메뉴 건너뛰기




Volumn 36, Issue 3, 2013, Pages 308-315

Replicating animal mitochondrial DNA

Author keywords

DNA replication; Mitochondria; mtSSB; Pol ; Twinkle

Indexed keywords

DNA BINDING PROTEIN; DNA DIRECTED DNA POLYMERASE GAMMA; DNA PRIMASE; DOUBLE STRANDED DNA; HELICASE; MITOCHONDRIAL DNA; RNA POLYMERASE; SINGLE STRANDED DNA;

EID: 84883309262     PISSN: 14154757     EISSN: 16784685     Source Type: Journal    
DOI: 10.1590/S1415-47572013000300002     Document Type: Review
Times cited : (56)

References (58)
  • 2
    • 0038109027 scopus 로고    scopus 로고
    • The mitochondrial DNA replication bubble has not burst
    • Bogenhagen DF and Clayton DA (2003a) The mitochondrial DNA replication bubble has not burst. Trends Biochem Sci 28:357-360.
    • (2003) Trends Biochem Sci , vol.28 , pp. 357-360
    • Bogenhagen, D.F.1    Clayton, D.A.2
  • 3
    • 0042157173 scopus 로고    scopus 로고
    • Concluding remarks: The mitochondrial DNA replication bubble has not burst
    • Bogenhagen DF and Clayton DA (2003b) Concluding remarks: The mitochondrial DNA replication bubble has not burst. Trends Biochem Sci 28:404-405.
    • (2003) Trends Biochem Sci , vol.28 , pp. 404-405
    • Bogenhagen, D.F.1    Clayton, D.A.2
  • 5
    • 84874591240 scopus 로고    scopus 로고
    • The role of mitochondria in aging
    • Bratic A and Larsson NG (2013) The role of mitochondria in aging. J Clin Invest 123:951-957.
    • (2013) J Clin Invest , vol.123 , pp. 951-957
    • Bratic, A.1    Larsson, N.G.2
  • 6
    • 26944500840 scopus 로고    scopus 로고
    • Replication of mitochondrial DNA occurs by strand displacement with alternative light-strand origins, not via a strand-coupled mechanism
    • Brown TA, Cecconi C, Tkachuk AN, Bustamante C and Clayton DA (2005) Replication of mitochondrial DNA occurs by strand displacement with alternative light-strand origins, not via a strand-coupled mechanism. Genes Dev 19:2466-2476.
    • (2005) Genes Dev , vol.19 , pp. 2466-2476
    • Brown, T.A.1    Cecconi, C.2    Tkachuk, A.N.3    Bustamante, C.4    Clayton, D.A.5
  • 8
    • 22444447945 scopus 로고    scopus 로고
    • The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA
    • Cheok CF, Wu L, Garcia PL, Janscak P and Hickson ID (2005) The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA. Nucleic Acids Res 33:3932-3941.
    • (2005) Nucleic Acids Res , vol.33 , pp. 3932-3941
    • Cheok, C.F.1    Wu, L.2    Garcia, P.L.3    Janscak, P.4    Hickson, I.D.5
  • 9
    • 77955269817 scopus 로고    scopus 로고
    • The clinical diagnosis of POLG disease and other mitochondrial DNA depletion disorders
    • Cohen BH and Naviaux RK (2010) The clinical diagnosis of POLG disease and other mitochondrial DNA depletion disorders. Methods 51:364-373.
    • (2010) Methods , vol.51 , pp. 364-373
    • Cohen, B.H.1    Naviaux, R.K.2
  • 10
    • 77953630947 scopus 로고    scopus 로고
    • The mtDNA mutator mouse: Dissecting mitochondrial involvement in aging
    • Edgar D and Trifunovic A (2009) The mtDNA mutator mouse: Dissecting mitochondrial involvement in aging. Aging 1:1028-1032.
