The role of calcium in hypoxia-induced signal transduction and gene expression

Cell Calcium

Volumn 36, Issue 3-4, 2004, Pages 331-340

  Seta, Karen A ^a   Yuan, Yong ^a   Spicer, Zachary ^a   Lu, Gang ^a   Bedard, James ^a   Ferguson, Tsuneo K ^a   Pathrose, Peterson ^a   Cole Strauss, Allyson ^a   Kaufhold, Alexa ^a   Millhorn, David E ^a  

^a UNIVERSITY OF CINCINNATI   (United States)

Author keywords

Calcium; Hypoxia; Oxygen sensing cells

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CALCIUM ION; CHELERYTHRINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; NEUROPROTECTIVE AGENT; NIFEDIPINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PROTEIN P42; PROTEIN P44; RAS PROTEIN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; VERAPAMIL;

BRAIN HYPOXIA; BRAIN ISCHEMIA; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CALCIUM TRANSPORT; DRUG MECHANISM; ENZYME INHIBITION; GENE EXPRESSION REGULATION; HUMAN; NERVE CELL MEMBRANE STEADY POTENTIAL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RETROSPECTIVE STUDY; REVIEW; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 3342955696     PISSN: 01434160     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ceca.2004.02.006     Document Type: Article

References (142)

1. 2 in the type I chemoreceptor cells Science 241 1988 580-582
2. + current Neurosci. Lett. 119 1990 253-256
3. Weir E.K. Archer S.L. The mechanism of acute hypoxic pulmonary vasoconsctiction, the tale of two channels FASEB J. 9 1995 183-189
4. Wang G.L. Semenza G.L. Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia J. Biol. Chem. 268 1993 21513-21518
5. Wang G.L. Semenza G.L. Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction Blood 82 1993 3610-3615
6. Wang G.L. Semenza G.L. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia Proc. Natl. Acad. Sci. 90 1993 4304-4308
7. Czyzyk-Krzeska M.F. Furnari B.A. Lawson E.E. Millhorn D.E. Hypoxia increases rate of transcription and stability of tyrosine hydroxylase mRNA in pheochromocytoma (PC12) cells J. Biol. Chem. 269 1994 760-764
8. + current Am. J. Physiol. 40 1996 C658-C665
9. + channel in rat PC12 cells by hypoxia J. Physiol. 502 1997 293-305
10. Green L.A. Tischler A.S. PC12 pheochromocytoma cultures in neurobiological research Proc. Nat. Acad. Sci. 3 1982 373-414
11. Beitner-Johnson D. Shull G.E. Dedman J.R. Millhorn D.E. Regulation of gene expression by hypoxia: a molecular approach Respir. Physiol. 110 1997 87-97
12. Zhu H. Bunn F. Oxygen sensing and signaling: impact on the regulation of physiologically important genes Respir. Physiol. 115 1999 239-247
13. + channel in the type-I cell of the rabbit carotid body FEBS Lett. 249 1989 195-198
14. Lopez-Barneo J. Oxygen-sensing ion channels and the regulation of cellular functions Trends Neurosci. 19 1996 435-440
15. Conforti L. Kobayashi S. Beitner-Johnson D. Conrad P.W. Freeman T. Millhorn D.E. Regulation of gene expression and secretory functions in oxygen-sensitive pheochromocytoma cells Respir. Physiol. 115 1999 249-260
16. Buckler K.J. Vaughan-Jones R.D. Effects of hypoxia on membrane potential and intracellular calcium in rat neonatal carotid body type I cells J. Physiol. 476 1994 423-428
17. 2-responsive sequences on the tyrosine hydroxylase gene J. Biol. Chem. 270 1995 23774-23779
18. Millhorn D.E. Conforti L. Beitner-Johnson D. Zhu W. Raymond R. Filisko T. Kobayashi S. Peng M. Genter M.B. Regulation of ionic conductances and gene expression by hypoxia in an oxygen sensitive cell line Adv. Exp. Med. Biol. 410 1996 135-142
19. Fishman M. Greene W.L. Platika D. Oxygen chemoreception by carotid body cells in culture Proc. Natl. Acad. Sci. U.S.A. 82 1985 1448-1450
