-
1
-
-
34548329486
-
Differentiation plasticity regulated by TGF-beta family proteins in development and disease
-
Derynck R and Akhurst RJ: Differentiation plasticity regulated by TGF-beta family proteins in development and disease. Nat Cell Biol 9: 1000-1004, 2007.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 1000-1004
-
-
Derynck, R.1
Akhurst, R.J.2
-
2
-
-
84876817355
-
Beyond TGFβ: Roles of other TGFβ superfamily members in cancer
-
Wakefield LM and Hill CS: Beyond TGFβ: roles of other TGFβ superfamily members in cancer. Nat Rev Cancer 13: 328-341, 2013.
-
(2013)
Nat Rev Cancer
, vol.13
, pp. 328-341
-
-
Wakefield, L.M.1
Hill, C.S.2
-
4
-
-
0037439630
-
Making sense of latent TGFbeta activation
-
Annes JP, Munger JS and Rifkin DB: Making sense of latent TGFbeta activation. J Cell Sci 116: 217-224, 2003.
-
(2003)
J Cell Sci
, vol.116
, pp. 217-224
-
-
Annes, J.P.1
Munger, J.S.2
Rifkin, D.B.3
-
5
-
-
0029860747
-
Identification and characterization of an eight-cysteine repeat of the latent transforming growth factor-beta binding protein-1 that mediates bonding to the latent transforming growth factor-beta1
-
Gleizes PE, Beavis RC, Mazzieri R, Shen B and Rifkin DB: Identification and characterization of an eight-cysteine repeat of the latent transforming growth factor-beta binding protein-1 that mediates bonding to the latent transforming growth factor-beta1. J Biol Chem 271: 29891-29896, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 29891-29896
-
-
Gleizes, P.E.1
Beavis, R.C.2
Mazzieri, R.3
Shen, B.4
Rifkin, D.B.5
-
6
-
-
0025765844
-
A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1
-
Miyazono K, Olofsson A, Colosetti P and Heldin CH: A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1. EMBO J 10: 1091-1101, 1991.
-
(1991)
EMBO J
, vol.10
, pp. 1091-1101
-
-
Miyazono, K.1
Olofsson, A.2
Colosetti, P.3
Heldin, C.H.4
-
7
-
-
0030058699
-
Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1
-
Saharinen J, Taipale J and Keski-Oja J: Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1. EMBO J 15: 245-253, 1996.
-
(1996)
EMBO J
, vol.15
, pp. 245-253
-
-
Saharinen, J.1
Taipale, J.2
Keski-Oja, J.3
-
8
-
-
0035153291
-
Latent TGF-beta binding protein LTBP-1 contains three potential extracellular matrix interacting domains
-
Unsöld C, Hyytiäinen M, Bruckner-Tuderman L and Keski-Oja J: Latent TGF-beta binding protein LTBP-1 contains three potential extracellular matrix interacting domains. J Cell Sci 114: 187-197, 2001.
-
(2001)
J Cell Sci
, vol.114
, pp. 187-197
-
-
Unsöld, C.1
Hyytiäinen, M.2
Bruckner-Tuderman, L.3
Keski-Oja, J.4
-
9
-
-
0030974902
-
Latent transforming growth factor-beta binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-beta
-
Nunes I, Gleizes PE, Metz CN and Rifkin DB: Latent transforming growth factor-beta binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-beta. J Cell Biol 136: 1151-1163, 1997.
-
(1997)
J Cell Biol
, vol.136
, pp. 1151-1163
-
-
Nunes, I.1
Gleizes, P.E.2
Metz, C.N.3
Rifkin, D.B.4
-
11
-
-
12344320716
-
Thrombospondin-1 is a major activator of TGF-beta1 in vivo
-
Crawford SE, Stellmach V, Murphy-Ullrich JE, et al: Thrombospondin-1 is a major activator of TGF-beta1 in vivo. Cell 93: 1159-1170, 1998.
-
(1998)
Cell
, vol.93
, pp. 1159-1170
-
-
Crawford, S.E.1
Stellmach, V.2
Murphy-Ullrich, J.E.3
-
12
-
-
0033532054
-
The activation sequence of thrombospondin-1 interacts with the latency-associated peptide to regulate activation of latent transforming growth factor-beta
-
Ribeiro SM, Poczatek M, Schultz-Cherry S, Villain M and Murphy-Ullrich JE: The activation sequence of thrombospondin-1 interacts with the latency-associated peptide to regulate activation of latent transforming growth factor-beta. J Biol Chem 274: 13586-13593, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 13586-13593
-
-
Ribeiro, S.M.1
Poczatek, M.2
Schultz-Cherry, S.3
Villain, M.4
Murphy-Ullrich, J.E.5
-
13
-
-
0028906190
-
Processing of transforming growth factor beta 1 precursor by human furin convertase
-
Dubois CM, Laprise MH, Blanchette F, Gentry LE and Leduc R: Processing of transforming growth factor beta 1 precursor by human furin convertase. J Biol Chem 270: 10618-10624, 1995.
-
(1995)
J Biol Chem
, vol.270
, pp. 10618-10624
-
-
Dubois, C.M.1
Laprise, M.H.2
Blanchette, F.3
Gentry, L.E.4
Leduc, R.5
-
14
-
-
0024382711
-
Inhibition of endothelial cell movement by pericytes and smooth muscle cells: Activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture
-
Sato Y and Rifkin DB: Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture. J Cell Biol 109: 309-315, 1989.
-
(1989)
J Cell Biol
, vol.109
, pp. 309-315
-
-
Sato, Y.1
Rifkin, D.B.2
-
15
-
-
0034650486
-
Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis
-
Yu Q and Stamenkovic I: Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev 14: 163-176, 2000.
-
(2000)
Genes Dev
, vol.14
, pp. 163-176
-
-
Yu, Q.1
Stamenkovic, I.2
-
16
-
-
0032442852
-
Smads: Transcriptional activators of TGF-beta responses
-
Derynck R, Zhang Y and Feng XH: Smads: transcriptional activators of TGF-beta responses. Cell 95: 737-740, 1998.
-
(1998)
Cell
, vol.95
, pp. 737-740
-
-
Derynck, R.1
Zhang, Y.2
Feng, X.H.3
-
17
-
-
0031685620
-
TGF-beta signal transduction
-
Massagué J: TGF-beta signal transduction. Annu Rev Biochem 67: 753-791, 1998.
-
(1998)
Annu Rev Biochem
, vol.67
, pp. 753-791
-
-
Massagué, J.1
-
19
-
-
0029834067
-
Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways
-
Lagna G, Hata A, Hemmati-Brivanlou A and Massagué J: Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways. Nature 383: 832-836, 1996.
-
(1996)
Nature
, vol.383
, pp. 832-836
-
-
Lagna, G.1
Hata, A.2
Hemmati-Brivanlou, A.3
Massagué, J.4
-
20
-
-
0030768644
-
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4
-
Nakao A, Imamura T, Souchelnytskyi S, et al: TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J 16: 5353-5362, 1997.
-
(1997)
EMBO J
, vol.16
, pp. 5353-5362
-
-
Nakao, A.1
Imamura, T.2
Souchelnytskyi, S.3
-
21
-
-
0031438047
-
TGF-beta signalling from cell membrane to nucleus through SMAD proteins
-
Heldin CH, Miyazono K and ten Dijke P: TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 390: 465-471, 1997.
-
(1997)
Nature
, vol.390
, pp. 465-471
-
-
Heldin, C.H.1
Miyazono, K.2
Ten Dijke, P.3
-
22
-
-
33745515023
-
Tumour microenvironment: TGFbeta: The molecular Jekyll and Hyde of cancer
-
Bierie B and Moses HL: Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer. Nat Rev Cancer 6: 506-520, 2006.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 506-520
-
-
Bierie, B.1
Moses, H.L.2
-
23
-
-
0034704753
-
Betaglycan binds inhibin and can mediate functional antagonism of activin signalling
-
Lewis KA, Gray PC, Blount AL, et al: Betaglycan binds inhibin and can mediate functional antagonism of activin signalling. Nature 404: 411-414, 2000.
-
(2000)
Nature
, vol.404
, pp. 411-414
-
-
Lewis, K.A.1
Gray, P.C.2
Blount, A.L.3
-
24
-
-
0028170226
-
Mechanism of activation of the TGF-beta receptor
-
Wrana JL, Attisano L, Wieser R, Ventura F and Massagué J: Mechanism of activation of the TGF-beta receptor. Nature 370: 341-347, 1994.
