-
1
-
-
0030819894
-
Telomerase catalytic subunit homologs from fission yeast and human
-
Nakamura TM, Morin GB, Chapman KB, et al. Telomerase catalytic subunit homologs from fission yeast and human. Science 1997; 277: 955-9.
-
(1997)
Science
, vol.277
, pp. 955-959
-
-
Nakamura, T.M.1
Morin, G.B.2
Chapman, K.B.3
-
2
-
-
33745849998
-
The structure and function of telomerase reverse transcriptase
-
Autexier C, Lue NF. The structure and function of telomerase reverse transcriptase. Annu Rev Biochem 2006; 75: 493-517.
-
(2006)
Annu Rev Biochem
, vol.75
, pp. 493-517
-
-
Autexier, C.1
Lue, N.F.2
-
3
-
-
0030659644
-
Reconstitution of human te-lomerase with the template RNA component hTR and the catalytic protein subunit hTRT
-
Weinrich SL, Pruzan R, Ma L, et al. Reconstitution of human te-lomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat Genet 1997; 17: 498-502.
-
(1997)
Nat Genet
, vol.17
, pp. 498-502
-
-
Weinrich, S.L.1
Pruzan, R.2
Ma, L.3
-
4
-
-
84879918842
-
Structure-function relationship and biogenesis regulation of the human telomerase holoenzyme
-
Hukezalie KR, Wong JM. Structure-function relationship and biogenesis regulation of the human telomerase holoenzyme. FEBS J 2013; 280: 3194-204.
-
(2013)
FEBS J
, vol.280
, pp. 3194-3204
-
-
Hukezalie, K.R.1
Wong, J.M.2
-
5
-
-
84856003327
-
The AAA-ATPase NVL2 is a telomerase component essential for holoenzyme assembly
-
Her J, Chung IK. The AAA-ATPase NVL2 is a telomerase component essential for holoenzyme assembly. Biochem Biophys Res Commun 2012; 417: 1086-92.
-
(2012)
Biochem Biophys Res Commun
, vol.417
, pp. 1086-1092
-
-
Her, J.1
Chung, I.K.2
-
6
-
-
84862260392
-
InTERTesting association between telom-erase, mTOR and phytochemicals
-
Sundin T, Hentosh P. InTERTesting association between telom-erase, mTOR and phytochemicals. Expert Rev Mol Med 2012; 14: e8.
-
(2012)
Expert Rev Mol Med
, vol.14
-
-
Sundin, T.1
Hentosh, P.2
-
7
-
-
84858750992
-
Regulation of the human catalytic subunit of telomerase (hTERT)
-
Daniel M, Peek GW, Tollefsbol TO. Regulation of the human catalytic subunit of telomerase (hTERT). Gene 2012; 498: 135-46.
-
(2012)
Gene
, vol.498
, pp. 135-146
-
-
Daniel, M.1
Peek, G.W.2
Tollefsbol, T.O.3
-
8
-
-
0034352944
-
The hTERTalpha splice variant is a dominant negative inhibitor of telomerase activity
-
Colgin LM, Wilkinson C, Englezou A, et al. The hTERTalpha splice variant is a dominant negative inhibitor of telomerase activity. Neoplasia 2000; 2: 426-32.
-
(2000)
Neoplasia
, vol.2
, pp. 426-432
-
-
Colgin, L.M.1
Wilkinson, C.2
Englezou, A.3
-
9
-
-
84877748662
-
The major reverse transcriptase-incompetent splice variant of the human telomerase protein inhibits telomerase activity but protects from apoptosis
-
Listerman I, Sun J, Gazzaniga FS, Lukas JL, Blackburn EH. The major reverse transcriptase-incompetent splice variant of the human telomerase protein inhibits telomerase activity but protects from apoptosis. Cancer Res 2013; 73: 2817-28.
-
(2013)
Cancer Res
, vol.73
, pp. 2817-2828
-
-
Listerman, I.1
Sun, J.2
Gazzaniga, F.S.3
Lukas, J.L.4
Blackburn, E.H.5
-
10
-
-
84868674716
-
Alternatively spliced telom-erase reverse transcriptase variants lacking telomerase activity stimulate cell proliferation
-
Hrdlickova R, Nehyba J, Bose HR, Jr. Alternatively spliced telom-erase reverse transcriptase variants lacking telomerase activity stimulate cell proliferation. Mol Cell Biol 2012; 32: 4283-96.
-
(2012)
Mol Cell Biol
, vol.32
, pp. 4283-4296
-
-
Hrdlickova, R.1
Nehyba, J.2
Bose, H.R.3
-
11
-
-
0031010342
-
A survey of telomerase activity in human cancer
-
Shay JW, Bacchetti S. A survey of telomerase activity in human cancer. Eur J Cancer 1997; 33: 787-91.
-
(1997)
Eur J Cancer
, vol.33
, pp. 787-791
-
-
Shay, J.W.1
Bacchetti, S.2
-
12
-
-
0029332152
-
The effect of the incomplete terminal repair of the linear double-stranded DNA molecule
-
Olovnikov AM. [The effect of the incomplete terminal repair of the linear double-stranded DNA molecule]. Izv Akad Nauk Ser Biol 1995: 501-3.
-
(1995)
Izv Akad Nauk Ser Biol
, pp. 501-503
-
-
Olovnikov, A.M.1
-
13
-
-
0029127226
-
Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: A model for senescence?
-
von Zglinicki T, Saretzki G, Docke W, Lotze C. Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence? Exp Cell Res 1995; 220: 186-93.
-
(1995)
Exp Cell Res
, vol.220
, pp. 186-193
-
-
von Zglinicki, T.1
Saretzki, G.2
Docke, W.3
Lotze, C.4
-
14
-
-
0033616762
-
Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening
-
Zhu J, Wang H, Bishop JM, Blackburn EH. Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc Natl Acad Sci USA 1999; 96: 3723-8.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 3723-3728
-
-
Zhu, J.1
Wang, H.2
Bishop, J.M.3
Blackburn, E.H.4
-
15
-
-
0034597794
-
Telomere states and cell fates
-
Blackburn EH. Telomere states and cell fates. Nature 2000; 408: 53-6.
-
(2000)
Nature
, vol.408
, pp. 53-56
-
-
Blackburn, E.H.1
-
16
-
-
0037102234
-
Different telomere damage signaling pathways in human and mouse cells
-
Smogorzewska A, de Lange T. Different telomere damage signaling pathways in human and mouse cells. EMBO J 2002; 21: 4338-48.
-
(2002)
EMBO J
, vol.21
, pp. 4338-4348
-
-
Smogorzewska, A.1
de Lange, T.2
-
17
-
-
0033575958
-
Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments
-
Saretzki G, Sitte N, Merkel U, Wurm RE, von Zglinicki T. Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments. Oncogene 1999; 18: 5148-58.
-
(1999)
Oncogene
, vol.18
, pp. 5148-5158
-
-
Saretzki, G.1
Sitte, N.2
Merkel, U.3
Wurm, R.E.4
von Zglinicki, T.5
-
18
-
-
0032054781
-
Accelerated telomere shortening in fibroblasts after extended periods of confluency
-
Sitte N, Saretzki G, von Zglinicki T. Accelerated telomere shortening in fibroblasts after extended periods of confluency. Free Radic Biol Med 1998; 24: 885-93.
-
(1998)
Free Radic Biol Med
, vol.24
, pp. 885-893
-
-
Sitte, N.1
Saretzki, G.2
von Zglinicki, T.3
-
19
-
-
0035884738
-
BJ fibroblasts display high antioxidant capacity and slow telomere shortening independent of hTERT transfection
-
Lorenz M, Saretzki G, Sitte N, Metzkow S, von Zglinicki T. BJ fibroblasts display high antioxidant capacity and slow telomere shortening independent of hTERT transfection. Free Radic Biol Med 2001; 31: 824-31.
-
(2001)
Free Radic Biol Med
, vol.31
, pp. 824-831
-
-
Lorenz, M.1
Saretzki, G.2
Sitte, N.3
Metzkow, S.4
von Zglinicki, T.5
-
20
-
-
84855491182
-
Telomere length measurement-caveats and a critical assessment of the available technologies and tools
-
Aubert G, Hills M, Lansdorp PM. Telomere length measurement-caveats and a critical assessment of the available technologies and tools. Mutat Res 2012; 730: 59-67.