    • (2009) Aging , vol.1 , pp. 1028-1032
    • Edgar, D.1    Trifunovic, A.2
  • 11
    • 81155124660 scopus 로고    scopus 로고
    • Clustering of Alpers disease mutations and catalytic defects in biochemical variants reveal new features of molecular mechanism of the human mitochondrial replicase, Pol gamma
    • Euro L, Farnum GA, Palin E, Suomalainen A and Kaguni LS (2011) Clustering of Alpers disease mutations and catalytic defects in biochemical variants reveal new features of molecular mechanism of the human mitochondrial replicase, Pol gamma. Nucleic Acids Res 39:9072-9084.
    • (2011) Nucleic Acids Res , vol.39 , pp. 9072-9084
    • Euro, L.1    Farnum, G.A.2    Palin, E.3    Suomalainen, A.4    Kaguni, L.S.5
  • 12
    • 0033578357 scopus 로고    scopus 로고
    • The accessory subunit of mtDNA polymerase shares structural homology with aminoacyl-tRNA synthetases: Implications for a dual role as a primer recognition factor and processivity clamp
    • Fan L, Sanschagrin PC, Kaguni LS and Kuhn LA (1999) The accessory subunit of mtDNA polymerase shares structural homology with aminoacyl-tRNA synthetases: Implications for a dual role as a primer recognition factor and processivity clamp. Proc Natl Acad Sci USA 96:9527-9532.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 9527-9532
    • Fan, L.1    Sanschagrin, P.C.2    Kaguni, L.S.3    Kuhn, L.A.4
  • 13
    • 33646085120 scopus 로고    scopus 로고
    • A novel processive mechanism for DNA synthesis revealed by structure, modeling and mutagenesis of the accessory subunit of human mitochondrial DNA polymerase
    • Fan L, Kim S, Farr CL, Schaefer KT, Randolph KM, Tainer JA and Kaguni LS (2006) A novel processive mechanism for DNA synthesis revealed by structure, modeling and mutagenesis of the accessory subunit of human mitochondrial DNA polymerase. J Mol Biol 358:1229-1243.
    • (2006) J Mol Biol , vol.358 , pp. 1229-1243
    • Fan, L.1    Kim, S.2    Farr, C.L.3    Schaefer, K.T.4    Randolph, K.M.5    Tainer, J.A.6    Kaguni, L.S.7
  • 14
    • 39149116732 scopus 로고    scopus 로고
    • The N-terminal domain of TWINKLE contributes to single-stranded DNA binding and DNA helicase activities
    • Farge G, Holmlund, T, Khvorostova J, Rofougaran R, Hofer A and Falkenberg M (2008) The N-terminal domain of TWINKLE contributes to single-stranded DNA binding and DNA helicase activities. Nucleic Acids Res 36:393-403.
    • (2008) Nucleic Acids Res , vol.36 , pp. 393-403
    • Farge, G.1    Holmlund, T.2    Khvorostova, J.3    Rofougaran, R.4    Hofer, A.5    Falkenberg, M.6
  • 15
    • 0033591435 scopus 로고    scopus 로고
    • Functional interactions of mitochondrial DNA polymerase and single-stranded DNA-binding protein. Template-primer DNA binding and initiation and elongation of DNA strand synthesis
    • Farr CL, Wang Y and Kaguni LS (1999) Functional interactions of mitochondrial DNA polymerase and single-stranded DNA-binding protein. Template-primer DNA binding and initiation and elongation of DNA strand synthesis. J Biol Chem 274:14779-14785.
    • (1999) J Biol Chem , vol.274 , pp. 14779-14785
    • Farr, C.L.1    Wang, Y.2    Kaguni, L.S.3
  • 16
    • 2342423632 scopus 로고    scopus 로고
    • Physiological and biochemical defects in functional interactions of mitochondrial DNA polymerase and DNA-binding mutants of single-stranded DNA-binding protein
    • Farr CL, Matsushima Y, Lagina AT, Luo N and Kaguni LS (2004) Physiological and biochemical defects in functional interactions of mitochondrial DNA polymerase and DNA-binding mutants of single-stranded DNA-binding protein. J Biol Chem 279:17047-17053.
