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Volumn 15, Issue 11, 2014, Pages 19791-19815

Hypoxic signaling during tissue repair and regenerative medicine

Author keywords

Angiogenesis; HIF 1 ; HIF 2 ; Hypoxia; Tissue engineering; Wound healing

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; FIBROBLAST GROWTH FACTOR 2; HEME OXYGENASE 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; HYPOXIA INDUCIBLE FACTOR 3ALPHA; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MANGANESE SUPEROXIDE DISMUTASE; MATRIX METALLOPROTEINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PLASMINOGEN ACTIVATOR; PLATELET DERIVED GROWTH FACTOR; REACTIVE OXYGEN METABOLITE; SOMATOMEDIN C; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 2; HYPOXIA INDUCIBLE FACTOR PROLINE DIOXYGENASE;

EID: 84908349650     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms151119791     Document Type: Review
Times cited : (81)

References (154)
  • 2
    • 2442538178 scopus 로고    scopus 로고
    • Understanding chronic wounds: A unifying hypothesis on their pathogenesis and implications for therapy
    • Mustoe, T. Understanding chronic wounds: A unifying hypothesis on their pathogenesis and implications for therapy. Am. J. Surg. 2004, 187, 65S-70S.
    • (2004) Am. J. Surg , vol.187 , pp. 65S-70S
    • Mustoe, T.1
  • 3
    • 0020062301 scopus 로고
    • Wound tissue can utilize a polymeric template to synthesize a functional extension of skin
    • Yannas, I.V; Burke, J.F.; Orgill, D.P.; Skrabut, E.M. Wound tissue can utilize a polymeric template to synthesize a functional extension of skin. Science 1982, 215, 174-176.
    • (1982) Science , vol.215 , pp. 174-176
    • Yannas, I.V.1    Burke, J.F.2    Orgill, D.P.3    Skrabut, E.M.4
  • 4
    • 0033649024 scopus 로고    scopus 로고
    • Tissue engineering
    • Langer, R. Tissue engineering. Mol. Ther. 2000, 1, 12-15.
    • (2000) Mol. Ther , vol.1 , pp. 12-15
    • Langer, R.1
  • 5
    • 33645560618 scopus 로고    scopus 로고
    • Oxygen gradients correlate with cell density and cell viability in engineered cardiac tissue
    • Radisic, M.; Malda, J.; Epping, E.; Geng, W.; Langer, R.; Vunjak-Novakovic, G. Oxygen gradients correlate with cell density and cell viability in engineered cardiac tissue. Biotechnol. Bioeng. 2006, 93, 332-343.
    • (2006) Biotechnol. Bioeng , vol.93 , pp. 332-343
    • Radisic, M.1    Malda, J.2    Epping, E.3    Geng, W.4    Langer, R.5    Vunjak-Novakovic, G.6
  • 9
    • 84868612850 scopus 로고    scopus 로고
    • Hypoxia-induced angiogenesis: Good and evil
    • Krock, B.L.; Skuli, N.; Simon, M.C. Hypoxia-induced angiogenesis: Good and evil. Genes Cancer 2011, 2, 1117-1133.
    • (2011) Genes Cancer , vol.2 , pp. 1117-1133
    • Krock, B.L.1    Skuli, N.2    Simon, M.C.3
  • 10
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau, W. Mechanisms of angiogenesis. Nature 1997, 6626, 671-674.
    • (1997) Nature , vol.6626 , pp. 671-674
    • Risau, W.1
  • 11
    • 78650416408 scopus 로고    scopus 로고
    • From vessel sprouting to normalization: Role of the prolyl hydroxylase domain protein/hypoxia-inducible factor oxygen-sensing machinery
    • Coulon, C.; Georgiadou, M.; Roncal, C.; de Bock, K.; Langenberg, T.; Carmeliet, P. From vessel sprouting to normalization: Role of the prolyl hydroxylase domain protein/hypoxia-inducible factor oxygen-sensing machinery. Arterioscler. Thromb. Vasc. Biol. 2010, 30, 2331-2336.
    • (2010) Arterioscler. Thromb. Vasc. Biol , vol.30 , pp. 2331-2336
    • Coulon, C.1    Georgiadou, M.2    Roncal, C.3    De Bock, K.4    Langenberg, T.5    Carmeliet, P.6
  • 12
    • 0038376002 scopus 로고    scopus 로고
    • Molecular regulation of vessel maturation
    • Jain, R.K. Molecular regulation of vessel maturation. Nat. Med. 2003, 9, 685-693.
    • (2003) Nat. Med , vol.9 , pp. 685-693
    • Jain, R.K.1
  • 13
    • 80052933197 scopus 로고    scopus 로고
    • Basic and therapeutic aspects of angiogenesis
    • Potente, M.; Gerhardt, H.; Carmeliet, P. Basic and therapeutic aspects of angiogenesis. Cell 2011, 146, 873-887.
    • (2011) Cell , vol.146 , pp. 873-887
    • Potente, M.1    Gerhardt, H.2    Carmeliet, P.3
  • 14
    • 0014248318 scopus 로고
    • Oxygen gradients in healing wounds
    • Remensnyder, J.P.; Majno, G. Oxygen gradients in healing wounds. Am. J. Pathol. 1968, 52, 301-323.
    • (1968) Am. J. Pathol , vol.52 , pp. 301-323
    • Remensnyder, J.P.1    Majno, G.2
  • 17
    • 0035168305 scopus 로고    scopus 로고
    • Biological responses to materials
    • Anderson, J. Biological responses to materials. Annu. Rev. Mater. Res. 2001, 31, 81-110.
    • (2001) Annu. Rev. Mater. Res , vol.31 , pp. 81-110
    • Anderson, J.1
  • 19
    • 0030934532 scopus 로고    scopus 로고
    • Wound healing-Aiming for perfect skin regeneration
    • Martin, P. Wound healing-Aiming for perfect skin regeneration. Science 1997, 276, 75-81.
    • (1997) Science , vol.276 , pp. 75-81
    • Martin, P.1
  • 20
    • 0023872010 scopus 로고
    • Platelets, platelet-derived growth factor and arteriosclerosis
    • Baumgartner, H.R.; Hosang, M. Platelets, platelet-derived growth factor and arteriosclerosis. Experientia 1988, 44, 109-112.
    • (1988) Experientia , vol.44 , pp. 109-112
    • Baumgartner, H.R.1    Hosang, M.2
  • 21
    • 0031029290 scopus 로고    scopus 로고
    • Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets
    • Möhle, R.; Green, D.; Moore, M.A.; Nachman, R.L.; Rafii, S. Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets. Proc. Natl. Acad. Sci. USA 1997, 94, 663-668.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 663-668
    • Möhle, R.1    Green, D.2    Moore, M.A.3    Nachman, R.L.4    Rafii, S.5
  • 22
    • 0016428338 scopus 로고
    • The role of the macrophage in wound repair
    • Leibovich, S.J.; Ross, R. The role of the macrophage in wound repair. Am. J. Pathol. 1975, 78, 71-100.