-
(2012)
Mutat Res
, vol.730
, pp. 59-67
-
-
Aubert, G.1
Hills, M.2
Lansdorp, P.M.3
-
21
-
-
79751503987
-
Measurement of telomere length by the Southern blot analysis of terminal restriction fragment lengths
-
Kimura M, Stone RC, Hunt SC, et al. Measurement of telomere length by the Southern blot analysis of terminal restriction fragment lengths. Nat Protoc 2010; 5: 1596-607.
-
(2010)
Nat Protoc
, vol.5
, pp. 1596-1607
-
-
Kimura, M.1
Stone, R.C.2
Hunt, S.C.3
-
22
-
-
2342419515
-
Telomere measurement by quantitative PCR
-
Cawthon RM. Telomere measurement by quantitative PCR. Nucleic Acids Res 2002; 30: e47.
-
(2002)
Nucleic Acids Res
, vol.30
-
-
Cawthon, R.M.1
-
23
-
-
0035706620
-
Telomere length measurement by Q-FISH
-
Slijepcevic P. Telomere length measurement by Q-FISH. Methods Cell Sci 2001; 23: 17-22.
-
(2001)
Methods Cell Sci
, vol.23
, pp. 17-22
-
-
Slijepcevic, P.1
-
24
-
-
0037313185
-
Extensive allelic variation and ultrashort telomeres in senescent human cells
-
Baird DM, Rowson J, Wynford-Thomas D, Kipling D. Extensive allelic variation and ultrashort telomeres in senescent human cells. Nat Genet 2003; 33: 203-7.
-
(2003)
Nat Genet
, vol.33
, pp. 203-207
-
-
Baird, D.M.1
Rowson, J.2
Wynford-Thomas, D.3
Kipling, D.4
-
25
-
-
0035812845
-
The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability
-
Hemann MT, Strong MA, Hao LY, Greider CW. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 2001; 107: 67-77.
-
(2001)
Cell
, vol.107
, pp. 67-77
-
-
Hemann, M.T.1
Strong, M.A.2
Hao, L.Y.3
Greider, C.W.4
-
26
-
-
0344441890
-
A DNA damage checkpoint response in telomere-initiated senescence
-
d'Adda di Fagagna F, Reaper PM, Clay-Farrace L, et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature 2003; 426: 194-8.
-
(2003)
Nature
, vol.426
, pp. 194-198
-
-
d'Adda di Fagagna, F.1
Reaper, P.M.2
Clay-Farrace, L.3
-
27
-
-
0042420304
-
DNA damage foci at dysfunctional telomeres
-
Takai H, Smogorzewska A, de Lange T. DNA damage foci at dysfunctional telomeres. Curr Biol 2003; 13: 1549-56.
-
(2003)
Curr Biol
, vol.13
, pp. 1549-1556
-
-
Takai, H.1
Smogorzewska, A.2
de Lange, T.3
-
28
-
-
84859372986
-
Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation
-
Fumagalli M, Rossiello F, Clerici M, et al. Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. Nat Cell Biol 2012; 14: 355-65.
-
(2012)
Nat Cell Biol
, vol.14
, pp. 355-365
-
-
Fumagalli, M.1
Rossiello, F.2
Clerici, M.3
-
29
-
-
84859352385
-
Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence
-
Hewitt G, Jurk D, Marques FD, et al. Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence. Nat Commun 2012; 3: 708.
-
(2012)
Nat Commun
, vol.3
, pp. 708
-
-
Hewitt, G.1
Jurk, D.2
Marques, F.D.3
-
30
-
-
78650419603
-
Factors that influence telomeric oxidative base damage and repair by DNA glycosylase OGG1
-
Rhee DB, Ghosh A, Lu J, Bohr VA, Liu Y. Factors that influence telomeric oxidative base damage and repair by DNA glycosylase OGG1. DNA Repair (Amst) 2011; 10: 34-44.
-
(2011)
DNA Repair (Amst)
, vol.10
, pp. 34-44
-
-
Rhee, D.B.1
Ghosh, A.2
Lu, J.3
Bohr, V.A.4
Liu, Y.5
-
31
-
-
0031821009
-
Preferential accumulation of single-stranded regions in telomeres of human fibroblasts
-
Petersen S, Saretzki G, von Zglinicki T. Preferential accumulation of single-stranded regions in telomeres of human fibroblasts. Exp Cell Res 1998; 239: 152-60.
-
(1998)
Exp Cell Res
, vol.239
, pp. 152-160
-
-
Petersen, S.1
Saretzki, G.2
von Zglinicki, T.3
-
32
-
-
0033614998
-
Creation of human tumour cells with defined genetic elements
-
Hahn WC, Counter CM, Lundberg AS, et al. Creation of human tumour cells with defined genetic elements. Nature 1999; 400: 464-8.
-
(1999)
Nature
, vol.400
, pp. 464-468
-
-
Hahn, W.C.1
Counter, C.M.2
Lundberg, A.S.3
-
33
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
Bodnar AG, Ouellette M, Frolkis M, et al. Extension of life-span by introduction of telomerase into normal human cells. Science 1998; 279: 349-52.
-
(1998)
Science
, vol.279
, pp. 349-352
-
-
Bodnar, A.G.1
Ouellette, M.2
Frolkis, M.3
-
34
-
-
0032924343
-
Absence of cancer-associated changes in human fibroblasts immortalized with telom-erase
-
Morales CP, Holt SE, Ouellette M, et al. Absence of cancer-associated changes in human fibroblasts immortalized with telom-erase. Nat Genet 1999; 21: 115-8.
-
(1999)
Nat Genet
, vol.21
, pp. 115-118
-
-
Morales, C.P.1
Holt, S.E.2
Ouellette, M.3
-
35
-
-
33644507072
-
Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, te-lomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells
-
Sato M, Vaughan MB, Girard L, et al. Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, te-lomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells. Cancer Res 2006; 66: 2116-28.
-
(2006)
Cancer Res
, vol.66
, pp. 2116-2128
-
-
Sato, M.1
Vaughan, M.B.2
Girard, L.3
-
36
-
-
84855493321
-
Maintenance of tumor initiating cells of defined genetic composition by nucleostemin
-
Okamoto N, Yasukawa M, Nguyen C, et al. Maintenance of tumor initiating cells of defined genetic composition by nucleostemin. Proc Natl Acad Sci USA 2011; 108: 20388-93.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 20388-20393
-
-
Okamoto, N.1
Yasukawa, M.2
Nguyen, C.3
-
37
-
-
84866324123
-
Cancer stem cells and epithelial-mesenchymal transition: Concepts and molecular links
-
Scheel C, Weinberg RA. Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links. Semin Cancer Biol 2012; 22: 396-403.
-
(2012)
Semin Cancer Biol
, vol.22
, pp. 396-403
-
-
Scheel, C.1
Weinberg, R.A.2
-
38
-
-
18644373013
-
Telomerase contributes to tumorigenesis by a telomere length-independent mechanism
-
Stewart SA, Hahn WC, O'Connor BF, et al. Telomerase contributes to tumorigenesis by a telomere length-independent mechanism. Proc Natl Acad Sci USA 2002; 99: 12606-11.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 12606-12611
-
-
Stewart, S.A.1
Hahn, W.C.2
O'Connor, B.F.3
-
39
-
-
0032440891
-
Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization
-
Counter CM, Hahn WC, Wei W, et al. Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Proc Natl Acad Sci USA 1998; 95: 14723-8.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 14723-14728
-
-
Counter, C.M.1
Hahn, W.C.2
Wei, W.3
-
40
-
-
0033608159
-
Telomerase activity does not always imply telomere maintenance
-
Ouellette MM, Aisner DL, Savre-Train I, Wright WE, Shay JW. Telomerase activity does not always imply telomere maintenance. Biochem Biophys Res Commun 1999; 254: 795-803.
-
(1999)
Biochem Biophys Res Commun
, vol.254
, pp. 795-803
-
-
Ouellette, M.M.1
Aisner, D.L.2
Savre-Train, I.3
Wright, W.E.4
Shay, J.W.5
-
42
-
-
0035963271
-
Alternative lengthening of telomeres is associated with chromosomal instability in osteosarcomas
-
Scheel C, Schaefer KL, Jauch A, et al. Alternative lengthening of telomeres is associated with chromosomal instability in osteosarcomas. Oncogene 2001; 20: 3835-44.
