Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 38, 2012, Pages 15101-15108

  Stylianopoulos, Triantafyllos ^a,b   Martin, John D ^a,c   Chauhan, Vikash P ^a,d   Jain, Saloni R ^a,c   Diop Frimpong, Benjamin ^a,d,e   Bardeesy, Nabeel ^f   Smith, Barbara L ^a   Ferrone, Cristina R ^a   Hornicek, Francis J ^a   Boucher, Yves ^a   Munn, Lance L ^a   Jain, Rakesh K ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF CYPRUS   (Cyprus)

^c Massachusetts Institute of Technology Cambridge   (United States)

^d HARVARD UNIVERSITY   (United States)

^e HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^f HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Desmoplastic tumors; Mathematical modeling; Pancreatic ductal adenocarcinoma; Sonic hedgehog pathway; Tumor microenvironment

Indexed keywords

COLLAGEN; HYALURONIC ACID; SONIC HEDGEHOG PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL; CANCER CELL; CELL STRESS; CONTROLLED STUDY; DEPLETION; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH VESSEL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TISSUE PERFUSION; TUMOR GROWTH;

ADENOCARCINOMA; ANIMALS; ANOXIA; BLOOD VESSELS; COLLAGEN; FEMALE; FIBROBLASTS; HUMANS; HYALURONIC ACID; IMMUNOTHERAPY; MICE; MICE, SCID; MODELS, THEORETICAL; NEOPLASM TRANSPLANTATION; NEOPLASMS; PANCREATIC DUCTS; PANCREATIC NEOPLASMS; STRESS, MECHANICAL; STROMAL CELLS;

ANIMALIA; ERINACEIDAE; MURINAE;

EID: 84866557942     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1213353109     Document Type: Article

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