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Volumn 103, Issue 8, 2012, Pages 1489-1492

Phase I trial of gemcitabine and candesartan combination therapy in normotensive patients with advanced pancreatic cancer: GECA1

Author keywords

[No Author keywords available]

Indexed keywords

CANDESARTAN; GEMCITABINE;

EID: 84864310711     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2012.02311.x     Document Type: Article
Times cited : (33)

References (29)
  • 1
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial
    • Burris HA 3rd, Moore MJ, Andersen J et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 1997; 15: 2403-13.
    • (1997) J Clin Oncol , vol.15 , pp. 2403-2413
    • Burris 3rd, H.A.1    Moore, M.J.2    Andersen, J.3
  • 2
    • 79955921754 scopus 로고    scopus 로고
    • FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer
    • Conroy T, Desseigne F, Ychou M et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med 2011; 364: 1817-25.
    • (2011) N Engl J Med , vol.364 , pp. 1817-1825
    • Conroy, T.1    Desseigne, F.2    Ychou, M.3
  • 3
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore MJ, Goldstein D, Hamm J et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2007; 25: 1960-6.
    • (2007) J Clin Oncol , vol.25 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3
  • 4
    • 77955914277 scopus 로고    scopus 로고
    • Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-directed intergroup trial S0205
    • Philip PA, Benedetti J, Corless CL et al. Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-directed intergroup trial S0205. J Clin Oncol 2010; 28: 3605-10.
    • (2010) J Clin Oncol , vol.28 , pp. 3605-3610
    • Philip, P.A.1    Benedetti, J.2    Corless, C.L.3
  • 5
    • 77955887676 scopus 로고    scopus 로고
    • Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: phase III trial of the Cancer and Leukemia Group B (CALGB 80303)
    • Kindler HL, Niedzwiecki D, Hollis D et al. Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: phase III trial of the Cancer and Leukemia Group B (CALGB 80303). J Clin Oncol 2010; 28: 3617-22.
    • (2010) J Clin Oncol , vol.28 , pp. 3617-3622
    • Kindler, H.L.1    Niedzwiecki, D.2    Hollis, D.3
  • 6
    • 79952036599 scopus 로고    scopus 로고
    • Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study
    • Kindler HL, Ioka T, Richel DJ et al. Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study. Lancet Oncol 2011; 12: 256-62.
    • (2011) Lancet Oncol , vol.12 , pp. 256-262
    • Kindler, H.L.1    Ioka, T.2    Richel, D.J.3
  • 7
    • 0032543880 scopus 로고    scopus 로고
    • Do inhibitors of angiotensin-I-converting enzyme protect against risk of cancer?
    • Lever AF, Hole DJ, Gillis CR et al. Do inhibitors of angiotensin-I-converting enzyme protect against risk of cancer? Lancet 1998; 352: 179-84.
    • (1998) Lancet , vol.352 , pp. 179-184
    • Lever, A.F.1    Hole, D.J.2    Gillis, C.R.3
  • 8
    • 51849135397 scopus 로고    scopus 로고
    • The renin-angiotensin system and malignancy
    • Ager EI, Neo J, Christophi C. The renin-angiotensin system and malignancy. Carcinogenesis 2008; 29: 1675-84.
    • (2008) Carcinogenesis , vol.29 , pp. 1675-1684
    • Ager, E.I.1    Neo, J.2    Christophi, C.3
  • 9
    • 56449112678 scopus 로고    scopus 로고
    • Does the renin-angiotensin system participate in regulation of human vasculogenesis and angiogenesis?
    • Khakoo AY, Sidman RL, Pasqualini R, Arap W. Does the renin-angiotensin system participate in regulation of human vasculogenesis and angiogenesis? Cancer Res 2008; 68: 9112-5.
    • (2008) Cancer Res , vol.68 , pp. 9112-9115
    • Khakoo, A.Y.1    Sidman, R.L.2    Pasqualini, R.3    Arap, W.4
  • 10
    • 68349096413 scopus 로고    scopus 로고
    • Synergistic inhibitory effect of gemcitabine and angiotensin type-1 receptor blocker, losartan, on murine pancreatic tumor growth via anti-angiogenic activities
    • Noguchi R, Yoshiji H, Ikenaka Y et al. Synergistic inhibitory effect of gemcitabine and angiotensin type-1 receptor blocker, losartan, on murine pancreatic tumor growth via anti-angiogenic activities. Oncol Rep 2009; 22: 355-60.
    • (2009) Oncol Rep , vol.22 , pp. 355-360
