-
1
-
-
0034597794
-
Telomere states and cell fates
-
Blackburn EH. Telomere states and cell fates. Nature 2000;408:53-6.
-
(2000)
Nature
, vol.408
, pp. 53-56
-
-
Blackburn, E.H.1
-
2
-
-
0029563009
-
Telomeres: Beginning to understand the end
-
Zakian VA. Telomeres: beginning to understand the end. Science 1995;270:1601-17.
-
(1995)
Science
, vol.270
, pp. 1601-1617
-
-
Zakian, V.A.1
-
3
-
-
0026523228
-
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
-
Counter CM, Avilion AA, LeFeuvre CE, et al. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J 1992;11:1921-9.
-
(1992)
EMBO J
, vol.11
, pp. 1921-1929
-
-
Counter, C.M.1
Avilion, A.A.2
LeFeuvre, C.E.3
-
4
-
-
0023663881
-
The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity
-
Greider CW, Blackburn EH. The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Cell 1987;51:887-98.
-
(1987)
Cell
, vol.51
, pp. 887-898
-
-
Greider, C.W.1
Blackburn, E.H.2
-
5
-
-
0024978857
-
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
-
Greider CW, Blackburn EH. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 1989;337:331-7.
-
(1989)
Nature
, vol.337
, pp. 331-337
-
-
Greider, C.W.1
Blackburn, E.H.2
-
6
-
-
0033614998
-
Creation of human tumour cells with defined genetic elements
-
Hahn WC, Counter CM, Lundberg AS, Beijersbergen RL, Brooks MW, Weinberg RA. Creation of human tumour cells with defined genetic elements. Nature 1999;400:464-8.
-
(1999)
Nature
, vol.400
, pp. 464-468
-
-
Hahn, W.C.1
Counter, C.M.2
Lundberg, A.S.3
Beijersbergen, R.L.4
Brooks, M.W.5
Weinberg, R.A.6
-
7
-
-
18644373013
-
Telomerase contributes to tumorigenesis by a telomere length-independent mechanism
-
Stewart SA, Hahn WC, O'Connor BF, et al. Telomerase contributes to tumorigenesis by a telomere length-independent mechanism. Proc Natl Acad Sci USA 2002;99:12606-11.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 12606-12611
-
-
Stewart, S.A.1
Hahn, W.C.2
O'Connor, B.F.3
-
8
-
-
0031010342
-
A survey of telomerase activity in human cancer
-
Shay JW, Bacchetti S. A survey of telomerase activity in human cancer. Eur J Cancer 1997;33:787-91.
-
(1997)
Eur J Cancer
, vol.33
, pp. 787-791
-
-
Shay, J.W.1
Bacchetti, S.2
-
9
-
-
0037148326
-
Clinical utility of telomerase in cancer
-
Hiyama E, Hiyama K. Clinical utility of telomerase in cancer. Oncogene 2002;21:643-9.
-
(2002)
Oncogene
, vol.21
, pp. 643-649
-
-
Hiyama, E.1
Hiyama, K.2
-
10
-
-
0029953160
-
Telomerase activity in human acute myelogenous leukemia: Inhibition of telomerase activity by differentiation-inducing agents
-
Zhang W, Piatyszek MA, Kobayashi T, et al. Telomerase activity in human acute myelogenous leukemia: inhibition of telomerase activity by differentiation-inducing agents. Clin Cancer Res 1996;2:799-803.
-
(1996)
Clin Cancer Res
, vol.2
, pp. 799-803
-
-
Zhang, W.1
Piatyszek, M.A.2
Kobayashi, T.3
-
11
-
-
0036782884
-
Telomerase: A target for cancer therapeutics
-
Shay JW, Wright WE. Telomerase: a target for cancer therapeutics. Cancer Cell 2002;2:257-65.
-
(2002)
Cancer Cell
, vol.2
, pp. 257-265
-
-
Shay, J.W.1
Wright, W.E.2
-
12
-
-
0033455559
-
Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death
-
Herbert B, Pitts AE, Baker SI, et al. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc Natl Acad Sci USA 1999;96:14276-81.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 14276-14281
-
-
Herbert, B.1
Pitts, A.E.2
Baker, S.I.3
-
13
-
-
0034775290
-
Ribozyme-mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells
-
Saretzki G, Ludwig A, von Zglinicki T, Runnebaum IB. Ribozyme-mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells. Cancer Gene Ther 2001;8:827-34.
-
(2001)
Cancer Gene Ther
, vol.8
, pp. 827-834
-
-
Saretzki, G.1
Ludwig, A.2
Von Zglinicki, T.3
Runnebaum, I.B.4
-
14
-
-
0032828652
-
Inhibition of telomerase limits the growth of human cancer cells
-
Hahn WC, Stewart SA, Brooks MW, et al. Inhibition of telomerase limits the growth of human cancer cells. Nat Med 1999;5:1164-70.
