cancer Res 2004;64:7794-800.
57. Boras-Granic K, Chang H, Grosschedl R, Hamel PA. Lef1 is required for the transition of Wnt signaling from mesenchymal to epithelial cells in the mouse embryonic mammary gland. Dev Biol 2006;295:219-31.
58. Madison BB, Braunstein K, Kuizon E, Portman K, Qiao XT, Gumucio DL. Epithelial hedgehog signals pattern the intestinal crypt-villus axis. Development 2005;132:279-89.
59. Sasai K, Romer JT, Lee Y, et al. Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies. Cancer Res 2006;66:4215-22.
60. Chen JK, Taipale J, Cooper MK, Beachy PA. Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev 2002;16:2743-8.
61. Frank-Kamenetsky M, Zhang XM, Bottega S, et al. Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened activity. J Biol 2002;1:10.
62. Chen JK, Taipale J, Young KE, Maiti T, Beachy PA. Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A 2002;99:14071-6.
63. Romer JT, Kimura H, Magdaleno S, et al. Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1 (+/-) p53(-/-) mice. Cancer Cell 2004;6:229-40.
64. Berman DM, Karhadkar SS, Hallahan AR, et al. Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 2002;297:1559-61.
65. Sanchez P, Ruiz i Altaba A. In vivo inhibition of endogenous brain tumors through systematic interference of Hedgehog signaling in mice. Mech Dev 2005;122:223-30.
66. Williams JA, Guicherit OM, Zaharian BI, et al. Identication of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions. Proc Natl Acad Sci U S A 2003;100:4616-21.