20. Gonzales C.Y. Kwok Y. Gibb J. Fidone S. Effects of hypoxia on tyrosine hydroxylase activity in rat carotid body J. Neurochem. 33 1979 713-719
21. Shaw K. Montague W. Pallot D.J. Biochemical studies on the release of catecholamines from the rat carotid body in vitro Biochim. Biophys. Acta 1013 1989 42-46
22. + channels: role of the Kv1.2-subunit in mediating the hypoxic response J. Physiol. 524 2000 783-793
23. Gonzalez C. Almaraz L. Obeso A. Rigual R. Carotid body chemoreceptors: from natural stimuli to senosry discharges Physiol. Rev. 74 1994 829-898
24. 2+ and PKC Kidney Int. 51 1997 536-541
25. Premkumar D.R. Adhikary G. Overholt J.L. Simonson M.S. Cherniack N.S. Prabhakar N.R. Intracellular pathways linking hypoxia to activation of c-fos and AP-1 Adv. Exp. Med. Biol. 475 2000 101-109
26. Kumar G.K. Overholt J.L. Bright G.R. Hui K.Y. Lu H. Gratzl M. Prabhakar N.R. Release of dopamine and norepinephrine by hypoxia from PC-12 cells Am. J. Physiol. 274 1998 C1592-C1600
27. 2+ exchanger Biochim. Biophys. Acta 1593 2003 269-276
28. Del Toro R. Levitsky K.L. Lopez-Barneo J. Chiara M.D. Induction of T-type calcium channel gene expression by chronic hypoxia J. Biol. Chem. 278 2003 22316-22324
29. Lev S. Moreno H. Martinez R. Canoll P. Peles E. Musacchio J.M. Plowman G.D. Rudy B. Schlessinger J. Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions Nature 376 1995 737-745
30. Sasaki H. Nagura K. Ishino M. Tobioka H. Kotani K. Sasaki T. Cloning and characterization of cell adhesion kinase beta, a novel protein-tyrosine kinase of the focal adhesion kinase subfamily J. Biol. Chem. 270 1995 21206-21219
31. Yu H. Li X. Marchetto G.S. Dy R. Hunter D. Calvo B. Dawson T.L. Wilm M. Anderegg R.J. Graves L.M. Earp H.S. Activation of a novel calcium-dependent protein-tyrosine kinase. Correlation with c-Jun N-terminal kinase but not mitogen-activated protein kinase activation J. Biol. Chem. 271 1996 29993-29998
32. Li J. Avraham H. Rogers R.A. Sandhya R. Avraham S. Characterization of RAFTK, a novel focal adhesion kinase, and its integrin-dependent phosphorylation and activation in megakaryocytes Blood 88 1996 417-428
33. Dikic I. Tokiwa G. Lev S. Courtneidge S.A. Schlessinger J. A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation Nature 383 1996 547-550
34. Felsch J.S. Cachero T.G. Peralta E.G. Activation of protein tyrosine kinase PYK2 by the m1 muscarinic acetylcholine receptor Proc. Natl. Acad. Sci. U.S.A. 95 1998 5051-5056
35. Frank G.D. Motley E.D. Inagami T. Eguchi S. Unique regulation of c-Jun N-terminal kinase by PYK2/CAK-beta in angiotensin II-stimulated vascular smooth muscle cells Biochem. Biophys. Res. Commun. 270 2000 761-765
36. Avraham S. London R. Fu Y. Ota S. Hiregowdara D. Li J. Jiang S. Pasztor L.M. White R.A. Groopman J.E. Avraham H. Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain J. Biol. Chem. 270 1995 27742-27751
37. Della Rocca G.J. van Biesen T. Daaka Y. Luttrell D.K. Luttrell L.M. Lefkowitz R.J. Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase J. Biol. Chem. 272 1997 19125-19132
38. Sieg D.J. Iiic D. Jones K.C. Damsky C.H. Hunter T. Schlaepfer D.D. Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK-cell migration EMBO J. 17 1998 5933-5947
39. Beitner-Johnson D. Ferguson T. Rust R. Kobayashi S. Millhorn D.E. Calcium-dependent activation of PYK2 by hypoxia Cell. Signal. 14 2002 133-137
40. Kobayashi S. Zimmermann H. Millhorn D.E. Chronic hypoxia enhances adenosine release in rat PC12 cells by altering adenosine metabolism and membrane transport J. Neurochem. 74 2001 621-632
41. 2A receptor J. Physiol. 508.1 1998 95-107
42. Kobayashi S. Millhorn D.E. Stimulation of expression for the Adenosine A2A receptor gene by hypoxia in PC12 cells, A potential role in cell protection J. Biol. Chem. 274 1999 20358-20365