-
(1999)
Nat Med
, vol.5
, pp. 1164-1170
-
-
Hahn, W.C.1
Stewart, S.A.2
Brooks, M.W.3
-
15
-
-
0034933876
-
A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation
-
Kim MM, Rivera MA, Botchkina IL, Shalaby R, Thor AD, Blackburn EH. A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation. Proc Natl Acad Sci USA 2001;98:7982-7.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 7982-7987
-
-
Kim, M.M.1
Rivera, M.A.2
Botchkina, I.L.3
Shalaby, R.4
Thor, A.D.5
Blackburn, E.H.6
-
16
-
-
0032566005
-
Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA
-
Kondo S, Kondo Y, Li G, Silverman RH, Cowell JK. Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA. Oncogene 1998;16:3323-30.
-
(1998)
Oncogene
, vol.16
, pp. 3323-3330
-
-
Kondo, S.1
Kondo, Y.2
Li, G.3
Silverman, R.H.4
Cowell, J.K.5
-
17
-
-
0034086475
-
Inhibition of telomerase activity by a hammerhead ribozyme targeting the RNA component of telomerase in human melanoma cells
-
Folini M, Colella G, Villa R, Lualdi S, Daidone MG, Zaffaroni N. Inhibition of telomerase activity by a hammerhead ribozyme targeting the RNA component of telomerase in human melanoma cells. J Investig Dermatol 2000;114:259-67.
-
(2000)
J Investig Dermatol
, vol.114
, pp. 259-267
-
-
Folini, M.1
Colella, G.2
Villa, R.3
Lualdi, S.4
Daidone, M.G.5
Zaffaroni, N.6
-
18
-
-
0030583250
-
Hammerhead ribozyme-mediated inhibition of telomerase activity in extracts of human hepatocellular carcinoma cells
-
Kanazawa Y, Ohkawa K, Ueda K, et al. Hammerhead ribozyme-mediated inhibition of telomerase activity in extracts of human hepatocellular carcinoma cells. Biochem Biophys Res Commun 1996;225:570-6.
-
(1996)
Biochem Biophys Res Commun
, vol.225
, pp. 570-576
-
-
Kanazawa, Y.1
Ohkawa, K.2
Ueda, K.3
-
19
-
-
0032403264
-
Attenuation of telomerase activity by a hammerhead ribozyme targeting the template region of telomerase RNA in endometrial carcinoma cells
-
Yokoyama Y, Takahashi Y, Shinohara A, et al. Attenuation of telomerase activity by a hammerhead ribozyme targeting the template region of telomerase RNA in endometrial carcinoma cells. Cancer Res 1998;58:5406-10.
-
(1998)
Cancer Res
, vol.58
, pp. 5406-5410
-
-
Yokoyama, Y.1
Takahashi, Y.2
Shinohara, A.3
-
20
-
-
0034730623
-
Non-replicating Epstein-Barr virus-based plasmids extend gene expression and can improve gene therapy in vivo
-
Tu G, Kirchmaier AL, Liggitt D, et al. Non-replicating Epstein-Barr virus-based plasmids extend gene expression and can improve gene therapy in vivo. J Biol Chem 2000;275:30408-16.
-
(2000)
J Biol Chem
, vol.275
, pp. 30408-30416
-
-
Tu, G.1
Kirchmaier, A.L.2
Liggitt, D.3
-
21
-
-
0037133572
-
Identification of gene function and functional pathways by systemic plasmid-based ribozyme targeting in adult mice
-
Kashani-Sabet M, Liu Y, Fong S, et al. Identification of gene function and functional pathways by systemic plasmid-based ribozyme targeting in adult mice. Proc Natl Acad Sci USA 2002;99:3878-83.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 3878-3883
-
-
Kashani-Sabet, M.1
Liu, Y.2
Fong, S.3
-
22
-
-
0033532052
-
Systemic gene delivery expands the repertoire of effective anti-angiogenic agents
-
Liu Y, Thor A, Shtivelman E, Cao Y, Heath T, Debs R. Systemic gene delivery expands the repertoire of effective anti-angiogenic agents. J Biol Chem 1999;274:13338-44.
-
(1999)
J Biol Chem
, vol.274
, pp. 13338-13344
-
-
Liu, Y.1
Thor, A.2
Shtivelman, E.3
Cao, Y.4
Heath, T.5
Debs, R.6
-
23
-
-
0034598919
-
Secondary structure of vertebrate telomerase RNA
-
Chen JL, Blasco MA, Greider CW. Secondary structure of vertebrate telomerase RNA. Cell 2000;100:503-14.
-
(2000)
Cell
, vol.100
, pp. 503-514
-
-
Chen, J.L.1
Blasco, M.A.2
Greider, C.W.3
-
24
-
-
0029096515
-
The RNA component of human telomerase
-
Feng J, Funk WD, Wang SS, et al. The RNA component of human telomerase. Science 1995;269:1236-41.
-
(1995)
Science
, vol.269
, pp. 1236-1241
-
-
Feng, J.1
Funk, W.D.2
Wang, S.S.3
-
25
-
-
0024291288
-
Simple RNA enzymes with new and highly specific endoribonuclease activities
-
Haseloff J, Gerlach WL. Simple RNA enzymes with new and highly specific endoribonuclease activities. Nature 1988;334:585-91.