-
(1994)
Nature
, vol.370
, pp. 341-347
-
-
Wrana, J.L.1
Attisano, L.2
Wieser, R.3
Ventura, F.4
Massagué, J.5
-
25
-
-
0038682002
-
Mechanisms of TGF-beta signaling from cell membrane to the nucleus
-
Shi Y and Massagué J: Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113: 685-700, 2003.
-
(2003)
Cell
, vol.113
, pp. 685-700
-
-
Shi, Y.1
Massagué, J.2
-
26
-
-
21344455768
-
BMP receptor signaling: Transcriptional targets, regulation of signals, and signaling cross-talk
-
Miyazono K, Maeda S and Imamura T: BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk. Cytokine Growth Factor Rev 16: 251-263, 2005.
-
(2005)
Cytokine Growth Factor Rev
, vol.16
, pp. 251-263
-
-
Miyazono, K.1
Maeda, S.2
Imamura, T.3
-
27
-
-
0142104985
-
Smad-dependent and Smad-independent pathways in TGF-beta family signalling
-
Derynck R and Zhang YE: Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425: 577-584, 2003.
-
(2003)
Nature
, vol.425
, pp. 577-584
-
-
Derynck, R.1
Zhang, Y.E.2
-
28
-
-
0030613249
-
TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling
-
Abdollah S, Macías-Silva M, Tsukazaki T, Hayashi H, Attisano L and Wrana JL: TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling. J Biol Chem 272: 27678-27685, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 27678-27685
-
-
Abdollah, S.1
Macías-Silva, M.2
Tsukazaki, T.3
Hayashi, H.4
Attisano, L.5
Wrana, J.L.6
-
29
-
-
0029786212
-
Receptor-associated Mad homologues synergize as effectors of the TGF-beta response
-
Zhang Y, Feng X, We R and Derynck R: Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. Nature 383: 168-172, 1996.
-
(1996)
Nature
, vol.383
, pp. 168-172
-
-
Zhang, Y.1
Feng, X.2
We, R.3
Derynck, R.4
-
30
-
-
0032428684
-
SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor
-
Tsukazaki T, Chiang TA, Davison AF, Attisano L and Wrana JL: SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. Cell 95: 779-791, 1998.
-
(1998)
Cell
, vol.95
, pp. 779-791
-
-
Tsukazaki, T.1
Chiang, T.A.2
Davison, A.F.3
Attisano, L.4
Wrana, J.L.5
-
31
-
-
0032528236
-
The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation
-
Feng XH, Zhang Y, Wu RY and Derynck R: The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation. Genes Dev 12: 2153-2163, 1998.
-
(1998)
Genes Dev
, vol.12
, pp. 2153-2163
-
-
Feng, X.H.1
Zhang, Y.2
Wu, R.Y.3
Derynck, R.4
-
32
-
-
0032527756
-
TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300
-
Janknecht R, Wells NJ and Hunter T: TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300. Genes Dev 12: 2114-2119, 1998.
-
(1998)
Genes Dev
, vol.12
, pp. 2114-2119
-
-
Janknecht, R.1
Wells, N.J.2
Hunter, T.3
-
33
-
-
0034326828
-
The transcriptional co-activator P/CAF potentiates TGF-beta/Smad signaling
-
Itoh S, Ericsson J, Nishikawa J, Heldin CH and ten Dijke P: The transcriptional co-activator P/CAF potentiates TGF-beta/Smad signaling. Nucleic Acids Res 28: 4291-4298, 2000.
-
(2000)
Nucleic Acids Res
, vol.28
, pp. 4291-4298
-
-
Itoh, S.1
Ericsson, J.2
Nishikawa, J.3
Heldin, C.H.4
Ten Dijke, P.5
-
34
-
-
0036119191
-
SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling
-
Bai RY, Koester C, Ouyang T, et al: SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling. Nat Cell Biol 4: 181-190, 2002.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 181-190
-
-
Bai, R.Y.1
Koester, C.2
Ouyang, T.3
-
35
-
-
0037067653
-
E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression
-
Chen CR, Kang Y, Siegel PM and Massagué J: E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression. Cell 110: 19-32, 2002.
-
(2002)
Cell
, vol.110
, pp. 19-32
-
-
Chen, C.R.1
Kang, Y.2
Siegel, P.M.3
Massagué, J.4
-
36
-
-
0038369998
-
A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells
-
Kang Y, Chen CR and Massagué J: A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol Cell 11: 915-926, 2003.
-
(2003)
Mol Cell
, vol.11
, pp. 915-926
-
-
Kang, Y.1
Chen, C.R.2
Massagué, J.3
-
37
-
-
0034800012
-
The Smad transcriptional corepressor TGIF recruits mSin3
-
Wotton D, Knoepfler PS, Laherty CD, Eisenman RN and Massagué J: The Smad transcriptional corepressor TGIF recruits mSin3. Cell Growth Differ 12: 457-463, 2001.
-
(2001)
Cell Growth Differ
, vol.12
, pp. 457-463
-
-
Wotton, D.1
Knoepfler, P.S.2
Laherty, C.D.3
Eisenman, R.N.4
Massagué, J.5
-
38
-
-
0033521032
-
c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads
-
Akiyoshi S, Inoue H, Hanai J, et al: c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads. J Biol Chem 274: 35269-35277, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 35269-35277
-
-
Akiyoshi, S.1
Inoue, H.2
Hanai, J.3
-
39
-
-
0033200361
-
The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling
-
Luo K, Stroschein SL, Wang W, et al: The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling. Genes Dev 13: 2196-2206, 1999.
-
(1999)
Genes Dev
, vol.13
, pp. 2196-2206
-
-
Luo, K.1
Stroschein, S.L.2
Wang, W.3
-
40
-
-
0033595704
-
Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein
-
Stroschein SL, Wang W, Zhou S, Zhou Q and Luo K: Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein. Science 286: 771-774, 1999.
-
(1999)
Science
, vol.286
, pp. 771-774
-
-
Stroschein, S.L.1
Wang, W.2
Zhou, S.3
Zhou, Q.4
Luo, K.5
-
41
-
-
0033213606
-
Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling
-
Sun Y, Liu X, Eaton EN, Lane WS, Lodish HF and Weinberg RA: Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling. Mol Cell 4: 499-509, 1999.
-
(1999)
Mol Cell
, vol.4
, pp. 499-509
-
-
Sun, Y.1
Liu, X.2
Eaton, E.N.3
Lane, W.S.4
Lodish, H.F.5
Weinberg, R.A.6
-
42
-
-
1642332084
-
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
-
Seoane J, Le HV, Shen L, Anderson SA and Massagué J: Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell 117: 211-223, 2004.
-
(2004)
Cell
, vol.117
, pp. 211-223
-
-
Seoane, J.1
Le, H.V.2
Shen, L.3
Anderson, S.A.4
Massagué, J.5
-
43
-
-
0034703083
-
Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta
-
Pardali K, Kurisaki A, Morén A, ten Dijke P, Kardassis D and Moustakas A: Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta. J Biol Chem 275: 29244-29256, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 29244-29256
-
-
Pardali, K.1
Kurisaki, A.2
Morén, A.3
Ten Dijke, P.4
Kardassis, D.5
Moustakas, A.6
-
44
-
-
0032572723
-
Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription
-
Zhang Y, Feng XH and Derynck R: Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature 394: 909-913, 1998.
-
(1998)
Nature
, vol.394
, pp. 909-913
-
-
Zhang, Y.1
Feng, X.H.2
Derynck, R.3
-
45
-
-
0344629431
-
Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription
-
Lin X, Liang YY, Sun B, et al: Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription. Mol Cell Biol 23: 9081-9093, 2003.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 9081-9093
-
-
Lin, X.1
Liang, Y.Y.2
Sun, B.3
-
46
-
-
84888855943
-
Sertad1 encodes a novel transcriptional co-activator of SMAD1 in mouse embryonic hearts
-
Peng Y, Zhao S, Song L, Wang M and Jiao K: Sertad1 encodes a novel transcriptional co-activator of SMAD1 in mouse embryonic hearts. Biochem Biophys Res Commun 441: 751-756, 2013.
-
(2013)
Biochem Biophys Res Commun
, vol.441
, pp. 751-756
-
-
Peng, Y.1
Zhao, S.2
Song, L.3
Wang, M.4
Jiao, K.5
-
47
-
-
0035353203
-
The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling
-
Izutsu K, Kurokawa M, Imai Y, Maki K, Mitani K and Hirai H: The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling. Blood 97: 2815-2822, 2001.
