Structure-function relationship and biogenesis regulation of the human telomerase holoenzyme

FEBS Journal

Volumn 280, Issue 14, 2013, Pages 3194-3204

  Hukezalie, Kyle R ^a   Wong, Judy M Y ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

biogenesis regulation; enzyme assembly; intracellular trafficking; nucleotide addition processivity; repeat addition processivity; structure activity relationship; subcellular localization; telomerase reverse transcriptase; telomerase RNA; telomere catalysis

Indexed keywords

HOLOENZYME; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; TELOMERASE RNA; UNCLASSIFIED DRUG;

BIOGENESIS; CATALYSIS; CELL DIVISION; CELL MIGRATION; CELLULAR DISTRIBUTION; DNA SYNTHESIS; ENZYME ACTIVITY; GENETIC SCREENING; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; RING FINGER MOTIF; STRUCTURE ACTIVITY RELATION; TELOMERE; TRIBOLIUM CASTANEUM; YEAST;

BIOGENESIS REGULATION; ENZYME ASSEMBLY; INTRACELLULAR TRAFFICKING; NUCLEOTIDE ADDITION PROCESSIVITY; REPEAT ADDITION PROCESSIVITY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBCELLULAR LOCALIZATION; TELOMERASE REVERSE TRANSCRIPTASE; TELOMERASE RNA; TELOMERE CATALYSIS;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BIOCATALYSIS; CATALYTIC DOMAIN; HUMANS; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; PROTEIN FOLDING; PROTEIN TRANSPORT; RNA; TELOMERASE; TELOMERE;

MAMMALIA;

EID: 84879918842     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12272     Document Type: Review

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