-
1
-
-
0015309272
-
Oxygen supply in healing tissue
-
Niinikoski, J.; Hunt, T.K.; Dunphy, J.E. Oxygen supply in healing tissue. Am. J. Surg. 1972, 123, 247-252.
-
(1972)
Am. J. Surg
, vol.123
, pp. 247-252
-
-
Niinikoski, J.1
Hunt, T.K.2
Dunphy, J.E.3
-
2
-
-
2442538178
-
Understanding chronic wounds: A unifying hypothesis on their pathogenesis and implications for therapy
-
Mustoe, T. Understanding chronic wounds: A unifying hypothesis on their pathogenesis and implications for therapy. Am. J. Surg. 2004, 187, 65S-70S.
-
(2004)
Am. J. Surg
, vol.187
, pp. 65S-70S
-
-
Mustoe, T.1
-
3
-
-
0020062301
-
Wound tissue can utilize a polymeric template to synthesize a functional extension of skin
-
Yannas, I.V; Burke, J.F.; Orgill, D.P.; Skrabut, E.M. Wound tissue can utilize a polymeric template to synthesize a functional extension of skin. Science 1982, 215, 174-176.
-
(1982)
Science
, vol.215
, pp. 174-176
-
-
Yannas, I.V.1
Burke, J.F.2
Orgill, D.P.3
Skrabut, E.M.4
-
4
-
-
0033649024
-
Tissue engineering
-
Langer, R. Tissue engineering. Mol. Ther. 2000, 1, 12-15.
-
(2000)
Mol. Ther
, vol.1
, pp. 12-15
-
-
Langer, R.1
-
5
-
-
33645560618
-
Oxygen gradients correlate with cell density and cell viability in engineered cardiac tissue
-
Radisic, M.; Malda, J.; Epping, E.; Geng, W.; Langer, R.; Vunjak-Novakovic, G. Oxygen gradients correlate with cell density and cell viability in engineered cardiac tissue. Biotechnol. Bioeng. 2006, 93, 332-343.
-
(2006)
Biotechnol. Bioeng
, vol.93
, pp. 332-343
-
-
Radisic, M.1
Malda, J.2
Epping, E.3
Geng, W.4
Langer, R.5
Vunjak-Novakovic, G.6
-
6
-
-
0036254850
-
Perfusion improves tissue architecture of engineered cardiac muscle
-
Carrier, R.L.; Rupnick, M.; Langer, R.; Schoen, F.J.; Freed, L.E.; Vunjak-Novakovic, G. Perfusion improves tissue architecture of engineered cardiac muscle. Tissue Eng. 2002, 8, 175-188.
-
(2002)
Tissue Eng
, vol.8
, pp. 175-188
-
-
Carrier, R.L.1
Rupnick, M.2
Langer, R.3
Schoen, F.J.4
Freed, L.E.5
Vunjak-Novakovic, G.6
-
7
-
-
1542510685
-
Oxygen gradients in tissue-engineered PEGT/PBT cartilaginous constructs: Measurement and modeling
-
Malda, J.; Rouwkema, J.; Martens, D.E.; le Comte, E.P.; Kooy, F.K.; Tramper, J.; van Blitterswijk, C.A.; Riesle, J. Oxygen gradients in tissue-engineered PEGT/PBT cartilaginous constructs: Measurement and modeling. Biotechnol. Bioeng. 2004, 86, 9-18.
-
(2004)
Biotechnol. Bioeng
, vol.86
, pp. 9-18
-
-
Malda, J.1
Rouwkema, J.2
Martens, D.E.3
Le Comte, E.P.4
Kooy, F.K.5
Tramper, J.6
Van Blitterswijk, C.A.7
Riesle, J.8
-
8
-
-
84904749172
-
The role of hypoxia-inducible factor in wound healing
-
Hong, W.X.; Hu, M.S.; Esquivel, M.; Liang, G.Y.; Rennert, R.C.; McArdle, A.; Paik, K.J.; Duscher, D.; Gurtner, G.C.; Lorenz, H.P.; et al. The role of hypoxia-inducible factor in wound healing. Adv. Wound Care 2014, 3, 390-399.
-
(2014)
Adv. Wound Care
, vol.3
, pp. 390-399
-
-
Hong, W.X.1
Hu, M.S.2
Esquivel, M.3
Liang, G.Y.4
Rennert, R.C.5
McArdle, A.6
Paik, K.J.7
Duscher, D.8
Gurtner, G.C.9
Lorenz, H.P.10
-
9
-
-
84868612850
-
Hypoxia-induced angiogenesis: Good and evil
-
Krock, B.L.; Skuli, N.; Simon, M.C. Hypoxia-induced angiogenesis: Good and evil. Genes Cancer 2011, 2, 1117-1133.
-
(2011)
Genes Cancer
, vol.2
, pp. 1117-1133
-
-
Krock, B.L.1
Skuli, N.2
Simon, M.C.3
-
10
-
-
0030952289
-
Mechanisms of angiogenesis
-
Risau, W. Mechanisms of angiogenesis. Nature 1997, 6626, 671-674.
-
(1997)
Nature
, vol.6626
, pp. 671-674
-
-
Risau, W.1
-
11
-
-
78650416408
-
From vessel sprouting to normalization: Role of the prolyl hydroxylase domain protein/hypoxia-inducible factor oxygen-sensing machinery
-
Coulon, C.; Georgiadou, M.; Roncal, C.; de Bock, K.; Langenberg, T.; Carmeliet, P. From vessel sprouting to normalization: Role of the prolyl hydroxylase domain protein/hypoxia-inducible factor oxygen-sensing machinery. Arterioscler. Thromb. Vasc. Biol. 2010, 30, 2331-2336.
-
(2010)
Arterioscler. Thromb. Vasc. Biol
, vol.30
, pp. 2331-2336
-
-
Coulon, C.1
Georgiadou, M.2
Roncal, C.3
De Bock, K.4
Langenberg, T.5
Carmeliet, P.6
-
12
-
-
0038376002
-
Molecular regulation of vessel maturation
-
Jain, R.K. Molecular regulation of vessel maturation. Nat. Med. 2003, 9, 685-693.
-
(2003)
Nat. Med
, vol.9
, pp. 685-693
-
-
Jain, R.K.1
-
13
-
-
80052933197
-
Basic and therapeutic aspects of angiogenesis
-
Potente, M.; Gerhardt, H.; Carmeliet, P. Basic and therapeutic aspects of angiogenesis. Cell 2011, 146, 873-887.
-
(2011)
Cell
, vol.146
, pp. 873-887
-
-
Potente, M.1
Gerhardt, H.2
Carmeliet, P.3
-
14
-
-
0014248318
-
Oxygen gradients in healing wounds
-
Remensnyder, J.P.; Majno, G. Oxygen gradients in healing wounds. Am. J. Pathol. 1968, 52, 301-323.
-
(1968)
Am. J. Pathol
, vol.52
, pp. 301-323
-
-
Remensnyder, J.P.1
Majno, G.2
-
15
-
-
84860424872
-
Hypoxia and hypoxia signaling in tissue repair and fibrosis
-
Lokmic, Z.; Musyoka, J.; Hewitson, T.D.; Darby, I.A. Hypoxia and hypoxia signaling in tissue repair and fibrosis. Int. Rev. Cell Mol. Biol. 2012, 296, 139-185.
-
(2012)
Int. Rev. Cell Mol. Biol
, vol.296
, pp. 139-185
-
-
Lokmic, Z.1
Musyoka, J.2
Hewitson, T.D.3
Darby, I.A.4
-
16
-
-
33745491890
-
The basic science of wound healing
-
Broughton, G., 2nd.; Janis, J.E.; Attinger, C.E. The basic science of wound healing. Plast. Reconstr. Surg. 2006, 117, 12S-34S.
-
(2006)
Plast. Reconstr. Surg
, vol.117
, pp. 12S-34S
-
-
Broughton, G.1
Janis, J.E.2
Attinger, C.E.3
-
17
-
-
0035168305
-
Biological responses to materials
-
Anderson, J. Biological responses to materials. Annu. Rev. Mater. Res. 2001, 31, 81-110.
-
(2001)
Annu. Rev. Mater. Res
, vol.31
, pp. 81-110
-
-
Anderson, J.1
-
18
-
-
33746499553
-
Fibrin structure and wound healing
-
Laurens, N.; Koolwijk, P.; de Maat, M.P.M. Fibrin structure and wound healing. J. Thromb. Haemost. 2006, 4, 932-939.
-
(2006)
J. Thromb. Haemost
, vol.4
, pp. 932-939
-
-
Laurens, N.1
Koolwijk, P.2
de Maat, M.P.M.3
-
19
-
-
0030934532
-
Wound healing-Aiming for perfect skin regeneration
-
Martin, P. Wound healing-Aiming for perfect skin regeneration. Science 1997, 276, 75-81.
-
(1997)
Science
, vol.276
, pp. 75-81
-
-
Martin, P.1
-
20
-
-
0023872010
-
Platelets, platelet-derived growth factor and arteriosclerosis
-
Baumgartner, H.R.; Hosang, M. Platelets, platelet-derived growth factor and arteriosclerosis. Experientia 1988, 44, 109-112.
-
(1988)
Experientia
, vol.44
, pp. 109-112
-
-
Baumgartner, H.R.1
Hosang, M.2
-
21
-
-
0031029290
-
Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets
-
Möhle, R.; Green, D.; Moore, M.A.; Nachman, R.L.; Rafii, S. Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets. Proc. Natl. Acad. Sci. USA 1997, 94, 663-668.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 663-668
-
-
Möhle, R.1
Green, D.2
Moore, M.A.3
Nachman, R.L.4
Rafii, S.5
-
22
-
-
0016428338
-
The role of the macrophage in wound repair
-
Leibovich, S.J.; Ross, R. The role of the macrophage in wound repair. Am. J. Pathol. 1975, 78, 71-100.
-
(1975)
Am. J. Pathol
, vol.78
, pp. 71-100
-
-
Leibovich, S.J.1
Ross, R.2
-
23
-
-
27744543102
-
Inflammatory cells during wound repair: The good, the bad and the ugly
-
Martin, P.; Leibovich, S.J. Inflammatory cells during wound repair: The good, the bad and the ugly. Trends Cell Biol. 2005, 15, 599-607.
-
(2005)
Trends Cell Biol
, vol.15
, pp. 599-607
-
-
Martin, P.1
Leibovich, S.J.2
-
24
-
-
84937092509
-
Wound healing: The role of the macrophage and other immune cells
-
DiPietro, L.A. Wound healing: The role of the macrophage and other immune cells. Shock 1995, 4, 233-240.