-
(2001)
Blood
, vol.97
, pp. 2815-2822
-
-
Izutsu, K.1
Kurokawa, M.2
Imai, Y.3
Maki, K.4
Mitani, K.5
Hirai, H.6
-
48
-
-
84455167662
-
A poised chromatin platform for TGF-β access to master regulators
-
Xi Q, Wang Z, Zaromytidou AI, et al: A poised chromatin platform for TGF-β access to master regulators. Cell 147: 1511-1524, 2011.
-
(2011)
Cell
, vol.147
, pp. 1511-1524
-
-
Xi, Q.1
Wang, Z.2
Zaromytidou, A.I.3
-
49
-
-
33749344476
-
Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription
-
Ross S, Cheung E, Petrakis TG, Howell M, Kraus WL and Hill CS: Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription. EMBO J 25: 4490-4502, 2006.
-
(2006)
EMBO J
, vol.25
, pp. 4490-4502
-
-
Ross, S.1
Cheung, E.2
Petrakis, T.G.3
Howell, M.4
Kraus, W.L.5
Hill, C.S.6
-
50
-
-
76249084838
-
Smad signaling is required to maintain epigenetic silencing during breast cancer progression
-
Papageorgis P, Lambert AW, Ozturk S, et al: Smad signaling is required to maintain epigenetic silencing during breast cancer progression. Cancer Res 70: 968-978, 2010.
-
(2010)
Cancer Res
, vol.70
, pp. 968-978
-
-
Papageorgis, P.1
Lambert, A.W.2
Ozturk, S.3
-
51
-
-
0030611757
-
Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling
-
Nakao A, Afrakhte M, Morén A, et al: Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling. Nature 389: 631-635, 1997.
-
(1997)
Nature
, vol.389
, pp. 631-635
-
-
Nakao, A.1
Afrakhte, M.2
Morén, A.3
-
52
-
-
0032582672
-
Transforming growth factor beta1 induces nuclear export of inhibitory Smad7
-
Itóh S, Landström M, Hermansson A, et al: Transforming growth factor beta1 induces nuclear export of inhibitory Smad7. J Biol Chem 273: 29195-29201, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 29195-29201
-
-
Itóh, S.1
Landström, M.2
Hermansson, A.3
-
53
-
-
0031587828
-
The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling
-
Hayashi H, Abdollah S, Qiu Y, et al: The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling. Cell 89: 1165-1173, 1997.
-
(1997)
Cell
, vol.89
, pp. 1165-1173
-
-
Hayashi, H.1
Abdollah, S.2
Qiu, Y.3
-
54
-
-
0035918274
-
Smurf1 interacts with transforming growth factor-beta type I Receptor through Smad7 and induces receptor degradation
-
Ebisawa T, Fukuchi M, Murakami G, et al: Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. J Biol Chem 276: 12477-12480, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 12477-12480
-
-
Ebisawa, T.1
Fukuchi, M.2
Murakami, G.3
-
55
-
-
0034517389
-
Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation
-
Kavsak P, Rasmussen RK, Causing CG, et al: Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation. Mol Cell 6: 1365-1375, 2000.
-
(2000)
Mol Cell
, vol.6
, pp. 1365-1375
-
-
Kavsak, P.1
Rasmussen, R.K.2
Causing, C.G.3
-
56
-
-
34250203586
-
Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation
-
Zhang S, Fei T, Zhang L, et al: Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation. Mol Cell Biol 27: 4488-4499, 2007.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 4488-4499
-
-
Zhang, S.1
Fei, T.2
Zhang, L.3
-
57
-
-
58149213801
-
Non-Smad pathways in TGF-beta signaling
-
Zhang YE: Non-Smad pathways in TGF-beta signaling. Cell Res 19: 128-139, 2009.
-
(2009)
Cell Res
, vol.19
, pp. 128-139
-
-
Zhang, Y.E.1
-
58
-
-
0028937610
-
Transforming growth factor beta activation of p44mapk in proliferating cultures of epithelial cells
-
Hartsough MT and Mulder KM: Transforming growth factor beta activation of p44mapk in proliferating cultures of epithelial cells. J Biol Chem 270: 7117-7124, 1995.
-
(1995)
J Biol Chem
, vol.270
, pp. 7117-7124
-
-
Hartsough, M.T.1
Mulder, K.M.2
-
59
-
-
0030609939
-
TGFbeta regulation of mitogen-activated protein kinases in human breast cancer cells
-
Frey RS and Mulder KM: TGFbeta regulation of mitogen-activated protein kinases in human breast cancer cells. Cancer Lett 117: 41-50, 1997.
-
(1997)
Cancer Lett
, vol.117
, pp. 41-50
-
-
Frey, R.S.1
Mulder, K.M.2
-
60
-
-
79551605347
-
Smad4 inactivation promotes malignancy and drug resistance of colon cancer
-
Papageorgis P, Cheng K, Ozturk S, et al: Smad4 inactivation promotes malignancy and drug resistance of colon cancer. Cancer Res 71: 998-1008, 2011.
-
(2011)
Cancer Res
, vol.71
, pp. 998-1008
-
-
Papageorgis, P.1
Cheng, K.2
Ozturk, S.3
-
61
-
-
0034623147
-
Transforming growth factor-beta 1-induced activation of the ERK pathway/activator protein-1 in human lung fibroblasts requires the autocrine induction of basic fibroblast growth factor
-
Finlay GA, Thannickal VJ, Fanburg BL and Paulson KE: Transforming growth factor-beta 1-induced activation of the ERK pathway/activator protein-1 in human lung fibroblasts requires the autocrine induction of basic fibroblast growth factor. J Biol Chem 275: 27650-27656, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 27650-27656
-
-
Finlay, G.A.1
Thannickal, V.J.2
Fanburg, B.L.3
Paulson, K.E.4
-
62
-
-
0034791087
-
Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling
-
Vinals F andPouysségur J: Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling. Mol Cell Biol 21: 7218-7230, 2001.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 7218-7230
-
-
Vinals, F.1
Pouysségur, J.2
-
63
-
-
0035872426
-
Transforming growth factor beta1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation
-
Ellenrieder V, Hendler SF, Boeck W, et al: Transforming growth factor beta1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation. Cancer Res 61: 4222-4228, 2001.
-
(2001)
Cancer Res
, vol.61
, pp. 4222-4228
-
-
Ellenrieder, V.1
Hendler, S.F.2
Boeck, W.3
-
64
-
-
6944248910
-
Activation of the Erk pathway is required for TGF-beta1-induced EMT in vitro
-
Xie L, Law BK, Chytil AM, Brown KA, Aakre ME and Moses HL: Activation of the Erk pathway is required for TGF-beta1-induced EMT in vitro. Neoplasia 6: 603-610, 2004.
-
(2004)
Neoplasia
, vol.6
, pp. 603-610
-
-
Xie, L.1
Law, B.K.2
Chytil, A.M.3
Brown, K.A.4
Aakre, M.E.5
Moses, H.L.6
-
65
-
-
34548386720
-
TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA
-
Lee MK, Pardoux C, Hall MC, et al: TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA. EMJO J 26: 3957-3967, 2007.
-
(2007)
EMJO J
, vol.26
, pp. 3957-3967
-
-
Lee, M.K.1
Pardoux, C.2
Hall, M.C.3
-
66
-
-
0035378992
-
The involvement of p38 MAPK in transforming growth factor beta1-induced apoptosis in murine hepatocytes
-
Liao JH, Chen JS, Chai MQ, Zhao S and Song JG: The involvement of p38 MAPK in transforming growth factor beta1-induced apoptosis in murine hepatocytes. Cell Res 11: 89-94, 2001.
-
(2001)
Cell Res
, vol.11
, pp. 89-94
-
-
Liao, J.H.1
Chen, J.S.2
Chai, M.Q.3
Zhao, S.4
Song, J.G.5
-
67
-
-
0034625342
-
BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6
-
Kimura N, Matsuo R, Shibuya H, Nakashima K and Taga T: BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6. J Biol Chem 275: 17647-17652, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 17647-17652
-
-
Kimura, N.1
Matsuo, R.2
Shibuya, H.3
Nakashima, K.4
Taga, T.5
-
68
-
-
0036674213
-
p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration
-
Bakin AV, Rinehart C, Tomlinson AK and Arteaga CL: p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration. J Cell Sci 115: 3193-3206, 2002.
-
(2002)
J Cell Sci
, vol.115
, pp. 3193-3206
-
-
Bakin, A.V.1
Rinehart, C.2
Tomlinson, A.K.3
Arteaga, C.L.4
-
69
-
-
0033104505
-
TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway
-
Hocevar BA, Brown TL and Howe PH: TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway. EMJO J 18: 1345-1356, 1999.