    • Noguchi, R.1    Yoshiji, H.2    Ikenaka, Y.3
  • 11
    • 16644396484 scopus 로고    scopus 로고
    • Angiotensin II activates MAP kinase and NF-kappaB through angiotensin II type I receptor in human pancreatic cancer cells
    • Amaya K, Ohta T, Kitagawa H et al. Angiotensin II activates MAP kinase and NF-kappaB through angiotensin II type I receptor in human pancreatic cancer cells. Int J Oncol 2004; 25: 849-56.
    • (2004) Int J Oncol , vol.25 , pp. 849-856
    • Amaya, K.1    Ohta, T.2    Kitagawa, H.3
  • 12
    • 77954129591 scopus 로고    scopus 로고
    • Blocking Angiotensin II Type 1 Receptor triggers Apoptotic cell death in human pancreatic cancer cells
    • Gong Q, Davis M, Chipitsyna G, Yeo CJ, Arafat HA. Blocking Angiotensin II Type 1 Receptor triggers Apoptotic cell death in human pancreatic cancer cells. Pancreas 2010; 39: 595-603.
    • (2010) Pancreas , vol.39 , pp. 595-603
    • Gong, Q.1    Davis, M.2    Chipitsyna, G.3    Yeo, C.J.4    Arafat, H.A.5
  • 13
    • 78650224339 scopus 로고    scopus 로고
    • Inhibition of renin-angiotensin system affects prognosis of advanced pancreatic cancer receiving gemcitabine
    • Nakai Y, Isayama H, Ijichi H et al. Inhibition of renin-angiotensin system affects prognosis of advanced pancreatic cancer receiving gemcitabine. Br J Cancer 2010; 103: 1644-8.
    • (2010) Br J Cancer , vol.103 , pp. 1644-1648
    • Nakai, Y.1    Isayama, H.2    Ijichi, H.3
  • 14
    • 84856696117 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in cancer progression and survival: a systematic review
    • Mc Menamin UC, Murray LJ, Cantwell MM, Hughes CM. Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in cancer progression and survival: a systematic review. Cancer Causes Control 2012; 23: 221-30.
    • (2012) Cancer Causes Control , vol.23 , pp. 221-230
    • Mc Menamin, U.C.1    Murray, L.J.2    Cantwell, M.M.3    Hughes, C.M.4
  • 15
    • 0034594628 scopus 로고    scopus 로고
    • New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada
    • Therasse P, Arbuck SG, Eisenhauer EA et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 2000; 92: 205-16.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 205-216
    • Therasse, P.1    Arbuck, S.G.2    Eisenhauer, E.A.3
  • 16
    • 33751247898 scopus 로고    scopus 로고
    • Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression
    • Ijichi H, Chytil A, Gorska AE et al. Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression. Genes Dev 2006; 20: 3147-60.
    • (2006) Genes Dev , vol.20 , pp. 3147-3160
    • Ijichi, H.1    Chytil, A.2    Gorska, A.E.3
  • 17
    • 53749100124 scopus 로고    scopus 로고
    • Effect of candesartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: randomised, placebo-controlled trials
    • Chaturvedi N, Porta M, Klein R et al. Effect of candesartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: randomised, placebo-controlled trials. Lancet 2008; 372: 1394-402.
    • (2008) Lancet , vol.372 , pp. 1394-1402
    • Chaturvedi, N.1    Porta, M.2    Klein, R.3
  • 18
    • 53749108177 scopus 로고    scopus 로고
    • Effect of candesartan on progression and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2): a randomised placebo-controlled trial
    • Sjolie AK, Klein R, Porta M et al. Effect of candesartan on progression and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2): a randomised placebo-controlled trial. Lancet 2008; 372: 1385-93.
    • (2008) Lancet , vol.372 , pp. 1385-1393
    • Sjolie, A.K.1    Klein, R.2    Porta, M.3
  • 19
    • 77954030665 scopus 로고    scopus 로고
    • Angiotensin-receptor blockade and risk of cancer: meta-analysis of randomised controlled trials
    • Sipahi I, Debanne SM, Rowland DY, Simon DI, Fang JC. Angiotensin-receptor blockade and risk of cancer: meta-analysis of randomised controlled trials. Lancet Oncol 2010; 11: 627-36.
    • (2010) Lancet Oncol , vol.11 , pp. 627-636
    • Sipahi, I.1    Debanne, S.M.2    Rowland, D.Y.3    Simon, D.I.4    Fang, J.C.5
  • 20
    • 78650703447 scopus 로고    scopus 로고
    • Antihypertensive drugs and risk of cancer: network meta-analyses and trial sequential analyses of 324,168 participants from randomised trials