43. Kobayashi S. Conforti L. Millhorn D.E. Gene expression and function of adenosine A(2A) receptor in the rat carotid body Am. J. Physiol. 279 2000 L273-L282
44. Kobayashi S. Beitner-Johnson D. Conforti L. Millhorn D.E. Chronic hypoxia reduces adenosine A2A receptor-mediated inhibition of calcium current in rat PC12 cells via downregulation of protein kinase A J. Physiol. 512.2 1998 351-363
45. West A.E. Chen W.G. Dalva M.B. Dolmetsch R.E. Kornhauser J.M. Shaywitz A.J. Takasu M.A. Tao X. Greenberg M.E. Calcium regulation of neuronal gene expression Proc. Natl. Acad. Sci. U.S.A. 98 2001 11024-11031
46. Wellman G.C. Cartin L. Eckman D.M. Stevenson A.S. Saundry C.M. Lederer W.J. Nelson M.T. Membrane depolarization, elevated Ca(2+) entry, and gene expression in cerebral arteries of hypertensive rats Am. J. Physiol. 281 2001 H2559-H2567
47. 2+-dependent regulation in neuronal gene expression Curr. Opin. Neurobiol. 7 1997 419-4429
48. Ghosh A. Greenberg M.E. Calcium signaling in neurons: molecular mechanisms and cellular consequences Cell Calcium 23 1998 143-150
49. Sheng M.E. McFadden G. Greenberg M.E. Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB Neuron 4 1990 571-582
50. Mottet D. Michel G. Renard P. Ninane N. Raes M. Michiels C. Role of ERK and calcium in the hypoxia-induced activation of HIF-1 J. Cell. Physiol. 194 2002 30-44
51. Conrad P.W. Freeman T.L. Beitner-Johnson D. Millhorn D.E. EPAS1 trans-activation during hypoxia requires p42/p44 MAPK J. Biol. Chem. 274 1999 33709-33713
52. Millhorn D.E. Beitner-Johnson D. Conforti L. Conrad P.W. Kobayashi S. Yuan Y. Rust R. Gene regulation during hypoxia in excitable oxygen-sensing cells: depolarization-transcription coupling Adv. Exp. Med. Biol. 475 2000 131-142
53. Widmann C. Gibson S. Jarpe B. Johnson G.L. Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human Physiol. Rev. 79 1999 143-180
54. Su B. Karin M. Mitogen-activated protein kinase cascades and regulation of gene expression Curr. Opin. Immunol. 8 1996 402-411
55. Garrington T.P. Johnson G.L. Organization and regulation of mitogen-activated protein kinase signaling pathways Curr. Opin. Cell Biol. 11 1999 211-218
56. Hibi M. Lin A. Smeal T. Minden A. Karin M. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain Genes Dev. 7 1993 2135-2148
57. Derijard B. Hibi M. Wu I.H. Barrett G. Su B. Deng T. Karin M. Davis R.J. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain Cell 76 1994 1025-1037
58. Kyriakis J. Banerjee P. Nikolakaki E. Dal T. Rubie E.A. Ahmad M.F. Avruch J. Woodgett J.R. The stress-activated protein kinase subfamily of c-Jun kinases Nature 369 1994 156-160
59. Han J. Lee J.D. Bibbs L. Ulevitch R.J. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells Science 265 1994 808-811
60. Kyriakis J. Avruch J. Sounding the alarm: protein kinase cascades activated by stress and inflammation J. Biol. Chem. 271 1996 24313-24316
61. Logan S. Falaska M. Hu P. Schlessinger J. Phosphatidylinositol 3-kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway Mol. Cell. Biol. 17 1997 5784-5790
62. Xing J. Kornhauser J.M. Xia Z. Thiele E.A. Greenberg M.E. Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine133 phosphorylation Mol. Cell. Biol. 18 1998 1946-1955
63. Whitmarsh A.J. Davis R.J. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways J. Mol. Med. 74 1994 589-607
64. Raingeaud J. Gupta S. Roger J.S. Dickens M. Han J. Ulevitc R.J. Davis R.J. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine J. Biol. Chem. 270 1995 7420-7426
65. Conrad P.W. Rust R.T. Han J. Millhorn D.E. Beitner-Johnson D. Selective activation of p38α and p38γ by hypoxia. Role in regulation of cyclin D1 by hypoxia in PC12 cells J. Biol. Chem. 274 1999 23570-23576