-
(1999)
EMJO J
, vol.18
, pp. 1345-1356
-
-
Hocevar, B.A.1
Brown, T.L.2
Howe, P.H.3
-
70
-
-
0037099745
-
TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses
-
Yu L, Hébert MC and Zhang YE: TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses. EMJO J 21: 3749-3759, 2002.
-
(2002)
EMJO J
, vol.21
, pp. 3749-3759
-
-
Yu, L.1
Hébert, M.C.2
Zhang, Y.E.3
-
71
-
-
0029551805
-
Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction
-
Yamaguchi K, Shirakabe K, Shibuya H, et al: Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science 270: 2008-2011, 1995.
-
(1995)
Science
, vol.270
, pp. 2008-2011
-
-
Yamaguchi, K.1
Shirakabe, K.2
Shibuya, H.3
-
72
-
-
27744577296
-
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
-
Shim JH, Xiao C, Paschal AE, et al: TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev 19: 2668-2681, 2005.
-
(2005)
Genes Dev
, vol.19
, pp. 2668-2681
-
-
Shim, J.H.1
Xiao, C.2
Paschal, A.E.3
-
73
-
-
53349164136
-
The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner
-
Sorrentino A, Thakur N, Grimsby S, et al: The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner. Nat Cell Biol 10: 1199-1207, 2008.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 1199-1207
-
-
Sorrentino, A.1
Thakur, N.2
Grimsby, S.3
-
74
-
-
52049111663
-
TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta
-
Yamashita M, Fatyol K, Jin C, Wang X, Liu Z and Zhang YE: TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta. Mol Cell 31: 918-924, 2008.
-
(2008)
Mol Cell
, vol.31
, pp. 918-924
-
-
Yamashita, M.1
Fatyol, K.2
Jin, C.3
Wang, X.4
Liu, Z.5
Zhang, Y.E.6
-
75
-
-
0042237016
-
A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure
-
Zhang L, Wang W, Hayashi Y, et al: A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure. EMJO J 22: 4443-4454, 2003.
-
(2003)
EMJO J
, vol.22
, pp. 4443-4454
-
-
Zhang, L.1
Wang, W.2
Hayashi, Y.3
-
76
-
-
3142741044
-
Mixed lineage kinase 3 (MLK3)-activated p38 MAP kinase mediates transforming growth factor-beta-induced apoptosis in hepatoma cells
-
Kim KY, Kim BC, Xu Z and Kim SJ: Mixed lineage kinase 3 (MLK3)-activated p38 MAP kinase mediates transforming growth factor-beta-induced apoptosis in hepatoma cells. J Biol Chem 279: 29478-29484, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 29478-29484
-
-
Kim, K.Y.1
Kim, B.C.2
Xu, Z.3
Kim, S.J.4
-
77
-
-
27944479854
-
Rho GTPases: Biochemistry and biology
-
Jaffe AB and Hall A: Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 21: 247-269, 2005.
-
(2005)
Annu Rev Cell Dev Biol
, vol.21
, pp. 247-269
-
-
Jaffe, A.B.1
Hall, A.2
-
78
-
-
0035185853
-
Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism
-
Bhowmick NA, Ghiassi M, Bakin A, et al: Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol Biol Cell 12: 27-36, 2001.
-
(2001)
Mol Biol Cell
, vol.12
, pp. 27-36
-
-
Bhowmick, N.A.1
Ghiassi, M.2
Bakin, A.3
-
79
-
-
0036197606
-
Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA
-
Edlund S, Landström M, Heldin CH and Aspenström P: Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA. Mol Biol Cell 13: 902-914, 2002.
-
(2002)
Mol Biol Cell
, vol.13
, pp. 902-914
-
-
Edlund, S.1
Landström, M.2
Heldin, C.H.3
Aspenström, P.4
-
80
-
-
14844364701
-
Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity
-
Ozdamar B, Bose R, Barrios-Rodiles M, Wang HR, Zhang Y and Wrana JL: Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science307: 1603-1609, 2005.
-
(2005)
Science
, vol.307
, pp. 1603-1609
-
-
Ozdamar, B.1
Bose, R.2
Barrios-Rodiles, M.3
Wang, H.R.4
Zhang, Y.5
Wrana, J.L.6
-
81
-
-
0034711307
-
Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration
-
Bakin AV, Tomlinson AK, Bhowmick NA, Moses HL and Arteaga CL: Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration. J Biol Chem 275: 36803-36810, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 36803-36810
-
-
Bakin, A.V.1
Tomlinson, A.K.2
Bhowmick, N.A.3
Moses, H.L.4
Arteaga, C.L.5
-
82
-
-
0035196587
-
Transforming growth factor beta enhances epithelial cell survival via Akt-dependent regulation of FKHRL1
-
Shin I, Bakin AV, Rodeck U, Brunet A and Arteaga CL: Transforming growth factor beta enhances epithelial cell survival via Akt-dependent regulation of FKHRL1. Mol Biol Cell 12: 3328-3339, 2001.
-
(2001)
Mol Biol Cell
, vol.12
, pp. 3328-3339
-
-
Shin, I.1
Bakin, A.V.2
Rodeck, U.3
Brunet, A.4
Arteaga, C.L.5
-
83
-
-
0034722888
-
The rapamycin-sensitive signal transduction pathway as a target for cancer therapy
-
Hidalgo M and Rowinsky EK: The rapamycin-sensitive signal transduction pathway as a target for cancer therapy. Oncogene 19: 6680-6686, 2000.
-
(2000)
Oncogene
, vol.19
, pp. 6680-6686
-
-
Hidalgo, M.1
Rowinsky, E.K.2
-
84
-
-
34547587877
-
Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway
-
Lamouille S and Derynck R: Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway. J Cell Biol 178: 437-451, 2007.
-
(2007)
J Cell Biol
, vol.178
, pp. 437-451
-
-
Lamouille, S.1
Derynck, R.2
-
85
-
-
0042307513
-
The two faces of transforming growth factor beta in carcinogenesis
-
Roberts AB and Wakefield LM: The two faces of transforming growth factor beta in carcinogenesis. Proc Natl Acad Sci USA 100: 8621-8623, 2003.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 8621-8623
-
-
Roberts, A.B.1
Wakefield, L.M.2
-
86
-
-
0242285692
-
TGF-beta switches from tumor suppressor to prometastatic factor in a model of breast cancer progression
-
Tang B, Vu M, Booker T, et al: TGF-beta switches from tumor suppressor to prometastatic factor in a model of breast cancer progression. J Clin Invest 112: 1116-1124, 2003.
-
(2003)
J Clin Invest
, vol.112
, pp. 1116-1124
-
-
Tang, B.1
Vu, M.2
Booker, T.3
-
87
-
-
0036467496
-
TGF-beta signaling: Positive and negative effects on tumorigenesis
-
Wakefield LM and Roberts AB: TGF-beta signaling: positive and negative effects on tumorigenesis. Curr Opin Genet Dev 12: 22-29, 2002.
-
(2002)
Curr Opin Genet Dev
, vol.12
, pp. 22-29
-
-
Wakefield, L.M.1
Roberts, A.B.2
-
88
-
-
0037816160
-
Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis
-
Siegel PM, Shu W, Cardiff RD, Muller WJ and Massagué J: Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis. Proc Natl Acad Sci USA 100: 8430-8435, 2003.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 8430-8435
-
-
Siegel, P.M.1
Shu, W.2
Cardiff, R.D.3
Muller, W.J.4
Massagué, J.5
-
89
-
-
0242499448
-
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer
-
Siegel PM and Massagué J: Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat Rev Cancer 3: 807-821, 2003.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 807-821
-
-
Siegel, P.M.1
Massagué, J.2
-
90
-
-
0029098259
-
Inhibition of capillary morphogenesis and associated apoptosis by dominant negative mutant transforming growth factor-beta receptors
-
Choi ME and Ballermann BJ: Inhibition of capillary morphogenesis and associated apoptosis by dominant negative mutant transforming growth factor-beta receptors. J Biol Chem 270: 21144-21150, 1995.
-
(1995)
J Biol Chem
, vol.270
, pp. 21144-21150
-
-
Choi, M.E.1
Ballermann, B.J.2
-
91
-
-
0036674283
-
Transforming growth factor-beta1 induces apoptosis in vascular endothelial cells by activation of mitogen-activated protein kinase
-
Hyman KM, Seghezzi G, Pintucci G, et al: Transforming growth factor-beta1 induces apoptosis in vascular endothelial cells by activation of mitogen-activated protein kinase. Surgery 132: 173-179, 2002.