    • (2004) J Biol Chem , vol.279 , pp. 17047-17053
    • Farr, C.L.1    Matsushima, Y.2    Lagina, A.T.3    Luo, N.4    Kaguni, L.S.5
  • 18
    • 67649948823 scopus 로고    scopus 로고
    • Mitochondrial DNA replication and repair: All a flap
    • Holt IJ (2009) Mitochondrial DNA replication and repair: All a flap. Trends Biochem Sci 34:358-365.
    • (2009) Trends Biochem Sci , vol.34 , pp. 358-365
    • Holt, I.J.1
  • 19
    • 0034598918 scopus 로고    scopus 로고
    • Coupled leading- and lagging-strand synthesis of mammalian mitochondrial DNA
    • Holt IJ, Lorimer HE and Jacobs HT (2000) Coupled leading- and lagging-strand synthesis of mammalian mitochondrial DNA. Cell 100:515-524.
    • (2000) Cell , vol.100 , pp. 515-524
    • Holt, I.J.1    Lorimer, H.E.2    Jacobs, H.T.3
  • 20
    • 82255185604 scopus 로고    scopus 로고
    • The mitochondrial DNA helicase TWINKLE can assemble on a closed circular template and support initiation of DNA synthesis
    • Jemt E, Farge G, Backstrom S, Holmlund T, Gustafsson CM and Falkenberg M (2011) The mitochondrial DNA helicase TWINKLE can assemble on a closed circular template and support initiation of DNA synthesis. Nucleic Acids Res 39:9238-9249.
    • (2011) Nucleic Acids Res , vol.39 , pp. 9238-9249
    • Jemt, E.1    Farge, G.2    Backstrom, S.3    Holmlund, T.4    Gustafsson, C.M.5    Falkenberg, M.6
  • 21
    • 84871875581 scopus 로고    scopus 로고
    • Analysis of replication intermediates indicates that Drosophila melanogaster mitochondrial DNA replicates by a strand-coupled theta mechanism
    • Joers P and Jacobs HT (2013) Analysis of replication intermediates indicates that Drosophila melanogaster mitochondrial DNA replicates by a strand-coupled theta mechanism. PLoS One 8:e53249.
    • (2013) PLoS One , vol.8
    • Joers, P.1    Jacobs, H.T.2
  • 22
    • 0030995020 scopus 로고    scopus 로고
    • In vivo determination of replication origins of human mitochondrial DNA by ligation-mediated polymerase chain reaction
    • Kang D, Miyako K, Kai Y, Irie T and Takeshige K (1997) In vivo determination of replication origins of human mitochondrial DNA by ligation-mediated polymerase chain reaction. J Biol Chem 272:15275-15279.
    • (1997) J Biol Chem , vol.272 , pp. 15275-15279
    • Kang, D.1    Miyako, K.2    Kai, Y.3    Irie, T.4    Takeshige, K.5
  • 23
    • 84864313793 scopus 로고    scopus 로고
    • The interface of transcription and DNA replication in the mitochondria
    • Kasiviswanathan R, Collins TR and Copeland WC (2012) The interface of transcription and DNA replication in the mitochondria. Biochim Biophys Acta 1819:970-978.
    • (2012) Biochim Biophys Acta , vol.1819 , pp. 970-978
    • Kasiviswanathan, R.1    Collins, T.R.2    Copeland, W.C.3
  • 24
    • 1542677230 scopus 로고    scopus 로고
    • TWINKLE Has5'->3'DNAhelicase activity and is specifically stimulated by mitochondrial single-stranded DNA-binding protein
    • Korhonen JA, Gaspari M and Falkenberg M (2003) TWINKLE Has5'->3'DNAhelicase activity and is specifically stimulated by mitochondrial single-stranded DNA-binding protein. J Biol Chem 278:48627-48632.
    • (2003) J Biol Chem , vol.278 , pp. 48627-48632
    • Korhonen, J.A.1    Gaspari, M.2    Falkenberg, M.3
  • 25
  • 27
    • 79951654552 scopus 로고    scopus 로고
    • TWINKLE gene mutation: Report of a French family with an autosomal dominant progressive external ophthalmoplegia and literature review
    • Martin-Negrier ML, Sole G, Jardel C, Vital C, Ferrer X and Vital A (2011) TWINKLE gene mutation: Report of a French family with an autosomal dominant progressive external ophthalmoplegia and literature review. Eur J Neurol 18:436-441.