    • (1975) Am. J. Pathol , vol.78 , pp. 71-100
    • Leibovich, S.J.1    Ross, R.2
  • 23
    • 27744543102 scopus 로고    scopus 로고
    • Inflammatory cells during wound repair: The good, the bad and the ugly
    • Martin, P.; Leibovich, S.J. Inflammatory cells during wound repair: The good, the bad and the ugly. Trends Cell Biol. 2005, 15, 599-607.
    • (2005) Trends Cell Biol , vol.15 , pp. 599-607
    • Martin, P.1    Leibovich, S.J.2
  • 24
    • 84937092509 scopus 로고
    • Wound healing: The role of the macrophage and other immune cells
    • DiPietro, L.A. Wound healing: The role of the macrophage and other immune cells. Shock 1995, 4, 233-240.
    • (1995) Shock , vol.4 , pp. 233-240
    • Dipietro, L.A.1
  • 25
    • 0026485002 scopus 로고
    • Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
    • Shweiki, D.; Itin, A.; Soffer, D.; Keshet, E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992, 359, 843-845.
    • (1992) Nature , vol.359 , pp. 843-845
    • Shweiki, D.1    Itin, A.2    Soffer, D.3    Keshet, E.4
  • 27
    • 0025688912 scopus 로고
    • Vascular permeability factor: A tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration
    • Clauss, M.; Gerlach, M.; Gerlach, H.; Brett, J.; Wang, F.; Familletti, P.C.; Pan, Y.C.; Olander, J. V; Connolly, D.T.; Stern, D. Vascular permeability factor: A tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration. J. Exp. Med. 1990, 172, 1535-1545.
    • (1990) J. Exp. Med , vol.172 , pp. 1535-1545
    • Clauss, M.1    Gerlach, M.2    Gerlach, H.3    Brett, J.4    Wang, F.5    Familletti, P.C.6    Pan, Y.C.7    Olander, J.V.8    Connolly, D.T.9    Stern, D.10
  • 28
    • 33847084614 scopus 로고    scopus 로고
    • Formation and function of the myofibroblast during tissue repair
    • Hinz, B. Formation and function of the myofibroblast during tissue repair. J. Investig. Dermatol. 2007, 127, 526-537.
    • (2007) J. Investig. Dermatol , vol.127 , pp. 526-537
    • Hinz, B.1
  • 29
    • 0034964284 scopus 로고    scopus 로고
    • Fibrin and wound healing
    • Clark, R.A. Fibrin and wound healing. Ann. N. Y. Acad. Sci. 2001, 936, 355-367.
    • (2001) Ann. N. Y. Acad. Sci , vol.936 , pp. 355-367
    • Clark, R.A.1
  • 31
    • 25444454359 scopus 로고    scopus 로고
    • Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptors
    • Sitkovsky, M.; Lukashev, D. Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptors. Nat. Rev. Immunol. 2005, 5, 712-721.
    • (2005) Nat. Rev. Immunol , vol.5 , pp. 712-721
    • Sitkovsky, M.1    Lukashev, D.2
  • 32
  • 36
    • 0042031047 scopus 로고    scopus 로고
    • A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets
    • Arsham, A.M.; Howell, J.J.; Simon, M.C. A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets. J. Biol. Chem. 2003, 278, 29655-29660.
    • (2003) J. Biol. Chem , vol.278 , pp. 29655-29660
    • Arsham, A.M.1    Howell, J.J.2    Simon, M.C.3
  • 37
    • 0036000028 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia
    • Lang, K.D.; Kappel, A.; Goodall, G.J. Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia. Mol. Biol. Cell 2002, 13, 1792-1801.
    • (2002) Mol. Biol. Cell , vol.13 , pp. 1792-1801
    • Lang, K.D.1    Kappel, A.2    Goodall, G.J.3
  • 39
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • Wang, G.L.; Jiang, B.H.; Rue, E.A.; Semenza, G.L. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl. Acad. Sci. USA 1995, 92, 5510-5514.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3    Semenza, G.L.4
  • 40
    • 0030937718 scopus 로고    scopus 로고
    • Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the alpha Subunit
    • Pugh, C.W.; Rourke, J.F.O.; Nagao, M.; Gleadle, J.M.; Ratcliffe, P.J. Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the alpha Subunit. J. Biol. Chem. 1997, 272, 11205-11214.
    • (1997) J. Biol. Chem , vol.272 , pp. 11205-11214
    • Pugh, C.W.1    Rourke, J.F.O.2    Nagao, M.3    Gleadle, J.M.4    Ratcliffe, P.J.5
  • 41
    • 0029753008 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit
    • Huang, L.E.; Arany, Z.; Livingston, D.M.; Bunn, H.F. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J. Biol. Chem. 1996, 271, 32253-32259.
    • (1996) J. Biol. Chem , vol.271 , pp. 32253-32259
    • Huang, L.E.1    Arany, Z.2    Livingston, D.M.3    Bunn, H.F.4
  • 42
    • 0030787469 scopus 로고    scopus 로고
    • Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1alpha. Modulation of transcriptional activity by oxygen tension
    • Jiang, B.-H.; Zheng, J.Z.; Leung, S.W.; Roe, R.; Semenza, G.L. Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1alpha. Modulation of transcriptional activity by oxygen tension. J. Biol. Chem. 1997, 272, 19253-19260.
    • (1997) J. Biol. Chem , vol.272 , pp. 19253-19260
    • Jiang, B.-H.1    Zheng, J.Z.2    Leung, S.W.3    Roe, R.4    Semenza, G.L.5
  • 43
    • 0026468180 scopus 로고
    • Nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    • Semenza, G.; Wang, G. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol. Cell. Biol. 1992, 12, 5447-5454.
    • (1992) Mol. Cell. Biol , vol.12 , pp. 5447-5454
    • Semenza, G.1    Wang, G.A.2
  • 44
    • 0031020884 scopus 로고    scopus 로고
    • Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
    • Tian, H.; McKnight, S.L.; Russell, D.W. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev. 1997, 11, 72-82.
    • (1997) Genes Dev , vol.11 , pp. 72-82
    • Tian, H.1    McKnight, S.L.2    Russell, D.W.3
  • 46
    • 0035810987 scopus 로고    scopus 로고
    • Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt
    • Keith, B.; Adelman, D.M.; Simon, M.C. Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt. Proc. Natl. Acad. Sci. USA 2001, 98, 6692-6697.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 6692-6697
    • Keith, B.1    Adelman, D.M.2    Simon, M.C.3
  • 47
    • 40949132841 scopus 로고    scopus 로고
    • Turn me on: Regulating HIF transcriptional activity
    • Lisy, K.; Peet, D.J. Turn me on: Regulating HIF transcriptional activity. Cell Death Differ. 2008, 15, 642-649.