-
(2002)
Surgery
, vol.132
, pp. 173-179
-
-
Hyman, K.M.1
Seghezzi, G.2
Pintucci, G.3
-
92
-
-
0033521118
-
Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines
-
Rich JN, Zhang M, Datto MB, Bigner DD and Wang XF: Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines. J Biol Chem 274: 35053-35058, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 35053-35058
-
-
Rich, J.N.1
Zhang, M.2
Datto, M.B.3
Bigner, D.D.4
Wang, X.F.5
-
93
-
-
0033104503
-
Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta
-
Yang X, Letterio JJ, Lechleider RJ, et al: Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta. EMJO J 18: 1280-1291, 1999.
-
(1999)
EMJO J
, vol.18
, pp. 1280-1291
-
-
Yang, X.1
Letterio, J.J.2
Lechleider, R.J.3
-
94
-
-
0025326725
-
Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation
-
Laiho M, DeCaprio JA, Ludlow JW, Livingston DM and Massagué J: Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation. Cell 62: 175-185, 1990.
-
(1990)
Cell
, vol.62
, pp. 175-185
-
-
Laiho, M.1
DeCaprio, J.A.2
Ludlow, J.W.3
Livingston, D.M.4
Massagué, J.5
-
95
-
-
0028168242
-
p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest
-
Hannon GJ and Beach D: p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature 371: 257-261, 1994.
-
(1994)
Nature
, vol.371
, pp. 257-261
-
-
Hannon, G.J.1
Beach, D.2
-
96
-
-
0029073142
-
Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism
-
Datto MB, Li Y, Panus JF, Howe DJ, Xiong Y and Wang XF: Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc Natl Acad Sci USA 92: 5545-5549, 1995.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 5545-5549
-
-
Datto, M.B.1
Li, Y.2
Panus, J.F.3
Howe, D.J.4
Xiong, Y.5
Wang, X.F.6
-
97
-
-
0028179669
-
p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest
-
Polyak K, Kato JY, Solomon MJ, et al: p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev 8: 9-22, 1994.
-
(1994)
Genes Dev
, vol.8
, pp. 9-22
-
-
Polyak, K.1
Kato, J.Y.2
Solomon, M.J.3
-
98
-
-
0025348820
-
TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains
-
Pietenpol JA, Stein RW, Moran E, et al: TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains. Cell 61: 777-785, 1990.
-
(1990)
Cell
, vol.61
, pp. 777-785
-
-
Pietenpol, J.A.1
Stein, R.W.2
Moran, E.3
-
99
-
-
0034471262
-
ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis
-
Norton JD: ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis. J Cell Sci 113: 3897-3905, 2000.
-
(2000)
J Cell Sci
, vol.113
, pp. 3897-3905
-
-
Norton, J.D.1
-
100
-
-
0031225015
-
Connective tissue growth factor: A mediator of TGF-beta action on fibroblasts
-
Grotendorst GR: Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts. Cytokine Growth Factor Rev 8: 171-179, 1997.
-
(1997)
Cytokine Growth Factor Rev
, vol.8
, pp. 171-179
-
-
Grotendorst, G.R.1
-
101
-
-
0028556486
-
Genetic changes in the transforming growth factor beta (TGF-beta) type II receptor gene in human gastric cancer cells: Correlation with sensitivity to growth inhibition by TGF-beta
-
Park K, Kim SJ, Bang YJ, et al: Genetic changes in the transforming growth factor beta (TGF-beta) type II receptor gene in human gastric cancer cells: correlation with sensitivity to growth inhibition by TGF-beta. Proc Natl Acad Sci USA 91: 8772-8776, 1994.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 8772-8776
-
-
Park, K.1
Kim, S.J.2
Bang, Y.J.3
-
102
-
-
0030048263
-
Genetic change in transforming growth factor beta (TGF-beta) receptor type I gene correlates with insensitivity to TGF-beta 1 in human prostate cancer cells
-
Kim IY, Ahn HJ, Zelner DJ, et al: Genetic change in transforming growth factor beta (TGF-beta) receptor type I gene correlates with insensitivity to TGF-beta 1 in human prostate cancer cells. Cancer Res 56: 44-48, 1996.
-
(1996)
Cancer Res
, vol.56
, pp. 44-48
-
-
Kim, I.Y.1
Ahn, H.J.2
Zelner, D.J.3
-
103
-
-
0029066689
-
Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability
-
Markowitz S, Wang J, Myeroff L, et al: Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science 268: 1336-1338, 1995.
-
(1995)
Science
, vol.268
, pp. 1336-1338
-
-
Markowitz, S.1
Wang, J.2
Myeroff, L.3
-
106
-
-
16044369574
-
MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma
-
Eppert K, Scherer SW, Ozcelik H, et al: MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell 86: 543-552, 1996.
-
(1996)
Cell
, vol.86
, pp. 543-552
-
-
Eppert, K.1
Scherer, S.W.2
Ozcelik, H.3
-
107
-
-
9044243025
-
Homozygous deletion map at 18q21.1 in pancreatic cancer
-
Hahn SA, Hoque AT, Moskaluk CA, et al: Homozygous deletion map at 18q21.1 in pancreatic cancer. Cancer Res 56: 490-494, 1996.
-
(1996)
Cancer Res
, vol.56
, pp. 490-494
-
-
Hahn, S.A.1
Hoque, A.T.2
Moskaluk, C.A.3
-
108
-
-
0030593038
-
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
-
Hahn SA, Schutte M, Hoque AT, et al: DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271: 350-353, 1996.
-
(1996)
Science
, vol.271
, pp. 350-353
-
-
Hahn, S.A.1
Schutte, M.2
Hoque, A.T.3
-
109
-
-
15844390729
-
Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers
-
Thiagalingam S, Lengauer C, Leach FS, et al: Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers. Nat Genet 13: 343-346, 1996.
-
(1996)
Nat Genet
, vol.13
, pp. 343-346
-
-
Thiagalingam, S.1
Lengauer, C.2
Leach, F.S.3
-
110
-
-
12944315074
-
Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis
-
Schwarte-Waldhoff I, Volpert OV, Bouck NP, et al: Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis. Proc Natl Acad Sci USA 97: 9624-9629, 2000.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 9624-9629
-
-
Schwarte-Waldhoff, I.1
Volpert, O.V.2
Bouck, N.P.3
-
111
-
-
0033106484
-
A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras
-
Kretzschmar M, Doody J, Timokhina I and Massagué J: A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras. Genes Dev 13: 804-816, 1999.
-
(1999)
Genes Dev
, vol.13
, pp. 804-816
-
-
Kretzschmar, M.1
Doody, J.2
Timokhina, I.3
Massagué, J.4
-
112
-
-
0030773834
-
Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1
-
Kretzschmar M, Doody J and Massagué J: Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1. Nature 389: 618-622, 1997.
-
(1997)
Nature
, vol.389
, pp. 618-622
-
-
Kretzschmar, M.1
Doody, J.2
Massagué, J.3
-
113
-
-
0347991862
-
Integration of Smad and MAPK pathways: A link and a linker revisited
-
Massagué J: Integration of Smad and MAPK pathways: a link and a linker revisited. Genes Dev 17: 2993-2997, 2003.
-
(2003)
Genes Dev
, vol.17
, pp. 2993-2997
-
-
Massagué, J.1
-
114
-
-
33748208668
-
C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells
-
Gomis RR, Alarcón C, Nadal C, Van Poznak C and Massagué J: C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells. Cancer Cell 10: 203-214, 2006.
-
(2006)
Cancer Cell
, vol.10
, pp. 203-214
-
-
Gomis, R.R.1
Alarcón, C.2
Nadal, C.3
Van Poznak, C.4
Massagué, J.5
-
115
-
-
41149157649
-
TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4
-
Padua D, Zhang XH, Wang Q, et al: TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell 133: 66-77, 2008.
-
(2008)
Cell
, vol.133
, pp. 66-77
-
-
Padua, D.1
Zhang, X.H.2
Wang, Q.3
-
116
-
-
0036595629
-
Epithelial-mesenchymal transitions in tumour progression
-
Thiery JP: Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2: 442-454, 2002.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 442-454
-
-
Thiery, J.P.1
-
117
-
-
2942707848
-
Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
-
Yang J, Mani SA, Donaher JL, et al: Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 117: 927-939, 2004.
-
(2004)
Cell
, vol.117
, pp. 927-939
-
-
Yang, J.1
Mani, S.A.2
Donaher, J.L.3
-
118
-
-
59449090107
-
TGF-beta-induced epithelial to mesenchymal transition
-
Xu J, Lamouille S and Derynck R: TGF-beta-induced epithelial to mesenchymal transition. Cell Res 19: 156-172, 2009.
