Sonic Hedgehog Signaling Pathway Supports Cancer Cell Growth during Cancer Radiotherapy

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Ma, Jingjing ^a   Tian, Ling ^a   Cheng, Jin ^a   Chen, Zhiwei ^a   Xu, Bing ^a   Wang, Liwei ^a   Li, Chuanyuan ^b   Huang, Qian ^a  

^a SHANGHAI FIRST PEOPLE S HOSPITAL   (China)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LUCIFERASE; SONIC HEDGEHOG PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BIOLUMINESCENCE; CANCER GROWTH; CANCER RADIOTHERAPY; CELL POPULATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION PROFILING; GROWTH STIMULATION; HETEROZYGOSITY; HUMAN; HUMAN CELL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REPORTER GENE; SIGNAL TRANSDUCTION;

APOPTOSIS; BLOTTING, WESTERN; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; COLONIC NEOPLASMS; FEEDER CELLS; GREEN FLUORESCENT PROTEINS; HEDGEHOG PROTEINS; HUMANS; LUCIFERASES; PANCREATIC NEOPLASMS; RADIOTHERAPY DOSAGE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; X-RAYS;

ERINACEIDAE;

EID: 84878847975     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0065032     Document Type: Article

References (25)

1. Withers HR, Taylor JM, Maciejewski B, (1988) The hazard of accelerated tumor clonogen repopulation during radiotherapy. Acta Oncol 27: 131-146.
2. Kim JJ, Tannock IF, (2005) Repopulation of cancer cells during therapy: an important cause of treatment failure. Nat Rev Cancer 5: 516-525.
3. Hooper JE, Scott MP, (2005) Communicating with Hedgehogs. Nat Rev Mol Cell Biol 6: 306-317.
4. Pasca di Magliano M, Hebrok M, (2003) Hedgehog signalling in cancer formation and maintenance. Nat Rev Cancer 3: 903-911.
5. Thayer SP, di Magliano MP, Heiser PW, Nielsen CM, Roberts DJ, et al. (2003) Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 425: 851-856.
6. Merchant AA, Matsui W, (2010) Targeting Hedgehog-a cancer stem cell pathway. Clin Cancer Res 16: 3130-3140.
7. Ruiz i Altaba A, Mas C, Stecca B, (2007) The Gli code: an information nexus regulating cell fate, stemness and cancer. Trends Cell Biol 17: 438-447.
8. Stecca B, Ruiz IAA, (2010) Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals. J Mol Cell Biol 2: 84-95.
9. Ryoo HD, Bergmann A, (2012) The role of apoptosis-induced proliferation for regeneration and cancer. Cold Spring Harb Perspect Biol 4: a008797.
10. Huang Q, Li F, Liu X, Li W, Shi W, et al. (2011) Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy. Nat Med 17: 860-866.
11. Li F, Huang Q, Chen J, Peng Y, Roop DR, et al. (2010) Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration. Sci Signal 3: ra13.
12. Sims-Mourtada J, Izzo JG, Apisarnthanarax S, Wu TT, Malhotra U, et al. (2006) Hedgehog: an attribute to tumor regrowth after chemoradiotherapy and a target to improve radiation response. Clin Cancer Res 12: 6565-6572.
13. Nishioka T, Yasuda M, Takeshima T, Haga H, Miyai Y, et al. (2011) Radiation-induced cancer cell repopulation: a possible mechanism implied by experiments using transplantable mouse-derived sarcoma cell line. Cell Struct Funct 36: 13-20.
14. Brade AM, Tannock IF, (2006) Scheduling of radiation and chemotherapy for limited-stage small-cell lung cancer: repopulation as a cause of treatment failure? J Clin Oncol 24: 1020-1022.
15. Moraes RC, Zhang X, Harrington N, Fung JY, Wu MF, et al. (2007) Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation and ductal dysplasia. Development 134: 1231-1242.
16. Shin K, Lee J, Guo N, Kim J, Lim A, et al. (2011) Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder. Nature 472: 110-114.
17. Hu WG, Liu T, Xiong JX, Wang CY, (2007) Blockade of sonic hedgehog signal pathway enhances antiproliferative effect of EGFR inhibitor in pancreatic cancer cells. Acta Pharmacol Sin 28: 1224-1230.
18. Rodova M, Fu J, Watkins DN, Srivastava RK, Shankar S, (2012) Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal. PLoS One 7: e46083.
19. Jimeno A, Feldmann G, Suarez-Gauthier A, Rasheed Z, Solomon A, et al. (2009) A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development. Mol Cancer Ther 8: 310-314.
20. Feldmann G, Habbe N, Dhara S, Bisht S, Alvarez H, et al. (2008) Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer. Gut 57: 1420-1430.
21. Pazzaglia S, Mancuso M, Atkinson MJ, Tanori M, Rebessi S, et al. (2002) High incidence of medulloblastoma following X-ray-irradiation of newborn Ptc1 heterozygous mice. Oncogene 21: 7580-7584.
22. Feldmann G, Dhara S, Fendrich V, Bedja D, Beaty R, et al. (2007) Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. Cancer Res 67: 2187-2196.
23. Rohatgi R, Milenkovic L, Corcoran RB, Scott MP, (2009) Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process. Proc Natl Acad Sci U S A 106: 3196-3201.
24. Metcalfe C, de Sauvage FJ, (2011) Hedgehog fights back: mechanisms of acquired resistance against Smoothened antagonists. Cancer Res 71: 5057-5061.
25. Kelleher FC, (2011) Hedgehog signaling and therapeutics in pancreatic cancer. Carcinogenesis 32: 445-451.