-
(1995)
Shock
, vol.4
, pp. 233-240
-
-
Dipietro, L.A.1
-
25
-
-
0026485002
-
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
-
Shweiki, D.; Itin, A.; Soffer, D.; Keshet, E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992, 359, 843-845.
-
(1992)
Nature
, vol.359
, pp. 843-845
-
-
Shweiki, D.1
Itin, A.2
Soffer, D.3
Keshet, E.4
-
26
-
-
0141640863
-
Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors
-
Yamakawa, M.; Liu, L.X.; Date, T.; Belanger, A.J.; Vincent, K.A.; Akita, G.Y.; Kuriyama, T.; Cheng, S.H.; Gregory, R.J.; Jiang, C. Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors. Circ. Res. 2003, 93, 664-673.
-
(2003)
Circ. Res
, vol.93
, pp. 664-673
-
-
Yamakawa, M.1
Liu, L.X.2
Date, T.3
Belanger, A.J.4
Vincent, K.A.5
Akita, G.Y.6
Kuriyama, T.7
Cheng, S.H.8
Gregory, R.J.9
Jiang, C.10
-
27
-
-
0025688912
-
Vascular permeability factor: A tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration
-
Clauss, M.; Gerlach, M.; Gerlach, H.; Brett, J.; Wang, F.; Familletti, P.C.; Pan, Y.C.; Olander, J. V; Connolly, D.T.; Stern, D. Vascular permeability factor: A tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration. J. Exp. Med. 1990, 172, 1535-1545.
-
(1990)
J. Exp. Med
, vol.172
, pp. 1535-1545
-
-
Clauss, M.1
Gerlach, M.2
Gerlach, H.3
Brett, J.4
Wang, F.5
Familletti, P.C.6
Pan, Y.C.7
Olander, J.V.8
Connolly, D.T.9
Stern, D.10
-
28
-
-
33847084614
-
Formation and function of the myofibroblast during tissue repair
-
Hinz, B. Formation and function of the myofibroblast during tissue repair. J. Investig. Dermatol. 2007, 127, 526-537.
-
(2007)
J. Investig. Dermatol
, vol.127
, pp. 526-537
-
-
Hinz, B.1
-
29
-
-
0034964284
-
Fibrin and wound healing
-
Clark, R.A. Fibrin and wound healing. Ann. N. Y. Acad. Sci. 2001, 936, 355-367.
-
(2001)
Ann. N. Y. Acad. Sci
, vol.936
, pp. 355-367
-
-
Clark, R.A.1
-
30
-
-
84900342698
-
Direct measurement of local oxygen concentration in the bone marrow of live animals
-
Spencer, J.A.; Ferraro, F.; Roussakis, E.; Klein, A.; Wu, J.; Runnels, J.M.; Zaher, W.; Mortensen, J.; Alt, C.; Turcotte, R.; et al. Direct measurement of local oxygen concentration in the bone marrow of live animals. Nature 2014, 508, 269-273.
-
(2014)
Nature
, vol.508
, pp. 269-273
-
-
Spencer, J.A.1
Ferraro, F.2
Roussakis, E.3
Klein, A.4
Wu, J.5
Runnels, J.M.6
Zaher, W.7
Mortensen, J.8
Alt, C.9
Turcotte, R.10
-
31
-
-
25444454359
-
Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptors
-
Sitkovsky, M.; Lukashev, D. Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptors. Nat. Rev. Immunol. 2005, 5, 712-721.
-
(2005)
Nat. Rev. Immunol
, vol.5
, pp. 712-721
-
-
Sitkovsky, M.1
Lukashev, D.2
-
32
-
-
27144458505
-
ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth
-
Bi, M.; Naczki, C.; Koritzinsky, M.; Fels, D.; Blais, J.; Hu, N.; Harding, H.; Novoa, I.; Varia, M.; Raleigh, J.; et al. ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. EMBO J. 2005, 24, 3470-3481.
-
(2005)
EMBO J
, vol.24
, pp. 3470-3481
-
-
Bi, M.1
Naczki, C.2
Koritzinsky, M.3
Fels, D.4
Blais, J.5
Hu, N.6
Harding, H.7
Novoa, I.8
Varia, M.9
Raleigh, J.10
-
33
-
-
33644852277
-
Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control
-
Koritzinsky, M.; Magagnin, M.; van den Beucken, T.; Seigneuric, R.; Savelkouls, K.; Dostie, J.; Pyronnet, S.; Kaufman, R.J.; Weppler, S.A.; Voncken, J.W.; et al. Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control. EMBO J. 2006, 25, 1114-1125.
-
(2006)
EMBO J
, vol.25
, pp. 1114-1125
-
-
Koritzinsky, M.1
Magagnin, M.2
Van Den Beucken, T.3
Seigneuric, R.4
Savelkouls, K.5
Dostie, J.6
Pyronnet, S.7
Kaufman, R.J.8
Weppler, S.A.9
Voncken, J.W.10
-
34
-
-
24344485624
-
Control of the hypoxic response through regulation of mRNA translation
-
Wouters, B.G.; van den Beucken, T.; Magagnin, M.G.; Koritzinsky, M.; Fels, D.; Koumenis, C. Control of the hypoxic response through regulation of mRNA translation. Semin. Cell Dev. Biol. 2005, 16, 487-501.
-
(2005)
Semin. Cell Dev. Biol
, vol.16
, pp. 487-501
-
-
Wouters, B.G.1
Van Den Beucken, T.2
Magagnin, M.G.3
Koritzinsky, M.4
Fels, D.5
Koumenis, C.6
-
35
-
-
3342955696
-
The role of calcium in hypoxia-induced signal transduction and gene expression
-
Seta, K.A.; Yuan, Y.; Spicer, Z.; Lu, G.; Bedard, J.; Ferguson, T.K.; Pathrose, P.; Cole-Strauss, A.; Kaufhold, A.; Millhorn, D.E. The role of calcium in hypoxia-induced signal transduction and gene expression. Cell Calcium 2004, 36, 331-340.
-
(2004)
Cell Calcium
, vol.36
, pp. 331-340
-
-
Seta, K.A.1
Yuan, Y.2
Spicer, Z.3
Lu, G.4
Bedard, J.5
Ferguson, T.K.6
Pathrose, P.7
Cole-Strauss, A.8
Kaufhold, A.9
Millhorn, D.E.10
-
36
-
-
0042031047
-
A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets
-
Arsham, A.M.; Howell, J.J.; Simon, M.C. A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets. J. Biol. Chem. 2003, 278, 29655-29660.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 29655-29660
-
-
Arsham, A.M.1
Howell, J.J.2
Simon, M.C.3
-
37
-
-
0036000028
-
Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia
-
Lang, K.D.; Kappel, A.; Goodall, G.J. Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia. Mol. Biol. Cell 2002, 13, 1792-1801.
-
(2002)
Mol. Biol. Cell
, vol.13
, pp. 1792-1801
-
-
Lang, K.D.1
Kappel, A.2
Goodall, G.J.3
-
38
-
-
4344660747
-
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth
-
Romero-Ramirez, L.; Cao, H.; Nelson, D.; Hammond, E.; Lee, A.-H.; Yoshida, H.; Mori, K.; Glimcher, L.H.; Denko, N.C.; Giaccia, A.J.; et al. XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Res. 2004, 64, 5943-5947.
-
(2004)
Cancer Res
, vol.64
, pp. 5943-5947
-
-
Romero-Ramirez, L.1
Cao, H.2
Nelson, D.3
Hammond, E.4
Lee, A.-H.5
Yoshida, H.6
Mori, K.7
Glimcher, L.H.8
Denko, N.C.9
Giaccia, A.J.10
-
39
-
-
0029051439
-
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
-
Wang, G.L.; Jiang, B.H.; Rue, E.A.; Semenza, G.L. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl. Acad. Sci. USA 1995, 92, 5510-5514.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 5510-5514
-
-
Wang, G.L.1
Jiang, B.H.2
Rue, E.A.3
Semenza, G.L.4
-
40
-
-
0030937718
-
Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the alpha Subunit
-
Pugh, C.W.; Rourke, J.F.O.; Nagao, M.; Gleadle, J.M.; Ratcliffe, P.J. Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the alpha Subunit. J. Biol. Chem. 1997, 272, 11205-11214.
-
(1997)
J. Biol. Chem
, vol.272
, pp. 11205-11214
-
-
Pugh, C.W.1
Rourke, J.F.O.2
Nagao, M.3
Gleadle, J.M.4
Ratcliffe, P.J.5
-
41
-
-
0029753008
-
Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit
-
Huang, L.E.; Arany, Z.; Livingston, D.M.; Bunn, H.F. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J. Biol. Chem. 1996, 271, 32253-32259.
-
(1996)
J. Biol. Chem
, vol.271
, pp. 32253-32259
-
-
Huang, L.E.1
Arany, Z.2
Livingston, D.M.3
Bunn, H.F.4
-
42
-
-
0030787469
-
Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1alpha. Modulation of transcriptional activity by oxygen tension
-
Jiang, B.-H.; Zheng, J.Z.; Leung, S.W.; Roe, R.; Semenza, G.L. Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1alpha. Modulation of transcriptional activity by oxygen tension. J. Biol. Chem. 1997, 272, 19253-19260.
-
(1997)
J. Biol. Chem
, vol.272
, pp. 19253-19260
-
-
Jiang, B.-H.1
Zheng, J.Z.2
Leung, S.W.3
Roe, R.4
Semenza, G.L.5
-
43
-
-
0026468180
-
Nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
-
Semenza, G.; Wang, G. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol. Cell. Biol. 1992, 12, 5447-5454.
-
(1992)
Mol. Cell. Biol
, vol.12
, pp. 5447-5454
-
-
Semenza, G.1
Wang, G.A.2
-
44
-
-
0031020884
-
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
-
Tian, H.; McKnight, S.L.; Russell, D.W. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev. 1997, 11, 72-82.
-
(1997)
Genes Dev
, vol.11
, pp. 72-82
-
-
Tian, H.1
McKnight, S.L.2
Russell, D.W.3
-
45
-
-
0035969508
-
Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression
-
Makino, Y.; Cao, R.; Svensson, K.; Bertilsson, G.; Asman, M.; Tanaka, H.; Cao, Y.; Berkenstam, A.; Poellinger, L. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature 2001, 414, 550-554.
