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Volumn 88, Issue , 2012, Pages 355-378

Aberrations and Therapeutics Involving the Developmental Pathway Hedgehog in Pancreatic cancer

Author keywords

Desmoplasia; GDC 0449; Hedgehog; Ligand; Pancreatic cancer; Paracrine; Patched; Smoothened; Stroma

Indexed keywords


EID: 84857716118     PISSN: 00836729     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-394622-5.00016-X     Document Type: Chapter
Times cited : (6)

References (48)
  • 2
    • 70349974840 scopus 로고    scopus 로고
    • Sonic hedgehog paracrine signalling regulates metastasis and lymphangiogenesis in pancreatic cancer
    • Bailey J.M., Mohr A.M., Hollingsworth M.A. Sonic hedgehog paracrine signalling regulates metastasis and lymphangiogenesis in pancreatic cancer. Oncogene 2009, 28(40):3513-3525.
    • (2009) Oncogene , vol.28 , Issue.40 , pp. 3513-3525
    • Bailey, J.M.1    Mohr, A.M.2    Hollingsworth, M.A.3
  • 6
    • 84857745316 scopus 로고    scopus 로고
    • Developmental genetics and birth defects. Chapter 14, P441. Genetics in medicine. Thompson and Thompson, ISBN 9781416030805
    • Developmental genetics and birth defects. Chapter 14, P441. Genetics in medicine. Thompson and Thompson, ISBN 9781416030805.
  • 10
    • 52649169761 scopus 로고    scopus 로고
    • Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer
    • Feldmann G., Habbe N., Dhara S., Bisht S., Alvarez H., Fendrich V. Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer. Gut 2008, 57(10):1420-1430.
    • (2008) Gut , vol.57 , Issue.10 , pp. 1420-1430
    • Feldmann, G.1    Habbe, N.2    Dhara, S.3    Bisht, S.4    Alvarez, H.5    Fendrich, V.6
  • 11
    • 77950554464 scopus 로고    scopus 로고
    • Stromal depletion goes on trial in pancreatic cancer
    • Cited abstract (2009) J. Clin. Oncol.27,15s (suppl; abstr 4525)
    • Garber K. Stromal depletion goes on trial in pancreatic cancer. J. Natl. Cancer Inst. 2010, 102(7):448-450. Cited abstract (2009) J. Clin. Oncol.27,15s (suppl; abstr 4525).
    • (2010) J. Natl. Cancer Inst. , vol.102 , Issue.7 , pp. 448-450
    • Garber, K.1
  • 14
    • 84857702155 scopus 로고    scopus 로고
    • Hedgehog signalling in human disease. Molecular biology intelligence unit. Ariel Ruiz i Altaba. Chapter 1, p2
    • Hedgehog signalling in human disease. Molecular biology intelligence unit. Ariel Ruiz i Altaba. Chapter 1, p2.
  • 15
    • 33745084564 scopus 로고    scopus 로고
    • Stabilization of beta-catenin impacts pancreas growth
    • Heiser P.W., Lau J., Taketo M.M., Herrera P.L., Hebrok M. Stabilization of beta-catenin impacts pancreas growth. Development 2006, 133(10):2023-2032.
    • (2006) Development , vol.133 , Issue.10 , pp. 2023-2032
    • Heiser, P.W.1    Lau, J.2    Taketo, M.M.3    Herrera, P.L.4    Hebrok, M.5
  • 16
    • 0036842027 scopus 로고    scopus 로고
    • Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation
    • Heller R.S., Dichmann D.S., Jensen J., Miller C., Wong G., Madsen O.D., Serup P. Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation. Dev. Dyn. 2002, 225(3):260-270.
    • (2002) Dev. Dyn. , vol.225 , Issue.3 , pp. 260-270
    • Heller, R.S.1    Dichmann, D.S.2    Jensen, J.3    Miller, C.4    Wong, G.5    Madsen, O.D.6    Serup, P.7
  • 17
    • 34548455927 scopus 로고    scopus 로고
    • Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
    • Hermann P.C., Huber S.L., Herrler T., Aicher A., Ellwart J.W., Guba M., Bruns C.J., Heeschen C. Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 2007, 1(3):313-323.
    • (2007) Cell Stem Cell , vol.1 , Issue.3 , pp. 313-323
