hTERT regulation by NF-κB and c-myc in irradiated HER2-positive breast cancer cells

International Journal of Radiation Biology

Volumn 87, Issue 6, 2011, Pages 609-621

  Papanikolaou, Vassilis ^a,b   Athanassiou, Evangelos ^a   Dubos, Stephanie ^b   Dimou, Ioannis ^c   Papathanasiou, Ioanna ^a   Kitsiou Tzeli, Sofia ^d   Kappas, Constantin ^a   Tsezou, Aspasia ^a,b  

^a UNIVERSITY OF THESSALY   (Greece)

^b Institute for Biomedical Research and Technology   (Greece)

^c TECHNICAL UNIVERSITY OF CRETE   (Greece)

^d UNIVERSITY OF ATHENS   (Greece)

Author keywords

breast cancer; c myc; HER2; ionising radiation; NF B; telomerase

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAX PROTEIN; MESSENGER RNA; MYC PROTEIN; PROGESTERONE RECEPTOR; PROTEIN KINASE B; PROTEIN MAD1; SMALL INTERFERING RNA; SURVIVIN; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CHROMATIN IMMUNOPRECIPITATION; CLINICAL ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IONIZING RADIATION; IRRADIATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TELOMERIC REPEAT AMPLIFICATION PROTOCOL; TUMOR BIOPSY; UPREGULATION;

APOPTOSIS; BREAST NEOPLASMS; CHROMATIN IMMUNOPRECIPITATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NF-KAPPA B; PHENOTYPE; PROTO-ONCOGENE PROTEINS C-MYC; RECEPTOR, ERBB-2; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; RNA, MESSENGER; TELOMERASE; TELOMERE; TIME FACTORS;

EID: 79958043792     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.3109/09553002.2011.572112     Document Type: Article

References (27)