-
(2009)
Cell Res
, vol.19
, pp. 156-172
-
-
Xu, J.1
Lamouille, S.2
Derynck, R.3
-
119
-
-
0033784843
-
The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
-
Cano A, Pérez-Moreno MA, Rodrigo I, et al: The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2: 76-83, 2000.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 76-83
-
-
Cano, A.1
Pérez-Moreno, M.A.2
Rodrigo, I.3
-
120
-
-
0031005659
-
The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition
-
Savagner P, Yamada KM and Thiery JP: The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. J Cell Biol 137: 1403-1419, 1997.
-
(1997)
J Cell Biol
, vol.137
, pp. 1403-1419
-
-
Savagner, P.1
Yamada, K.M.2
Thiery, J.P.3
-
121
-
-
20144388095
-
DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells
-
Eger A, Aigner K, Sonderegger S, et al: DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells. Oncogene 24: 2375-2385, 2005.
-
(2005)
Oncogene
, vol.24
, pp. 2375-2385
-
-
Eger, A.1
Aigner, K.2
Sonderegger, S.3
-
122
-
-
0034964418
-
The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion
-
Comijn J, Berx G, Vermassen P, et al: The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol Cell 7: 1267-1278, 2001.
-
(2001)
Mol Cell
, vol.7
, pp. 1267-1278
-
-
Comijn, J.1
Berx, G.2
Vermassen, P.3
-
123
-
-
33746034613
-
Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition
-
Thuault S, Valcourt U, Petersen M, Manfioletti G, Heldin CH and Moustakas A: Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition. J Cell Biol 174: 175-183, 2006.
-
(2006)
J Cell Biol
, vol.174
, pp. 175-183
-
-
Thuault, S.1
Valcourt, U.2
Petersen, M.3
Manfioletti, G.4
Heldin, C.H.5
Moustakas, A.6
-
124
-
-
34547141894
-
Mesenchyme forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers
-
Mani SA, Yang J, Brooks M, et al: Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc Natl Acad Sci USA 104: 10069-10074, 2007.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 10069-10074
-
-
Mani, S.A.1
Yang, J.2
Brooks, M.3
-
125
-
-
0034785348
-
TGF-beta signaling in tumor suppression and cancer progression
-
Derynck R, Akhurst RJ and Balmain A: TGF-beta signaling in tumor suppression and cancer progression. Nat Genet 29: 117-129, 2001.
-
(2001)
Nat Genet
, vol.29
, pp. 117-129
-
-
Derynck, R.1
Akhurst, R.J.2
Balmain, A.3
-
126
-
-
44449144396
-
Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis
-
Yang J and Weinberg RA: Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell 14: 818-829, 2008.
-
(2008)
Dev Cell
, vol.14
, pp. 818-829
-
-
Yang, J.1
Weinberg, R.A.2
-
127
-
-
33749017960
-
Prohibitin and cofilin are intracellular effectors of transforming growth factor beta signaling in human prostate cancer cells
-
Zhu B, Fukada K, Zhu H and Kyprianou N: Prohibitin and cofilin are intracellular effectors of transforming growth factor beta signaling in human prostate cancer cells. Cancer Res 66: 8640-8647, 2006.
-
(2006)
Cancer Res
, vol.66
, pp. 8640-8647
-
-
Zhu, B.1
Fukada, K.2
Zhu, H.3
Kyprianou, N.4
-
128
-
-
33644534795
-
The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells
-
Deckers M, van Dinther M, Buijs J, et al: The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells. Cancer Res 66: 2202-2209, 2006.
-
(2006)
Cancer Res
, vol.66
, pp. 2202-2209
-
-
Deckers, M.1
Van Dinther, M.2
Buijs, J.3
-
129
-
-
4043052971
-
Epithelial-mesenchymal transitions: Twist in development and metastasis
-
Kang Y and Massagué J: Epithelial-mesenchymal transitions: twist in development and metastasis. Cell 118: 277-279, 2004.
-
(2004)
Cell
, vol.118
, pp. 277-279
-
-
Kang, Y.1
Massagué, J.2
-
130
-
-
0031031976
-
Role of transforming growth factor-beta in tissue injury and repair
-
Grande JP: Role of transforming growth factor-beta in tissue injury and repair. Proc Soc Exp Biol Med 214: 27-40, 1997.
-
(1997)
Proc Soc Exp Biol Med
, vol.214
, pp. 27-40
-
-
Grande, J.P.1
-
131
-
-
0033517356
-
Cutaneous wound healing
-
Singer AJ and Clark RA: Cutaneous wound healing. N Engl J Med 341: 738-746, 1999.
-
(1999)
N Engl J Med
, vol.341
, pp. 738-746
-
-
Singer, A.J.1
Clark, R.A.2
-
132
-
-
84888639681
-
The roles of TGFβ in the tumour microenvironment
-
Pickup M, Novitskiy S and Moses HL: The roles of TGFβ in the tumour microenvironment. Nat Rev Cancer 13: 788-799, 2013.
-
(2013)
Nat Rev Cancer
, vol.13
, pp. 788-799
-
-
Pickup, M.1
Novitskiy, S.2
Moses, H.L.3
-
133
-
-
0027742864
-
Immunocytochemical localization of secreted transforming growth factor-beta 1 to the advancing edges of primary tumors and to lymph node metastases of human mammary carcinoma
-
Dalal BI, Keown PA and Greenberg AH: Immunocytochemical localization of secreted transforming growth factor-beta 1 to the advancing edges of primary tumors and to lymph node metastases of human mammary carcinoma. Am J Pathol 143: 381-389, 1993.
-
(1993)
Am J Pathol
, vol.143
, pp. 381-389
-
-
Dalal, B.I.1
Keown, P.A.2
Greenberg, A.H.3
-
135
-
-
35348940144
-
Pathobiology of transforming growth factor beta in cancer, fibrosis and immunologic disease, and therapeutic considerations
-
Prud'homme GJ: Pathobiology of transforming growth factor beta in cancer, fibrosis and immunologic disease, and therapeutic considerations. Lab Invest 87: 1077-1091, 2007.
-
(2007)
Lab Invest
, vol.87
, pp. 1077-1091
-
-
Prud'Homme, G.J.1
-
136
-
-
34848857434
-
Transforming growth factor-beta and the immune response: Implications for anti-cancer therapy
-
Wrzesinski SH, Wan YY and Flavell RA: Transforming growth factor-beta and the immune response: implications for anti-cancer therapy. Clin Cancer Res 13: 5262-5270, 2007.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 5262-5270
-
-
Wrzesinski, S.H.1
Wan, Y.Y.2
Flavell, R.A.3
-
137
-
-
84866985855
-
Targeting the TGFβ signalling pathway in disease
-
Akhurst RJ and Hata A: Targeting the TGFβ signalling pathway in disease. Nat Rev Drug Discov 11: 790-811, 2012.
-
(2012)
Nat Rev Drug Discov
, vol.11
, pp. 790-811
-
-
Akhurst, R.J.1
Hata, A.2
-
139
-
-
20644472421
-
Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma
-
Laouar Y, Sutterwala FS, Gorelik L and Flavell RA: Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma. Nat Immunol 6: 600-607, 2005.
-
(2005)
Nat Immunol
, vol.6
, pp. 600-607
-
-
Laouar, Y.1
Sutterwala, F.S.2
Gorelik, L.3
Flavell, R.A.4
-
140
-
-
34249678653
-
TGFbeta signalling in control of T-cell-mediated self-reactivity
-
Rubtsov YP and Rudensky AY: TGFbeta signalling in control of T-cell-mediated self-reactivity. Nat Rev Immunol 7: 443-453, 2007.
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 443-453
-
-
Rubtsov, Y.P.1
Rudensky, A.Y.2
-
141
-
-
0036839143
-
Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
-
Mantovani A, Sozzani S, Locati M, Allavena P and Sica A: Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 23: 549-555, 2002.
-
(2002)
Trends Immunol
, vol.23
, pp. 549-555
-
-
Mantovani, A.1
Sozzani, S.2
Locati, M.3
Allavena, P.4
Sica, A.5
-
142
-
-
84862180623
-
TGFβ signaling plays a critical role in promoting alternative macrophage activation
-
Gong D, Shi W, Yi SJ, Chen H, Groffen J and Heisterkamp N: TGFβ signaling plays a critical role in promoting alternative macrophage activation. BMC Immunol 13: 31, 2012.