-
(2001)
Oncogene
, vol.20
, pp. 3835-3844
-
-
Scheel, C.1
Schaefer, K.L.2
Jauch, A.3
-
43
-
-
0034998040
-
Coexistence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM847 cells
-
Perrem K, Colgin LM, Neumann AA, Yeager TR, Reddel RR. Coexistence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM847 cells. Mol Cell Biol 2001; 21: 3862-75.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3862-3875
-
-
Perrem, K.1
Colgin, L.M.2
Neumann, A.A.3
Yeager, T.R.4
Reddel, R.R.5
-
44
-
-
51649112247
-
Genes involved in differentiation, stem cell renewal, and tumorigenesis are modulated in te-lomerase-immortalized human urothelial cells
-
Chapman EJ, Kelly G, Knowles MA. Genes involved in differentiation, stem cell renewal, and tumorigenesis are modulated in te-lomerase-immortalized human urothelial cells. Mol Cancer Res 2008; 6: 1154-68.
-
(2008)
Mol Cancer Res
, vol.6
, pp. 1154-1168
-
-
Chapman, E.J.1
Kelly, G.2
Knowles, M.A.3
-
45
-
-
16844382627
-
The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpression
-
Cayuela ML, Flores JM, Blasco MA. The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpression. EMBO Rep 2005; 6: 268-74.
-
(2005)
EMBO Rep
, vol.6
, pp. 268-274
-
-
Cayuela, M.L.1
Flores, J.M.2
Blasco, M.A.3
-
46
-
-
21244502260
-
Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of te-lomerase RNA
-
Li S, Crothers J, Haqq CM, Blackburn EH. Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of te-lomerase RNA. J Biol Chem 2005; 280: 23709-17.
-
(2005)
J Biol Chem
, vol.280
, pp. 23709-23717
-
-
Li, S.1
Crothers, J.2
Haqq, C.M.3
Blackburn, E.H.4
-
47
-
-
0035964313
-
Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival
-
Oh H, Taffet GE, Youker KA, et al. Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival. Proc Natl Acad Sci USA 2001; 98: 10308-13.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10308-10313
-
-
Oh, H.1
Taffet, G.E.2
Youker, K.A.3
-
48
-
-
43149087522
-
Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress
-
Ahmed S, Passos JF, Birket MJ, et al. Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress. J Cell Sci 2008; 121: 1046-53.
-
(2008)
J Cell Sci
, vol.121
, pp. 1046-1053
-
-
Ahmed, S.1
Passos, J.F.2
Birket, M.J.3
-
49
-
-
77955580389
-
Immediate and gradual gene expression changes in telomerase over-expressing fibroblasts
-
Daniels DJ, Clothier C, Swan DC, Saretzki G. Immediate and gradual gene expression changes in telomerase over-expressing fibroblasts. Biochem Biophys Res Commun 2010; 399: 7-13.
-
(2010)
Biochem Biophys Res Commun
, vol.399
, pp. 7-13
-
-
Daniels, D.J.1
Clothier, C.2
Swan, D.C.3
Saretzki, G.4
-
50
-
-
0037427086
-
hTERT associates with human telomeres and enhances genomic stability and DNA repair
-
Sharma GG, Gupta A, Wang H, et al. hTERT associates with human telomeres and enhances genomic stability and DNA repair. Oncogene 2003; 22: 131-46.
-
(2003)
Oncogene
, vol.22
, pp. 131-146
-
-
Sharma, G.G.1
Gupta, A.2
Wang, H.3
-
51
-
-
10744219897
-
Prolonged culture of telom-erase-immortalized human fibroblasts leads to a premalignant phenotype
-
Milyavsky M, Shats I, Erez N, et al. Prolonged culture of telom-erase-immortalized human fibroblasts leads to a premalignant phenotype. Cancer Res 2003; 63: 7147-57.
-
(2003)
Cancer Res
, vol.63
, pp. 7147-7157
-
-
Milyavsky, M.1
Shats, I.2
Erez, N.3
-
52
-
-
3242723326
-
Reconstitution of active telomerase in primary human foreskin fibroblasts: Effects on proliferative characteristics and response to ionizing radiation
-
Kampinga HH, Van Waarde-Verhagen MA, Van Assen-Bolt AJ, et al. Reconstitution of active telomerase in primary human foreskin fibroblasts: effects on proliferative characteristics and response to ionizing radiation. Int J Radiat Biol 2004; 80: 377-88.
-
(2004)
Int J Radiat Biol
, vol.80
, pp. 377-388
-
-
Kampinga, H.H.1
Van Waarde-Verhagen, M.A.2
Van Assen-Bolt, A.J.3
-
53
-
-
77952424612
-
Genetic alterations in a telom-erase-immortalized human esophageal epithelial cell line: Implications for carcinogenesis
-
Cheung PY, Deng W, Man C, et al. Genetic alterations in a telom-erase-immortalized human esophageal epithelial cell line: implications for carcinogenesis. Cancer Lett 2010; 293: 41-51.
-
(2010)
Cancer Lett
, vol.293
, pp. 41-51
-
-
Cheung, P.Y.1
Deng, W.2
Man, C.3
-
54
-
-
84856939046
-
Cross-analysis of gene and miRNA genome-wide expression profiles in human fibroblasts at different stages of transformation
-
Ostano P, Bione S, Belgiovine C, et al. Cross-analysis of gene and miRNA genome-wide expression profiles in human fibroblasts at different stages of transformation. OMICS 2012; 16: 24-36.
-
(2012)
OMICS
, vol.16
, pp. 24-36
-
-
Ostano, P.1
Bione, S.2
Belgiovine, C.3
-
55
-
-
0032487675
-
Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
-
Kiyono T, Foster SA, Koop JI, et al. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 1998; 396: 84-8.
-
(1998)
Nature
, vol.396
, pp. 84-88
-
-
Kiyono, T.1
Foster, S.A.2
Koop, J.I.3
-
56
-
-
0035836727
-
Expression of the telom-erase catalytic subunit, hTERT, induces resistance to transforming growth factor beta growth inhibition in p16INK4A(-) human mammary epithelial cells
-
Stampfer MR, Garbe J, Levine G, et al. Expression of the telom-erase catalytic subunit, hTERT, induces resistance to transforming growth factor beta growth inhibition in p16INK4A(-) human mammary epithelial cells. Proc Natl Acad Sci USA 2001; 98: 4498-503.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 4498-4503
-
-
Stampfer, M.R.1
Garbe, J.2
Levine, G.3
-
57
-
-
79958833651
-
Telomerase-based immortalization modifies the angiogenic/inflammatory responses of human coronary artery endothelial cells
-
Baumer Y, Scholz B, Ivanov S, Schlosshauer B. Telomerase-based immortalization modifies the angiogenic/inflammatory responses of human coronary artery endothelial cells. Exp Biol Med (Maywood) 2011; 236: 692-700.
-
(2011)
Exp Biol Med (Maywood)
, vol.236
, pp. 692-700
-
-
Baumer, Y.1
Scholz, B.2
Ivanov, S.3
Schlosshauer, B.4
-
58
-
-
0038056347
-
Telomerase modulates expression of growth-controlling genes and enhances cell proliferation
-
Smith LL, Coller HA, Roberts JM. Telomerase modulates expression of growth-controlling genes and enhances cell proliferation. Nat Cell Biol 2003; 5: 474-9.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 474-479
-
-
Smith, L.L.1
Coller, H.A.2
Roberts, J.M.3
-
59
-
-
79959919116
-
Telomerase activity-independent function of TERT allows glioma cells to attain cancer stem cell characteristics by inducing EGFR expression
-
Beck S, Jin X, Sohn YW, et al. Telomerase activity-independent function of TERT allows glioma cells to attain cancer stem cell characteristics by inducing EGFR expression. Mol Cells 2011; 31: 9-15.