66. MAPK pathway J. Biol. Chem. 271 1996 20608-20616
67. Baldin V. Lucas J. Marcote M.J. Pagano M. Draetta G. Cyclin D1 is a nuclear protein required for cell cycle progression in G1 Genes Dev. 7 1993 812-821
68. Quelle D.E. Ashmum R.A. Shurtleff S.A. Kato J. Bar-Sagi D. Roussel M.F. Sherr C.J. Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts Genes Dev. 7 1993 1559-1571
69. P.W. Conrad, D.E. Millhorn, D. Beitner-Johnson, Hypoxia differentially regulates the mitogen- and stress-activated protein kinases. Role of Ca2+/CaM in the activation of MAPK and p38γ, in: S. Lahiri (Ed.), Oxygen Sensing: Molecule to Man, Kluwer Academic/Plenum Publishers, 2000, pp. 293-302.
70. Hipskind R.A. Buscher D. Nordheim A. Baccarini M. Ras/MAP kinase-dependent and -independent signaling pathways target distinct ternary complex factors Genes Dev. 8 1994 1803-1816
71. Bernstein L.R. Ferris D.K. Colburn N.H. Sobel M.E. A family of mitogen-activated protein kinase-related proteins interacts in vivo with activator protein-1 transcription factor J. Biol. Chem. 269 1994 9401-9404
72. Tian H. McKnight S.I. Russell D.W. Endothelial PAS domain protein 1 [EPAS1], a transcription factor selectively expressed in endothelial cells Genes Dev. 11 1997 72-82
73. Minet E. Arnould T. Michel G. Roland I. Mottet D. Raes M. Remacle J. Michiels C. ERK activation upon hypoxia: involvement in HIF-1 activation FEBS Lett. 468 2000 53-58
74. Muller J.M. Krauss B. Kaltschmidt C. Baeuerle P.A. Rupec R.A. Hypoxia induces c-fos transcription via a mitogen-activated protein kinase-dependent pathway J. Biol. Chem. 272 1997 23435-23439
75. Lee Y.J. Corry P.M. Hypoxia-induced bFGF gene expression is mediated through the JNK signal transduction pathway Mol. Cell. Biochem. 202 1999 1-8
76. Milanini J. Vinals F. Pouyssegur J. Pages G. p42/p44 MAP kinase module plays a key role in the transcriptional regulation of the vascular endothelial growth factor gene in fibroblasts J. Biol. Chem. 273 1998 18165-18172
77. Berra E. Pages G. Pouyssegur J. MAP kinases and hypoxia in the control of VEGF expression Cancer Metastasis Rev. 19 2000 139-145
78. Baek J.H. Jang J.E. Kang C.M. Chung H.Y. Kim N.D. Kim K.W. Hypoxia-induced VEGF enhances tumor survivability via suppression of serum deprivation-induced apoptosis Oncogene 19 2000 4621-4631
79. Das M. Bouchey D.M. Moore M.J. Hopkins D.C. Nemenoff R.A. Stenmark K.R. Hypoxia-induced proliferative response of vascular adventitial fibroblasts is dependent on G protein-mediated activation of mitogen-activated protein kinases J. Biol. Chem. 276 2001 15631-15640
80. Salceda S. Beck I. Srinivas V. Caro J. Complex role of protein phosphorylation in gene activation by hypoxia Kidney Int. 51 1997 556-559
81. Hur E. Young K. Lee E. Lee S-K. Park H. Mitogen-activated protein kinase kinase inhibitor PD98059 blocks the trans-activation but not the stabilization or DNA binding ability of hypoxia-inducible factor-1α Mol. Pharmacol. 59 2001 1216-1224
82. Sang N. Stiehl D.P. Bohensky J. Leshchinsky I. Srinivas V. Caro J. MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300 J. Biol. Chem. 278 2003 14013-14019
83. Charles C.H. Abler A.S. Lau L.F. cDNA sequence of a growth factor-inducible immediate-early gene and characterization of its encoded protein Oncogene 7 1992 187-190
84. Martell K.J. Angelotti T. Ullrich A. The "VH1-like" dual-specificity protein tyrosine phosphatases Mol. Cells 8 1998 2-11
85. Camps M. Nichols A. Gillieron C. Antonsson B. Muda M. Chabert C. Boschert U. Arkinstall S. Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase Science 280 1998 1262-1265