-
(2012)
BMC Immunol
, vol.13
, pp. 31
-
-
Gong, D.1
Shi, W.2
Yi, S.J.3
Chen, H.4
Groffen, J.5
Heisterkamp, N.6
-
143
-
-
69249222379
-
Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN
-
Fridlender ZG, Sun J, Kim S, et al: Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN. Cancer Cell 16: 183-194, 2009.
-
(2009)
Cancer Cell
, vol.16
, pp. 183-194
-
-
Fridlender, Z.G.1
Sun, J.2
Kim, S.3
-
144
-
-
0030893704
-
Contrasting effects of TGF-beta 1 and TNF-alpha on the development of dendritic cells from progenitors in mouse bone marrow
-
Yamaguchi Y, Tsumura H, Miwa M and Inaba K: Contrasting effects of TGF-beta 1 and TNF-alpha on the development of dendritic cells from progenitors in mouse bone marrow. Stem Cells 15: 144-153, 1997.
-
(1997)
Stem Cells
, vol.15
, pp. 144-153
-
-
Yamaguchi, Y.1
Tsumura, H.2
Miwa, M.3
Inaba, K.4
-
145
-
-
60749137393
-
Transforming growth factor beta (TGFbeta)-induced apoptosis: The rise & fall of bim
-
Ramesh S, Wildey GM and Howe PH: Transforming growth factor beta (TGFbeta)-induced apoptosis: the rise & fall of Bim. Cell Cycle 8: 11-17, 2009.
-
(2009)
Cell Cycle
, vol.8
, pp. 11-17
-
-
Ramesh, S.1
Wildey, G.M.2
Howe, P.H.3
-
146
-
-
84865407523
-
TGF-β is responsible for NK cell immaturity during ontogeny and increased susceptibility to infection during mouse infancy
-
Marcoe JP, Lim JR, Schaubert KL, et al: TGF-β is responsible for NK cell immaturity during ontogeny and increased susceptibility to infection during mouse infancy. Nat Immunol 13: 843-850, 2012.
-
(2012)
Nat Immunol
, vol.13
, pp. 843-850
-
-
Marcoe, J.P.1
Lim, J.R.2
Schaubert, K.L.3
-
147
-
-
37249044357
-
Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix
-
Wipff PJ, Rifkin DB, Meister JJ and Hinz B: Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix. J Cell Biol 179: 1311-1323, 2007.
-
(2007)
J Cell Biol
, vol.179
, pp. 1311-1323
-
-
Wipff, P.J.1
Rifkin, D.B.2
Meister, J.J.3
Hinz, B.4
-
148
-
-
62949238352
-
Myofibroblasts work best under stress
-
Wipff PJ and Hinz B: Myofibroblasts work best under stress. J Bodyw Mov Ther 13: 121-127, 2009.
-
(2009)
J Bodyw Mov Ther
, vol.13
, pp. 121-127
-
-
Wipff, P.J.1
Hinz, B.2
-
149
-
-
0036277026
-
Myofibroblasts and mechano-regulation of connective tissue remodelling
-
Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C and Brown RA: Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol 3: 349-363, 2002.
-
(2002)
Nat Rev Mol Cell Biol
, vol.3
, pp. 349-363
-
-
Tomasek, J.J.1
Gabbiani, G.2
Hinz, B.3
Chaponnier, C.4
Brown, R.A.5
-
150
-
-
84869225491
-
Cancer-associated fibroblasts drive the progression of metastasis through both paracrine and mechanical pressure on cancer tissue
-
Karagiannis GS, Poutahidis T, Erdman SE, Kirsch R, Riddell RH and Diamandis EP: Cancer-associated fibroblasts drive the progression of metastasis through both paracrine and mechanical pressure on cancer tissue. Mol Cancer Res 10: 1403-1418, 2012.
-
(2012)
Mol Cancer Res
, vol.10
, pp. 1403-1418
-
-
Karagiannis, G.S.1
Poutahidis, T.2
Erdman, S.E.3
Kirsch, R.4
Riddell, R.H.5
Diamandis, E.P.6
-
151
-
-
24944547482
-
Tensional homeostasis and the malignant phenotype
-
Paszek MJ, Zahir N, Johnson KR, et al: Tensional homeostasis and the malignant phenotype. Cancer Cell 8: 241-254, 2005.
-
(2005)
Cancer Cell
, vol.8
, pp. 241-254
-
-
Paszek, M.J.1
Zahir, N.2
Johnson, K.R.3
-
152
-
-
79958735965
-
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth
-
Samuel MS, Lopez JI, McGhee EJ, et al: Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell 19: 776-791, 2011.
-
(2011)
Cancer Cell
, vol.19
, pp. 776-791
-
-
Samuel, M.S.1
Lopez, J.I.2
McGhee, E.J.3
-
154
-
-
77957221459
-
Dynamic interplay between the collagen scaffold and tumor evolution
-
Egeblad M, Rasch MG and Weaver VM: Dynamic interplay between the collagen scaffold and tumor evolution. Curr Opin Cell Biol 22: 697-706, 2010.
-
(2010)
Curr Opin Cell Biol
, vol.22
, pp. 697-706
-
-
Egeblad, M.1
Rasch, M.G.2
Weaver, V.M.3
-
155
-
-
84890697696
-
Tumor stromal architecture can define the intrinsic tumor response to VEGF-targeted therapy
-
Smith NR, Baker D, Farren M, et al: Tumor stromal architecture can define the intrinsic tumor response to VEGF-targeted therapy. Clin Cancer Res 19: 6943-6956, 2013.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 6943-6956
-
-
Smith, N.R.1
Baker, D.2
Farren, M.3
-
156
-
-
84887478772
-
Combining two strategies to improve perfusion and drug delivery in solid tumors
-
Stylianopoulos T and Jain RK: Combining two strategies to improve perfusion and drug delivery in solid tumors. Proc Natl Acad Sci USA 110: 18632-18637, 2013.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 18632-18637
-
-
Stylianopoulos, T.1
Jain, R.K.2
-
157
-
-
84866557942
-
Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors
-
Stylianopoulos T, Martin JD, Chauhan VP,et al : Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors. Proc Natl Acad Sci USA 109: 15101-15108, 2012.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 15101-15108
-
-
Stylianopoulos, T.1
Martin, J.D.2
Chauhan, V.P.3
-
158
-
-
78149282625
-
Gene expression profiles in 3D tumor analogs indicate compressive strain differentially enhances metastatic potential
-
Demou ZN: Gene expression profiles in 3D tumor analogs indicate compressive strain differentially enhances metastatic potential. Ann Biomed Eng 38: 3509-3520, 2010.
-
(2010)
Ann Biomed Eng
, vol.38
, pp. 3509-3520
-
-
Demou, Z.N.1
-
159
-
-
84856403028
-
Mechanical compression drives cancer cells toward invasive phenotype
-
Tse JM, Cheng G, Tyrrell JA, et al: Mechanical compression drives cancer cells toward invasive phenotype. Proc Natl Acad Sci USA 109: 911-916, 2012.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 911-916
-
-
Tse, J.M.1
Cheng, G.2
Tyrrell, J.A.3
-
160
-
-
84885129359
-
Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumor blood vessels
-
Chauhan VP, Martin JD, Liu H, et al: Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumor blood vessels. Nat Commun 4: 2516, 2013.
-
(2013)
Nat Commun
, vol.4
, pp. 2516
-
-
Chauhan, V.P.1
Martin, J.D.2
Liu, H.3
-
161
-
-
79960393113
-
Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells
-
Facciabene A, Peng X, Hagemann IS, et al: Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells. Nature 475: 226-230, 2011.
-
(2011)
Nature
, vol.475
, pp. 226-230
-
-
Facciabene, A.1
Peng, X.2
Hagemann, I.S.3
-
162
-
-
79957534572
-
Targeting hypoxia in cancer therapy
-
Wilson WR and Hay MP: Targeting hypoxia in cancer therapy. Nat Rev Cancer 11: 393-410, 2011.
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 393-410
-
-
Wilson, W.R.1
Hay, M.P.2
-
165
-
-
84886310583
-
Strategies for advancing cancer nanomedicine
-
Chauhan VP and Jain RK: Strategies for advancing cancer nanomedicine. Nat Mater 12: 958-962, 2013.
-
(2013)
Nat Mater
, vol.12
, pp. 958-962
-
-
Chauhan, V.P.1
Jain, R.K.2
-
166
-
-
78149420535
-
A nanoparticle size series for in vivo fluorescence imaging
-
Popović Z, Liu W, Chauhan VP, et al: A nanoparticle size series for in vivo fluorescence imaging. Angew Chem Int Ed Engl 49: 8649-8652, 2010.