-
(2011)
Mol Cells
, vol.31
, pp. 9-15
-
-
Beck, S.1
Jin, X.2
Sohn, Y.W.3
-
60
-
-
79952087345
-
EGFR overexpression induces activation of telomerase via PI3K/AKT-mediated phosphorylation and transcriptional regulation through Hif1-alpha in a cellular model of oral-esophageal carcinogenesis
-
Heeg S, Hirt N, Queisser A, et al. EGFR overexpression induces activation of telomerase via PI3K/AKT-mediated phosphorylation and transcriptional regulation through Hif1-alpha in a cellular model of oral-esophageal carcinogenesis. Cancer Sci 2011; 102: 351-60.
-
(2011)
Cancer Sci
, vol.102
, pp. 351-360
-
-
Heeg, S.1
Hirt, N.2
Queisser, A.3
-
61
-
-
33746257301
-
Expression of mTert in primary murine cells links the growth-promoting effects of telomerase to transforming growth factor-beta signaling
-
Geserick C, Tejera A, Gonzalez-Suarez E, Klatt P, Blasco MA. Expression of mTert in primary murine cells links the growth-promoting effects of telomerase to transforming growth factor-beta signaling. Oncogene 2006; 25: 4310-9.
-
(2006)
Oncogene
, vol.25
, pp. 4310-4319
-
-
Geserick, C.1
Tejera, A.2
Gonzalez-Suarez, E.3
Klatt, P.4
Blasco, M.A.5
-
63
-
-
84879978463
-
Implications of telomere-independent activities of telomerase reverse transcriptase in human cancer
-
Ding D, Zhou J, Wang M, Cong YS. Implications of telomere-independent activities of telomerase reverse transcriptase in human cancer. FEBS J 2013; 280: 3205-11.
-
(2013)
FEBS J
, vol.280
, pp. 3205-3211
-
-
Ding, D.1
Zhou, J.2
Wang, M.3
Cong, Y.S.4
-
64
-
-
23944516520
-
Conditional telomerase induction causes proliferation of hair follicle stem cells
-
Sarin KY, Cheung P, Gilison D, et al. Conditional telomerase induction causes proliferation of hair follicle stem cells. Nature 2005; 436: 1048-52.
-
(2005)
Nature
, vol.436
, pp. 1048-1052
-
-
Sarin, K.Y.1
Cheung, P.2
Gilison, D.3
-
65
-
-
38949156672
-
TERT promotes epithelial proliferation through transcriptional control of a Myc-and Wnt-related developmental program
-
Choi J, Southworth LK, Sarin KY, et al. TERT promotes epithelial proliferation through transcriptional control of a Myc-and Wnt-related developmental program. PLoS Genet 2008; 4: e10.
-
(2008)
PLoS Genet
, vol.4
-
-
Choi, J.1
Southworth, L.K.2
Sarin, K.Y.3
-
66
-
-
67650065306
-
Telomerase modulates Wnt signalling by association with target gene chromatin
-
Park JI, Venteicher AS, Hong JY, et al. Telomerase modulates Wnt signalling by association with target gene chromatin. Nature 2009; 460: 66-72.
-
(2009)
Nature
, vol.460
, pp. 66-72
-
-
Park, J.I.1
Venteicher, A.S.2
Hong, J.Y.3
-
67
-
-
79954565935
-
Human telomerase reverse transcriptase regulates cyclin D1 and G1/S phase transition in laryngeal squamous carcinoma
-
Li J, Huang X, Xie X, Wang J, Duan M. Human telomerase reverse transcriptase regulates cyclin D1 and G1/S phase transition in laryngeal squamous carcinoma. Acta Otolaryngol 2011; 131: 546-51.
-
(2011)
Acta Otolaryngol
, vol.131
, pp. 546-551
-
-
Li, J.1
Huang, X.2
Xie, X.3
Wang, J.4
Duan, M.5
-
68
-
-
49249111098
-
A key role for telomerase reverse transcriptase unit in modulating human embryonic stem cell proliferation, cell cycle dynamics, and in vitro differentiation
-
Yang C, Przyborski S, Cooke MJ, et al. A key role for telomerase reverse transcriptase unit in modulating human embryonic stem cell proliferation, cell cycle dynamics, and in vitro differentiation. Stem Cells 2008; 26: 850-63.
-
(2008)
Stem Cells
, vol.26
, pp. 850-863
-
-
Yang, C.1
Przyborski, S.2
Cooke, M.J.3
-
69
-
-
84866551580
-
Human telomerase reverse transcriptase (hTERT) is a novel target of the Wnt/beta-catenin pathway in human cancer
-
Zhang Y, Toh L, Lau P, Wang X. Human telomerase reverse transcriptase (hTERT) is a novel target of the Wnt/beta-catenin pathway in human cancer. J Biol Chem 2012; 287: 32494-511.
-
(2012)
J Biol Chem
, vol.287
, pp. 32494-32511
-
-
Zhang, Y.1
Toh, L.2
Lau, P.3
Wang, X.4
-
70
-
-
84862617605
-
Wnt/beta-catenin signaling regulates telomerase in stem cells and cancer cells
-
Hoffmeyer K, Raggioli A, Rudloff S, et al. Wnt/beta-catenin signaling regulates telomerase in stem cells and cancer cells. Science 2012; 336: 1549-54.
-
(2012)
Science
, vol.336
, pp. 1549-1554
-
-
Hoffmeyer, K.1
Raggioli, A.2
Rudloff, S.3
-
71
-
-
79958053622
-
Phenotypes in mTERT(+)/(-) and mTERT(-)/(-) mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase
-
Strong MA, Vidal-Cardenas SL, Karim B, et al. Phenotypes in mTERT(+)/(-) and mTERT(-)/(-) mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase. Mol Cell Biol 2011; 31: 2369-79.
-
(2011)
Mol Cell Biol
, vol.31
, pp. 2369-2379
-
-
Strong, M.A.1
Vidal-Cardenas, S.L.2
Karim, B.3
-
72
-
-
84891427530
-
An investigation of the effects of the core protein telomerase reverse transcriptase on wnt signaling in breast cancer cells
-
Listerman I, Gazzaniga FS, Blackburn EH. An investigation of the effects of the core protein telomerase reverse transcriptase on wnt signaling in breast cancer cells. Mol Cell Biol 2014; 34: 280-9.
-
(2014)
Mol Cell Biol
, vol.34
, pp. 280-289
-
-
Listerman, I.1
Gazzaniga, F.S.2
Blackburn, E.H.3
-
73
-
-
84883743387
-
Telomerase reverse transcriptase promotes epithelial-mesenchymal transition and stem cell-like traits in cancer cells
-
Liu Z, Li Q, Li K, et al. Telomerase reverse transcriptase promotes epithelial-mesenchymal transition and stem cell-like traits in cancer cells. Oncogene 2013; 32: 4203-13.
-
(2013)
Oncogene
, vol.32
, pp. 4203-4213
-
-
Liu, Z.1
Li, Q.2
Li, K.3
-
74
-
-
47249161129
-
Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function
-
Cheng GZ, Zhang WZ, Sun M, et al. Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function. J Biol Chem 2008; 283: 14665-73.
-
(2008)
J Biol Chem
, vol.283
, pp. 14665-14673
-
-
Cheng, G.Z.1
Zhang, W.Z.2
Sun, M.3
-
75
-
-
36749010238
-
Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation
-
Fu D, Collins K. Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation. Mol Cell 2007; 28: 773-85.
-
(2007)
Mol Cell
, vol.28
, pp. 773-785
-
-
Fu, D.1
Collins, K.2
-
76
-
-
0037207872
-
Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein
-
Akiyama M, Hideshima T, Hayashi T, et al. Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein. Cancer Res 2003; 63: 18-21.
-
(2003)
Cancer Res
, vol.63
, pp. 18-21
-
-
Akiyama, M.1
Hideshima, T.2
Hayashi, T.3
-
77
-
-
84870616090
-
Telomerase directly regulates NF-kappaB-dependent transcription
-
Ghosh A, Saginc G, Leow SC, et al. Telomerase directly regulates NF-kappaB-dependent transcription. Nat Cell Biol 2012; 14: 1270-81.
-
(2012)
Nat Cell Biol
, vol.14
, pp. 1270-1281
-
-
Ghosh, A.1
Saginc, G.2
Leow, S.C.3
-
78
-
-
0034711223
-
NF-kappa B regulates transcription of the mouse telomerase catalytic subunit
-
Yin L, Hubbard AK, Giardina C. NF-kappa B regulates transcription of the mouse telomerase catalytic subunit. J Biol Chem 2000; 275: 36671-5.