    • (2008) Cell Death Differ , vol.15 , pp. 642-649
    • Lisy, K.1    Peet, D.J.2
  • 48
    • 43649093915 scopus 로고    scopus 로고
    • Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
    • Kaelin, W.G.; Ratcliffe, P.J. Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway. Mol. Cell 2008, 30, 393-402.
    • (2008) Mol. Cell , vol.30 , pp. 393-402
    • Kaelin, W.G.1    Ratcliffe, P.J.2
  • 49
    • 0032493368 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway
    • Huang, L.E.; Gu, J.; Schau, M.; Bunn, H.F. Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc. Natl. Acad. Sci. USA 1998, 95, 7987-7992.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 7987-7992
    • Huang, L.E.1    Gu, J.2    Schau, M.3    Bunn, H.F.4
  • 51
    • 27544434803 scopus 로고    scopus 로고
    • Signalling hypoxia by HIF hydroxylases. Biochem. Biophys
    • Schofield, C.J.; Ratcliffe, P.J. Signalling hypoxia by HIF hydroxylases. Biochem. Biophys. Res. Commun. 2005, 338, 617-626.
    • (2005) Res. Commun , vol.338 , pp. 617-626
    • Schofield, C.J.1    Ratcliffe, P.J.2
  • 52
    • 0027427588 scopus 로고
    • Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia
    • Wang, G.L.; Semenza, G.L. Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. J. Biol. Chem. 1993, 268, 21513-21518.
    • (1993) J. Biol. Chem , vol.268 , pp. 21513-21518
    • Wang, G.L.1    Semenza, G.L.2
  • 53
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza, G.L. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 2003, 3, 721-732.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 54
    • 33745303045 scopus 로고    scopus 로고
    • Hypoxia signalling in cancer and approaches to enforce tumour regression
    • Pouysségur, J.; Dayan, F.; Mazure, N.M. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 2006, 441, 437-443.
    • (2006) Nature , vol.441 , pp. 437-443
    • Pouysségur, J.1    Dayan, F.2    Mazure, N.M.3
  • 55
    • 4644275138 scopus 로고    scopus 로고
    • HIF-1: The knowns and unknowns of hypoxia sensing
    • Zagórska, A.; Dulak, J. HIF-1: The knowns and unknowns of hypoxia sensing. Acta Biochim. Pol. 2004, 51, 563-585.
    • (2004) Acta Biochim. Pol , vol.51 , pp. 563-585
    • Zagórska, A.1    Dulak, J.2
  • 56
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of Hypoxia-inducible Factor 1a expression by epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
    • Zhong, H.; Chiles, K.; Feldser, D.; Laughner, E.; Hanrahan, C.; Georgescu, M.-M.; Simons, J.W.; Semenza, G.L. Modulation of Hypoxia-inducible Factor 1a expression by epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics. Cancer Res. 2000, 60, 1541-1545.
    • (2000) Cancer Res , vol.60 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3    Laughner, E.4    Hanrahan, C.5    Georgescu, M.-M.6    Simons, J.W.7    Semenza, G.L.8
  • 57
    • 0037064010 scopus 로고    scopus 로고
    • Insulin-like   growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
    • Fukuda, R.; Hirota, K.; Fan, F.; Jung, Y.D.; Ellis, L.M.; Semenza, G.L. Insulin-like   growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J. Biol. Chem. 2002, 277, 38205-38211.
    • (2002) J. Biol. Chem , vol.277 , pp. 38205-38211
    • Fukuda, R.1    Hirota, K.2    Fan, F.3    Jung, Y.D.4    Ellis, L.M.5    Semenza, G.L.6
  • 58
    • 0032725554 scopus 로고    scopus 로고
    • p42/p44 Mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1
    • Richard, D.E.; Berra, E.; Gothié, E.; Roux, D.; Pouysségur, J. p42/p44 Mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1. J. Biol. Chem. 1999, 274, 32631-32637.
    • (1999) J. Biol. Chem , vol.274 , pp. 32631-32637
    • Richard, D.E.1    Berra, E.2    Gothié, E.3    Roux, D.4    Pouysségur, J.5
  • 59
    • 0028785860 scopus 로고
    • Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1
    • Wang, G.L.; Jiang, B.H.; Semenza, G.L. Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1. Biochem. Biophys. Res. Commun. 1995, 216, 669-675.
    • (1995) Biochem. Biophys. Res. Commun , vol.216 , pp. 669-675
    • Wang, G.L.1    Jiang, B.H.2    Semenza, G.L.3
  • 60
    • 84908315254 scopus 로고    scopus 로고
    • Available online, (accessed on 30 October 2014)
    • HIF NIH3T3 Reporter Stable Cell Line. Available online: http://www.affymetrix.com/catalog/prod660088/USB/HIF+NIH3T3+Reporter+Stable#1_1 (accessed on 30 October 2014).
    • HIF NIH3T3 Reporter Stable Cell Line
  • 61
    • 7944224442 scopus 로고    scopus 로고
    • Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
    • Tang, N.; Wang, L.; Esko, J.; Giordano, F.J.; Huang, Y.; Gerber, H.-P.; Ferrara, N.; Johnson, R.S. Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 2004, 6, 485-495.
    • (2004) Cancer Cell , vol.6 , pp. 485-495
    • Tang, N.1    Wang, L.2    Esko, J.3    Giordano, F.J.4    Huang, Y.5    Gerber, H.-P.6    Ferrara, N.7    Johnson, R.S.8
  • 62
    • 17144416530 scopus 로고    scopus 로고
    • Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells
    • Wang, V.; Davis, D.A.; Haque, M.; Huang, L.E.; Yarchoan, R. Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells. Cancer Res. 2005, 65, 3299-3306.
    • (2005) Cancer Res , vol.65 , pp. 3299-3306
    • Wang, V.1    Davis, D.A.2    Haque, M.3    Huang, L.E.4    Yarchoan, R.5
  • 63
    • 35848938945 scopus 로고    scopus 로고
    • The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha
    • Hu, C.-J.; Sataur, A.; Wang, L.; Chen, H.; Simon, M.C. The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha. Mol. Biol. Cell 2007, 18, 4528-4542.
    • (2007) Mol. Biol. Cell , vol.18 , pp. 4528-4542
    • Hu, C.-J.1    Sataur, A.2    Wang, L.3    Chen, H.4    Simon, M.C.5
  • 64
    • 38949147367 scopus 로고    scopus 로고
    • Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS
    • Yamashita, T.; Ohneda, O.; Nagano, M.; Iemitsu, M.; Makino, Y.; Tanaka, H.; Miyauchi, T.; Goto, K.; Ohneda, K.; Fujii-Kuriyama, Y.; et al. Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS. Mol. Cell. Biol. 2008, 28, 1285-1297.