    • (2011) Eur J Neurol , vol.18 , pp. 436-441
    • Martin-Negrier, M.L.1    Sole, G.2    Jardel, C.3    Vital, C.4    Ferrer, X.5    Vital, A.6
  • 28
    • 34248170868 scopus 로고    scopus 로고
    • Differential phenotypes of active site and human autosomal dominant progressive external ophthalmoplegia mutations in Drosophila mitochondrial DNA helicase expressed in Schneider cells
    • Matsushima Y and Kaguni LS (2007) Differential phenotypes of active site and human autosomal dominant progressive external ophthalmoplegia mutations in Drosophila mitochondrial DNA helicase expressed in Schneider cells. J Biol Chem 282:9436-9444.
    • (2007) J Biol Chem , vol.282 , pp. 9436-9444
    • Matsushima, Y.1    Kaguni, L.S.2
  • 29
    • 67349214108 scopus 로고    scopus 로고
    • Functional importance of the conserved N-terminal domain of the mitochondrial replicative DNA helicase
    • Matsushima Y and Kaguni LS (2009) Functional importance of the conserved N-terminal domain of the mitochondrial replicative DNA helicase. Biochim Biophys Acta 1787:290-295.
    • (2009) Biochim Biophys Acta , vol.1787 , pp. 290-295
    • Matsushima, Y.1    Kaguni, L.S.2
  • 30
    • 53049089197 scopus 로고    scopus 로고
    • Physiological and biochemical defects in carboxyl-terminal mutants of mitochondrial DNA helicase
    • Matsushima Y, Farr CL, Fan L and Kaguni LS (2008) Physiological and biochemical defects in carboxyl-terminal mutants of mitochondrial DNA helicase. J Biol Chem 283:23964-23971.
    • (2008) J Biol Chem , vol.283 , pp. 23964-23971
    • Matsushima, Y.1    Farr, C.L.2    Fan, L.3    Kaguni, L.S.4
  • 32
    • 0019199903 scopus 로고
    • Analysis of the two heavy and light strand origins and the direction of replication of mitochondrial DNA within a detailed physical map of this genome in transformed hamster cells
    • Nass MM (1980a) Analysis of the two heavy and light strand origins and the direction of replication of mitochondrial DNA within a detailed physical map of this genome in transformed hamster cells. J Mol Biol 140:231-256.
    • (1980) J Mol Biol , vol.140 , pp. 231-256
    • Nass, M.M.1
  • 33
    • 0019209539 scopus 로고
    • Pulse-label analysis and mapping of the two terminal regions of asynchronous complementary strand replication of mitochondrial DNA in transformed hamster cells
    • Nass MM (1980b) Pulse-label analysis and mapping of the two terminal regions of asynchronous complementary strand replication of mitochondrial DNA in transformed hamster cells. J Mol Biol 140:257-281.
    • (1980) J Mol Biol , vol.140 , pp. 257-281
    • Nass, M.M.1
  • 34
    • 84858376953 scopus 로고    scopus 로고
    • Mitochondria: In sickness and in health
    • Nunnari J and Suomalainen A (2012) Mitochondria: In sickness and in health. Cell 148:1145-1159.
    • (2012) Cell , vol.148 , pp. 1145-1159
    • Nunnari, J.1    Suomalainen, A.2
  • 35
    • 78149459202 scopus 로고    scopus 로고
    • Functional roles of the N- and C-terminal regions of the human mitochondrial singlestranded DNA-binding protein
    • Oliveira MT and Kaguni LS (2010) Functional roles of the N- and C-terminal regions of the human mitochondrial singlestranded DNA-binding protein. PLoS One 5:e15379.
    • (2010) PLoS One , vol.5
    • Oliveira, M.T.1    Kaguni, L.S.2
  • 36
    • 81755171474 scopus 로고    scopus 로고
    • Reduced stimulation of recombinant DNA polymerase gamma and mitochondrial DNA (mtDNA) helicase by variants of mitochondrial single-stranded DNA-binding protein (mtSSB) correlates with defects in mtDNA replication in animal cells
    • Oliveira MT and Kaguni LS (2011) Reduced stimulation of recombinant DNA polymerase gamma and mitochondrial DNA (mtDNA) helicase by variants of mitochondrial single-stranded DNA-binding protein (mtSSB) correlates with defects in mtDNA replication in animal cells. J Biol Chem 286:40649-40658.