    • Hermann, P.C.1    Huber, S.L.2    Herrler, T.3    Aicher, A.4    Ellwart, J.W.5    Guba, M.6    Bruns, C.J.7    Heeschen, C.8
  • 18
    • 34347253037 scopus 로고    scopus 로고
    • Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells
    • Ji Z., Mei F.C., Xie J., Cheng X. Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells. J. Biol. Chem. 2007, 282(19):14048-14055.
    • (2007) J. Biol. Chem. , vol.282 , Issue.19 , pp. 14048-14055
    • Ji, Z.1    Mei, F.C.2    Xie, J.3    Cheng, X.4
  • 19
    • 52149123619 scopus 로고    scopus 로고
    • Core signalling pathways in human pancreatic cancers revealed by global genomic analyses
    • Jones S., Zhang X., Parsons D.W., Lin J.C., Leary R.J., Angenendt P., et al. Core signalling pathways in human pancreatic cancers revealed by global genomic analyses. Science 2008, 321(5897):1801-1806.
    • (2008) Science , vol.321 , Issue.5897 , pp. 1801-1806
    • Jones, S.1    Zhang, X.2    Parsons, D.W.3    Lin, J.C.4    Leary, R.J.5    Angenendt, P.6
  • 20
    • 33745065756 scopus 로고    scopus 로고
    • Common critical pathways in embryogenesis and cancer
    • Kelleher F.C., et al. Common critical pathways in embryogenesis and cancer. Acta Oncol. 2006, 45(4):375-388.
    • (2006) Acta Oncol. , vol.45 , Issue.4 , pp. 375-388
    • Kelleher, F.C.1
  • 21
    • 40149091426 scopus 로고    scopus 로고
    • Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure
    • Kimura H., Ng J.M., Curran T. Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure. Cancer Cell 2008, 13(3):249-260.
    • (2008) Cancer Cell , vol.13 , Issue.3 , pp. 249-260
    • Kimura, H.1    Ng, J.M.2    Curran, T.3
  • 22
    • 0142121292 scopus 로고    scopus 로고
    • Treatment of locally advanced pancreatic cancer in the real world: Population-based practices and effectiveness
    • Krzyanowska M.K., Weeks J.C., Earle C.C. Treatment of locally advanced pancreatic cancer in the real world: Population-based practices and effectiveness. J. Clin. Oncol. 2003, 21(18):3409-3414.
    • (2003) J. Clin. Oncol. , vol.21 , Issue.18 , pp. 3409-3414
    • Krzyanowska, M.K.1    Weeks, J.C.2    Earle, C.C.3
  • 23
    • 34249867843 scopus 로고    scopus 로고
    • Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
    • Lauth M., Bergström A., Shimokawa T., Toftgård R. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc. Natl. Acad. Sci. USA 2007, 104(20):8455-8460.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , Issue.20 , pp. 8455-8460
    • Lauth, M.1    Bergström, A.2    Shimokawa, T.3    Toftgård, R.4
  • 26
    • 61549102790 scopus 로고    scopus 로고
    • Arterial and venous resection for pancreatic adenocarcinoma: Operative and long-term outcomes
    • Martin R.C., Scoggins C.R., Egnatashvili V., Staley C.A., McMasters K.M., Kooby D.A. Arterial and venous resection for pancreatic adenocarcinoma: Operative and long-term outcomes. Arch. Surg. 2009, 144(2):154-159.
    • (2009) Arch. Surg. , vol.144 , Issue.2 , pp. 154-159
    • Martin, R.C.1    Scoggins, C.R.2    Egnatashvili, V.3    Staley, C.A.4    McMasters, K.M.5    Kooby, D.A.6
  • 27
    • 77953693899 scopus 로고    scopus 로고
    • Targeting hedgehog-A cancer stem cell pathway
    • Merchant A.A., Matsui W. Targeting hedgehog-A cancer stem cell pathway. Clin. Cancer Res. 2010, 16(12):3130-3150.
    • (2010) Clin. Cancer Res. , vol.16 , Issue.12 , pp. 3130-3150
    • Merchant, A.A.1    Matsui, W.2
  • 28
    • 31544458968 scopus 로고    scopus 로고
    • Cytotoxic effects induced by a combination of cyclopamine and gefitinib, the selective hedgehog and epidermal growth factor receptor signalling inhibitors, in prostate cancer cells