86. Hutter D. Chen P. Barnes J. Liu Y. Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by binding to p38 MAP kinase: critical role of the p38 C-terminal domain in its negative regulation Biochem. J. 352 2000 155-163
87. Nichols A. Camps M. Gillieron C. Chabert C. Brunet A. Wisbacher J. Cobb M. Pouyssegur J. Shaw J.P. Arkinstall S. Substrate recognition domains within extracellular signal-regulated kinase mediate binding and catalytic activation of mitogen-activated protein kinase phosphatase-3 J. Biol. Chem. 275 2000 24613-24621
88. Zhou B. Wu L. Shen K. Zhang J. Lawrence D.S. Zhang Z.-Y. Multiple regions of MAP kinase phosphatase 3 are involved in its recognition and activation by ERK2 J. Biol. Chem. 276 2001 6506-6515
89. Brondello J.M. Brunet A. Pouyssegur J. McKenzie J. The dual specificity mitogen-activated protein kinase phosphatase-1 and -2 are induced by the p42/p44MAPK cascad J. Biol. Chem. 272 1997 1368-1376
90. 2+-dependent signal pathways in Rat-1 cells J. Biol. Chem. 272 1997 13309-13319
91. Seta K.A. Kim R. Kim H.-W. Millhorn D.E. Beitner-Johnson D. Hypoxia-induced regulation of MAPK phosphatase-1 as identified by subtractive suppression hybridization and cDNA microarray analysis J. Biol. Chem. 276 2001 44405-44412
92. Scimeca J.C. Servant M.J. Dyer J.O. Meloche S. Essential role of calcium in the regulation of MAP kinase phosphatase-1 expression Oncogene 15 1997 717-726
93. Durham P.L. Russo A.F. Differential regulation of mitogen-activated protein kinase-responsive genes by the duration of a calcium signal Mol. Endocrinol. 14 2000 1570-1582
94. Bokemeyer D. Sorokin A. Yan M. Ahn N.G. Templeton D.J. Dunn M.J. Induction of mitogen-activated protein kinase phosphatase 1 by the stress-activated protein kinase signaling pathway but not by extracellular signal-regulated kinase in fibroblasts J. Biol. Chem. 271 1996 639-642
95. Li C. Hu Y. Mayr M. Xu Q. Cyclic strain stress-induced mitogen-activated protein kinase (MAPK) phosphatase 1 expression in vascular smooth muscle cells is regulated by Ras/Rac-MAPK pathways J. Biol. Chem. 274 1999 25273-25280
96. Datta S.R. Brunet A. Greenberg M.E. Cellular survival: a play in three Akts Genes Dev. 13 1999 2905-2927
97. Vanhaeselbroeck B. Alessi D.R. The PI3K-PDK1 connection: more than just a road to PKB Biochem. J. 346 2000 561-576
98. Dubek H. Datta S.R. Franke T.F. Birnbaum M.J. Yao R. Cooper G.M. Segal R.A. Kaplan D.R. Greenberg M.E. Regulation of neuronal survival by the serine-threonine protein kinase Akt Science 275 1997 661-665
99. Konishi H. Matsuzaki H. Tanaka M. Ono Y. Tokunaga C. Kuroda S. Kikkawa U. Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase Proc. Natl. Acad. Sci. U.S.A. 93 1996 7639-7643
100. 2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2 Biochem. J. 336 1998 241-246
101. Meier R. Thelen M. Hemmings B.A. Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha) promoted by hyperosmotic stress EMBO J. 17 1998 7294-7303
102. Meier R. Alessi D.R. Cron P. Andjeldovik M. Hemmings B.A. Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase B beta J. Biol. Chem. 272 1997 31515-31524
103. Beitner-Johnson D. Rust R.T. Hsieh T.C. Millhorn D.E. Hypoxia activates Akt and induces phosphorylation of GSK-3 in PC12 cells Cell. Signal. 13 2001 23-27
104. Cross D.A. Alessi D.R. Cohen P. Andjelkovich M. Hemmings B.A. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B Nature 378 1995 785-789
105. Hajduch E. Alessi D.R. Hemmings B.A. Hundal H.S. Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells Diabetes 47 1998 1006-1013
106. Pap M. Cooper G.M. Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway J. Biol. Chem. 273 1998 19929-19932
107. Mazure N.M. Chen E.Y. Laderoute K.R. Giaccia A.J. Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element Blood 90 1997 3322-3331