-
(1988)
Nature
, vol.334
, pp. 585-591
-
-
Haseloff, J.1
Gerlach, W.L.2
-
26
-
-
0029114221
-
Telomerase activity in normal and malignant murine tissues
-
Chadeneau C, Siegel P, Harley C, Muller WJ, Bachetti S. Telomerase activity in normal and malignant murine tissues. Oncogene 1995;11:893-8.
-
(1995)
Oncogene
, vol.11
, pp. 893-898
-
-
Chadeneau, C.1
Siegel, P.2
Harley, C.3
Muller, W.J.4
Bachetti, S.5
-
27
-
-
0031049765
-
Factors influencing the efficiency of cationic liposome-mediated intravenous gene delivery
-
Liu Y, Mounkes LC, Liggitt HD, et al. Factors influencing the efficiency of cationic liposome-mediated intravenous gene delivery. Nat Biotechnol 1997;15:167-73.
-
(1997)
Nat Biotechnol
, vol.15
, pp. 167-173
-
-
Liu, Y.1
Mounkes, L.C.2
Liggitt, H.D.3
-
28
-
-
0029973653
-
Regulation of telomerase activity in immortal cell lines
-
Holt SE, Wright WE, Shay JW. Regulation of telomerase activity in immortal cell lines. Mol Cell Biol 1996;16:2932-9.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 2932-2939
-
-
Holt, S.E.1
Wright, W.E.2
Shay, J.W.3
-
29
-
-
0037367441
-
Increased uptake of liposomal-DNA complexes by lung metastases following intravenous administration
-
Ito I, Began G, Mohiuddin I, et al. Increased uptake of liposomal-DNA complexes by lung metastases following intravenous administration. Mol Ther 2003;3:409-18.
-
(2003)
Mol Ther
, vol.3
, pp. 409-418
-
-
Ito, I.1
Began, G.2
Mohiuddin, I.3
-
30
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001;411:494-8.
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
Harborth, J.2
Lendeckel, W.3
Yalcin, A.4
Weber, K.5
Tuschl, T.6
-
31
-
-
0036256430
-
Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells
-
Lee NS, Dohjima T, Bauer G, et al. Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells. Nat Biotechnol 2002;19:500-5.
-
(2002)
Nat Biotechnol
, vol.19
, pp. 500-505
-
-
Lee, N.S.1
Dohjima, T.2
Bauer, G.3
-
32
-
-
0037019339
-
RNA interference in adult mice
-
McCaffrey AP, Meuse L, Pham TT, Conklin DS, Hannon GJ, Kay MA. RNA interference in adult mice. Nature 2002;418:38-9.
-
(2002)
Nature
, vol.418
, pp. 38-39
-
-
McCaffrey, A.P.1
Meuse, L.2
Pham, T.T.3
Conklin, D.S.4
Hannon, G.J.5
Kay, M.A.6
-
33
-
-
0037685280
-
Expression profiling reveals off-target gene regulation by RNAi
-
Jackson AL, Bartz SR, Schelter J, et al. Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol 2003;21:635-7.
-
(2003)
Nat Biotechnol
, vol.21
, pp. 635-637
-
-
Jackson, A.L.1
Bartz, S.R.2
Schelter, J.3
-
34
-
-
0034798245
-
The experimental use of antisense oligonucleotides: A guide for the perplexed
-
Stein CA. The experimental use of antisense oligonucleotides: a guide for the perplexed. J Clin Investig 2001;108:641-4.
-
(2001)
J Clin Investig
, vol.108
, pp. 641-644
-
-
Stein, C.A.1
-
35
-
-
0348014774
-
Approaches for the sequence-specific knockdown of mRNA
-
Scherer LJ, Rossi JJ. Approaches for the sequence-specific knockdown of mRNA. Nat Biotechnol 2003;21:1457-65.
-
(2003)
Nat Biotechnol
, vol.21
, pp. 1457-1465
-
-
Scherer, L.J.1
Rossi, J.J.2
-
36
-
-
0027970092
-
Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma
-
O'Reilly MS, Holmgren L, Shing Y, et al. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 1994;79:315-28.
-
(1994)
Cell
, vol.79
, pp. 315-328
-
-
O'Reilly, M.S.1
Holmgren, L.2
Shing, Y.3
-
37
-
-
0028951043
-
Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression
-
Holmgren L, O'Reilly MS, Folkman J. Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nat Med 1995;1:149-53.
-
(1995)
Nat Med
, vol.1
, pp. 149-153
-
-
Holmgren, L.1
O'Reilly, M.S.2
Folkman, J.3
-
38
-
-
0036674501
-
Dissemination and growth of cancer cells in metastatic sites
-
Chambers AF, Groom AC, MacDonald IC. Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2002;2:563-72.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 563-572
-
-
Chambers, A.F.1
Groom, A.C.2
MacDonald, I.C.3
|