-
(2010)
Angew Chem Int Ed Engl
, vol.49
, pp. 8649-8652
-
-
Popović, Z.1
Liu, W.2
Chauhan, V.P.3
-
167
-
-
77956562428
-
Diffusion of particles in the extracellular matrix: The effect of repulsive electrostatic interactions
-
Stylianopoulos T, Poh MZ, Insin N, et al: Diffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions. Biophys J 99: 1342-1349, 2010.
-
(2010)
Biophys J
, vol.99
, pp. 1342-1349
-
-
Stylianopoulos, T.1
Poh, M.Z.2
Insin, N.3
-
168
-
-
76749102053
-
Anti-transforming growth factor beta receptor II antibody has therapeutic efficacy against primary tumor growth and metastasis through multieffects on cancer, stroma, and immune cells
-
Zhong Z, Carroll KD, Policarpio D, et al: Anti-transforming growth factor beta receptor II antibody has therapeutic efficacy against primary tumor growth and metastasis through multieffects on cancer, stroma, and immune cells. Clin Cancer Res 16: 1191-1205, 2010.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 1191-1205
-
-
Zhong, Z.1
Carroll, K.D.2
Policarpio, D.3
-
169
-
-
7444226411
-
SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo
-
Uhl M, Aulwurm S, Wischhusen J, et al: SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo. Cancer Res 64: 7954-7961, 2004.
-
(2004)
Cancer Res
, vol.64
, pp. 7954-7961
-
-
Uhl, M.1
Aulwurm, S.2
Wischhusen, J.3
-
170
-
-
57749107585
-
Systemic blockade of transforming growth factor-beta signaling augments the efficacy of immunogene therapy
-
Kim S, Buchlis G, Fridlender ZG, et al: Systemic blockade of transforming growth factor-beta signaling augments the efficacy of immunogene therapy. Cancer Res 68: 10247-10256, 2008.
-
(2008)
Cancer Res
, vol.68
, pp. 10247-10256
-
-
Kim, S.1
Buchlis, G.2
Fridlender, Z.G.3
-
171
-
-
67650305810
-
Tranilast inhibits the growth and metastasis of mammary carcinoma
-
Chakrabarti R, Subramaniam V, Abdalla S, Jothy S and Prud'homme GJ: Tranilast inhibits the growth and metastasis of mammary carcinoma. Anticancer Drugs 20: 334-345, 2009.
-
(2009)
Anticancer Drugs
, vol.20
, pp. 334-345
-
-
Chakrabarti, R.1
Subramaniam, V.2
Abdalla, S.3
Jothy, S.4
Prud'Homme, G.J.5
-
172
-
-
84874760851
-
Inflammation-mediated genetic and epigenetic alterations drive cancer development in the neighboring epithelium upon stromal abrogation of TGF-β signaling
-
Achyut BR, Bader DA, Robles AI, et al: Inflammation-mediated genetic and epigenetic alterations drive cancer development in the neighboring epithelium upon stromal abrogation of TGF-β signaling. PLoS Genet 9: e1003251, 2013.
-
(2013)
PLoS Genet
, vol.9
-
-
Achyut, B.R.1
Bader, D.A.2
Robles, A.I.3
-
173
-
-
84887219089
-
TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling
-
Bragado P, Estrada Y, Parikh F, et al: TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling. Nat Cell Biol 15: 1351-1361, 2013.
-
(2013)
Nat Cell Biol
, vol.15
, pp. 1351-1361
-
-
Bragado, P.1
Estrada, Y.2
Parikh, F.3
-
174
-
-
84896708967
-
Attenuation of TGF-β signaling supports tumor progression of a mesenchymal-like mammary tumor cell line in a syngeneic murine model
-
Biswas T, Gu X, Yang J, Ellies LG and Sun LZ: Attenuation of TGF-β signaling supports tumor progression of a mesenchymal-like mammary tumor cell line in a syngeneic murine model. Cancer Lett 346: 129-138, 2014.
-
(2014)
Cancer Lett
, vol.346
, pp. 129-138
-
-
Biswas, T.1
Gu, X.2
Yang, J.3
Ellies, L.G.4
Sun, L.Z.5
-
175
-
-
57649112725
-
Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis
-
Stockmann C, Doedens A, Weidemann A, et al: Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis. Nature 456: 814-818, 2008.
-
(2008)
Nature
, vol.456
, pp. 814-818
-
-
Stockmann, C.1
Doedens, A.2
Weidemann, A.3
-
176
-
-
84856088337
-
EMT and dissemination precede pancreatic tumor formation
-
Rhim AD, Mirek ET, Aiello NM, et al: EMT and dissemination precede pancreatic tumor formation. Cell 148: 349-361, 2012.
-
(2012)
Cell
, vol.148
, pp. 349-361
-
-
Rhim, A.D.1
Mirek, E.T.2
Aiello, N.M.3
-
177
-
-
79952594233
-
Losartan inhibits collagen I Synthesis and improves the distribution and efficacy of nanotherapeutics in tumors
-
Diop-Frimpong B, Chauhan VP, Krane S, Boucher Y and Jain RK: Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors. Proc Natl Acad Sci USA 108: 2909-2914, 2011.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 2909-2914
-
-
Diop-Frimpong, B.1
Chauhan, V.P.2
Krane, S.3
Boucher, Y.4
Jain, R.K.5
-
178
-
-
69049113864
-
Impact of angiotensin I converting enzyme inhibitors and angiotensin II type 1 receptor blockers on survival in patients with advanced non-small-cell lung cancer undergoing first-line platinum-based chemotherapy
-
Wilop S, von Hobe S, Crysandt M, Esser A, Osieka R and Jost E: Impact of angiotensin I converting enzyme inhibitors and angiotensin II type 1 receptor blockers on survival in patients with advanced non-small-cell lung cancer undergoing first-line platinum-based chemotherapy. J Cancer Res Clin Oncol 135: 1429-1435, 2009.
-
(2009)
J Cancer Res Clin Oncol
, vol.135
, pp. 1429-1435
-
-
Wilop, S.1
Von Hobe, S.2
Crysandt, M.3
Esser, A.4
Osieka, R.5
Jost, E.6
-
179
-
-
80051889719
-
Angiotensin system inhibitors and outcome of sunitinib treatment in patients with metastatic renal cell carcinoma: A retrospective examination
-
Keizman D, Huang P, Eisenberger MA, et al: Angiotensin system inhibitors and outcome of sunitinib treatment in patients with metastatic renal cell carcinoma: a retrospective examination. Eur J Cancer 47: 1955-1961, 2011.
-
(2011)
Eur J Cancer
, vol.47
, pp. 1955-1961
-
-
Keizman, D.1
Huang, P.2
Eisenberger, M.A.3
-
180
-
-
84864310711
-
Phase I trial of gemcitabine and candesartan combination therapy in normotensive patients with advanced pancreatic cancer: GECA1
-
Nakai Y, Isayama H, Ijichi H, et al: Phase I trial of gemcitabine and candesartan combination therapy in normotensive patients with advanced pancreatic cancer: GECA1. Cancer Sci 103: 1489-1492, 2012.
-
(2012)
Cancer Sci
, vol.103
, pp. 1489-1492
-
-
Nakai, Y.1
Isayama, H.2
Ijichi, H.3
-
181
-
-
84867362497
-
TGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma
-
Liu J, Liao S, Diop-Frimpong B, et al: TGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma. Proc Natl Acad Sci USA 109: 16618-16623, 2012.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 16618-16623
-
-
Liu, J.1
Liao, S.2
Diop-Frimpong, B.3
-
182
-
-
84875992738
-
Pirfenidone inhibits pancreatic cancer desmoplasia by regulating stellate cells
-
Kozono S, Ohuchida K, Eguchi D, et al: Pirfenidone inhibits pancreatic cancer desmoplasia by regulating stellate cells. Cancer Res 73: 2345-2356, 2013.
-
(2013)
Cancer Res
, vol.73
, pp. 2345-2356
-
-
Kozono, S.1
Ohuchida, K.2
Eguchi, D.3
-
183
-
-
80455144497
-
TGFβ1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo
-
Bouquet F, Pal A, Pilones KA, et al: TGFβ1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo. Clin Cancer Res 17: 6754-6765, 2011.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 6754-6765
-
-
Bouquet, F.1
Pal, A.2
Pilones, K.A.3
-
184
-
-
82655181475
-
Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma
-
Zhang M, Kleber S, Röhrich M, et al: Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma. Cancer Res 71: 7155-7167, 2011.
-
(2011)
Cancer Res
, vol.71
, pp. 7155-7167
-
-
Zhang, M.1
Kleber, S.2
Röhrich, M.3
|