-
(2001)
Nature
, vol.414
, pp. 550-554
-
-
Makino, Y.1
Cao, R.2
Svensson, K.3
Bertilsson, G.4
Asman, M.5
Tanaka, H.6
Cao, Y.7
Berkenstam, A.8
Poellinger, L.9
-
46
-
-
0035810987
-
Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt
-
Keith, B.; Adelman, D.M.; Simon, M.C. Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt. Proc. Natl. Acad. Sci. USA 2001, 98, 6692-6697.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 6692-6697
-
-
Keith, B.1
Adelman, D.M.2
Simon, M.C.3
-
47
-
-
40949132841
-
Turn me on: Regulating HIF transcriptional activity
-
Lisy, K.; Peet, D.J. Turn me on: Regulating HIF transcriptional activity. Cell Death Differ. 2008, 15, 642-649.
-
(2008)
Cell Death Differ
, vol.15
, pp. 642-649
-
-
Lisy, K.1
Peet, D.J.2
-
48
-
-
43649093915
-
Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
-
Kaelin, W.G.; Ratcliffe, P.J. Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway. Mol. Cell 2008, 30, 393-402.
-
(2008)
Mol. Cell
, vol.30
, pp. 393-402
-
-
Kaelin, W.G.1
Ratcliffe, P.J.2
-
49
-
-
0032493368
-
Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway
-
Huang, L.E.; Gu, J.; Schau, M.; Bunn, H.F. Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc. Natl. Acad. Sci. USA 1998, 95, 7987-7992.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 7987-7992
-
-
Huang, L.E.1
Gu, J.2
Schau, M.3
Bunn, H.F.4
-
50
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell, P.H.; Wiesener, M.S.; Chang, G.W.; Clifford, S.C.; Vaux, E.C.; Cockman, M.E.; Wykoff, C.C.; Pugh, C.W.; Maher, E.R.; Ratcliffe, P.J. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 1999, 399, 271-275.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
51
-
-
27544434803
-
Signalling hypoxia by HIF hydroxylases. Biochem. Biophys
-
Schofield, C.J.; Ratcliffe, P.J. Signalling hypoxia by HIF hydroxylases. Biochem. Biophys. Res. Commun. 2005, 338, 617-626.
-
(2005)
Res. Commun
, vol.338
, pp. 617-626
-
-
Schofield, C.J.1
Ratcliffe, P.J.2
-
52
-
-
0027427588
-
Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia
-
Wang, G.L.; Semenza, G.L. Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. J. Biol. Chem. 1993, 268, 21513-21518.
-
(1993)
J. Biol. Chem
, vol.268
, pp. 21513-21518
-
-
Wang, G.L.1
Semenza, G.L.2
-
53
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza, G.L. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 2003, 3, 721-732.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
54
-
-
33745303045
-
Hypoxia signalling in cancer and approaches to enforce tumour regression
-
Pouysségur, J.; Dayan, F.; Mazure, N.M. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 2006, 441, 437-443.
-
(2006)
Nature
, vol.441
, pp. 437-443
-
-
Pouysségur, J.1
Dayan, F.2
Mazure, N.M.3
-
55
-
-
4644275138
-
HIF-1: The knowns and unknowns of hypoxia sensing
-
Zagórska, A.; Dulak, J. HIF-1: The knowns and unknowns of hypoxia sensing. Acta Biochim. Pol. 2004, 51, 563-585.
-
(2004)
Acta Biochim. Pol
, vol.51
, pp. 563-585
-
-
Zagórska, A.1
Dulak, J.2
-
56
-
-
0034654174
-
Modulation of Hypoxia-inducible Factor 1a expression by epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
-
Zhong, H.; Chiles, K.; Feldser, D.; Laughner, E.; Hanrahan, C.; Georgescu, M.-M.; Simons, J.W.; Semenza, G.L. Modulation of Hypoxia-inducible Factor 1a expression by epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics. Cancer Res. 2000, 60, 1541-1545.
-
(2000)
Cancer Res
, vol.60
, pp. 1541-1545
-
-
Zhong, H.1
Chiles, K.2
Feldser, D.3
Laughner, E.4
Hanrahan, C.5
Georgescu, M.-M.6
Simons, J.W.7
Semenza, G.L.8
-
57
-
-
0037064010
-
Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
-
Fukuda, R.; Hirota, K.; Fan, F.; Jung, Y.D.; Ellis, L.M.; Semenza, G.L. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J. Biol. Chem. 2002, 277, 38205-38211.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 38205-38211
-
-
Fukuda, R.1
Hirota, K.2
Fan, F.3
Jung, Y.D.4
Ellis, L.M.5
Semenza, G.L.6
-
58
-
-
0032725554
-
p42/p44 Mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1
-
Richard, D.E.; Berra, E.; Gothié, E.; Roux, D.; Pouysségur, J. p42/p44 Mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1. J. Biol. Chem. 1999, 274, 32631-32637.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 32631-32637
-
-
Richard, D.E.1
Berra, E.2
Gothié, E.3
Roux, D.4
Pouysségur, J.5
-
59
-
-
0028785860
-
Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1
-
Wang, G.L.; Jiang, B.H.; Semenza, G.L. Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1. Biochem. Biophys. Res. Commun. 1995, 216, 669-675.
-
(1995)
Biochem. Biophys. Res. Commun
, vol.216
, pp. 669-675
-
-
Wang, G.L.1
Jiang, B.H.2
Semenza, G.L.3
-
60
-
-
84908315254
-
-
Available online, (accessed on 30 October 2014)
-
HIF NIH3T3 Reporter Stable Cell Line. Available online: http://www.affymetrix.com/catalog/prod660088/USB/HIF+NIH3T3+Reporter+Stable#1_1 (accessed on 30 October 2014).
-
HIF NIH3T3 Reporter Stable Cell Line
-
-
-
61
-
-
7944224442
-
Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
-
Tang, N.; Wang, L.; Esko, J.; Giordano, F.J.; Huang, Y.; Gerber, H.-P.; Ferrara, N.; Johnson, R.S. Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 2004, 6, 485-495.
-
(2004)
Cancer Cell
, vol.6
, pp. 485-495
-
-
Tang, N.1
Wang, L.2
Esko, J.3
Giordano, F.J.4
Huang, Y.5
Gerber, H.-P.6
Ferrara, N.7
Johnson, R.S.8
-
62
-
-
17144416530
-
Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells
-
Wang, V.; Davis, D.A.; Haque, M.; Huang, L.E.; Yarchoan, R. Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells. Cancer Res. 2005, 65, 3299-3306.
-
(2005)
Cancer Res
, vol.65
, pp. 3299-3306
-
-
Wang, V.1
Davis, D.A.2
Haque, M.3
Huang, L.E.4
Yarchoan, R.5
-
63
-
-
35848938945
-
The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha
-
Hu, C.-J.; Sataur, A.; Wang, L.; Chen, H.; Simon, M.C. The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha. Mol. Biol. Cell 2007, 18, 4528-4542.
-
(2007)
Mol. Biol. Cell
, vol.18
, pp. 4528-4542
-
-
Hu, C.-J.1
Sataur, A.2
Wang, L.3
Chen, H.4
Simon, M.C.5
-
64
-
-
38949147367
-
Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS
-
Yamashita, T.; Ohneda, O.; Nagano, M.; Iemitsu, M.; Makino, Y.; Tanaka, H.; Miyauchi, T.; Goto, K.; Ohneda, K.; Fujii-Kuriyama, Y.; et al. Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS. Mol. Cell. Biol. 2008, 28, 1285-1297.
-
(2008)
Mol. Cell. Biol
, vol.28
, pp. 1285-1297
-
-
Yamashita, T.1
Ohneda, O.2
Nagano, M.3
Iemitsu, M.4
Makino, Y.5
Tanaka, H.6
Miyauchi, T.7
Goto, K.8
Ohneda, K.9
Fujii-Kuriyama, Y.10
-
65
-
-
82255186546
-
Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response
-
Heikkilä, M.; Pasanen, A.; Kivirikko, K.I.; Myllyharju, J. Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response. Cell. Mol. Life Sci. 2011, 68, 3885-3901.
-
(2011)
Cell. Mol. Life Sci
, vol.68
, pp. 3885-3901
-
-
Heikkilä, M.1
Pasanen, A.2
Kivirikko, K.I.3
Myllyharju, J.4
-
66
-
-
0345491599
-
Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation
-
Hu, C.-J.; Wang, L.-Y.; Chodosh, L.A.; Keith, B.; Simon, C.M. Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation. Mol. Cell. Biol. 2003, 23, 9361-9374.
-
(2003)
Mol. Cell. Biol
, vol.23
, pp. 9361-9374
-
-
Hu, C.-J.1
Wang, L.-Y.2
Chodosh, L.A.3
Keith, B.4
Simon, C.M.5
-
67
-
-
15444342958
-
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1alpha
-
Iyer, N.V.; Kotch, L.E.; Agani, F.; Leung, S.W.; Laughner, E.; Wenger, R.H.; Gassmann, M.; Gearhart, J.D.; Lawler, A.M.; Yu, A.Y.; et al. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1alpha. Genes Dev. 1998, 12, 149-162.
-
(1998)
Genes Dev
, vol.12
, pp. 149-162
-
-
Iyer, N.V.1
Kotch, L.E.2
Agani, F.3
Leung, S.W.4
Laughner, E.5
Wenger, R.H.6
Gassmann, M.7
Gearhart, J.D.8
Lawler, A.M.9
Yu, A.Y.10
-
68
-
-
0344826529
-
Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/-mice
-
Scortegagna, M.; Ding, K.; Oktay, Y.; Gaur, A.; Thurmond, F.; Yan, L.-J.; Marck, B.T.; Matsumoto, A.M.; Shelton, J.M.; Richardson, J.A.; et al. Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/-mice. Nat. Genet. 2003, 35, 331-340.
-
(2003)
Nat. Genet
, vol.35
, pp. 331-340
-
-
Scortegagna, M.1
Ding, K.2
Oktay, Y.3
Gaur, A.4
Thurmond, F.5
Yan, L.-J.6
Marck, B.T.7
Matsumoto, A.M.8
Shelton, J.M.9
Richardson, J.A.10
-
69
-
-
70149106164
-
HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses
-
Bertout, J.A.; Majmundar, A.J.; Gordan, J.D.; Lam, J.C.; Ditsworth, D.; Keith, B.; Brown, E.J.; Nathanson, K.L.; Simon, M.C. HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses. Proc. Natl. Acad. Sci. USA 2009, 106, 14391-14396.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 14391-14396
-
-
Bertout, J.A.1
Majmundar, A.J.2
Gordan, J.D.3
Lam, J.C.4
Ditsworth, D.5
Keith, B.6
Brown, E.J.7
Nathanson, K.L.8
Simon, M.C.9
-
70
-
-
67651098992
-
Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis
-
Skuli, N.; Liu, L.; Runge, A.; Wang, T.; Yuan, L.; Patel, S.; Iruela-Arispe, L.; Simon, M.C.; Keith, B. Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis. Blood 2009, 114, 469-477.
