Pancreatic intraepithelial neoplasia: A new nomenclature and classification system for pancreatic duct lesions

American Journal of Surgical Pathology

Volumn 25, Issue 5, 2001, Pages 579-586

  Hruban, Ralph H ^a,b   Adsay, N Volkan ^a,c   Albores Saavedra, Jorge ^a,d   Compton, Carolyn ^a,e   Garrett, Elizabeth S ^a,b   Goodman, Steven N ^a,b   Kern, Scott E ^a,b   Klimstra, David S ^a,f   Klöppel, Günter ^a,g   Longnecker, Daniel S ^a,h   Lüttges, Jutta ^a,g   Offerhaus, G Johan A ^a,i  

^a Department of Pathology ^*  (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

^c WAYNE STATE UNIVERSITY   (United States)

^d UNIVERSITY OF TEXAS AT DALLAS   (United States)

^e MCGILL UNIVERSITY   (Canada)

^f MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^g UNIVERSITY OF KIEL   (Germany)

^h DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

ⁱ UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Carcinoma; In situ; Neoplasia; Pancreas; Pancreatic

Indexed keywords

ARTICLE; CARCINOMA IN SITU; CELL PROLIFERATION; DISEASE CLASSIFICATION; DYSPLASIA; HISTOPATHOLOGY; HUMAN; HYPERPLASIA; METAPLASIA; NOMENCLATURE; PANCREAS DUCT; PANCREAS INTRAEPITHELIAL NEOPLASIA; PANCREAS TUMOR; SQUAMOUS CELL METAPLASIA; STANDARDIZATION;

CARCINOMA IN SITU; HUMANS; OBSERVER VARIATION; PANCREATIC DUCTS; PANCREATIC NEOPLASMS; PRECANCEROUS CONDITIONS; REFERENCE STANDARDS; TERMINOLOGY;

EID: 0035020633     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-200105000-00003     Document Type: Article

References (33)

1. Early diagnosis and treatment of pancreatic dysplasia in patients with a family history of pancreatic cancer
2. Mutations in the p53 gene: An early marker of neoplastic progression in ulcerative colitis
3. Progression of atypical ductal hyperplasia/carcinoma in situ of the pancreas to invasive adenocarcinoma
4. Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia
5. Morphological lesions associated with human primary invasive nonendocrine pancreas cancer
6. Immunohistochemical evaluation of HER-2/neu oncogene expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasms
7. Overexpression of p53 protein in adenocarcinoma of the pancreas
8. Detection of K-ras mutations in mucinous pancreatic duct hyperplasia from a patient with a family history of pancreatic carcinoma
9. A critical appraisal of existing classification systems of epithelial hyperplasia and in situ neoplasia of the breast with proposals for future methods of categorization: Where are we going?
10. Varying grades of epithelial atypia in the pancreatic ducts of humans. Classification based on morphometry and multivariate analysis and correlated with positive reactions of carcinoembryonic antigen
11. BRCA2 is inactivated late in the development of pancreatic intraepithelial neoplasia: Evidence and implications
12. Barrett's esophagus, dysplasia, and adenocarcinoma
13. Molecular analysis of microdissected tumors and preneoplastic intraductal lesions in pancreatic carcinoma
14. Genetic progression in the pancreatic ducts
15. A 'white paper': The product of a pancreas cancer think tank
16. K-ras mutations in pancreatic ductal proliferative lesions
17. Relation of pancreatic duct hyperplasia to carcinoma
18. The quest for preneoplastic lesions in the pancreas
19. Duct changes and K-ras mutations in the disease-free pancreas: Analysis of type, age relation and spatial distribution
20. The K-ras mutation pattern in pancreatic ductal adenocarcinoma usually is identical to that in associated normal, hyperplastic, and metaplastic ductal epithelium
21. p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma
22. Hyperplastic, preneoplastic and neoplastic lesions found in 83 human pancreases
23. Pancolonic chromosomal instability precedes dysplasia and cancer in ulcerative colitis
24. A theory of cervical carcinogenesis
25. Natural history of cervical intraepithelial neoplasia
26. Dysplasia in inflammatory bowel disease: Standardized classification with provisional clinical applications
27. Pancreatic duct hyperplasia and cancer
28. Intraductal papillary mucinous tumors of the pancreas confined to secondary ducts show less aggressive pathologic features as compared with those involving the main pancreatic duct
29. Molecular markers for diagnostic cytology of neoplasms in the head region of the pancreas: Mutation of K-ras and overexpression of the p53 protein product
30. Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: Loss of intranuclear expression
31. Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: Evidence that DPC4 inactivation occurs late in neoplastic progression
32. Genetic progression and divergence in pancreatic carcinoma