Gli1 regulates the proliferation and differentiation of HSCs and myeloid progenitors

Blood

Volumn 115, Issue 12, 2010, Pages 2391-2396

  Merchant, Akil ^a   Joseph, Giselle ^a   Wang, Qiuju ^a   Brennan, Sarah ^a   Matsui, William ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; FLUOROURACIL; GRANULOCYTE COLONY STIMULATING FACTOR; TRANSCRIPTION FACTOR GLI1; CCND1 PROTEIN, MOUSE; CELL SURFACE RECEPTOR; G PROTEIN COUPLED RECEPTOR; GLI PROTEIN, MOUSE; KRUPPEL LIKE FACTOR; PATCHED RECEPTORS; SMO PROTEIN, MOUSE; SONIC HEDGEHOG PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CELL STRESS; CHEMOTHERAPY; COLONY FORMATION; CONTROLLED STUDY; FEMALE; GENE DELETION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HOMOZYGOSITY; IN VITRO STUDY; LEUKOCYTE; MALE; MOUSE; MYELOID PROGENITOR CELL; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BONE MARROW CELL; CELL DIVISION; CYTOLOGY; DRUG EFFECT; GENETICS; HUMAN; LACTOSE OPERON; METABOLISM; MOUSE MUTANT; PHYSIOLOGICAL STRESS; PHYSIOLOGY;

ANIMALS; CELL DIFFERENTIATION; CELL DIVISION; CYCLIN D1; FEMALE; GENE DELETION; GRANULOCYTE COLONY-STIMULATING FACTOR; HEDGEHOG PROTEINS; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; LAC OPERON; MALE; MICE; MICE, MUTANT STRAINS; MYELOID CELLS; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; STRESS, PHYSIOLOGICAL;

EID: 77950624255     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-09-241703     Document Type: Article

References (29)

1. Stier S, Cheng T, Dombkowski D, Carlesso N, Scadden DT. Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome. Blood. 2002;99(7):2369-2378. (Pubitemid 34525422)
2. Reya T, Duncan AW, Ailles L, et al. A role for wnt signalling in self-renewal of haematopoietic stem cells. Nature. 2003;423(6938):409-414. (Pubitemid 36626987)
3. Duncan AW, Rattis FM, DiMascio LN, et al. Integration of notch and wnt signaling in hematopoietic stem cell maintenance. Nat Immunol. 2005;6(3):314-322. (Pubitemid 41724769)
4. Malhotra S, Kincade PW. Wnt-related molecules and signaling pathway equilibrium in hematopoiesis. Cell Stem Cell. 2009;4(1):27-36.
5. Taipale J, Beachy PA. The hedgehog and wnt signalling pathways in cancer. Nature. 2001;411(6835):349-354. (Pubitemid 32467044)
6. Zhao C, Chen A, Jamieson CH, et al. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature. 2009;458(7239):776-779.
7. Dierks C, Beigi R, Guo GR, et al. Expansion of bcr-abl-positive leukemic stem cells is dependent on hedgehog pathway activation. Cancer Cell. 2008;14(3):238-249.
8. Gao J, Graves S, Koch U, et al. Hedgehog signaling is dispensable for adult hematopoietic stem cell function. Cell Stem Cell. 2009;4(6):548-558.
9. Hofmann I, Stover EH, Cullen DE, et al. Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis. Cell Stem Cell. 2009;4(6):559-567.
10. Bai CB, Auerbach W, Lee JS, Stephen D, Joyner AL. Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway. Development. 2002;129(20):4753-4761. (Pubitemid 35277202)
11. Fleming HE, Janzen V, Lo Celso C, et al. Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo. Cell Stem Cell. 2008;2(3):274-283. (Pubitemid 351298592)
12. Byrne P, Huang W, Wallace VM, et al. Chimerism analysis in sex-mismatched murine transplantation using quantitative real-time PCR. BioTechniques. 2002;32(2):279-80, 282-4, 286.
13. Noubissi FK, Goswami S, Sanek NA, et al. Wnt signaling stimulates transcriptional outcome of the hedgehog pathway by stabilizing GLI1 mRNA. Cancer Res. 2009;69(22):8572-8578.
14. Yang L, Bryder D, Adolfsson J, et al. Identification of lin-Sca1+kit+CD34+Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients. Blood. 2005;105(7):2717-2723.
15. Akashi K, Traver D, Miyamoto T, Weissman IL. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature. 2000;404(6774):193- 197. (Pubitemid 30154488)
16. Duman-Scheel M, Weng L, Xin S, Du W. Hedgehog regulates cell growth and proliferation by inducing cyclin D and cyclin E. Nature. 2002;417(6886):299-304. (Pubitemid 34534713)
17. Furukawa Y, Kikuchi J, Nakamura M, Iwase S, Yamada H, Matsuda M. Lineage-specific regulation of cell cycle control gene expression during haematopoietic cell differentiation. Br J Haematol. 2000;110(3):663-673.
18. Ahn S, Joyner AL. In vivo analysis of quiescent adult neural stem cells responding to sonic hedgehog. Nature. 2005;437(7060):894-897. (Pubitemid 41486765)
19. Bhardwaj G, Murdoch B, Wu D, et al. Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nat Immunol. 2001;2(2):172-180. (Pubitemid 33707938)
20. Trowbridge JJ, Scott MP, Bhatia M. Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration. Proc Natl Acad Sci U S A. 2006;103(38):14134-14139. (Pubitemid 44452992)
21. Gering M, Patient R. Hedgehog signaling is required for adult blood stem cell formation in zebrafish embryos. Dev Cell. 2005;8(3):389-400. (Pubitemid 40309809)
22. Bai CB, Joyner AL. Gli1 can rescue the in vivo function of Gli2. Development. 2001;128(24):5161-5172.
23. Tian H, Callahan CA, DuPree KJ, et al. Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis. Proc Natl Acad Sci U S A. 2009;106(11):4254-4259.
24. Bai LY, Chiu CF, Lin CW, et al. Differential expression of sonic hedgehog and Gli1 in hematological malignancies. Leukemia. 2008;22(1):226-228.
25. Ji Z, Mei FC, Xie J, Cheng X. Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells. J Biol Chem. 2007;282(19):14048-14055. (Pubitemid 47100411)
26. Nolan-Stevaux O, Lau J, Truitt ML, et al. GLI1 is regulated through smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. Genes Dev. 2009;23(1):24-36.
27. Beauchamp E, Bulut G, Abaan O, et al. GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein. J Biol Chem. 2009;284(14):9074-9082.
28. Merchant AA, Joseph GA, Jones E, et al. Hedgehog signaling in normal and malignant hematopoiesis [abstract]. Blood (ASH Annual Meeting Abstracts). 2007;110(11): Abstract 3381.
29. Lauth M, Toftgard R. Non-canonical activation of GLI transcription factors: Implications for targeted anti-cancer therapy. Cell Cycle. 2007;6(20):2458-2463. (Pubitemid 350058663)