-
(2009)
Blood
, vol.114
, pp. 469-477
-
-
Skuli, N.1
Liu, L.2
Runge, A.3
Wang, T.4
Yuan, L.5
Patel, S.6
Iruela-Arispe, L.7
Simon, M.C.8
Keith, B.9
-
71
-
-
0345490692
-
Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1α
-
Compernolle, V.; Brusselmans, K.; Franco, D.; Moorman, A.; Dewerchin, M.; Collen, D.; Carmeliet, P. Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1α. Cardiovasc. Res. 2003, 60, 569-579.
-
(2003)
Cardiovasc. Res
, vol.60
, pp. 569-579
-
-
Compernolle, V.1
Brusselmans, K.2
Franco, D.3
Moorman, A.4
Dewerchin, M.5
Collen, D.6
Carmeliet, P.7
-
72
-
-
0032100732
-
HIF-1 alpha is required for solid tumor formation and embryonic vascularization
-
Ryan, H.E.; Lo, J.; Johnson, R.S. HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J. 1998, 17, 3005-3015.
-
(1998)
EMBO J
, vol.17
, pp. 3005-3015
-
-
Ryan, H.E.1
Lo, J.2
Johnson, R.S.3
-
73
-
-
0033562569
-
Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death
-
Kotch, L.E.; Iyer, N.V; Laughner, E.; Semenza, G.L. Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. Dev. Biol. 1999, 209, 254-267.
-
(1999)
Dev. Biol
, vol.209
, pp. 254-267
-
-
Kotch, L.E.1
Iyer, N.V.2
Laughner, E.3
Semenza, G.L.4
-
74
-
-
0032581277
-
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
-
Carmeliet, P.; Dor, Y.; Herbert, J.; Fukumura, D.; Brusselmans, K.; Dewerchin, M.; Neeman, M.; Bono, F.; Abramovitch, R.; Maxwell, P.; et al. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 1998, 394, 485-490.
-
(1998)
Nature
, vol.394
, pp. 485-490
-
-
Carmeliet, P.1
Dor, Y.2
Herbert, J.3
Fukumura, D.4
Brusselmans, K.5
Dewerchin, M.6
Neeman, M.7
Bono, F.8
Abramovitch, R.9
Maxwell, P.10
-
75
-
-
0033104847
-
Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
-
Yu, A.Y.; Shimoda, L.A.; Iyer, N.V.; Huso, D.L.; Sun, X.; McWilliams, R.; Beaty, T.; Sham, J.S.K.; Wiener, C.M.; Sylvester, J.T.; et al. Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α. J. Clin. Investig. 1999, 103, 691-696.
-
(1999)
J. Clin. Investig
, vol.103
, pp. 691-696
-
-
Yu, A.Y.1
Shimoda, L.A.2
Iyer, N.V.3
Huso, D.L.4
Sun, X.5
McWilliams, R.6
Beaty, T.7
Sham, J.S.K.8
Wiener, C.M.9
Sylvester, J.T.10
-
76
-
-
84859700702
-
Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes
-
Skuli, N.; Majmundar, A.J.; Krock, B.L.; Mesquita, R.C.; Mathew, L.K.; Quinn, Z.L.; Runge, A.; Liu, L.; Kim, M.N.; Liang, J.; et al. Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes. J. Clin. Investig. 2012, 122, 1427-1443.
-
(2012)
J. Clin. Investig
, vol.122
, pp. 1427-1443
-
-
Skuli, N.1
Majmundar, A.J.2
Krock, B.L.3
Mesquita, R.C.4
Mathew, L.K.5
Quinn, Z.L.6
Runge, A.7
Liu, L.8
Kim, M.N.9
Liang, J.10
-
77
-
-
0032213236
-
The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
-
Tian, H.; Hammer, R.E.; Matsumoto, A.M.; Russell, D.W.; McKnight, S.L. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev. 1998, 12, 3320-3324.
-
(1998)
Genes Dev
, vol.12
, pp. 3320-3324
-
-
Tian, H.1
Hammer, R.E.2
Matsumoto, A.M.3
Russell, D.W.4
McKnight, S.L.5
-
78
-
-
84894102384
-
Epidermal Deletion of HIF-2α Stimulates Wound Closure
-
Cowburn, A.; Alexander, L.; Southwood, M.; Nizet, V.; Chilvers, E.; Johnson, R. Epidermal Deletion of HIF-2α Stimulates Wound Closure. J. Investig. Dermatol. 2014, 134, 801-808.
-
(2014)
J. Investig. Dermatol
, vol.134
, pp. 801-808
-
-
Cowburn, A.1
Alexander, L.2
Southwood, M.3
Nizet, V.4
Chilvers, E.5
Johnson, R.6
-
79
-
-
0034682513
-
The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling
-
Peng, J.; Zhang, L.; Drysdale, L.; Fong, G.H. The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling. Proc. Natl. Acad. Sci. USA 2000, 97, 8386-8391.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 8386-8391
-
-
Peng, J.1
Zhang, L.2
Drysdale, L.3
Fong, G.H.4
-
80
-
-
18244372452
-
Endothelium-intrinsic requirement for Hif-2alpha during vascular development
-
Duan, L.-J.; Zhang-Benoit, Y.; Fong, G.-H. Endothelium-intrinsic requirement for Hif-2alpha during vascular development. Circulation 2005, 111, 2227-2232.
-
(2005)
Circulation
, vol.111
, pp. 2227-2232
-
-
Duan, L.-J.1
Zhang-Benoit, Y.2
Fong, G.-H.3
-
81
-
-
0035983324
-
Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
-
Compernolle, V.; Brusselmans, K.; Acker, T.; Hoet, P.; Tjwa, M.; Beck, H.; Plaisance, S.; Dor, Y.; Keshet, E.; Lupu, F.; et al. Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat. Med. 2002, 8, 702-710.
-
(2002)
Nat. Med
, vol.8
, pp. 702-710
-
-
Compernolle, V.1
Brusselmans, K.2
Acker, T.3
Hoet, P.4
Tjwa, M.5
Beck, H.6
Plaisance, S.7
Dor, Y.8
Keshet, E.9
Lupu, F.10
-
82
-
-
33847796951
-
Acute postnatal ablation of Hif-2a results in anemia
-
Gruber, M.; Hu, C.; Johnson, R.S.; Brown, E.J.; Keith, B.; Simon, M.C. Acute postnatal ablation of Hif-2a results in anemia. Proc. Natl. Acad. Sci. USA 2007, 104, 2301-2306.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 2301-2306
-
-
Gruber, M.1
Hu, C.2
Johnson, R.S.3
Brown, E.J.4
Keith, B.5
Simon, M.C.6
-
83
-
-
85047691081
-
Heterozygous deficiency of hypoxia-inducible factor-2α protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia
-
Brusselmans, K.; Compernolle, V.; Tjwa, M.; Wiesener, M.S.; Maxwell, P.H.; Collen, D.; Carmeliet, P. Heterozygous deficiency of hypoxia-inducible factor-2α protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. J. Clin. Investig. 2003, 111, 1519-1527.
-
(2003)
J. Clin. Investig
, vol.111
, pp. 1519-1527
-
-
Brusselmans, K.1
Compernolle, V.2
Tjwa, M.3
Wiesener, M.S.4
Maxwell, P.H.5
Collen, D.6
Carmeliet, P.7
-
84
-
-
47249111254
-
HIF-2alpha-haploinsufficient mice have blunted retinal neovascularization due to impaired expression of a proangiogenic gene battery
-
Dioum, E.M.; Clarke, S.L.; Ding, K.; Repa, J.J.; Garcia, J.A. HIF-2alpha-haploinsufficient mice have blunted retinal neovascularization due to impaired expression of a proangiogenic gene battery. Investig. Ophthalmol. Vis. Sci. 2008, 49, 2714-2720.
-
(2008)
Investig. Ophthalmol. Vis. Sci
, vol.49
, pp. 2714-2720
-
-
Dioum, E.M.1
Clarke, S.L.2
Ding, K.3
Repa, J.J.4
Garcia, J.A.5
-
85
-
-
70350692093
-
The human HIF (hypoxia-inducible factor)-3alpha gene is a HIF-1 target gene and may modulate hypoxic gene induction
-
Tanaka, T.; Wiesener, M.; Bernhardt, W.; Eckardt, K.-U.; Warnecke, C. The human HIF (hypoxia-inducible factor)-3alpha gene is a HIF-1 target gene and may modulate hypoxic gene induction. Biochem. J. 2009, 424, 143-151.
-
(2009)
Biochem. J
, vol.424
, pp. 143-151
-
-
Tanaka, T.1
Wiesener, M.2
Bernhardt, W.3
Eckardt, K.-U.4
Warnecke, C.5
-
86
-
-
17544384815
-
ARNT-deficient mice and placental differentiation
-
Kozak, K.; Abbott, B.; Hankinson, O. ARNT-deficient mice and placental differentiation. Dev. Biol. 1997, 191, 297-305.
-
(1997)
Dev. Biol
, vol.191
, pp. 297-305
-
-
Kozak, K.1
Abbott, B.2
Hankinson, O.3
-
87
-
-
0030943461
-
Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
-
Maltepe, E.; Schmidt, J.V.; Baunoch, D.; Bradfield, C.A.; Simon, M.C. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature 1997, 386, 403-407.
-
(1997)
Nature
, vol.386
, pp. 403-407
-
-
Maltepe, E.1
Schmidt, J.V.2
Baunoch, D.3
Bradfield, C.A.4
Simon, M.C.5
-
88
-
-
0033214848
-
Multilineage embryonic hematopoiesis requires hypoxic ARNT activity
-
Adelman, D.; Maltepe, E.; Simon, M. Multilineage embryonic hematopoiesis requires hypoxic ARNT activity. Genes Dev. 1999, 13, 2478-2483.
-
(1999)
Genes Dev
, vol.13
, pp. 2478-2483
-
-
Adelman, D.1
Maltepe, E.2
Simon, M.3
-
89
-
-
0034671706
-
Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses
-
Adelman, D.; Gertsenstein, M.; Nagy, A.; Simon, M.; Maltepe, E. Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses. Genes Dev. 2000, 14, 3191-3203.
-
(2000)
Genes Dev
, vol.14
, pp. 3191-3203
-
-
Adelman, D.1
Gertsenstein, M.2
Nagy, A.3
Simon, M.4
Maltepe, E.5
-
90
-
-
33745490023
-
HIF-Dependent hematopoietic factors regulate the development of the embryonic vasculature
-
Ramírez-Bergeron, D.L.; Runge, A.; Adelman, D.M.; Gohil, M.; Simon, M.C. HIF-Dependent hematopoietic factors regulate the development of the embryonic vasculature. Dev. Cell 2006, 11, 81-92.