-
(2000)
J Biol Chem
, vol.275
, pp. 36671-36675
-
-
Yin, L.1
Hubbard, A.K.2
Giardina, C.3
-
79
-
-
4944240745
-
Transcriptional activation of hTERT through the NF-kappaB pathway in HTLV-I-transformed cells
-
Sinha-Datta U, Horikawa I, Michishita E, et al. Transcriptional activation of hTERT through the NF-kappaB pathway in HTLV-I-transformed cells. Blood 2004; 104: 2523-31.
-
(2004)
Blood
, vol.104
, pp. 2523-2531
-
-
Sinha-Datta, U.1
Horikawa, I.2
Michishita, E.3
-
80
-
-
79958043792
-
hTERT regulation by NF-kappaB and c-myc in irradiated HER2-positive breast cancer cells
-
Papanikolaou V, Athanassiou E, Dubos S, et al. hTERT regulation by NF-kappaB and c-myc in irradiated HER2-positive breast cancer cells. Int J Radiat Biol 2011; 87: 609-21.
-
(2011)
Int J Radiat Biol
, vol.87
, pp. 609-621
-
-
Papanikolaou, V.1
Athanassiou, E.2
Dubos, S.3
-
81
-
-
84887041006
-
Human telomerase reverse transcriptase regulates MMP expression independently of telomerase activity via NF-kappaB-dependent transcription
-
Ding D, Xi P, Zhou J, Wang M, Cong YS. Human telomerase reverse transcriptase regulates MMP expression independently of telomerase activity via NF-kappaB-dependent transcription. FASEB J 2013; 27: 4375-83.
-
(2013)
FASEB J
, vol.27
, pp. 4375-4383
-
-
Ding, D.1
Xi, P.2
Zhou, J.3
Wang, M.4
Cong, Y.S.5
-
82
-
-
84856917044
-
Matrix metalloproteinases and their role in oncogenesis: A review
-
Pytliak M, Vargova V, Mechirova V. Matrix metalloproteinases and their role in oncogenesis: a review. Onkologie 2012; 35: 49-53.
-
(2012)
Onkologie
, vol.35
, pp. 49-53
-
-
Pytliak, M.1
Vargova, V.2
Mechirova, V.3
-
83
-
-
4143124424
-
Antitumor activity of systemi-cally delivered ribozymes targeting murine telomerase RNA
-
Nosrati M, Li S, Bagheri S, et al. Antitumor activity of systemi-cally delivered ribozymes targeting murine telomerase RNA. Clin Cancer Res 2004; 10: 4983-90.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 4983-4990
-
-
Nosrati, M.1
Li, S.2
Bagheri, S.3
-
84
-
-
33746591648
-
Genes and pathways downstream of telomerase in melanoma metastasis
-
Bagheri S, Nosrati M, Li S, et al. Genes and pathways downstream of telomerase in melanoma metastasis. Proc Natl Acad Sci USA 2006; 103: 11306-11.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 11306-11311
-
-
Bagheri, S.1
Nosrati, M.2
Li, S.3
-
85
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat Rev Cancer 2004; 4: 891-9.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
86
-
-
3042822263
-
Telomere length mediates the effects of telomerase on the cellular response to genotoxic stress
-
Rubio MA, Davalos AR, Campisi J. Telomere length mediates the effects of telomerase on the cellular response to genotoxic stress. Exp Cell Res 2004; 298: 17-27.
-
(2004)
Exp Cell Res
, vol.298
, pp. 17-27
-
-
Rubio, M.A.1
Davalos, A.R.2
Campisi, J.3
-
87
-
-
0032580369
-
Inhibition of telomerase increases the susceptibility of human malignant glioblastoma cells to cisplatin-induced apoptosis
-
Kondo Y, Kondo S, Tanaka Y, et al. Inhibition of telomerase increases the susceptibility of human malignant glioblastoma cells to cisplatin-induced apoptosis. Oncogene 1998; 16: 2243-8.
-
(1998)
Oncogene
, vol.16
, pp. 2243-2248
-
-
Kondo, Y.1
Kondo, S.2
Tanaka, Y.3
-
88
-
-
0035300424
-
Ribozyme cleavage of te-lomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase
-
Ludwig A, Saretzki G, Holm PS, et al. Ribozyme cleavage of te-lomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase. Cancer Res 2001; 61: 3053-61.
-
(2001)
Cancer Res
, vol.61
, pp. 3053-3061
-
-
Ludwig, A.1
Saretzki, G.2
Holm, P.S.3
-
89
-
-
79956020200
-
hTERT promotes imatinib resistance in chronic myeloid leukemia cells: Therapeutic implications
-
Deville L, Hillion J, Pendino F, et al. hTERT promotes imatinib resistance in chronic myeloid leukemia cells: therapeutic implications. Mol Cancer Ther 2011; 10: 711-9.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 711-719
-
-
Deville, L.1
Hillion, J.2
Pendino, F.3
-
90
-
-
33748316825
-
Telomerase inhibition enhances the response to anticancer drug treatment in human breast cancer cells
-
Cerone MA, Londono-Vallejo JA, Autexier C. Telomerase inhibition enhances the response to anticancer drug treatment in human breast cancer cells. Mol Cancer Ther 2006; 5: 1669-75.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 1669-1675
-
-
Cerone, M.A.1
Londono-Vallejo, J.A.2
Autexier, C.3
-
91
-
-
1842478446
-
Introduction of human telomerase reverse transcriptase to normal human fibroblasts enhances DNA repair capacity
-
Shin KH, Kang MK, Dicterow E, et al. Introduction of human telomerase reverse transcriptase to normal human fibroblasts enhances DNA repair capacity. Clin Cancer Res 2004; 10: 2551-60.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 2551-2560
-
-
Shin, K.H.1
Kang, M.K.2
Dicterow, E.3
-
92
-
-
0032721132
-
Cell cycle dependent localization of the te-lomeric PARP, tankyrase, to nuclear pore complexes and centro-somes
-
Smith S, de Lange T. Cell cycle dependent localization of the te-lomeric PARP, tankyrase, to nuclear pore complexes and centro-somes. J Cell Sci 1999; 112 (Pt 21): 3649-56.
-
(1999)
J Cell Sci
, vol.112
, pp. 3649-3656
-
-
Smith, S.1
de Lange, T.2
-
93
-
-
0032842477
-
Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability
-
d'Adda di Fagagna F, Hande MP, Tong WM, et al. Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability. Nat Genet 1999; 23: 76-80.
-
(1999)
Nat Genet
, vol.23
, pp. 76-80
-
-
d'Adda di Fagagna, F.1
Hande, M.P.2
Tong, W.M.3
-
94
-
-
0033592950
-
DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes
-
Bailey SM, Meyne J, Chen DJ, et al. DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes. Proc Natl Acad Sci USA 1999; 96: 14899-904.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 14899-14904
-
-
Bailey, S.M.1
Meyne, J.2
Chen, D.J.3
-
95
-
-
0342561644
-
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
-
Zhu XD, Kuster B, Mann M, Petrini JH, de Lange T. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Nat Genet 2000; 25: 347-52.
-
(2000)
Nat Genet
, vol.25
, pp. 347-352
-
-
Zhu, X.D.1
Kuster, B.2
Mann, M.3
Petrini, J.H.4
de Lange, T.5
-
96
-
-
0033987424
-
Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts
-
Wyllie FS, Jones CJ, Skinner JW, et al. Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts. Nat Genet 2000; 24: 16-7.
-
(2000)
Nat Genet
, vol.24
, pp. 16-17
-
-
Wyllie, F.S.1
Jones, C.J.2
Skinner, J.W.3
-
98
-
-
0043199578
-
Telomerase maintains telomere structure in normal human cells
-
Masutomi K, Yu EY, Khurts S, et al. Telomerase maintains telomere structure in normal human cells. Cell 2003; 114: 241-53.