    • (2011) J Biol Chem , vol.286 , pp. 40649-40658
    • Oliveira, M.T.1    Kaguni, L.S.2
  • 37
    • 77953360335 scopus 로고    scopus 로고
    • Animal models of mitochondrial DNA transactions in disease and ageing
    • Oliveira MT, Garesse R and Kaguni LS (2010) Animal models of mitochondrial DNA transactions in disease and ageing. Exp Gerontol 45:489-502.
    • (2010) Exp Gerontol , vol.45 , pp. 489-502
    • Oliveira, M.T.1    Garesse, R.2    Kaguni, L.S.3
  • 40
    • 13544268333 scopus 로고    scopus 로고
    • Bidirectional replication initiates at sites throughout the mitochondrial genome of birds
    • Reyes A, Yang MY, Bowmaker M and Holt IJ (2005) Bidirectional replication initiates at sites throughout the mitochondrial genome of birds. J Biol Chem 280:3242-3250.
    • (2005) J Biol Chem , vol.280 , pp. 3242-3250
    • Reyes, A.1    Yang, M.Y.2    Bowmaker, M.3    Holt, I.J.4
  • 41
    • 84878835055 scopus 로고    scopus 로고
    • Mitochondrial DNA replication proceeds via a 'bootlace' mechanism involving the incorporation of processed transcripts
    • Reyes A, Kazak L, Wood SR, Yasukawa T, Jacobs HT and Holt IJ (2013) Mitochondrial DNA replication proceeds via a 'bootlace' mechanism involving the incorporation of processed transcripts. Nucleic Acids Res 41:5837-5850.
    • (2013) Nucleic Acids Res , vol.41 , pp. 5837-5850
    • Reyes, A.1    Kazak, L.2    Wood, S.R.3    Yasukawa, T.4    Jacobs, H.T.5    Holt, I.J.6
  • 42
    • 0015302555 scopus 로고
    • Replication of mitochondrial DNA. Circular replicative intermediates in mouse L cells
    • Robberson DL, Kasamatsu H and Vinograd J (1972) Replication of mitochondrial DNA. Circular replicative intermediates in mouse L cells. Proc Natl Acad Sci USA 69:737-741.
    • (1972) Proc Natl Acad Sci USA , vol.69 , pp. 737-741
    • Robberson, D.L.1    Kasamatsu, H.2    Vinograd, J.3
  • 43
    • 0004235430 scopus 로고    scopus 로고
    • 2nd edition. J. Wiley and Sons, Inc., Hoboken
    • Scheffler IE (2008) Mitochondria. 2nd edition. J. Wiley and Sons, Inc., Hoboken, 462 pp.
    • (2008) Mitochondria , pp. 462
    • Scheffler, I.E.1
  • 44
    • 84860379072 scopus 로고    scopus 로고
    • Human mitochondrial DNA helicase TWINKLE is both an unwinding and annealing helicase
    • Sen D, Nandakumar D, Tang GQ and Patel SS (2012) Human mitochondrial DNA helicase TWINKLE is both an unwinding and annealing helicase. J Biol Chem 287:14545-14556.
    • (2012) J Biol Chem , vol.287 , pp. 14545-14556
    • Sen, D.1    Nandakumar, D.2    Tang, G.Q.3    Patel, S.S.4
  • 45
    • 31444454598 scopus 로고    scopus 로고
    • Bacteriophage origins of mitochondrial replication and transcription proteins
    • Shutt TE and Gray MW (2006a) Bacteriophage origins of mitochondrial replication and transcription proteins. Trends Genet 22:90-95.