-
(2006)
Dev. Cell
, vol.11
, pp. 81-92
-
-
Ramírez-Bergeron, D.L.1
Runge, A.2
Adelman, D.M.3
Gohil, M.4
Simon, M.C.5
-
91
-
-
33748918542
-
Disruption of the Arnt gene in endothelial cells causes hepatic vascular defects and partial embryonic lethality in mice
-
Yim, S.; Shah, Y.; Tomita, S.; Morris, H.; Gavrilova, O.; Lambert, G.; Ward, J.; Gonzalez, F. Disruption of the Arnt gene in endothelial cells causes hepatic vascular defects and partial embryonic lethality in mice. Hepatology 2006, 44, 550-560.
-
(2006)
Hepatology
, vol.44
, pp. 550-560
-
-
Yim, S.1
Shah, Y.2
Tomita, S.3
Morris, H.4
Gavrilova, O.5
Lambert, G.6
Ward, J.7
Gonzalez, F.8
-
92
-
-
0035661664
-
HIF-1 expression in healing wounds: HIF-1alpha induction in primary inflammatory cells by TNF-alpha
-
Albina, J.E.; Mastrofrancesco, B.; Vessella, J.A.; Louis, C.A.; Henry, W.L.; Reichner, J.S. HIF-1 expression in healing wounds: HIF-1alpha induction in primary inflammatory cells by TNF-alpha. Am. J. Physiol. Cell Physiol. 2001, 281, C1971-C1977.
-
(2001)
Am. J. Physiol. Cell Physiol
, vol.281
, pp. C1971-C1977
-
-
Albina, J.E.1
Mastrofrancesco, B.2
Vessella, J.A.3
Louis, C.A.4
Henry, W.L.5
Reichner, J.S.6
-
93
-
-
0033962899
-
Early wound healing exhibits cytokine surge without evidence of hypoxia
-
Haroon, Z.A.; Raleigh, J.A.; Greenberg, C.S.; Dewhirst, M.W. Early wound healing exhibits cytokine surge without evidence of hypoxia. Ann. Surg. 2000, 231, 137-147.
-
(2000)
Ann. Surg
, vol.231
, pp. 137-147
-
-
Haroon, Z.A.1
Raleigh, J.A.2
Greenberg, C.S.3
Dewhirst, M.W.4
-
94
-
-
34250158361
-
Cutting edge: Essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis
-
Peyssonnaux, C.; Cejudo-Martin, P.; Doedens, A.; Zinkernagel, A.S.; Johnson, R.S.; Nizet, V. Cutting edge: Essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis. J. Immunol. 2007, 178, 7516-7519.
-
(2007)
J. Immunol
, vol.178
, pp. 7516-7519
-
-
Peyssonnaux, C.1
Cejudo-Martin, P.2
Doedens, A.3
Zinkernagel, A.S.4
Johnson, R.S.5
Nizet, V.6
-
95
-
-
77955295091
-
Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation
-
Imtiyaz, H.Z.; Williams, E.P.; Hickey, M.M.; Patel, S.A.; Durham, A.C.; Yuan, L.-J.; Hammond, R.; Gimotty, P.A.; Keith, B.; Simon, M.C. Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation. J. Clin. Investig. 2010, 120, 2699-2714.
-
(2010)
J. Clin. Investig
, vol.120
, pp. 2699-2714
-
-
Imtiyaz, H.Z.1
Williams, E.P.2
Hickey, M.M.3
Patel, S.A.4
Durham, A.C.5
Yuan, L.-J.6
Hammond, R.7
Gimotty, P.A.8
Keith, B.9
Simon, M.C.10
-
96
-
-
0034326273
-
Coordinate up-regulation of hypoxia inducible factor (HIF)-1α and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing
-
Elson, D.; Ryan, H.; Snow, J.; Johnson, R.; Arbeit, J. Coordinate up-regulation of hypoxia inducible factor (HIF)-1α and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing. Cancer Res. 2000, 21, 6189-6195.
-
(2000)
Cancer Res
, vol.21
, pp. 6189-6195
-
-
Elson, D.1
Ryan, H.2
Snow, J.3
Johnson, R.4
Arbeit, J.5
-
97
-
-
77949902408
-
Impaired angiogenesis and mobilization of circulating angiogenic cells in HIF-1alpha heterozygous-null mice after burn wounding
-
Zhang, X.; Liu, L.; Wei, X.; Tan, Y.S.; Tong, L.; Chang, R.; Ghanamah, M.S.; Reinblatt, M.; Marti, G.P.; Harmon, J.W.; et al. Impaired angiogenesis and mobilization of circulating angiogenic cells in HIF-1alpha heterozygous-null mice after burn wounding. Wound Repair Regen. 2010, 18, 193-201.
-
(2010)
Wound Repair Regen
, vol.18
, pp. 193-201
-
-
Zhang, X.1
Liu, L.2
Wei, X.3
Tan, Y.S.4
Tong, L.5
Chang, R.6
Ghanamah, M.S.7
Reinblatt, M.8
Marti, G.P.9
Harmon, J.W.10
-
98
-
-
80755140481
-
Aging impairs the mobilization and homing of bone marrow-derived angiogenic cells to burn wounds
-
Zhang, X.; Sarkar, K.; Rey, S.; Sebastian, R.; Andrikopoulou, E.; Marti, G.P.; Fox-Talbot, K.; Semenza, G.L.; Harmon, J.W. Aging impairs the mobilization and homing of bone marrow-derived angiogenic cells to burn wounds. J. Mol. Med. 2011, 89, 985-995.
-
(2011)
J. Mol. Med
, vol.89
, pp. 985-995
-
-
Zhang, X.1
Sarkar, K.2
Rey, S.3
Sebastian, R.4
Andrikopoulou, E.5
Marti, G.P.6
Fox-Talbot, K.7
Semenza, G.L.8
Harmon, J.W.9
-
99
-
-
84555188569
-
Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells
-
Sarkar, K.; Rey, S.; Zhang, X.; Sebastian, R.; Marti, G.P.; Fox-Talbot, K.; Cardona, A.V.; Du, J.; Tan, Y.S.; Liu, L.; et al. Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells. Cardiovasc. Res. 2012, 93, 162-169.
-
(2012)
Cardiovasc. Res
, vol.93
, pp. 162-169
-
-
Sarkar, K.1
Rey, S.2
Zhang, X.3
Sebastian, R.4
Marti, G.P.5
Fox-Talbot, K.6
Cardona, A.V.7
Du, J.8
Tan, Y.S.9
Liu, L.10
-
100
-
-
0036790429
-
Esophageal ulceration triggers expression of hypoxia-inducible factor-1 alpha and activates vascular endothelial growth factor gene: Implications for angiogenesis and ulcer healing
-
Baatar, D.; Jones, M.K.; Tsugawa, K.; Pai, R.; Moon, W.S.; Koh, G.Y.; Kim, I.; Kitano, S.; Tarnawski, A.S. Esophageal ulceration triggers expression of hypoxia-inducible factor-1 alpha and activates vascular endothelial growth factor gene: Implications for angiogenesis and ulcer healing. Am. J. Pathol. 2002, 161, 1449-1457.
-
(2002)
Am. J. Pathol
, vol.161
, pp. 1449-1457
-
-
Baatar, D.1
Jones, M.K.2
Tsugawa, K.3
Pai, R.4
Moon, W.S.5
Koh, G.Y.6
Kim, I.7
Kitano, S.8
Tarnawski, A.S.9
-
101
-
-
0035834295
-
Activation of hypoxia inducible factor-1alpha in gastric mucosa in response to ethanol injury: A trigger for angiogenesis?
-
Szabo, I.L.; Kawanaka, H.; Jones, M.K.; Pai, R.; Soreghan, B.A.; Baatar, D.; Husain, S.S.; Tarnawski, A.S. Activation of hypoxia inducible factor-1alpha in gastric mucosa in response to ethanol injury: A trigger for angiogenesis? Life Sci. 2001, 69, 3035-3044.
-
(2001)
Life Sci
, vol.69
, pp. 3035-3044
-
-
Szabo, I.L.1
Kawanaka, H.2
Jones, M.K.3
Pai, R.4
Soreghan, B.A.5
Baatar, D.6
Husain, S.S.7
Tarnawski, A.S.8
-
102
-
-
36249029881
-
Persistent ischemia impairs myofibroblast development in wound granulation tissue: A new model of delayed wound healing
-
Alizadeh, N.; Pepper, M.S.; Modarressi, A.; Alfo, K.; Schlaudraff, K.; Montandon, D.; Gabbiani, G.; Bochaton-Piallat, M.-L.; Pittet, B. Persistent ischemia impairs myofibroblast development in wound granulation tissue: A new model of delayed wound healing. Wound Repair Regen. 2007, 15, 809-816.
-
(2007)
Wound Repair Regen
, vol.15
, pp. 809-816
-
-
Alizadeh, N.1
Pepper, M.S.2
Modarressi, A.3
Alfo, K.4
Schlaudraff, K.5
Montandon, D.6
Gabbiani, G.7
Bochaton-Piallat, M.-L.8
Pittet, B.9
-
103
-
-
58049209727
-
Stabilization of HIF-1α is critical to improve wound healing in diabetic mice
-
Botusan, I.; Sunkari, V.; Savu, O.; Catrina, A.; Grünler, J.; Lindberg, S.; Pereira, T.; Ylä-Herttuala, S.; Poellinger, L.; Brismar, K.; et al. Stabilization of HIF-1α is critical to improve wound healing in diabetic mice. Proc. Natl. Acad. Sci. USA 2008, 105, 19426-19431.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 19426-19431
-
-
Botusan, I.1
Sunkari, V.2
Savu, O.3
Catrina, A.4
Grünler, J.5
Lindberg, S.6
Pereira, T.7
Ylä-Herttuala, S.8
Poellinger, L.9
Brismar, K.10
-
104
-
-
37349021749
-
Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1alpha stabilization during ischemia
-
Chang, E.I.; Loh, S.A.; Ceradini, D.J.; Chang, E.I.; Lin, S.; Bastidas, N.; Aarabi, S.; Chan, D.A.; Freedman, M.L.; Giaccia, A.J.; et al. Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1alpha stabilization during ischemia. Circulation 2007, 116, 2818-2829.