    • (2008) Mol. Cell. Biol , vol.28 , pp. 1285-1297
    • Yamashita, T.1    Ohneda, O.2    Nagano, M.3    Iemitsu, M.4    Makino, Y.5    Tanaka, H.6    Miyauchi, T.7    Goto, K.8    Ohneda, K.9    Fujii-Kuriyama, Y.10
  • 65
    • 82255186546 scopus 로고    scopus 로고
    • Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response
    • Heikkilä, M.; Pasanen, A.; Kivirikko, K.I.; Myllyharju, J. Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response. Cell. Mol. Life Sci. 2011, 68, 3885-3901.
    • (2011) Cell. Mol. Life Sci , vol.68 , pp. 3885-3901
    • Heikkilä, M.1    Pasanen, A.2    Kivirikko, K.I.3    Myllyharju, J.4
  • 66
    • 0345491599 scopus 로고    scopus 로고
    • Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation
    • Hu, C.-J.; Wang, L.-Y.; Chodosh, L.A.; Keith, B.; Simon, C.M. Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation. Mol. Cell. Biol. 2003, 23, 9361-9374.
    • (2003) Mol. Cell. Biol , vol.23 , pp. 9361-9374
    • Hu, C.-J.1    Wang, L.-Y.2    Chodosh, L.A.3    Keith, B.4    Simon, C.M.5
  • 70
    • 67651098992 scopus 로고    scopus 로고
    • Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis
    • Skuli, N.; Liu, L.; Runge, A.; Wang, T.; Yuan, L.; Patel, S.; Iruela-Arispe, L.; Simon, M.C.; Keith, B. Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis. Blood 2009, 114, 469-477.
    • (2009) Blood , vol.114 , pp. 469-477
    • Skuli, N.1    Liu, L.2    Runge, A.3    Wang, T.4    Yuan, L.5    Patel, S.6    Iruela-Arispe, L.7    Simon, M.C.8    Keith, B.9
  • 71
    • 0345490692 scopus 로고    scopus 로고
    • Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1α
    • Compernolle, V.; Brusselmans, K.; Franco, D.; Moorman, A.; Dewerchin, M.; Collen, D.; Carmeliet, P. Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1α. Cardiovasc. Res. 2003, 60, 569-579.
    • (2003) Cardiovasc. Res , vol.60 , pp. 569-579
    • Compernolle, V.1    Brusselmans, K.2    Franco, D.3    Moorman, A.4    Dewerchin, M.5    Collen, D.6    Carmeliet, P.7
  • 72
    • 0032100732 scopus 로고    scopus 로고
    • HIF-1 alpha is required for solid tumor formation and embryonic vascularization
    • Ryan, H.E.; Lo, J.; Johnson, R.S. HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J. 1998, 17, 3005-3015.
    • (1998) EMBO J , vol.17 , pp. 3005-3015
    • Ryan, H.E.1    Lo, J.2    Johnson, R.S.3
  • 73
    • 0033562569 scopus 로고    scopus 로고
    • Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death
    • Kotch, L.E.; Iyer, N.V; Laughner, E.; Semenza, G.L. Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. Dev. Biol. 1999, 209, 254-267.
    • (1999) Dev. Biol , vol.209 , pp. 254-267
    • Kotch, L.E.1    Iyer, N.V.2    Laughner, E.3    Semenza, G.L.4
  • 77
    • 0032213236 scopus 로고    scopus 로고
    • The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
    • Tian, H.; Hammer, R.E.; Matsumoto, A.M.; Russell, D.W.; McKnight, S.L. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev. 1998, 12, 3320-3324.
    • (1998) Genes Dev , vol.12 , pp. 3320-3324
    • Tian, H.1    Hammer, R.E.2    Matsumoto, A.M.3    Russell, D.W.4    McKnight, S.L.5
  • 79
    • 0034682513 scopus 로고    scopus 로고
    • The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling
    • Peng, J.; Zhang, L.; Drysdale, L.; Fong, G.H. The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling. Proc. Natl. Acad. Sci. USA 2000, 97, 8386-8391.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 8386-8391
    • Peng, J.1    Zhang, L.2    Drysdale, L.3    Fong, G.H.4
  • 80
    • 18244372452 scopus 로고    scopus 로고
    • Endothelium-intrinsic requirement for Hif-2alpha during vascular development
    • Duan, L.-J.; Zhang-Benoit, Y.; Fong, G.-H. Endothelium-intrinsic requirement for Hif-2alpha during vascular development. Circulation 2005, 111, 2227-2232.
    • (2005) Circulation , vol.111 , pp. 2227-2232
    • Duan, L.-J.1    Zhang-Benoit, Y.2    Fong, G.-H.3
  • 81
    • 0035983324 scopus 로고    scopus 로고
    • Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
    • Compernolle, V.; Brusselmans, K.; Acker, T.; Hoet, P.; Tjwa, M.; Beck, H.; Plaisance, S.; Dor, Y.; Keshet, E.; Lupu, F.; et al. Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat. Med. 2002, 8, 702-710.
    • (2002) Nat. Med , vol.8 , pp. 702-710
    • Compernolle, V.1    Brusselmans, K.2    Acker, T.3    Hoet, P.4    Tjwa, M.5    Beck, H.6    Plaisance, S.7    Dor, Y.8    Keshet, E.9    Lupu, F.10
  • 83
    • 85047691081 scopus 로고    scopus 로고
    • Heterozygous deficiency of hypoxia-inducible factor-2α protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia
    • Brusselmans, K.; Compernolle, V.; Tjwa, M.; Wiesener, M.S.; Maxwell, P.H.; Collen, D.; Carmeliet, P. Heterozygous deficiency of hypoxia-inducible factor-2α protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. J. Clin. Investig. 2003, 111, 1519-1527.
    • (2003) J. Clin. Investig , vol.111 , pp. 1519-1527
    • Brusselmans, K.1    Compernolle, V.2    Tjwa, M.3    Wiesener, M.S.4    Maxwell, P.H.5    Collen, D.6    Carmeliet, P.7
  • 84
    • 47249111254 scopus 로고    scopus 로고
    • HIF-2alpha-haploinsufficient mice have blunted retinal neovascularization due to impaired expression of a proangiogenic gene battery
    • Dioum, E.M.; Clarke, S.L.; Ding, K.; Repa, J.J.; Garcia, J.A. HIF-2alpha-haploinsufficient mice have blunted retinal neovascularization due to impaired expression of a proangiogenic gene battery. Investig. Ophthalmol. Vis. Sci. 2008, 49, 2714-2720.
    • (2008) Investig. Ophthalmol. Vis. Sci , vol.49 , pp. 2714-2720
    • Dioum, E.M.1    Clarke, S.L.2    Ding, K.3    Repa, J.J.4    Garcia, J.A.5
  • 85
    • 70350692093 scopus 로고    scopus 로고
    • The human HIF (hypoxia-inducible factor)-3alpha gene is a HIF-1 target gene and may modulate hypoxic gene induction
    • Tanaka, T.; Wiesener, M.; Bernhardt, W.; Eckardt, K.-U.; Warnecke, C. The human HIF (hypoxia-inducible factor)-3alpha gene is a HIF-1 target gene and may modulate hypoxic gene induction. Biochem. J. 2009, 424, 143-151.