1. Asanuma H, Torigoe T, Kamiguchi K, Hirohashi Y, Ohmura T, Hirata K, Sato M, Sato N. 2005. Survivin expression is regulated by coexpression of human epidermal growth factor receptor 2 and epidermal growth factor receptor via phosphatidylinositol 3-kinase/AKT signaling pathway in breast cancer cells. Cancer Research 65:11018-11025. (Pubitemid 41713372)
2. Baud V, Karin M. 2009. Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nature Reviews Drug Discovery 8:33-40.
3. Cosgrave N, Hill AD, Young LS. 2006. Growth factor-dependent regulation of survivin by c-myc in human breast cancer. Journal of Molecular Endocrinology 37:377-390. (Pubitemid 46085164)
4. Flint J, Craddock CF, Villegas A, Bentley DP, Williams HJ, Galanello R, Cao A, Wood WG, Ayyub H, Higgs DR. 1994. Healing of broken human chromosomes by the addition of telomeric repeats. American Journal of Human Genetics 55:505-512. (Pubitemid 24272405)
5. Fujiki T, Miura T, Maura M, Shiraishi H, Nishimura S, Imada Y, Uehara N, Tashiro K, Shirahata S, Katakura Y. 2007. TAK1 represses transcription of the human telomerase reverse transcriptase gene. Oncogene 26:5258-5266. (Pubitemid 47237626)
6. Gee JM, Nicholson RI. 2003. Expanding the therapeutic repertoire of epidermal growth factor receptor blockade: Radiosensitization. Breast Cancer Research 5:126-129. (Pubitemid 36519404)
7. Goueli BS, Janknecht R. 2004. Upregulation of the catalytic telomerase subunit by the transcription factor ER81 and oncogenic HER2/Neu, Ras, or Raf. Molecular and Cellular Biology 24:25-35. (Pubitemid 38010032)
8. Horikawa I, Barrett JC. 2003. Transcriptional regulation of the telomerase hTERT gene as a target for cellular and viral oncogenic mechanisms. Carcinogenesis 24:1167-1176. (Pubitemid 36927056)
9. Hynes NE, Stern DF. 1994. The biology of erbB-2/neu/HER-2 and its role in cancer. Biochimica et Biophysica Acta 1198:165-184.
10. Jameel JK, Rao VS, Cawkwell L, Drew PJ. 2004. Radioresistance in carcinoma of the breast. Breast 13:452-460. (Pubitemid 39618816)
11. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. 2009. Cancer statistics, 2009. CA: A Cancer Journal for Clinicians 59:225-249.
12. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL, Shay JW. 1994. Specific association of human telomerase activity with immortal cells and cancer. Science 266:2011-2015.
13. Kyo S, Inoue M. 2002. Complex regulatory mechanisms of telomerase activity in normal and cancer cells: How can we apply them for cancer therapy? Oncogene 21:688-697. (Pubitemid 34146272)
14. Kyo S, Takakura M, Kanaya T, Zhuo W, Fujimoto K, Nishio Y, Orimo A, Inoue M. 1999. Estrogen activates telomerase. Cancer Research 59:5917-5921. (Pubitemid 30004951)
15. Liang K, Lu Y, Jin W, Ang KK, Milas L, Fan Z. 2003. Sensitization of breast cancer cells to radiation by trastuzumab. Molecular Cancer Therapeutics 2:1113-1120.
16. Lin Z, Lim S, Viani MA, Sapp M, Lim MS. 2001. Downregulation of telomerase activity in malignant lymphomas by radiation and chemotherapeutic agents. American Journal of Pathology 159:711-719. (Pubitemid 32751101)
17. Pandita TK, Roti Roti JL. 2003. Role of telomerase in radiocurability (Review). Oncology Reports 10:263-270.
18. Papanikolaou V, Iliopoulos D, Dimou I, Dubos S, Tsougos I, Theodorou K, Kitsiou-Tzeli S, Tsezou A. 2009. The involvement of HER2 and p53 status in the regulation of telomerase in irradiated breast cancer cells. International Journal of Oncology 35:1141-1149.
19. Satra M, Tsougos I, Papanikolaou V, Theodorou K, Kappas C, Tsezou A. 2006. Correlation between radiation-induced telomerase activity and human telomerase reverse transcriptase mRNA expression in HeLa cells. International Journal of Radiation Biology 82:401-409. (Pubitemid 44086993)
20. Sawant SG, Gregoire V, Dhar S, Umbricht CB, Cvilic S, Sukumar S, Pandita TK. 1999. Telomerase activity as a measure for monitoring radiocurability of tumor cells. Faseb Journal 13:1047-1054. (Pubitemid 29249730)
21. Sethi G, Ahn KS, Aggarwal BB. 2008. Targeting nuclear factor-kappa B activation pathway by thymoquinone: Role in suppression of antiapoptotic gene products and enhancement of apoptosis. Molecular Cancer Research 6:1059-1070.
22. Shay JW, Bacchetti S. 1997. A survey of telomerase activity in human cancer. European Journal of Cancer 33:787-791.
23. Tsezou A, Oikonomou P, Kollia P, Mademtzis I, Kostopoulou E, Messinis I, Vamvakopoulos N. 2005. The role of human telomerase catalytic subunit mRNA expression in cervical dysplasias. Experimental Biology and Medicine (Maywood) 230:263-270. (Pubitemid 40478251)
24. Wang Z, Kyo S, Takakura M, Tanaka M, Yatabe N, Maida Y, Fujiwara M, Hayakawa J, Ohmichi M, Koike K, et al. 2000. Progesterone regulates human telomerase reverse transcriptase gene expression via activation of mitogen-activated protein kinase signaling pathway. Cancer Research 60:5376-5381.
25. Wilkie AO, Lamb J, Harris PC, Finney RD, Higgs DR. 1990. A truncated human chromosome 16 associated with alpha thalassaemia is stabilized by addition of telomeric repeat (TTAGGG)n. Nature 346: 868-871.
26. Xu D, Popov N, Hou M, Wang Q, Bjorkholm M, Gruber A, Menkel AR, Henriksson M. 2001. Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells. Proceedings of the National Academy of Sciences of the USA 98:3826-3831. (Pubitemid 32249856)
27. Yarden Y. 2001. Biology of HER2 and its importance in breast cancer. Oncology 61(Suppl. 2):1-13. (Pubitemid 33033419)