-
(2007)
Circulation
, vol.116
, pp. 2818-2829
-
-
Chang, E.I.1
Loh, S.A.2
Ceradini, D.J.3
Chang, E.I.4
Lin, S.5
Bastidas, N.6
Aarabi, S.7
Chan, D.A.8
Freedman, M.L.9
Giaccia, A.J.10
-
105
-
-
34848879004
-
Sustained expression of Hif-1α in the diabetic environment promotes angiogenesis and cutaneous wound repair
-
Mace, K.A.; Yu, D.H.; Paydar, K.Z.; Boudreau, N.; Young, D.M. Sustained expression of Hif-1α in the diabetic environment promotes angiogenesis and cutaneous wound repair. Wound Repair Regen. 2007, 15, 636-645.
-
(2007)
Wound Repair Regen
, vol.15
, pp. 636-645
-
-
Mace, K.A.1
Yu, D.H.2
Paydar, K.Z.3
Boudreau, N.4
Young, D.M.5
-
106
-
-
9444296528
-
Hyperglycemia regulates hypoxia-inducible factor-1alpha protein stability and function
-
Catrina, S.-B.; Okamoto, K.; Pereira, T.; Brismar, K.; Poellinger, L. Hyperglycemia regulates hypoxia-inducible factor-1alpha protein stability and function. Diabetes 2004, 53, 3226-3232.
-
(2004)
Diabetes
, vol.53
, pp. 3226-3232
-
-
Catrina, S.-B.1
Okamoto, K.2
Pereira, T.3
Brismar, K.4
Poellinger, L.5
-
107
-
-
69449108536
-
The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues
-
Thangarajah, H.; Yao, D.; Chang, E.I.; Shi, Y.; Jazayeri, L.; Vial, I.N.; Galiano, R.D.; Du, X.-L.; Grogan, R.; Galvez, M.G.; et al. The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues. Proc. Natl. Acad. Sci. USA 2009, 106, 13505-13510.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 13505-13510
-
-
Thangarajah, H.1
Yao, D.2
Chang, E.I.3
Shi, Y.4
Jazayeri, L.5
Vial, I.N.6
Galiano, R.D.7
Du, X.-L.8
Grogan, R.9
Galvez, M.G.10
-
108
-
-
51449105857
-
Age-dependent impairment of HIF-1alpha expression in diabetic mice: Correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells
-
Liu, L.; Marti, G.P.; Wei, X.; Zhang, X.; Zhang, H.; Liu, Y.V; Nastai, M.; Semenza, G.L.; Harmon, J.W. Age-dependent impairment of HIF-1alpha expression in diabetic mice: Correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells. J. Cell. Physiol. 2008, 217, 319-327.
-
(2008)
J. Cell. Physiol
, vol.217
, pp. 319-327
-
-
Liu, L.1
Marti, G.P.2
Wei, X.3
Zhang, X.4
Zhang, H.5
Liu, Y.V.6
Nastai, M.7
Semenza, G.L.8
Harmon, J.W.9
-
109
-
-
0037026951
-
Determination of oxygen gradients in engineered tissue using a fluorescent sensor
-
Kellner, K.; Liebsch, G.; Klimant, I.; Wolfbeis, O.S.; Blunk, T.; Schulz, M.B.; Göpferich, A. Determination of oxygen gradients in engineered tissue using a fluorescent sensor. Biotechnol. Bioeng. 2002, 80, 73-83.
-
(2002)
Biotechnol. Bioeng
, vol.80
, pp. 73-83
-
-
Kellner, K.1
Liebsch, G.2
Klimant, I.3
Wolfbeis, O.S.4
Blunk, T.5
Schulz, M.B.6
Göpferich, A.7
-
110
-
-
12944315083
-
In vivo formation of complex microvessels lined by human endothelial cells in an immunodeficient mouse
-
Schechner, J.S.; Nath, A.K.; Zheng, L.; Kluger, M.S.; Hughes, C.C.; Sierra-Honigmann, M.R.; Lorber, M.I.; Tellides, G.; Kashgarian, M.; Bothwell, A.L.; et al. In vivo formation of complex microvessels lined by human endothelial cells in an immunodeficient mouse. Proc. Natl. Acad. Sci. USA 2000, 97, 9191-9196.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 9191-9196
-
-
Schechner, J.S.1
Nath, A.K.2
Zheng, L.3
Kluger, M.S.4
Hughes, C.C.5
Sierra-Honigmann, M.R.6
Lorber, M.I.7
Tellides, G.8
Kashgarian, M.9
Bothwell, A.L.10
-
111
-
-
0034509645
-
Angiogenesis in wound healing
-
Tonnesen, M.G.; Feng, X.; Clark, R.A. Angiogenesis in wound healing. J. Investig. Dermatol. Symp. Proc. 2000, 5, 40-46.
-
(2000)
J. Investig. Dermatol. Symp. Proc
, vol.5
, pp. 40-46
-
-
Tonnesen, M.G.1
Feng, X.2
Clark, R.A.3
-
112
-
-
20344385551
-
Modelling oxygen diffusion and cell growth in a porous, vascularising scaffold for soft tissue engineering applications
-
Croll, T.I.; Gentz, S.; Mueller, K.; Davidson, M.; O’Connor, A.J.; Stevens, G.W.; Cooper-White, J.J. Modelling oxygen diffusion and cell growth in a porous, vascularising scaffold for soft tissue engineering applications. Chem. Eng. Sci. 2005, 60, 4924-4934.
-
(2005)
Chem. Eng. Sci
, vol.60
, pp. 4924-4934
-
-
Croll, T.I.1
Gentz, S.2
Mueller, K.3
Davidson, M.4
O’connor, A.J.5
Stevens, G.W.6
Cooper-White, J.J.7
-
113
-
-
0343471403
-
Increased vascularization and heterogeneity of vascular structures occurring in polyglycolide matrices containing aortic endothelial cells implanted in the rat
-
Holder, W.D., Jr.; Gruber, H.E.; Roland, W.D.; Moore, A.L.; Culberson, C.R.; Loebsack, A.B.; Burg, K.J.L.; Mooney, D.J. Increased vascularization and heterogeneity of vascular structures occurring in polyglycolide matrices containing aortic endothelial cells implanted in the rat. Tissue Eng. 1997, 3, 149-160.
-
(1997)
Tissue Eng
, vol.3
, pp. 149-160
-
-
Holder, W.D.1
Gruber, H.E.2
Roland, W.D.3
Moore, A.L.4
Culberson, C.R.5
Loebsack, A.B.6
Burg, K.J.L.7
Mooney, D.J.8
-
114
-
-
33749441325
-
Rapid vascular regrowth in tumors after reversal of VEGF inhibition
-
Mancuso, M.R.; Davis, R.; Norberg, S.M.; O’Brien, S.; Sennino, B.; Nakahara, T.; Yao, V.J.; Inai, T.; Brooks, P.; Freimark, B.; et al. Rapid vascular regrowth in tumors after reversal of VEGF inhibition. J. Clin. Investig. 2006, 116, 2610-2621.
-
(2006)
J. Clin. Investig
, vol.116
, pp. 2610-2621
-
-
Mancuso, M.R.1
Davis, R.2
Norberg, S.M.3
O’brien, S.4
Sennino, B.5
Nakahara, T.6
Yao, V.J.7
Inai, T.8
Brooks, P.9
Freimark, B.10
-
115
-
-
0033839080
-
Openings between defective endothelial cells explain tumor vessel leakiness
-
Hashizume, H.; Baluk, P.; Morikawa, S.; McLean, J.W.; Thurston, G.; Roberge, S.; Jain, R.K.; McDonald, D.M. Openings between defective endothelial cells explain tumor vessel leakiness. Am. J. Pathol. 2000, 156, 1363-1380.
-
(2000)
Am. J. Pathol
, vol.156
, pp. 1363-1380
-
-
Hashizume, H.1
Baluk, P.2
Morikawa, S.3
McLean, J.W.4
Thurston, G.5
Roberge, S.6
Jain, R.K.7
McDonald, D.M.8
-
116
-
-
79960096827
-
Normalization of the vasculature for treatment of cancer and other diseases
-
Goel, S.; Duda, D.G.; Xu, L.; Munn, L.L.; Boucher, Y.; Fukumura, D.; Jain, R.K. Normalization of the vasculature for treatment of cancer and other diseases. Physiol. Rev. 2011, 91, 1071-1121.
-
(2011)
Physiol. Rev
, vol.91
, pp. 1071-1121
-
-
Goel, S.1
Duda, D.G.2
Xu, L.3
Munn, L.L.4
Boucher, Y.5
Fukumura, D.6
Jain, R.K.7
-
117
-
-
0030069177
-
Hypoxia and Radiation Response in Human Tumors
-
Höckel, M.; Schlenger, K.; Mitze, M.; Schäffer, U.; Vaupel, P. Hypoxia and Radiation Response in Human Tumors. Semin. Radiat. Oncol. 1996, 6, 3-9.
-
(1996)
Semin. Radiat. Oncol
, vol.6
, pp. 3-9
-
-
Höckel, M.1
Schlenger, K.2
Mitze, M.3
Schäffer, U.4
Vaupel, P.5
-
118
-
-
60649106195
-
Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
-
Pàez-Ribes, M.; Allen, E.; Hudock, J.; Takeda, T.; Okuyama, H.; Viñals, F.; Inoue, M.; Bergers, G.; Hanahan, D.; Casanovas, O. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009, 15, 220-231.
-
(2009)
Cancer Cell
, vol.15
, pp. 220-231
-
-
Pàez-Ribes, M.1
Allen, E.2
Hudock, J.3
Takeda, T.4
Okuyama, H.5
Viñals, F.6
Inoue, M.7
Bergers, G.8
Hanahan, D.9
Casanovas, O.10
-
119
-
-
0034575632
-
The angiogenesis inhibitor endostatin impairs blood vessel maturation during wound healing
-
Bloch, W.; Huggel, K.; Sasaki, T.; Grose, R.; Bugnon, P.; Addicks, K.; Timpl, R.; Werner, S. The angiogenesis inhibitor endostatin impairs blood vessel maturation during wound healing. FASEB J. 2000, 14, 2373-2376.
-
(2000)
FASEB J
, vol.14
, pp. 2373-2376
-
-
Bloch, W.1
Huggel, K.2
Sasaki, T.3
Grose, R.4
Bugnon, P.5
Addicks, K.6
Timpl, R.7
Werner, S.8
-
120
-
-
77950901310
-
Vascular responses to hypoxia and ischemia
-
Semenza, G.L. Vascular responses to hypoxia and ischemia. Arterioscler. Thromb. Vasc. Biol. 2010, 30, 648-652.