    • Mimeault M., Moore E., Moniaux N., Hénichart J.P., Depreux P., Lin M.F., Batra S.K. Cytotoxic effects induced by a combination of cyclopamine and gefitinib, the selective hedgehog and epidermal growth factor receptor signalling inhibitors, in prostate cancer cells. Int. J. Cancer 2006, 118(4):1022-1031.
    • (2006) Int. J. Cancer , vol.118 , Issue.4 , pp. 1022-1031
    • Mimeault, M.1    Moore, E.2    Moniaux, N.3    Hénichart, J.P.4    Depreux, P.5    Lin, M.F.6    Batra, S.K.7
  • 29
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore M.J., Goldstein D., Hamm J., Figer A., Hecht J.R., Gallinger S., Au H.J., Murawa P., Walde D., Wolff R.A., Campos D., Lim R., et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J. Clin. Oncol. 2007, 25:1960.
    • (2007) J. Clin. Oncol. , vol.25 , pp. 1960
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3    Figer, A.4    Hecht, J.R.5    Gallinger, S.6    Au, H.J.7    Murawa, P.8    Walde, D.9    Wolff, R.A.10    Campos, D.11    Lim, R.12
  • 32
    • 33846405332 scopus 로고    scopus 로고
    • Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: A randomized controlled trial
    • Oettle H., Post S., Neuhaus P., Gellert K., Langrehr J., Ridwelski K., Schramm H., Fahlke J., Zuelke C., Burkart C., Gutberlet K., Kettner E., et al. Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: A randomized controlled trial. JAMA 2007, 297(3):267-277.
    • (2007) JAMA , vol.297 , Issue.3 , pp. 267-277
    • Oettle, H.1    Post, S.2    Neuhaus, P.3    Gellert, K.4    Langrehr, J.5    Ridwelski, K.6    Schramm, H.7    Fahlke, J.8    Zuelke, C.9    Burkart, C.10    Gutberlet, K.11    Kettner, E.12
  • 35
    • 33645220566 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signalling
    • Riobó N.A., Lu K., Ai X., Haines G.M., Emerson C.P. Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signalling. Proc. Natl. Acad. Sci. USA 2006, 103(12):4505-4510.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , Issue.12 , pp. 4505-4510
    • Riobó, N.A.1    Lu, K.2    Ai, X.3    Haines, G.M.4    Emerson, C.P.5
  • 37
    • 33751549095 scopus 로고    scopus 로고
    • Targeting the Hedgehog pathway in cancer
    • Rubin L.L., de Sauvage F.J. Targeting the Hedgehog pathway in cancer. Nat. Rev. Drug Discov. 2006, 5(12):1026-1033.
    • (2006) Nat. Rev. Drug Discov. , vol.5 , Issue.12 , pp. 1026-1033
    • Rubin, L.L.1    de Sauvage, F.J.2
  • 39
    • 77953722426 scopus 로고    scopus 로고
    • A first-in-human, phase I study of an oral hedgehog pathway antagonist, BMS-833923 (XL139), in subjects with advanced or metastatic solid tumors
    • Abstract
    • Siu L.L., Papadopoulos K.P., Alberts S.R., Taylor S., Patnaik A., Chen E.X., et al. A first-in-human, phase I study of an oral hedgehog pathway antagonist, BMS-833923 (XL139), in subjects with advanced or metastatic solid tumors. Mol. Cancer Ther. 2009, 8:A55. Abstract. 10.1158/1535-7163.TARG-09-A55.
    • (2009) Mol. Cancer Ther. , vol.8
    • Siu, L.L.1    Papadopoulos, K.P.2    Alberts, S.R.3    Taylor, S.4    Patnaik, A.5    Chen, E.X.6
  • 44
    • 77949719411 scopus 로고    scopus 로고
    • Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts
    • Walter K., Omura N., Hong S.M., Griffith M., Vincent A., Borges M., Goggins M. Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts. Clin. Cancer Res. 2010, 16(6):1781-1789.
    • (2010) Clin. Cancer Res. , vol.16 , Issue.6 , pp. 1781-1789
    • Walter, K.1    Omura, N.2    Hong, S.M.3    Griffith, M.4    Vincent, A.5    Borges, M.6    Goggins, M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.