-
(2003)
Cell
, vol.114
, pp. 241-253
-
-
Masutomi, K.1
Yu, E.Y.2
Khurts, S.3
-
99
-
-
20444371017
-
The telomerase reverse transcriptase regulates chromatin state and DNA damage responses
-
Masutomi K, Possemato R, Wong JM, et al. The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. Proc Natl Acad Sci USA 2005; 102: 8222-7.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 8222-8227
-
-
Masutomi, K.1
Possemato, R.2
Wong, J.M.3
-
100
-
-
0034775749
-
N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo
-
Armbruster BN, Banik SS, Guo C, Smith AC, Counter CM. N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo. Mol Cell Biol 2001; 21: 7775-86.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 7775-7786
-
-
Armbruster, B.N.1
Banik, S.S.2
Guo, C.3
Smith, A.C.4
Counter, C.M.5
-
101
-
-
77949449274
-
Cellular senescence in the development and treatment of cancer
-
Saretzki G. Cellular senescence in the development and treatment of cancer. Curr Pharm Des 2010; 16: 79-100.
-
(2010)
Curr Pharm Des
, vol.16
, pp. 79-100
-
-
Saretzki, G.1
-
102
-
-
0034775290
-
Ribozyme-mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells
-
Saretzki G, Ludwig A, von Zglinicki T, Runnebaum IB. Ribozyme-mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells. Cancer Gene Ther 2001; 8: 827-34.
-
(2001)
Cancer Gene Ther
, vol.8
, pp. 827-834
-
-
Saretzki, G.1
Ludwig, A.2
von Zglinicki, T.3
Runnebaum, I.B.4
-
103
-
-
33746851957
-
hTERT: A novel endogenous inhibitor of the mitochondrial cell death pathway
-
Massard C, Zermati Y, Pauleau AL, et al. hTERT: a novel endogenous inhibitor of the mitochondrial cell death pathway. Oncogene 2006; 25: 4505-14.
-
(2006)
Oncogene
, vol.25
, pp. 4505-4514
-
-
Massard, C.1
Zermati, Y.2
Pauleau, A.L.3
-
105
-
-
6344247581
-
Death receptor signaling regulatory function for telomerase: HTERT abolishes TRAIL-induced apoptosis, independently of telomere maintenance
-
Dudognon C, Pendino F, Hillion J, et al. Death receptor signaling regulatory function for telomerase: hTERT abolishes TRAIL-induced apoptosis, independently of telomere maintenance. Oncogene 2004; 23: 7469-74.
-
(2004)
Oncogene
, vol.23
, pp. 7469-7474
-
-
Dudognon, C.1
Pendino, F.2
Hillion, J.3
-
106
-
-
27344446189
-
Involvement of hTERT in apoptosis induced by interference with Bcl-2 expression and function
-
Del Bufalo D, Rizzo A, Trisciuoglio D, et al. Involvement of hTERT in apoptosis induced by interference with Bcl-2 expression and function. Cell Death Differ 2005; 12: 1429-38.
-
(2005)
Cell Death Differ
, vol.12
, pp. 1429-1438
-
-
Del Bufalo, D.1
Rizzo, A.2
Trisciuoglio, D.3
-
107
-
-
13844272923
-
Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage
-
Santos JH, Meyer JN, Skorvaga M, Annab LA, Van Houten B. Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage. Aging Cell 2004; 3: 399-411.
-
(2004)
Aging Cell
, vol.3
, pp. 399-411
-
-
Santos, J.H.1
Meyer, J.N.2
Skorvaga, M.3
Annab, L.A.4
Van Houten, B.5
-
108
-
-
66349130192
-
Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage
-
Haendeler J, Drose S, Buchner N, et al. Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage. Arterioscler Thromb Vasc Biol 2009; 29: 929-35.
-
(2009)
Arterioscler Thromb Vasc Biol
, vol.29
, pp. 929-935
-
-
Haendeler, J.1
Drose, S.2
Buchner, N.3
-
109
-
-
0037432156
-
Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation
-
Haendeler J, Hoffmann J, Rahman S, Zeiher AM, Dimmeler S. Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation. FEBS Lett 2003; 536: 180-6.
-
(2003)
FEBS Lett
, vol.536
, pp. 180-186
-
-
Haendeler, J.1
Hoffmann, J.2
Rahman, S.3
Zeiher, A.M.4
Dimmeler, S.5
-
110
-
-
0031006856
-
Bcl-2 modulates telomerase activity
-
Mandal M, Kumar R. Bcl-2 modulates telomerase activity. J Biol Chem 1997; 272: 14183-7.
-
(1997)
J Biol Chem
, vol.272
, pp. 14183-14187
-
-
Mandal, M.1
Kumar, R.2
-
111
-
-
84866456626
-
Silencing of the hTERT gene through RNA interference induces apoptosis via bax/bcl-2 in human glioma cells
-
Wang T, Xue Y, Wang M, Sun Q. Silencing of the hTERT gene through RNA interference induces apoptosis via bax/bcl-2 in human glioma cells. Oncol Rep 2012; 28: 1153-8.
-
(2012)
Oncol Rep
, vol.28
, pp. 1153-1158
-
-
Wang, T.1
Xue, Y.2
Wang, M.3
Sun, Q.4
-
113
-
-
22244442162
-
Telomerase can act as a template-and RNA-independent terminal transferase
-
Lue NF, Bosoy D, Moriarty TJ, et al. Telomerase can act as a template-and RNA-independent terminal transferase. Proc Natl Acad Sci USA 2005; 102: 9778-83.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 9778-9783
-
-
Lue, N.F.1
Bosoy, D.2
Moriarty, T.J.3
-
114
-
-
70249114371
-
An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
-
Maida Y, Yasukawa M, Furuuchi M, et al. An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA. Nature 2009; 461: 230-5.
-
(2009)
Nature
, vol.461
, pp. 230-235
-
-
Maida, Y.1
Yasukawa, M.2
Furuuchi, M.3
-
116
-
-
77956049347
-
Of proteins and RNA: The RNase P/MRP family
-
Esakova O, Krasilnikov AS. Of proteins and RNA: the RNase P/MRP family. RNA 2010; 16: 1725-47.
-
(2010)
RNA
, vol.16
, pp. 1725-1747
-
-
Esakova, O.1
Krasilnikov, A.S.2
-
117
-
-
79952828816
-
Characterization of MRP RNA-protein interactions within the perinucleolar compartment
-
Pollock C, Daily K, Nguyen VT, et al. Characterization of MRP RNA-protein interactions within the perinucleolar compartment. Mol Biol Cell 2011; 22: 858-67.
-
(2011)
Mol Biol Cell
, vol.22
, pp. 858-867
-
-
Pollock, C.1
Daily, K.2
Nguyen, V.T.3
-
118
-
-
34247188473
-
Telomere and telomerase in stem cells
-
Hiyama E, Hiyama K. Telomere and telomerase in stem cells. Br J Cancer 2007; 96: 1020-4.
-
(2007)
Br J Cancer
, vol.96
, pp. 1020-1024
-
-
Hiyama, E.1
Hiyama, K.2
-
119
-
-
84855905939
-
Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria
-
Sharma NK, Reyes A, Green P, et al. Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria. Nucleic Acids Res 2012; 40: 712-25.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 712-725
-
-
Sharma, N.K.1
Reyes, A.2
Green, P.3
-
120
-
-
31944444988
-
Cell cycle-regulated trafficking of human telomerase to telomeres
-
Tomlinson RL, Ziegler TD, Supakorndej T, Terns RM, Terns MP. Cell cycle-regulated trafficking of human telomerase to telomeres. Mol Biol Cell 2006; 17: 955-65.
-
(2006)
Mol Biol Cell
, vol.17
, pp. 955-965
-
-
Tomlinson, R.L.1
Ziegler, T.D.2
Supakorndej, T.3
Terns, R.M.4
Terns, M.P.5
-
121
-
-
0037025334
-
The nucleolar localization domain of the catalytic subunit of human telomerase
-
Etheridge KT, Banik SS, Armbruster BN, et al The nucleolar localization domain of the catalytic subunit of human telomerase. J Biol Chem 2002; 277: 24764-70.
-
(2002)
J Biol Chem
, vol.277
, pp. 24764-24770
-
-
Etheridge, K.T.1
Banik, S.S.2
Armbruster, B.N.3
-
122
-
-
33846170040
-
Characterization of a novel effect of hPinX1 on hTERT nucleolar localization
-
Lin J, Jin R, Zhang B, et al. Characterization of a novel effect of hPinX1 on hTERT nucleolar localization. Biochem Biophys Res Commun 2007; 353: 946-52.