-
(2010)
Arterioscler. Thromb. Vasc. Biol
, vol.30
, pp. 648-652
-
-
Semenza, G.L.1
-
121
-
-
0031126380
-
Intravitreal sustained release of VEGF causes retinal neovascularization in rabbits and breakdown of the blood-retinal barrier in rabbits and primates
-
Ozaki, H.; Hayashi, H.; Vinores, S.A.; Moromizato, Y.; Campochiaro, P.A.; Oshima, K. Intravitreal sustained release of VEGF causes retinal neovascularization in rabbits and breakdown of the blood-retinal barrier in rabbits and primates. Exp. Eye Res. 1997, 64, 505-517.
-
(1997)
Exp. Eye Res
, vol.64
, pp. 505-517
-
-
Ozaki, H.1
Hayashi, H.2
Vinores, S.A.3
Moromizato, Y.4
Campochiaro, P.A.5
Oshima, K.6
-
122
-
-
0033601357
-
Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1
-
Thurston, G.; Suri, C.; Smith, K.; McClain, J.; Sato, T.N.; Yancopoulos, G.D.; McDonald, D.M. Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science 1999, 286, 2511-2514.
-
(1999)
Science
, vol.286
, pp. 2511-2514
-
-
Thurston, G.1
Suri, C.2
Smith, K.3
McClain, J.4
Sato, T.N.5
Yancopoulos, G.D.6
McDonald, D.M.7
-
123
-
-
13844253297
-
In vivo gene delivery of Ad-VEGF121 to full-thickness wounds in aged pigs results in high levels of VEGF expression but not in accelerated healing
-
Vranckx, J.J.; Yao, F.; Petrie, N.; Augustinova, H.; Hoeller, D.; Visovatti, S.; Slama, J.; Eriksson, E. In vivo gene delivery of Ad-VEGF121 to full-thickness wounds in aged pigs results in high levels of VEGF expression but not in accelerated healing. Wound Repair Regen. 2005, 13, 51-60.
-
(2005)
Wound Repair Regen
, vol.13
, pp. 51-60
-
-
Vranckx, J.J.1
Yao, F.2
Petrie, N.3
Augustinova, H.4
Hoeller, D.5
Visovatti, S.6
Slama, J.7
Eriksson, E.8
-
124
-
-
84921359151
-
The use of adipose mesenchymal stem cells and human umbilical vascular endothelial cells on a fibrin matrix for endothelialized skin substitue
-
Sánchez Muñoz, I.; Granados, R.; Holguín Holgado, P.; García Vela, J.A.; Casares, C.; Casares, M. The use of adipose mesenchymal stem cells and human umbilical vascular endothelial cells on a fibrin matrix for endothelialized skin substitue. Tissue Eng. Part A 2014, doi:10.1089/ten.tea.2013.0626.
-
(2014)
Tissue Eng. Part A
-
-
SáNchez MuñOz, I.1
Granados, R.2
HolguíN Holgado, P.3
GarcíA Vela, J.A.4
Casares, C.5
Casares, M.6
-
125
-
-
41449114479
-
The effect of matrix density on the regulation of 3-D capillary morphogenesis
-
Ghajar, C.M.; Chen, X.; Harris, J.W.; Suresh, V.; Hughes, C.C.W.; Jeon, N.L.; Putnam, A.J.; George, S.C. The effect of matrix density on the regulation of 3-D capillary morphogenesis. Biophys. J. 2008, 94, 1930-1941.
-
(2008)
Biophys. J
, vol.94
, pp. 1930-1941
-
-
Ghajar, C.M.1
Chen, X.2
Harris, J.W.3
Suresh, V.4
Hughes, C.C.W.5
Jeon, N.L.6
Putnam, A.J.7
George, S.C.8
-
126
-
-
17644392452
-
Inosculation of tissue-engineered capillaries with the host’s vasculature in a reconstructed skin transplanted on mice
-
Tremblay, P.-L.; Hudon, V.; Berthod, F.; Germain, L.; Auger, F.A. Inosculation of tissue-engineered capillaries with the host’s vasculature in a reconstructed skin transplanted on mice. Am. J. Transplant. 2005, 5, 1002-1010.
-
(2005)
Am. J. Transplant
, vol.5
, pp. 1002-1010
-
-
Tremblay, P.-L.1
Hudon, V.2
Berthod, F.3
Germain, L.4
Auger, F.A.5
-
127
-
-
70350493787
-
The effect of hypoxia on in vitro prevascularization of a thick soft tissue
-
Griffith, C.K.; George, S.C. The effect of hypoxia on in vitro prevascularization of a thick soft tissue. Tissue Eng. Part A 2009, 15, 2423-2434.
-
(2009)
Tissue Eng. Part A
, vol.15
, pp. 2423-2434
-
-
Griffith, C.K.1
George, S.C.2
-
128
-
-
0005974723
-
Differential effects of oxygen on human dermal fibroblasts: Acute versus chronic hypoxia
-
Siddiqui, A.; Galiano, R.D.; Connors, D.; Gruskin, E.; Wu, L.; Mustoe, T.A. Differential effects of oxygen on human dermal fibroblasts: Acute versus chronic hypoxia. Wound Repair Regen. 1996, 4, 211-218.
-
(1996)
Wound Repair Regen
, vol.4
, pp. 211-218
-
-
Siddiqui, A.1
Galiano, R.D.2
Connors, D.3
Gruskin, E.4
Wu, L.5
Mustoe, T.A.6
-
129
-
-
0031440073
-
Hypoxia increases human keratinocyte motility on connective tissue
-
O’Toole, E.A.; Marinkovich, M.P.; Peavey, C.L.; Amieva, M.R.; Furthmayr, H.; Mustoe, T.A.; Woodley, D.T. Hypoxia increases human keratinocyte motility on connective tissue. J. Clin. Investig. 1997, 100, 2881-2891.
-
(1997)
J. Clin. Investig
, vol.100
, pp. 2881-2891
-
-
O’toole, E.A.1
Marinkovich, M.P.2
Peavey, C.L.3
Amieva, M.R.4
Furthmayr, H.5
Mustoe, T.A.6
Woodley, D.T.7
-
130
-
-
1642269211
-
Oxygen in wound healing--more than a nutrient. World
-
Tandara, A.; Mustoe, T. Oxygen in wound healing--more than a nutrient. World J. Surg. 2004, 28, 294-300.
-
(2004)
J. Surg
, vol.28
, pp. 294-300
-
-
Tandara, A.1
Mustoe, T.2
-
131
-
-
0032943898
-
Transforming growth factor-beta1 fails to stimulate wound healing and impairs its signal transduction in an aged ischemic ulcer model: Importance of oxygen and age
-
Wu, L.; Xia, Y.P.; Roth, S.I.; Gruskin, E.; Mustoe, T.A. Transforming growth factor-beta1 fails to stimulate wound healing and impairs its signal transduction in an aged ischemic ulcer model: Importance of oxygen and age. Am. J. Pathol. 1999, 154, 301-309.
-
(1999)
Am. J. Pathol
, vol.154
, pp. 301-309
-
-
Wu, L.1
Xia, Y.P.2
Roth, S.I.3
Gruskin, E.4
Mustoe, T.A.5
-
132
-
-
0025327460
-
Effects of ischemia on ulcer wound healing: A new model in the rabbit ear
-
Ahn, S.T.; Mustoe, T.A. Effects of ischemia on ulcer wound healing: A new model in the rabbit ear. Ann. Plast. Surg. 1990, 24, 17-23.
-
(1990)
Ann. Plast. Surg
, vol.24
, pp. 17-23
-
-
Ahn, S.T.1
Mustoe, T.A.2
-
133
-
-
77951043486
-
Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds
-
Biswas, S.; Roy, S.; Banerjee, J.; Hussain, S.-R.A.; Khanna, S.; Meenakshisundaram, G.; Kuppusamy, P.; Friedman, A.; Sen, C.K. Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds. Proc. Natl. Acad. Sci. USA 2010, 107, 6976-6981.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 6976-6981
-
-
Biswas, S.1
Roy, S.2
Banerjee, J.3
Hussain, S.-R.A.4
Khanna, S.5
Meenakshisundaram, G.6
Kuppusamy, P.7
Friedman, A.8
Sen, C.K.9
-
134
-
-
15644382445
-
Wound hypoxia and acidosis limit neutrophil bacterial killing mechanisms
-
Allen, D.B.; Maguire, J.J.; Mahdavian, M.; Wicke, C.; Marcocci, L.; Scheuenstuhl, H.; Chang, M.; Le, A.X.; Hopf, H.W.; Hunt, T.K. Wound hypoxia and acidosis limit neutrophil bacterial killing mechanisms. Arch. Surg. 1997, 132, 991-996.
-
(1997)
Arch. Surg
, vol.132
, pp. 991-996
-
-
Allen, D.B.1
Maguire, J.J.2
Mahdavian, M.3
Wicke, C.4
Marcocci, L.5
Scheuenstuhl, H.6
Chang, M.7
Le, A.X.8
Hopf, H.W.9
Hunt, T.K.10
-
135
-
-
0021351258
-
Oxygen as an Antibiotic. The Effect of Inspired oxygen on infection
-
Knighton, D.R.; Halliday, B.; Hunt, T.K. Oxygen as an Antibiotic. The Effect of Inspired oxygen on infection. Arch. Surg. 1984, 119, 199-204.
-
(1984)
Arch. Surg
, vol.119
, pp. 199-204
-
-
Knighton, D.R.1
Halliday, B.2
Hunt, T.K.3
-
136
-
-
0025157118
-
Oxygen as an Antibiotic. The Effect of Inspired Oxygen on Bacterial Clearance
-
Knighton, D.R.; Fiegel, V.D.; Halverson, T.; Schneider, S.; Brown, T.; Wells, C.L. Oxygen as an Antibiotic. The Effect of Inspired Oxygen on Bacterial Clearance. Arch. Biochem. Biophys. 1990, 125, 97-100.
-
(1990)
Arch. Biochem. Biophys
, vol.125
, pp. 97-100
-
-
Knighton, D.R.1
Fiegel, V.D.2
Halverson, T.3
Schneider, S.4
Brown, T.5
Wells, C.L.6
-
137
-
-
84885418780
-
Concerted inhibition of HIF-1α and-2α expression markedly suppresses angiogenesis in cultured RPE cells
-
Nakajima, T.; Nakajima, E.; Shearer, T.R.; Azuma, M. Concerted inhibition of HIF-1α and-2α expression markedly suppresses angiogenesis in cultured RPE cells. Mol. Cell. Biochem. 2013, 383, 113-122.