108. Zhong H. Chiles K. Feldser D. Laughner E. Hanrahan C. Georgescu M.M. Simons J.W. Semenza G. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics Cancer Res. 60 2000 1541-1545
109. Noshita N. Lewen A. Sugawara T. Chan P.H. Evidence of phosphorylation of Akt and neuronal survival after transient focal cerebral ischemia in mice J. Cereb. Blood Flow Metab. 21 2001 1442-1450
110. Blancher C. Moore J.W. Robertson N. Harris A.L. Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3′-kinase/Akt signaling pathway Cancer Res. 61 2001 7349-7355
111. Sodhi A. Montaner S. Miyazaki H. Gutkind J.S. MAPK and Akt act cooperatively but independently on hypoxia inducible factor-1alpha in rasV12 upregulation of VEGF Biochem. Biophys. Res. Commun. 287 2001 292-300
112. Gonzalez G.A. Montminy M.R. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133 Cell 59 1989 675-680
113. Frank D A. Greenberg M.E. CREB: a mediator of long-term memory from mollusks to mammals Cell 79 1994 5-8
114. Ginty D.D. Bonni A. Greenberg M.E. Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB Cell 79 1994 713-725
115. Deisseroth K. Bito H. Tsien R.W. Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity Neuron 16 1996 89-101
116. Tan Y. Rouse J. Zhang A. Cariati S. Cohen P. Comb M.J. FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2 EMBO J. 15 1996 4629-4642
117. Pende M. Fisher T.L. Simpson P.B. Russel J.T. Blenis J. Gallo V. Pende M. Neurotransmitter- and growth factor-induced cAMP response element binding protein phosphorylation in glial cell progenitors: role of calcium ions, protein kinase C, and mitogen-activated protein kinase/ribosomal S6 kinase pathway J. Neurosci. 17 1997 1291-1301
118. Iordanov M. Bender K. Ade T. Schmid W. Sachsenmaier C. Engel K. Gaestel M. Rahmsdorf H.J. Herrlich P. CREB is activated by UVC through a p38/HOG-1-dependent protein kinase EMBO J. 16 1997 1009-1022
119. Yamamoto K.K. Gonzalez G.A. Biggs W.H. Montminy M.R. Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB Nature 334 1988 494-498
120. Xie H. Rothstein T.L. Protein kinase C mediates activation of nuclear cAMP response element-binding protein (CREB) in B lymphocytes stimulated through surface Ig J. Immunol. 154 1995 1717-1723
121. Xing J. Ginty D.D. Greenberg M.E. Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase Science 273 1996 959-963
122. Kwok R. Lundblad J. Chrivia J. Richards J. Bachinger H. Brennan R. Roberts S. Green M. Goodman R. Nuclear protein CBP is a coactivator for the transcription factor CREB Nature 370 1994 223-226
123. Arias J. Alberts A. Brindle P. Claret F. Smeal T. Karin M. Feramisco J. Montminy M. Activation of cAMP and mitogen responsive genes relies on a common nuclear factor Nature 370 1994 226-228
124. Brindle P. Nakajima T. Montminy M. Multiple protein kinase-A regulated events are required for transcriptional induction by cAMP Proc. Natl. Acad. Sci. 92 1995 10521-10525
125. Du K. Asahara H. Jhala U.S. Wagner B.L. Montminy M. Characterization of a CREB gain-of-function mutant with constitutive transcriptional activity in vivo Mol. Cell. Biol. 20 2000 4320-4327
126. Beitner-Johnson D. Millhorn D.E. Hypoxia induces phosphorylation of the cyclic AMP response element-binding protein by a novel signaling mechanism J. Biol. Chem. 273 1998 19834-19839
127. Kim K.-S. Park D.H. Wessel T.C. Song B. Wagner J.A. Joh T.H. A dual role for the cAMP-dependent protein kinase in tyrosine hydroxylase gene expression Proc. Natl. Acad. Sci. 90 1993 3473-3475
128. K.A. Seta, Y. Yuan, Z. Spicer, G. Lu, D.E. Millhorn, Molecular adaptation to hypoxia, in: S. Lahiri, G.L. Semenza, N.R. Prabhakar (Eds.), Oxygen Sensing: Responses and Adaptation to Hypoxia, Marcel Dekker, Inc., New York, 2003, pp. 123-152.