-
(2007)
Biochem Biophys Res Commun
, vol.353
, pp. 946-952
-
-
Lin, J.1
Jin, R.2
Zhang, B.3
-
123
-
-
0035798379
-
The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor
-
Zhou XZ, Lu KP. The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell 2001; 107: 347-59.
-
(2001)
Cell
, vol.107
, pp. 347-359
-
-
Zhou, X.Z.1
Lu, K.P.2
-
124
-
-
48049088130
-
Nucleolar localization of TERT is unrelated to telomerase function in human cells
-
Lin J, Jin R, Zhang B, et al. Nucleolar localization of TERT is unrelated to telomerase function in human cells. J Cell Sci 2008; 121: 2169-76.
-
(2008)
J Cell Sci
, vol.121
, pp. 2169-2176
-
-
Lin, J.1
Jin, R.2
Zhang, B.3
-
125
-
-
0036711651
-
Subnuclear shuttling of human telomerase induced by transformation and DNA damage
-
Wong JM, Kusdra L, Collins K. Subnuclear shuttling of human telomerase induced by transformation and DNA damage. Nat Cell Biol 2002; 4: 731-6.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 731-736
-
-
Wong, J.M.1
Kusdra, L.2
Collins, K.3
-
126
-
-
0028128516
-
Healing of broken human chromosomes by the addition of telomeric repeats
-
Flint J, Craddock CF, Villegas A, et al. Healing of broken human chromosomes by the addition of telomeric repeats. Am J Hum Genet 1994; 55: 505-12.
-
(1994)
Am J Hum Genet
, vol.55
, pp. 505-512
-
-
Flint, J.1
Craddock, C.F.2
Villegas, A.3
-
127
-
-
70350400854
-
Novel role of nucleostemin in the maintenance of nucleolar architecture and integrity of small nucleolar ribonucleoproteins and the telomerase complex
-
Romanova L, Kellner S, Katoku-Kikyo N, Kikyo N. Novel role of nucleostemin in the maintenance of nucleolar architecture and integrity of small nucleolar ribonucleoproteins and the telomerase complex. J Biol Chem 2009; 284: 26685-94.
-
(2009)
J Biol Chem
, vol.284
, pp. 26685-26694
-
-
Romanova, L.1
Kellner, S.2
Katoku-Kikyo, N.3
Kikyo, N.4
-
128
-
-
0034212582
-
Involvement of 14-3-3 proteins in nuclear localization of telomerase
-
Seimiya H, Sawada H, Muramatsu Y, et al. Involvement of 14-3-3 proteins in nuclear localization of telomerase. EMBO J 2000; 19: 2652-61.
-
(2000)
EMBO J
, vol.19
, pp. 2652-2661
-
-
Seimiya, H.1
Sawada, H.2
Muramatsu, Y.3
-
129
-
-
0037390962
-
TERT suppresses apoptotis at a premitochondrial step by a mechanism requiring reverse transcriptase activity and 14-3-3 protein-binding ability
-
Zhang P, Chan SL, Fu W, Mendoza M, Mattson MP. TERT suppresses apoptotis at a premitochondrial step by a mechanism requiring reverse transcriptase activity and 14-3-3 protein-binding ability. FASEB J 2003; 17: 767-9.
-
(2003)
FASEB J
, vol.17
, pp. 767-769
-
-
Zhang, P.1
Chan, S.L.2
Fu, W.3
Mendoza, M.4
Mattson, M.P.5
-
130
-
-
1542512436
-
TNFalpha induces rapid activation and nuclear translocation of telomerase in human lymphocytes
-
Akiyama M, Yamada O, Hideshima T, et al. TNFalpha induces rapid activation and nuclear translocation of telomerase in human lymphocytes. Biochem Biophys Res Commun 2004; 316: 528-32.
-
(2004)
Biochem Biophys Res Commun
, vol.316
, pp. 528-532
-
-
Akiyama, M.1
Yamada, O.2
Hideshima, T.3
-
131
-
-
0035871710
-
Cutting edge: Telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocation
-
Liu K, Hodes RJ, Weng N. Cutting edge: telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocation. J Immunol 2001; 166: 4826-30.
-
(2001)
J Immunol
, vol.166
, pp. 4826-4830
-
-
Liu, K.1
Hodes, R.J.2
Weng, N.3
-
132
-
-
84864966476
-
Nuclear import of hTERT requires a bipartite nuclear localization signal and Akt-mediated phosphorylation
-
Chung J, Khadka P, Chung IK. Nuclear import of hTERT requires a bipartite nuclear localization signal and Akt-mediated phosphorylation. J Cell Sci 2012; 125: 2684-97.
-
(2012)
J Cell Sci
, vol.125
, pp. 2684-2697
-
-
Chung, J.1
Khadka, P.2
Chung, I.K.3
-
133
-
-
34250193219
-
The loss of telomerase activity in highly differentiated CD8+CD28-CD27-T cells is associated with decreased Akt (Ser473) phosphorylation
-
Plunkett FJ, Franzese O, Finney HM, et al. The loss of telomerase activity in highly differentiated CD8+CD28-CD27-T cells is associated with decreased Akt (Ser473) phosphorylation. J Immunol 2007; 178: 7710-9.
-
(2007)
J Immunol
, vol.178
, pp. 7710-7719
-
-
Plunkett, F.J.1
Franzese, O.2
Finney, H.M.3
-
135
-
-
17844380300
-
IL-2 increases human telom-erase reverse transcriptase activity transcriptionally and posttransla-tionally through phosphatidylinositol 3'-kinase/Akt, heat shock protein 90, and mammalian target of rapamycin in transformed NK cells
-
Kawauchi K, Ihjima K, Yamada O. IL-2 increases human telom-erase reverse transcriptase activity transcriptionally and posttransla-tionally through phosphatidylinositol 3'-kinase/Akt, heat shock protein 90, and mammalian target of rapamycin in transformed NK cells. J Immunol 2005; 174: 5261-9.
-
(2005)
J Immunol
, vol.174
, pp. 5261-5269
-
-
Kawauchi, K.1
Ihjima, K.2
Yamada, O.3
-
136
-
-
84879889714
-
eIF4E-Overexpression imparts perillyl alcohol and rapamycin-mediated regulation of telomerase reverse transcriptase
-
Sundin T, Peffley D, Hentosh P. eIF4E-Overexpression imparts perillyl alcohol and rapamycin-mediated regulation of telomerase reverse transcriptase. Exp Cell Res 2013; 319: 2103-12.
-
(2013)
Exp Cell Res
, vol.319
, pp. 2103-2112
-
-
Sundin, T.1
Peffley, D.2
Hentosh, P.3
-
137
-
-
84873056486
-
Disruption of an hTERT-mTOR-RAPTOR protein complex by a phytochemical perillyl alcohol and rapamycin
-
Sundin T, Peffley DM, Hentosh P. Disruption of an hTERT-mTOR-RAPTOR protein complex by a phytochemical perillyl alcohol and rapamycin. Mol Cell Biochem 2013; 375: 97-104.
-
(2013)
Mol Cell Biochem
, vol.375
, pp. 97-104
-
-
Sundin, T.1
Peffley, D.M.2
Hentosh, P.3
-
138
-
-
84892558088
-
Endoplasmic reticulum stress activates telomerase
-
Zhou J, Mao B, Zhou Q, et al. Endoplasmic reticulum stress activates telomerase. Aging Cell 2014; 13: 197-200.
-
(2014)
Aging Cell
, vol.13
, pp. 197-200
-
-
Zhou, J.1
Mao, B.2
Zhou, Q.3
-
139
-
-
8744260946
-
Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase
-
Hung JH, Su IJ, Lei HY, et al. Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase. J Biol Chem 2004; 279: 46384-92.
-
(2004)
J Biol Chem
, vol.279
, pp. 46384-46392
-
-
Hung, J.H.1
Su, I.J.2
Lei, H.Y.3
-
140
-
-
84879147334
-
Cytoplasmic TERT Associates to RNA Granules in Fully Mature Neurons: Role in the Translational Control of the Cell Cycle Inhibitor p15INK4B
-
Iannilli F, Zalfa F, Gartner A, Bagni C, Dotti CG. Cytoplasmic TERT Associates to RNA Granules in Fully Mature Neurons: Role in the Translational Control of the Cell Cycle Inhibitor p15INK4B. PLoS One 2013; 8: e66602.