    • (2006) Trends Genet , vol.22 , pp. 90-95
    • Shutt, T.E.1    Gray, M.W.2
  • 46
    • 33745637944 scopus 로고    scopus 로고
    • Twinkle, the mitochondrial replicative DNA helicase, is widespread in the eukaryotic radiation and may also be the mitochondrial DNA primase in most eukaryotes
    • Shutt TE and Gray MW (2006b) Twinkle, the mitochondrial replicative DNA helicase, is widespread in the eukaryotic radiation and may also be the mitochondrial DNA primase in most eukaryotes. J Mol Evol 62:588-599.
    • (2006) J Mol Evol , vol.62 , pp. 588-599
    • Shutt, T.E.1    Gray, M.W.2
  • 47
    • 0034938364 scopus 로고    scopus 로고
    • Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria
    • Spelbrink JN, Li FY, Tiranti V, Nikali K, Yuan QP, Tariq M, Wanrooij S, Garrido N, Comi G, Morandi L, et al. (2001) Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria. Nat Genet 28:223-231.
    • (2001) Nat Genet , vol.28 , pp. 223-231
    • Spelbrink, J.N.1    Li, F.Y.2    Tiranti, V.3    Nikali, K.4    Yuan, Q.P.5    Tariq, M.6    Wanrooij, S.7    Garrido, N.8    Comi, G.9    Morandi, L.10
  • 48
    • 78651369034 scopus 로고    scopus 로고
    • Mitochondrial DNA replication and disease: Insights from DNA polymerase gamma mutations
    • Stumpf JD and Copeland WC (2011) Mitochondrial DNA replication and disease: Insights from DNA polymerase gamma mutations. Cell Mol Life Sci 68:219-233.
    • (2011) Cell Mol Life Sci , vol.68 , pp. 219-233
    • Stumpf, J.D.1    Copeland, W.C.2
  • 50
    • 0019888066 scopus 로고
    • Mechanism of replication of human mitochondrial DNA. Localization of the 5' ends of nascent daughter strands
    • Tapper DP and Clayton DA (1981) Mechanism of replication of human mitochondrial DNA. Localization of the 5' ends of nascent daughter strands. J Biol Chem 256:5109-5115.
    • (1981) J Biol Chem , vol.256 , pp. 5109-5115
    • Tapper, D.P.1    Clayton, D.A.2
  • 54
    • 34250868951 scopus 로고    scopus 로고
    • Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes
    • Wanrooij S, Goffart S, Pohjoismaki JL, Yasukawa T and Spelbrink JN (2007) Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes. Nucleic Acids Res 35:3238-3251.
    • (2007) Nucleic Acids Res , vol.35 , pp. 3238-3251
    • Wanrooij, S.1    Goffart, S.2    Pohjoismaki, J.L.3    Yasukawa, T.4    Spelbrink, J.N.5
  • 56
    • 0037112343 scopus 로고    scopus 로고
    • Biased incorporation of ribonucleotides on the mitochondrial L-strand accounts for apparent strand-asymmetric DNA replication
    • Yang MY, Bowmaker M, Reyes A, Vergani L, Angeli P, Gringeri E, Jacobs HT and Holt IJ (2002) Biased incorporation of ribonucleotides on the mitochondrial L-strand accounts for apparent strand-asymmetric DNA replication. Cell 111:495-505.
    • (2002) Cell , vol.111 , pp. 495-505
    • Yang, M.Y.1    Bowmaker, M.2    Reyes, A.3    Vergani, L.4    Angeli, P.5    Gringeri, E.6    Jacobs, H.T.7    Holt, I.J.8
  • 57
    • 33751088000 scopus 로고    scopus 로고
    • Replication of vertebrate mitochondrial DNA entails transient ribonucleotide incorporation throughout the lagging strand
    • Yasukawa T, Reyes A, Cluett TJ, Yang MY, Bowmaker M, Jacobs HT and Holt IJ (2006) Replication of vertebrate mitochondrial DNA entails transient ribonucleotide incorporation throughout the lagging strand. EMBO J 25:5358-5371.
    • (2006) EMBO J , vol.25 , pp. 5358-5371
    • Yasukawa, T.1    Reyes, A.2    Cluett, T.J.3    Yang, M.Y.4    Bowmaker, M.5    Jacobs, H.T.6    Holt, I.J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.