    • (2009) Biochem. J , vol.424 , pp. 143-151
    • Tanaka, T.1    Wiesener, M.2    Bernhardt, W.3    Eckardt, K.-U.4    Warnecke, C.5
  • 86
    • 17544384815 scopus 로고    scopus 로고
    • ARNT-deficient mice and placental differentiation
    • Kozak, K.; Abbott, B.; Hankinson, O. ARNT-deficient mice and placental differentiation. Dev. Biol. 1997, 191, 297-305.
    • (1997) Dev. Biol , vol.191 , pp. 297-305
    • Kozak, K.1    Abbott, B.2    Hankinson, O.3
  • 87
    • 0030943461 scopus 로고    scopus 로고
    • Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
    • Maltepe, E.; Schmidt, J.V.; Baunoch, D.; Bradfield, C.A.; Simon, M.C. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature 1997, 386, 403-407.
    • (1997) Nature , vol.386 , pp. 403-407
    • Maltepe, E.1    Schmidt, J.V.2    Baunoch, D.3    Bradfield, C.A.4    Simon, M.C.5
  • 88
    • 0033214848 scopus 로고    scopus 로고
    • Multilineage embryonic hematopoiesis requires hypoxic ARNT activity
    • Adelman, D.; Maltepe, E.; Simon, M. Multilineage embryonic hematopoiesis requires hypoxic ARNT activity. Genes Dev. 1999, 13, 2478-2483.
    • (1999) Genes Dev , vol.13 , pp. 2478-2483
    • Adelman, D.1    Maltepe, E.2    Simon, M.3
  • 89
    • 0034671706 scopus 로고    scopus 로고
    • Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses
    • Adelman, D.; Gertsenstein, M.; Nagy, A.; Simon, M.; Maltepe, E. Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses. Genes Dev. 2000, 14, 3191-3203.
    • (2000) Genes Dev , vol.14 , pp. 3191-3203
    • Adelman, D.1    Gertsenstein, M.2    Nagy, A.3    Simon, M.4    Maltepe, E.5
  • 90
    • 33745490023 scopus 로고    scopus 로고
    • HIF-Dependent hematopoietic factors regulate the development of the embryonic vasculature
    • Ramírez-Bergeron, D.L.; Runge, A.; Adelman, D.M.; Gohil, M.; Simon, M.C. HIF-Dependent hematopoietic factors regulate the development of the embryonic vasculature. Dev. Cell 2006, 11, 81-92.
    • (2006) Dev. Cell , vol.11 , pp. 81-92
    • Ramírez-Bergeron, D.L.1    Runge, A.2    Adelman, D.M.3    Gohil, M.4    Simon, M.C.5
  • 91
    • 33748918542 scopus 로고    scopus 로고
    • Disruption of the Arnt gene in endothelial cells causes hepatic vascular defects and partial embryonic lethality in mice
    • Yim, S.; Shah, Y.; Tomita, S.; Morris, H.; Gavrilova, O.; Lambert, G.; Ward, J.; Gonzalez, F. Disruption of the Arnt gene in endothelial cells causes hepatic vascular defects and partial embryonic lethality in mice. Hepatology 2006, 44, 550-560.
    • (2006) Hepatology , vol.44 , pp. 550-560
    • Yim, S.1    Shah, Y.2    Tomita, S.3    Morris, H.4    Gavrilova, O.5    Lambert, G.6    Ward, J.7    Gonzalez, F.8
  • 93
    • 0033962899 scopus 로고    scopus 로고
    • Early wound healing exhibits cytokine surge without evidence of hypoxia
    • Haroon, Z.A.; Raleigh, J.A.; Greenberg, C.S.; Dewhirst, M.W. Early wound healing exhibits cytokine surge without evidence of hypoxia. Ann. Surg. 2000, 231, 137-147.
    • (2000) Ann. Surg , vol.231 , pp. 137-147
    • Haroon, Z.A.1    Raleigh, J.A.2    Greenberg, C.S.3    Dewhirst, M.W.4
  • 94
    • 34250158361 scopus 로고    scopus 로고
    • Cutting edge: Essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis
    • Peyssonnaux, C.; Cejudo-Martin, P.; Doedens, A.; Zinkernagel, A.S.; Johnson, R.S.; Nizet, V. Cutting edge: Essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis. J. Immunol. 2007, 178, 7516-7519.
    • (2007) J. Immunol , vol.178 , pp. 7516-7519
    • Peyssonnaux, C.1    Cejudo-Martin, P.2    Doedens, A.3    Zinkernagel, A.S.4    Johnson, R.S.5    Nizet, V.6
  • 96
    • 0034326273 scopus 로고    scopus 로고
    • Coordinate up-regulation of hypoxia inducible factor (HIF)-1α and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing
    • Elson, D.; Ryan, H.; Snow, J.; Johnson, R.; Arbeit, J. Coordinate up-regulation of hypoxia inducible factor (HIF)-1α and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing. Cancer Res. 2000, 21, 6189-6195.
    • (2000) Cancer Res , vol.21 , pp. 6189-6195
    • Elson, D.1    Ryan, H.2    Snow, J.3    Johnson, R.4    Arbeit, J.5
  • 97
    • 77949902408 scopus 로고    scopus 로고
    • Impaired angiogenesis and mobilization of circulating angiogenic cells in HIF-1alpha heterozygous-null mice after burn wounding
    • Zhang, X.; Liu, L.; Wei, X.; Tan, Y.S.; Tong, L.; Chang, R.; Ghanamah, M.S.; Reinblatt, M.; Marti, G.P.; Harmon, J.W.; et al. Impaired angiogenesis and mobilization of circulating angiogenic cells in HIF-1alpha heterozygous-null mice after burn wounding. Wound Repair Regen. 2010, 18, 193-201.
    • (2010) Wound Repair Regen , vol.18 , pp. 193-201
    • Zhang, X.1    Liu, L.2    Wei, X.3    Tan, Y.S.4    Tong, L.5    Chang, R.6    Ghanamah, M.S.7    Reinblatt, M.8    Marti, G.P.9    Harmon, J.W.10
  • 100
    • 0036790429 scopus 로고    scopus 로고
    • Esophageal ulceration triggers expression of hypoxia-inducible factor-1 alpha and activates vascular endothelial growth factor gene: Implications for angiogenesis and ulcer healing
    • Baatar, D.; Jones, M.K.; Tsugawa, K.; Pai, R.; Moon, W.S.; Koh, G.Y.; Kim, I.; Kitano, S.; Tarnawski, A.S. Esophageal ulceration triggers expression of hypoxia-inducible factor-1 alpha and activates vascular endothelial growth factor gene: Implications for angiogenesis and ulcer healing. Am. J. Pathol. 2002, 161, 1449-1457.