-
(2013)
PLoS One
, vol.8
-
-
Iannilli, F.1
Zalfa, F.2
Gartner, A.3
Bagni, C.4
Dotti, C.G.5
-
141
-
-
1842611977
-
Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells
-
Haendeler J, Hoffmann J, Diehl JF, et al. Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells. Circ Res 2004; 94: 768-75.
-
(2004)
Circ Res
, vol.94
, pp. 768-775
-
-
Haendeler, J.1
Hoffmann, J.2
Diehl, J.F.3
-
142
-
-
78651386195
-
hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells
-
Indran IR, Hande MP, Pervaiz S. hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells. Cancer Res 2011; 71: 266-76.
-
(2011)
Cancer Res
, vol.71
, pp. 266-276
-
-
Indran, I.R.1
Hande, M.P.2
Pervaiz, S.3
-
143
-
-
77953256244
-
A mutant telomerase defective in nuclear-cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction
-
Kovalenko OA, Caron MJ, Ulema P, et al. A mutant telomerase defective in nuclear-cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction. Aging Cell 2010; 9: 203-19.
-
(2010)
Aging Cell
, vol.9
, pp. 203-219
-
-
Kovalenko, O.A.1
Caron, M.J.2
Ulema, P.3
-
144
-
-
33744745014
-
Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis
-
Santos JH, Meyer JN, Van Houten B. Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis. Hum Mol Genet 2006; 15: 1757-68.
-
(2006)
Hum Mol Genet
, vol.15
, pp. 1757-1768
-
-
Santos, J.H.1
Meyer, J.N.2
Van Houten, B.3
-
145
-
-
84872251777
-
Mitochondrial telomerase protects cancer cells from nuclear DNA damage and apoptosis
-
Singhapol C, Pal D, Czapiewski R, et al. Mitochondrial telomerase protects cancer cells from nuclear DNA damage and apoptosis. PLoS One 2013; 8: e52989.
-
(2013)
PLoS One
, vol.8
-
-
Singhapol, C.1
Pal, D.2
Czapiewski, R.3
-
146
-
-
77953362149
-
Downregulation of mitochondrial telomerase reverse transcriptase induced by H2O2 is Src kinase dependent
-
Buchner N, Zschauer TC, Lukosz M, Altschmied J, Haendeler J. Downregulation of mitochondrial telomerase reverse transcriptase induced by H2O2 is Src kinase dependent. Exp Gerontol 2010; 45: 558-62.
-
(2010)
Exp Gerontol
, vol.45
, pp. 558-562
-
-
Buchner, N.1
Zschauer, T.C.2
Lukosz, M.3
Altschmied, J.4
Haendeler, J.5
-
147
-
-
77954473217
-
Well-known signaling proteins exert new functions in the nucleus and mitochondria
-
Buchner N, Altschmied J, Jakob S, Saretzki G, Haendeler J. Well-known signaling proteins exert new functions in the nucleus and mitochondria. Antioxid Redox Signal 2010; 13: 551-8.
-
(2010)
Antioxid Redox Signal
, vol.13
, pp. 551-558
-
-
Buchner, N.1
Altschmied, J.2
Jakob, S.3
Saretzki, G.4
Haendeler, J.5
-
148
-
-
54049083894
-
Localization of PTP-1B, SHP-2, and Src exclusively in rat brain mitochondria and functional consequences
-
Arachiche A, Augereau O, Decossas M, et al. Localization of PTP-1B, SHP-2, and Src exclusively in rat brain mitochondria and functional consequences. J Biol Chem 2008; 283: 24406-11.
-
(2008)
J Biol Chem
, vol.283
, pp. 24406-24411
-
-
Arachiche, A.1
Augereau, O.2
Decossas, M.3
-
149
-
-
70449568292
-
Akt1 intramito-chondrial cycling is a crucial step in the redox modulation of cell cycle progression
-
Antico Arciuch VG, Galli S, Franco MC, et al. Akt1 intramito-chondrial cycling is a crucial step in the redox modulation of cell cycle progression. PLoS One 2009; 4: e7523.
-
(2009)
PLoS One
, vol.4
-
-
Antico Arciuch, V.G.1
Galli, S.2
Franco, M.C.3
-
150
-
-
53649111012
-
hTERT gene expression levels and telomerase activity in drug resistant MCF-7 cells
-
Sakin V, Eskiocak U, Kars MD, Iseri OD, Gunduz U. hTERT gene expression levels and telomerase activity in drug resistant MCF-7 cells. Exp Oncol 2008; 30: 202-5.
-
(2008)
Exp Oncol
, vol.30
, pp. 202-205
-
-
Sakin, V.1
Eskiocak, U.2
Kars, M.D.3
Iseri, O.D.4
Gunduz, U.5
-
151
-
-
7444223594
-
Hydrogen peroxide-mediated cytosolic acidification is a signal for mitochondrial translocation of Bax during drug-induced apoptosis of tumor cells
-
Ahmad KA, Iskandar KB, Hirpara JL, Clement MV, Pervaiz S. Hydrogen peroxide-mediated cytosolic acidification is a signal for mitochondrial translocation of Bax during drug-induced apoptosis of tumor cells. Cancer Res 2004; 64: 7867-78.
-
(2004)
Cancer Res
, vol.64
, pp. 7867-7878
-
-
Ahmad, K.A.1
Iskandar, K.B.2
Hirpara, J.L.3
Clement, M.V.4
Pervaiz, S.5
-
152
-
-
77956269805
-
Expression of (NES-)hTERT in cancer cells delays cell cycle progression and increases sensitivity to genotoxic stress
-
Kovalenko OA, Kaplunov J, Herbig U, et al. Expression of (NES-)hTERT in cancer cells delays cell cycle progression and increases sensitivity to genotoxic stress. PLoS One 2010; 5: e10812.
-
(2010)
PLoS One
, vol.5
-
-
Kovalenko, O.A.1
Kaplunov, J.2
Herbig, U.3
-
153
-
-
84879151792
-
Induced tRNA import into human mitochondria: Implication of a host aminoacyl-tRNA-synthetase
-
Gowher A, Smirnov A, Tarassov I, Entelis N. Induced tRNA import into human mitochondria: implication of a host aminoacyl-tRNA-synthetase. PLoS One 2013; 8: e66228.
-
(2013)
PLoS One
, vol.8
-
-
Gowher, A.1
Smirnov, A.2
Tarassov, I.3
Entelis, N.4
-
154
-
-
84883309262
-
Replicating animal mitochondrial DNA
-
McKinney EA, Oliveira MT. Replicating animal mitochondrial DNA. Genet Mol Biol 2013; 36: 308-315.
-
(2013)
Genet Mol Biol
, vol.36
, pp. 308-315
-
-
McKinney, E.A.1
Oliveira, M.T.2
-
155
-
-
84866557880
-
Role of mitochondrial translocation of telomerase in hepatocellular carcinoma cells with multidrug resistance
-
Ling X, Wen L, Zhou Y. Role of mitochondrial translocation of telomerase in hepatocellular carcinoma cells with multidrug resistance. Int J Med Sci 2012; 9: 545-54.
-
(2012)
Int J Med Sci
, vol.9
, pp. 545-554
-
-
Ling, X.1
Wen, L.2
Zhou, Y.3
-
156
-
-
84878254677
-
Mitochondrial dysfunction and nuclear-mitochondrial shuttling of TERT are involved in cell proliferation arrest induced by G-quadruplex ligands
-
Zhuang XY, Yao YG. Mitochondrial dysfunction and nuclear-mitochondrial shuttling of TERT are involved in cell proliferation arrest induced by G-quadruplex ligands. FEBS Lett 2013; 587: 1656-62.
-
(2013)
FEBS Lett
, vol.587
, pp. 1656-1662
-
-
Zhuang, X.Y.1
Yao, Y.G.2
-
157
-
-
84865072128
-
Methods of studying telomere damage induced by quadruplex-ligand complexes
-
Rizzo A, Salvati E, Biroccio A. Methods of studying telomere damage induced by quadruplex-ligand complexes. Methods 2012; 57: 93-9.
-
(2012)
Methods
, vol.57
, pp. 93-99
-
-
Rizzo, A.1
Salvati, E.2
Biroccio, A.3
|