-
(2013)
Mol. Cell. Biochem
, vol.383
, pp. 113-122
-
-
Nakajima, T.1
Nakajima, E.2
Shearer, T.R.3
Azuma, M.4
-
138
-
-
0344874751
-
Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1
-
Kelly, B.D.; Hackett, F.; Hirota, K.; Oshima, Y.; Cai, Z.; Berg-Dixon, S.; Rowan, A.; Yan, Z.; Campochiaro, P.A.; Semenza, G.L. Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1. Circ. Res. 2003, 93, 1074-1081.
-
(2003)
Circ. Res
, vol.93
, pp. 1074-1081
-
-
Kelly, B.D.1
Hackett, F.2
Hirota, K.3
Oshima, Y.4
Cai, Z.5
Berg-Dixon, S.6
Rowan, A.7
Yan, Z.8
Campochiaro, P.A.9
Semenza, G.L.10
-
139
-
-
0035476509
-
Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha
-
Elson, D.A.; Thurston, G.; Huang, L.E.; Ginzinger, D.E.; McDonald, D.; Johnson, R.S.; Arbeit, J.M. Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha. Genes Dev. 2001, 15, 2520-2532.
-
(2001)
Genes Dev
, vol.15
, pp. 2520-2532
-
-
Elson, D.A.1
Thurston, G.2
Huang, L.E.3
Ginzinger, D.E.4
McDonald, D.5
Johnson, R.S.6
Arbeit, J.M.7
-
140
-
-
0033970878
-
PR39, a peptide regulator of angiogenesis
-
Li, J.; Post, M.; Volk, R.; Gao, Y.; Li, M.; Metais, C.; Sato, K.; Tsai, J.; Aird, W.; Rosenberg, R. D.; et al. PR39, a peptide regulator of angiogenesis. Nat. Med. 2000, 6, 49-55.
-
(2000)
Nat. Med
, vol.6
, pp. 49-55
-
-
Li, J.1
Post, M.2
Volk, R.3
Gao, Y.4
Li, M.5
Metais, C.6
Sato, K.7
Tsai, J.8
Aird, W.9
Rosenberg, R.D.10
-
141
-
-
0037390915
-
The antimycotic ciclopirox olamine induces HIF-1alpha stability, VEGF expression, and angiogenesis
-
Linden, T.; Katschinski, D.M.; Eckhardt, K.; Scheid, A.; Pagel, H.; Wenger, R.H. The antimycotic ciclopirox olamine induces HIF-1alpha stability, VEGF expression, and angiogenesis. FASEB J. 2003, 17, 761-763.
-
(2003)
FASEB J
, vol.17
, pp. 761-763
-
-
Linden, T.1
Katschinski, D.M.2
Eckhardt, K.3
Scheid, A.4
Pagel, H.5
Wenger, R.H.6
-
142
-
-
23444450886
-
Stabilized HIF-1alpha is superior to VEGF for angiogenesis in skeletal muscle via adeno-associated virus gene transfer
-
Pajusola, K.; Künnapuu, J.; Vuorikoski, S.; Soronen, J.; André, H.; Pereira, T.; Korpisalo, P.; Ylä-Herttuala, S.; Poellinger, L.; Alitalo, K. Stabilized HIF-1alpha is superior to VEGF for angiogenesis in skeletal muscle via adeno-associated virus gene transfer. FASEB J. 2005, 19, 1365-1367.
-
(2005)
FASEB J
, vol.19
, pp. 1365-1367
-
-
Pajusola, K.1
Künnapuu, J.2
Vuorikoski, S.3
Soronen, J.4
André, H.5
Pereira, T.6
Korpisalo, P.7
Ylä-Herttuala, S.8
Poellinger, L.9
Alitalo, K.10
-
143
-
-
33644533818
-
Peptide-matrix-mediated gene transfer of an variant for local induction of angiogenesis
-
Trentin, D.; Hall, H.; Wechsler, S.; Hubbell, J.A. Peptide-matrix-mediated gene transfer of an variant for local induction of angiogenesis. Proc. Natl. Acad. Sci. USA 2006, 103, 2506-2511.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 2506-2511
-
-
Trentin, D.1
Hall, H.2
Wechsler, S.3
Hubbell, J.A.4
-
144
-
-
37149006718
-
Hypoxia-induced increase in the production of extracellular matrix proteins in systemic sclerosis
-
Distler, J.H.W.; Jüngel, A.; Pileckyte, M.; Zwerina, J.; Michel, B.A.; Gay, R.E.; Kowal-Bielecka, O.; Matucci-Cerinic, M.; Schett, G.; Marti, H.H.; et al. Hypoxia-induced increase in the production of extracellular matrix proteins in systemic sclerosis. Arthritis Rheumatol. 2007, 56, 4203-4215.
-
(2007)
Arthritis Rheumatol
, vol.56
, pp. 4203-4215
-
-
Distler, J.H.W.1
Jüngel, A.2
Pileckyte, M.3
Zwerina, J.4
Michel, B.A.5
Gay, R.E.6
Kowal-Bielecka, O.7
Matucci-Cerinic, M.8
Schett, G.9
Marti, H.H.10
-
145
-
-
34848904509
-
Hypertrophic scar formation following burns and trauma: New approaches to treatment
-
Aarabi, S.; Longaker, M.T.; Gurtner, G.C. Hypertrophic scar formation following burns and trauma: New approaches to treatment. PLoS Med. 2007, 4, e234.
-
(2007)
PLoS Med
, vol.4
, pp. e234
-
-
Aarabi, S.1
Longaker, M.T.2
Gurtner, G.C.3
-
146
-
-
57149142495
-
The impact of O2 availability on human cancer
-
Bertout, J.A.; Patel, S.A.; Simon, M.C. The impact of O2 availability on human cancer. Nat. Rev. Cancer 2008, 8, 967-975.
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 967-975
-
-
Bertout, J.A.1
Patel, S.A.2
Simon, M.C.3
-
147
-
-
24344488419
-
The HIF pathway in cancer
-
Maxwell, P.H. The HIF pathway in cancer. Semin. Cell Dev. Biol. 2005, 16, 523-530.
-
(2005)
Semin. Cell Dev. Biol
, vol.16
, pp. 523-530
-
-
Maxwell, P.H.1
-
148
-
-
34547098129
-
Targeting hypoxia cell signaling for cancer therapy
-
Melillo, G. Targeting hypoxia cell signaling for cancer therapy. Cancer Metastasis Rev. 2007, 26, 341-352.
-
(2007)
Cancer Metastasis Rev
, vol.26
, pp. 341-352
-
-
Melillo, G.1
-
149
-
-
60549092506
-
Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells
-
Lee, K.A.; Qian, D.Z.; Rey, S.; Wei, H.; Liu, J.O.; Semenza, G.L. Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proc. Natl. Acad. Sci. USA 2009, 106, 2353-2358.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 2353-2358
-
-
Lee, K.A.1
Qian, D.Z.2
Rey, S.3
Wei, H.4
Liu, J.O.5
Semenza, G.L.6
-
150
-
-
75149120592
-
Therapeutic manipulation of the HIF hydroxylases
-
Nagel, S.; Talbot, N.P.; Mecinović, J.; Smith, T.G.; Buchan, A.M.; Schofield, C.J. Therapeutic manipulation of the HIF hydroxylases. Antioxid. Redox Signal. 2010, 12, 481-501.
-
(2010)
Antioxid. Redox Signal
, vol.12
, pp. 481-501
-
-
Nagel, S.1
Talbot, N.P.2
Mecinović, J.3
Smith, T.G.4
Buchan, A.M.5
Schofield, C.J.6
-
151
-
-
34548829081
-
HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques
-
Hsieh, M.M.; Linde, N.S.; Wynter, A.; Metzger, M.; Wong, C.; Langsetmo, I.; Lin, A.; Smith, R.; Rodgers, G.P.; Donahue, R.E.; et al. HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques. Blood 2007, 110, 2140-2147.
-
(2007)
Blood
, vol.110
, pp. 2140-2147
-
-
Hsieh, M.M.1
Linde, N.S.2
Wynter, A.3
Metzger, M.4
Wong, C.5
Langsetmo, I.6
Lin, A.7
Smith, R.8
Rodgers, G.P.9
Donahue, R.E.10
-
152
-
-
84885339373
-
Nrf2 acts cell-autonomously in endothelium to regulate tip cell formation and vascular branching
-
Wei, Y.; Gong, J.; Thimmulappa, R.K.; Kosmider, B.; Biswal, S.; Duh, E.J. Nrf2 acts cell-autonomously in endothelium to regulate tip cell formation and vascular branching. Proc. Natl. Acad. Sci. USA 2013, 110, E3910-E3918.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. E3910-E3918
-
-
Wei, Y.1
Gong, J.2
Thimmulappa, R.K.3
Kosmider, B.4
Biswal, S.5
Duh, E.J.6
-
153
-
-
77956355633
-
Int6/eIF3e silencing promotes functional blood vessel outgrowth and enhances wound healing by upregulating hypoxia-induced factor 2alpha expression
-
Chen, L.; Endler, A.; Uchida, K.; Horiguchi, S.; Morizane, Y.; Iijima, O.; Toi, M.; Shibasaki, F. Int6/eIF3e silencing promotes functional blood vessel outgrowth and enhances wound healing by upregulating hypoxia-induced factor 2alpha expression. Circulation 2010, 122, 910-919.
-
(2010)
Circulation
, vol.122
, pp. 910-919
-
-
Chen, L.1
Endler, A.2
Uchida, K.3
Horiguchi, S.4
Morizane, Y.5
Iijima, O.6
Toi, M.7
Shibasaki, F.8
-
154
-
-
34249278128
-
Expression of vascular endothelial growth factor, stromal cell-derived factor-1, and CXCR4 in human limb muscle with acute and chronic ischemia
-
Van Weel, V.; Seghers, L.; de Vries, M.R.; Kuiper, E.J.; Schlingemann, R.O.; Bajema, I.M.; Lindeman, J.H.N.; Delis-van Diemen, P.M.; van Hinsbergh, V.W.M.; van Bockel, J.H.; et al. Expression of vascular endothelial growth factor, stromal cell-derived factor-1, and CXCR4 in human limb muscle with acute and chronic ischemia. Arterioscler. Thromb. Vasc. Biol. 2007, 27, 1426-1432.
-
(2007)
Arterioscler. Thromb. Vasc. Biol
, vol.27
, pp. 1426-1432
-
-
Van Weel, V.1
Seghers, L.2
De Vries, M.R.3
Kuiper, E.J.4
Schlingemann, R.O.5
Bajema, I.M.6
Lindeman, J.H.N.7
Delis-Van Diemen, P.M.8
Van Hinsbergh, V.W.M.9
Van Bockel, J.H.10
|