    • (2002) Am. J. Pathol , vol.161 , pp. 1449-1457
    • Baatar, D.1    Jones, M.K.2    Tsugawa, K.3    Pai, R.4    Moon, W.S.5    Koh, G.Y.6    Kim, I.7    Kitano, S.8    Tarnawski, A.S.9
  • 101
    • 0035834295 scopus 로고    scopus 로고
    • Activation of hypoxia inducible factor-1alpha in gastric mucosa in response to ethanol injury: A trigger for angiogenesis?
    • Szabo, I.L.; Kawanaka, H.; Jones, M.K.; Pai, R.; Soreghan, B.A.; Baatar, D.; Husain, S.S.; Tarnawski, A.S. Activation of hypoxia inducible factor-1alpha in gastric mucosa in response to ethanol injury: A trigger for angiogenesis? Life Sci. 2001, 69, 3035-3044.
    • (2001) Life Sci , vol.69 , pp. 3035-3044
    • Szabo, I.L.1    Kawanaka, H.2    Jones, M.K.3    Pai, R.4    Soreghan, B.A.5    Baatar, D.6    Husain, S.S.7    Tarnawski, A.S.8
  • 104
    • 37349021749 scopus 로고    scopus 로고
    • Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1alpha stabilization during ischemia
    • Chang, E.I.; Loh, S.A.; Ceradini, D.J.; Chang, E.I.; Lin, S.; Bastidas, N.; Aarabi, S.; Chan, D.A.; Freedman, M.L.; Giaccia, A.J.; et al. Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1alpha stabilization during ischemia. Circulation 2007, 116, 2818-2829.
    • (2007) Circulation , vol.116 , pp. 2818-2829
    • Chang, E.I.1    Loh, S.A.2    Ceradini, D.J.3    Chang, E.I.4    Lin, S.5    Bastidas, N.6    Aarabi, S.7    Chan, D.A.8    Freedman, M.L.9    Giaccia, A.J.10
  • 105
    • 34848879004 scopus 로고    scopus 로고
    • Sustained expression of Hif-1α in the diabetic environment promotes angiogenesis and cutaneous wound repair
    • Mace, K.A.; Yu, D.H.; Paydar, K.Z.; Boudreau, N.; Young, D.M. Sustained expression of Hif-1α in the diabetic environment promotes angiogenesis and cutaneous wound repair. Wound Repair Regen. 2007, 15, 636-645.
    • (2007) Wound Repair Regen , vol.15 , pp. 636-645
    • Mace, K.A.1    Yu, D.H.2    Paydar, K.Z.3    Boudreau, N.4    Young, D.M.5
  • 106
    • 9444296528 scopus 로고    scopus 로고
    • Hyperglycemia regulates hypoxia-inducible factor-1alpha protein stability and function
    • Catrina, S.-B.; Okamoto, K.; Pereira, T.; Brismar, K.; Poellinger, L. Hyperglycemia regulates hypoxia-inducible factor-1alpha protein stability and function. Diabetes 2004, 53, 3226-3232.
    • (2004) Diabetes , vol.53 , pp. 3226-3232
    • Catrina, S.-B.1    Okamoto, K.2    Pereira, T.3    Brismar, K.4    Poellinger, L.5
  • 108
    • 51449105857 scopus 로고    scopus 로고
    • Age-dependent impairment of HIF-1alpha expression in diabetic mice: Correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells
    • Liu, L.; Marti, G.P.; Wei, X.; Zhang, X.; Zhang, H.; Liu, Y.V; Nastai, M.; Semenza, G.L.; Harmon, J.W. Age-dependent impairment of HIF-1alpha expression in diabetic mice: Correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells. J. Cell. Physiol. 2008, 217, 319-327.
    • (2008) J. Cell. Physiol , vol.217 , pp. 319-327
    • Liu, L.1    Marti, G.P.2    Wei, X.3    Zhang, X.4    Zhang, H.5    Liu, Y.V.6    Nastai, M.7    Semenza, G.L.8    Harmon, J.W.9
  • 112
    • 20344385551 scopus 로고    scopus 로고
    • Modelling oxygen diffusion and cell growth in a porous, vascularising scaffold for soft tissue engineering applications
    • Croll, T.I.; Gentz, S.; Mueller, K.; Davidson, M.; O’Connor, A.J.; Stevens, G.W.; Cooper-White, J.J. Modelling oxygen diffusion and cell growth in a porous, vascularising scaffold for soft tissue engineering applications. Chem. Eng. Sci. 2005, 60, 4924-4934.
    • (2005) Chem. Eng. Sci , vol.60 , pp. 4924-4934
    • Croll, T.I.1    Gentz, S.2    Mueller, K.3    Davidson, M.4    O’connor, A.J.5    Stevens, G.W.6    Cooper-White, J.J.7
  • 113
    • 0343471403 scopus 로고    scopus 로고
    • Increased vascularization and heterogeneity of vascular structures occurring in polyglycolide matrices containing aortic endothelial cells implanted in the rat
    • Holder, W.D., Jr.; Gruber, H.E.; Roland, W.D.; Moore, A.L.; Culberson, C.R.; Loebsack, A.B.; Burg, K.J.L.; Mooney, D.J. Increased vascularization and heterogeneity of vascular structures occurring in polyglycolide matrices containing aortic endothelial cells implanted in the rat. Tissue Eng. 1997, 3, 149-160.
    • (1997) Tissue Eng , vol.3 , pp. 149-160
    • Holder, W.D.1    Gruber, H.E.2    Roland, W.D.3    Moore, A.L.4    Culberson, C.R.5    Loebsack, A.B.6    Burg, K.J.L.7    Mooney, D.J.8
  • 116
    • 79960096827 scopus 로고    scopus 로고
    • Normalization of the vasculature for treatment of cancer and other diseases
    • Goel, S.; Duda, D.G.; Xu, L.; Munn, L.L.; Boucher, Y.; Fukumura, D.; Jain, R.K. Normalization of the vasculature for treatment of cancer and other diseases. Physiol. Rev. 2011, 91, 1071-1121.
    • (2011) Physiol. Rev , vol.91 , pp. 1071-1121
    • Goel, S.1    Duda, D.G.2    Xu, L.3    Munn, L.L.4    Boucher, Y.5    Fukumura, D.6    Jain, R.K.7
  • 119
    • 0034575632 scopus 로고    scopus 로고
    • The angiogenesis inhibitor endostatin impairs blood vessel maturation during wound healing
    • Bloch, W.; Huggel, K.; Sasaki, T.; Grose, R.; Bugnon, P.; Addicks, K.; Timpl, R.; Werner, S. The angiogenesis inhibitor endostatin impairs blood vessel maturation during wound healing. FASEB J. 2000, 14, 2373-2376.
    • (2000) FASEB J , vol.14 , pp. 2373-2376
    • Bloch, W.1    Huggel, K.2    Sasaki, T.3    Grose, R.4    Bugnon, P.5    Addicks, K.6    Timpl, R.7    Werner, S.8
  • 120
    • 77950901310 scopus 로고    scopus 로고
    • Vascular responses to hypoxia and ischemia
    • Semenza, G.L. Vascular responses to hypoxia and ischemia. Arterioscler. Thromb. Vasc. Biol. 2010, 30, 648-652.