    • Bangalore S, Kumar S, Kjeldsen SE et al. Antihypertensive drugs and risk of cancer: network meta-analyses and trial sequential analyses of 324, 168 participants from randomised trials. Lancet Oncol 2011; 12: 65-82.
    • (2011) Lancet Oncol , vol.12 , pp. 65-82
    • Bangalore, S.1    Kumar, S.2    Kjeldsen, S.E.3
  • 21
    • 80051660023 scopus 로고    scopus 로고
    • Angiotensin receptor blockade and risk of cancer in type 2 diabetes mellitus: a nationwide case-control study
    • Chang CH, Lin JW, Wu LC, Lai MS. Angiotensin receptor blockade and risk of cancer in type 2 diabetes mellitus: a nationwide case-control study. J Clin Oncol 2011; 29: 3001-7.
    • (2011) J Clin Oncol , vol.29 , pp. 3001-3007
    • Chang, C.H.1    Lin, J.W.2    Wu, L.C.3    Lai, M.S.4
  • 22
    • 0030754056 scopus 로고    scopus 로고
    • Enhanced expression of vascular endothelial growth factor in human pancreatic cancer correlates with local disease progression
    • Itakura J, Ishiwata T, Friess H et al. Enhanced expression of vascular endothelial growth factor in human pancreatic cancer correlates with local disease progression. Clin Cancer Res 1997; 3: 1309-16.
    • (1997) Clin Cancer Res , vol.3 , pp. 1309-1316
    • Itakura, J.1    Ishiwata, T.2    Friess, H.3
  • 23
    • 0034657029 scopus 로고    scopus 로고
    • High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma
    • Seo Y, Baba H, Fukuda T, Takashima M, Sugimachi K. High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma. Cancer 2000; 88: 2239-45.
    • (2000) Cancer , vol.88 , pp. 2239-2245
    • Seo, Y.1    Baba, H.2    Fukuda, T.3    Takashima, M.4    Sugimachi, K.5
  • 24
    • 79955472083 scopus 로고    scopus 로고
    • Meta-analysis of immunohistochemical prognostic markers in resected pancreatic cancer
    • Smith RA, Tang J, Tudur-Smith C, Neoptolemos JP, Ghaneh P. Meta-analysis of immunohistochemical prognostic markers in resected pancreatic cancer. Br J Cancer 2011; 104: 1440-51.
    • (2011) Br J Cancer , vol.104 , pp. 1440-1451
    • Smith, R.A.1    Tang, J.2    Tudur-Smith, C.3    Neoptolemos, J.P.4    Ghaneh, P.5
  • 25
    • 34247511935 scopus 로고    scopus 로고
    • Antihypertensives as novel antineoplastics: angiotensin-I-converting enzyme inhibitors and angiotensin II type 1 receptor blockers in pancreatic ductal adenocarcinoma
    • Arafat HA, Gong Q, Chipitsyna G, Rizvi A, Saa CT, Yeo CJ. Antihypertensives as novel antineoplastics: angiotensin-I-converting enzyme inhibitors and angiotensin II type 1 receptor blockers in pancreatic ductal adenocarcinoma. J Am Coll Surg 2007; 204: 996-1005.
    • (2007) J Am Coll Surg , vol.204 , pp. 996-1005
    • Arafat, H.A.1    Gong, Q.2    Chipitsyna, G.3    Rizvi, A.4    Saa, C.T.5    Yeo, C.J.6
  • 26
    • 80053405625 scopus 로고    scopus 로고
    • Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma
    • Ijichi H, Chytil A, Gorska AE et al. Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma. J Clin Invest 2011; 121: 4106-17.
    • (2011) J Clin Invest , vol.121 , pp. 4106-4117
    • Ijichi, H.1    Chytil, A.2    Gorska, A.E.3
  • 27
    • 67149134933 scopus 로고    scopus 로고
    • Cancer. Breaching the cancer fortress
    • Olson P, Hanahan D. Cancer. Breaching the cancer fortress. Science 2009; 324: 1400-1.
    • (2009) Science , vol.324 , pp. 1400-1401
    • Olson, P.1    Hanahan, D.2
  • 28
    • 0036483708 scopus 로고    scopus 로고
    • Microvascular angiogenesis and the renin-angiotensin system
    • Greene AS, Amaral SL. Microvascular angiogenesis and the renin-angiotensin system. Curr Hypertens Rep 2002; 4: 56-62.
    • (2002) Curr Hypertens Rep , vol.4 , pp. 56-62
    • Greene, A.S.1    Amaral, S.L.2
  • 29
    • 0035957683 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptor expression in human pancreatic cancer and growth inhibition by angiotensin II type 1 receptor antagonist
    • Fujimoto Y, Sasaki T, Tsuchida A, Chayama K. Angiotensin II type 1 receptor expression in human pancreatic cancer and growth inhibition by angiotensin II type 1 receptor antagonist. FEBS Lett 2001; 495: 197-200.
    • (2001) FEBS Lett , vol.495 , pp. 197-200
    • Fujimoto, Y.1    Sasaki, T.2    Tsuchida, A.3    Chayama, K.4


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