129. Czyzyk-Krzeska M.F. Dominski Z. Kole R. Millhorn D.E. Hypoxia stimulates binding of a cytoplasmic protein to a pyrimidine-rich sequence in the 3′-untranslated region of rat tyrosine hydroxylase mRNA J. Biol. Chem. 269 1994 9940-9945
130. Taylor C.T. Fueki N. Agah A. Hershberg R.M. Colgan S.P. Critical role of cAMP response element binding protein expression in hypoxia-elicited induction of epithelial tumor necrosis factor-alpha J. Biol. Chem. 274 1999 19447-19454
131. Freeland K. Boxer L.M. Latchman D.S. The cyclic AMP response element in the Bcl-2 promoter confers inducibility by hypoxia in neuronal cells Brain Res. Mol. Brain Res. 92 2001 98-106
132. Klemm D.J. Watson P.A. Frid M.G. Dempsey E.C. Schaack J. Colton L.A. Nesterova A. Stenmark K.R. Reusch J.E. cAMP response element-binding protein content is a molecular determinant of smooth muscle cell proliferation and migration J. Biol. Chem. 276 2001 46132-46141
133. Simkhovich B.Z. Przyklenk K. Kloner R.A. Role of protein kinase C as a cellular mediator of ischemic preconditioning: a critical review Cardiovasc. Res. 40 1998 9-22
134. Suzuma K. Takahara N. Suzuma I. Isshiki K. Ueki K. Leitges M. Aiello L.P. King G.L. Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization Proc. Natl. Acad. Sci. 99 2002 721-726
135. Lo L.W. Cheng J.J. Chiu J.J. Wung B.S. Liu Y.C. Wang D.L. Endothelial exposure to hypoxia induces Egr-1 expression involving PKCalpha-mediated Ras/Raf-1/ERK1/2 pathway J. Cell. Physiol. 188 2001 304-312
136. Peck R.C. Lefer A.M. Protective effect of nifedipine in the hypoxic perfused cat liver Agents and Actions 11 1981 421-424
137. Lee H.C. Lum B.K. Protective action of calcium entry blockers in endotoxin shock Circ. Shock 18 1986 193-203
138. Jones D.P. Renal metabolism during normoxia, hypoxia, and ischemic injury Ann. Rev. Physiol. 48 1986 33-50
139. Brezis M. Shina A. Kidroni G. Epstein F.H. Rosen S. Calcium and hypoxic injury in the renal medulla of the perfused rat kidney Kidney Int. 34 1988 186-194
140. Shanley P.F. Johnson G.C. Calcium and acidosis in renal hypoxia Lab. Invest. 65 1991 298-305
141. Okuno F. Orrego H. Israel Y. Calcium requirement for anoxic liver cell injury Res. Commun. Chem. Pathol. Pharmacol. 39 1983 437-444
142. Strubelt O. Younes M. The involvement of extracellular calcium in hypoxic injury to the isolated rat liver Res. Commun. Chem. Pathol. Pharmacol. 61 1988 327-334