    • (2010) Arterioscler. Thromb. Vasc. Biol , vol.30 , pp. 648-652
    • Semenza, G.L.1
  • 121
    • 0031126380 scopus 로고    scopus 로고
    • Intravitreal sustained release of VEGF causes retinal neovascularization in rabbits and breakdown of the blood-retinal barrier in rabbits and primates
    • Ozaki, H.; Hayashi, H.; Vinores, S.A.; Moromizato, Y.; Campochiaro, P.A.; Oshima, K. Intravitreal sustained release of VEGF causes retinal neovascularization in rabbits and breakdown of the blood-retinal barrier in rabbits and primates. Exp. Eye Res. 1997, 64, 505-517.
    • (1997) Exp. Eye Res , vol.64 , pp. 505-517
    • Ozaki, H.1    Hayashi, H.2    Vinores, S.A.3    Moromizato, Y.4    Campochiaro, P.A.5    Oshima, K.6
  • 123
    • 13844253297 scopus 로고    scopus 로고
    • In vivo gene delivery of Ad-VEGF121 to full-thickness wounds in aged pigs results in high levels of VEGF expression but not in accelerated healing
    • Vranckx, J.J.; Yao, F.; Petrie, N.; Augustinova, H.; Hoeller, D.; Visovatti, S.; Slama, J.; Eriksson, E. In vivo gene delivery of Ad-VEGF121 to full-thickness wounds in aged pigs results in high levels of VEGF expression but not in accelerated healing. Wound Repair Regen. 2005, 13, 51-60.
    • (2005) Wound Repair Regen , vol.13 , pp. 51-60
    • Vranckx, J.J.1    Yao, F.2    Petrie, N.3    Augustinova, H.4    Hoeller, D.5    Visovatti, S.6    Slama, J.7    Eriksson, E.8
  • 124
    • 84921359151 scopus 로고    scopus 로고
    • The use of adipose mesenchymal stem cells and human umbilical vascular endothelial cells on a fibrin matrix for endothelialized skin substitue
    • Sánchez Muñoz, I.; Granados, R.; Holguín Holgado, P.; García Vela, J.A.; Casares, C.; Casares, M. The use of adipose mesenchymal stem cells and human umbilical vascular endothelial cells on a fibrin matrix for endothelialized skin substitue. Tissue Eng. Part A 2014, doi:10.1089/ten.tea.2013.0626.
    • (2014) Tissue Eng. Part A
    • SáNchez MuñOz, I.1    Granados, R.2    HolguíN Holgado, P.3    GarcíA Vela, J.A.4    Casares, C.5    Casares, M.6
  • 126
    • 17644392452 scopus 로고    scopus 로고
    • Inosculation of tissue-engineered capillaries with the host’s vasculature in a reconstructed skin transplanted on mice
    • Tremblay, P.-L.; Hudon, V.; Berthod, F.; Germain, L.; Auger, F.A. Inosculation of tissue-engineered capillaries with the host’s vasculature in a reconstructed skin transplanted on mice. Am. J. Transplant. 2005, 5, 1002-1010.
    • (2005) Am. J. Transplant , vol.5 , pp. 1002-1010
    • Tremblay, P.-L.1    Hudon, V.2    Berthod, F.3    Germain, L.4    Auger, F.A.5
  • 127
    • 70350493787 scopus 로고    scopus 로고
    • The effect of hypoxia on in vitro prevascularization of a thick soft tissue
    • Griffith, C.K.; George, S.C. The effect of hypoxia on in vitro prevascularization of a thick soft tissue. Tissue Eng. Part A 2009, 15, 2423-2434.
    • (2009) Tissue Eng. Part A , vol.15 , pp. 2423-2434
    • Griffith, C.K.1    George, S.C.2
  • 128
    • 0005974723 scopus 로고    scopus 로고
    • Differential effects of oxygen on human dermal fibroblasts: Acute versus chronic hypoxia
    • Siddiqui, A.; Galiano, R.D.; Connors, D.; Gruskin, E.; Wu, L.; Mustoe, T.A. Differential effects of oxygen on human dermal fibroblasts: Acute versus chronic hypoxia. Wound Repair Regen. 1996, 4, 211-218.
    • (1996) Wound Repair Regen , vol.4 , pp. 211-218
    • Siddiqui, A.1    Galiano, R.D.2    Connors, D.3    Gruskin, E.4    Wu, L.5    Mustoe, T.A.6
  • 130
    • 1642269211 scopus 로고    scopus 로고
    • Oxygen in wound healing--more than a nutrient. World
    • Tandara, A.; Mustoe, T. Oxygen in wound healing--more than a nutrient. World J. Surg. 2004, 28, 294-300.
    • (2004) J. Surg , vol.28 , pp. 294-300
    • Tandara, A.1    Mustoe, T.2
  • 131
    • 0032943898 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 fails to stimulate wound healing and impairs its signal transduction in an aged ischemic ulcer model: Importance of oxygen and age
    • Wu, L.; Xia, Y.P.; Roth, S.I.; Gruskin, E.; Mustoe, T.A. Transforming growth factor-beta1 fails to stimulate wound healing and impairs its signal transduction in an aged ischemic ulcer model: Importance of oxygen and age. Am. J. Pathol. 1999, 154, 301-309.
    • (1999) Am. J. Pathol , vol.154 , pp. 301-309
    • Wu, L.1    Xia, Y.P.2    Roth, S.I.3    Gruskin, E.4    Mustoe, T.A.5
  • 132
    • 0025327460 scopus 로고
    • Effects of ischemia on ulcer wound healing: A new model in the rabbit ear
    • Ahn, S.T.; Mustoe, T.A. Effects of ischemia on ulcer wound healing: A new model in the rabbit ear. Ann. Plast. Surg. 1990, 24, 17-23.
    • (1990) Ann. Plast. Surg , vol.24 , pp. 17-23
    • Ahn, S.T.1    Mustoe, T.A.2
  • 135
    • 0021351258 scopus 로고
    • Oxygen as an Antibiotic. The Effect of Inspired oxygen on infection
    • Knighton, D.R.; Halliday, B.; Hunt, T.K. Oxygen as an Antibiotic. The Effect of Inspired oxygen on infection. Arch. Surg. 1984, 119, 199-204.
    • (1984) Arch. Surg , vol.119 , pp. 199-204
    • Knighton, D.R.1    Halliday, B.2    Hunt, T.K.3
  • 137
    • 84885418780 scopus 로고    scopus 로고
    • Concerted inhibition of HIF-1α and-2α expression markedly suppresses angiogenesis in cultured RPE cells
    • Nakajima, T.; Nakajima, E.; Shearer, T.R.; Azuma, M. Concerted inhibition of HIF-1α and-2α expression markedly suppresses angiogenesis in cultured RPE cells. Mol. Cell. Biochem. 2013, 383, 113-122.
    • (2013) Mol. Cell. Biochem , vol.383 , pp. 113-122
    • Nakajima, T.1    Nakajima, E.2    Shearer, T.R.3    Azuma, M.4
  • 138
    • 0344874751 scopus 로고    scopus 로고
    • Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1
    • Kelly, B.D.; Hackett, F.; Hirota, K.; Oshima, Y.; Cai, Z.; Berg-Dixon, S.; Rowan, A.; Yan, Z.; Campochiaro, P.A.; Semenza, G.L. Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1. Circ. Res. 2003, 93, 1074-1081.
    • (2003) Circ. Res , vol.93 , pp. 1074-1081
    • Kelly, B.D.1    Hackett, F.2    Hirota, K.3    Oshima, Y.4    Cai, Z.5    Berg-Dixon, S.6    Rowan, A.7    Yan, Z.8    Campochiaro, P.A.9    Semenza, G.L.10
  • 139
    • 0035476509 scopus 로고    scopus 로고
    • Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha
    • Elson, D.A.; Thurston, G.; Huang, L.E.; Ginzinger, D.E.; McDonald, D.; Johnson, R.S.; Arbeit, J.M. Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha. Genes Dev. 2001, 15, 2520-2532.
    • (2001) Genes Dev , vol.15 , pp. 2520-2532
    • Elson, D.A.1    Thurston, G.2    Huang, L.E.3    Ginzinger, D.E.4    McDonald, D.5    Johnson, R.S.6    Arbeit, J.M.7
  • 141
    • 0037390915 scopus 로고    scopus 로고
    • The antimycotic ciclopirox olamine induces HIF-1alpha stability, VEGF expression, and angiogenesis
    • Linden, T.; Katschinski, D.M.; Eckhardt, K.; Scheid, A.; Pagel, H.; Wenger, R.H. The antimycotic ciclopirox olamine induces HIF-1alpha stability, VEGF expression, and angiogenesis. FASEB J. 2003, 17, 761-763.
    • (2003) FASEB J , vol.17 , pp. 761-763
    • Linden, T.1    Katschinski, D.M.2    Eckhardt, K.3    Scheid, A.4    Pagel, H.5    Wenger, R.H.6
  • 143
    • 33644533818 scopus 로고    scopus 로고
    • Peptide-matrix-mediated gene transfer of an variant for local induction of angiogenesis
    • Trentin, D.; Hall, H.; Wechsler, S.; Hubbell, J.A. Peptide-matrix-mediated gene transfer of an variant for local induction of angiogenesis. Proc. Natl. Acad. Sci. USA 2006, 103, 2506-2511.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 2506-2511
    • Trentin, D.1    Hall, H.2    Wechsler, S.3    Hubbell, J.A.4
  • 145
    • 34848904509 scopus 로고    scopus 로고
    • Hypertrophic scar formation following burns and trauma: New approaches to treatment
    • Aarabi, S.; Longaker, M.T.; Gurtner, G.C. Hypertrophic scar formation following burns and trauma: New approaches to treatment. PLoS Med. 2007, 4, e234.
    • (2007) PLoS Med , vol.4 , pp. e234
    • Aarabi, S.1    Longaker, M.T.2    Gurtner, G.C.3
  • 146
    • 57149142495 scopus 로고    scopus 로고
    • The impact of O2 availability on human cancer
    • Bertout, J.A.; Patel, S.A.; Simon, M.C. The impact of O2 availability on human cancer. Nat. Rev. Cancer 2008, 8, 967-975.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 967-975
    • Bertout, J.A.1    Patel, S.A.2    Simon, M.C.3
  • 147
    • 24344488419 scopus 로고    scopus 로고
    • The HIF pathway in cancer
    • Maxwell, P.H. The HIF pathway in cancer. Semin. Cell Dev. Biol. 2005, 16, 523-530.
    • (2005) Semin. Cell Dev. Biol , vol.16 , pp. 523-530
    • Maxwell, P.H.1
  • 148
    • 34547098129 scopus 로고    scopus 로고
    • Targeting hypoxia cell signaling for cancer therapy
    • Melillo, G. Targeting hypoxia cell signaling for cancer therapy. Cancer Metastasis Rev. 2007, 26, 341-352.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 341-352
    • Melillo, G.1
  • 149
    • 60549092506 scopus 로고    scopus 로고
    • Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells
    • Lee, K.A.; Qian, D.Z.; Rey, S.; Wei, H.; Liu, J.O.; Semenza, G.L. Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proc. Natl. Acad. Sci. USA 2009, 106, 2353-2358.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 2353-2358
    • Lee, K.A.1    Qian, D.Z.2    Rey, S.3    Wei, H.4    Liu, J.O.5    Semenza, G.L.6
  • 151
    • 34548829081 scopus 로고    scopus 로고
    • HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques
    • Hsieh, M.M.; Linde, N.S.; Wynter, A.; Metzger, M.; Wong, C.; Langsetmo, I.; Lin, A.; Smith, R.; Rodgers, G.P.; Donahue, R.E.; et al. HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques. Blood 2007, 110, 2140-2147.
    • (2007) Blood , vol.110 , pp. 2140-2147
    • Hsieh, M.M.1    Linde, N.S.2    Wynter, A.3    Metzger, M.4    Wong, C.5    Langsetmo, I.6    Lin, A.7    Smith, R.8    Rodgers, G.P.9    Donahue, R.E.10
  • 152
    • 84885339373 scopus 로고    scopus 로고
    • Nrf2 acts cell-autonomously in endothelium to regulate tip cell formation and vascular branching
    • Wei, Y.; Gong, J.; Thimmulappa, R.K.; Kosmider, B.; Biswal, S.; Duh, E.J. Nrf2 acts cell-autonomously in endothelium to regulate tip cell formation and vascular branching. Proc. Natl. Acad. Sci. USA 2013, 110, E3910-E3918.
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. E3910-E3918
    • Wei, Y.1    Gong, J.2    Thimmulappa, R.K.3    Kosmider, B.4    Biswal, S.5    Duh, E.J.6
  • 153
    • 77956355633 scopus 로고    scopus 로고
    • Int6/eIF3e silencing promotes functional blood vessel outgrowth and enhances wound healing by upregulating hypoxia-induced factor 2alpha expression
    • Chen, L.; Endler, A.; Uchida, K.; Horiguchi, S.; Morizane, Y.; Iijima, O.; Toi, M.; Shibasaki, F. Int6/eIF3e silencing promotes functional blood vessel outgrowth and enhances wound healing by upregulating hypoxia-induced factor 2alpha expression. Circulation 2010, 122, 910-919.
    • (2010) Circulation , vol.122 , pp. 910-919
    • Chen, L.1    Endler, A.2    Uchida, K.3    Horiguchi, S.4    Morizane, Y.5    Iijima, O.6    Toi, M.7    Shibasaki, F.8


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