Fibrin and wound healing

Annals of the New York Academy of Sciences

Volumn 936, Issue , 2001, Pages 355-367

  Clark, Richard A F ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

Angiogenesis; Endothelial cells; Epidermal cells; Epidermal injury; Fibrinogen; Fibroblasts; Fibronectin; Fibroplasia; Wounds

Indexed keywords

ANAPHYLATOXIN; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C5A; FIBRIN; FIBRINOGEN; FIBRONECTIN; GROWTH FACTOR; INTEGRIN; PROTEINASE;

ANGIOGENESIS; BLOOD CLOTTING; CELL MIGRATION; COMPLEMENT ALTERNATIVE PATHWAY; CONFERENCE PAPER; DEBRIDEMENT; ENDOTHELIUM CELL; EPIDERMIS; EPITHELIZATION; FIBRIN CLOT; FIBRIN FORMATION; FIBROBLAST; GRANULATION TISSUE; HEMOSTASIS; HUMAN; INFLAMMATION; LEG ULCER; WOUND CARE; WOUND HEALING;

EID: 0034964284     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2001.tb03522.x     Document Type: Conference Paper

References (110)

1. Kininogens, kinins and kinships
2. Activation of classic pathway of complement by Hageman factor fragment
3. Chemotactic response to human C3a and C5a anaphylatoxins. I. Evaluation of C3a and C5a leukotaxis in vitro and under simulated in vivo conditions
4. Release of leukotrienes from guinea pig lung stimulated by C5a des arg anaphylatoxin
5. Induction of lysosomal enzyme secretion by macrophages in response to the purified complement fragments C5a and C5a des Arg
6. Provisional matrix
7. Macrophage migration in fibrin gel matrices
8. Macrophage migration in fibrin gel matrices II. Effects of clotting factor XIII, fibronectin, and glycosaminoglycan content on cell migration
9. Role of fibronectin in the migration of fibroblasts into plasma clots
10. Fibroblast migration in fibrin gel matrices
11. Fibronectin provides a conduit for fibroblast transmigration from a collagen gel into a fibrin gel
12. Transient functional expression of αvβ3 on vascular cells during wound repair
13. Integrins: Versatility, modulation, and signaling in cell adhesion
14. Integrins in wound repair
15. Recognition of distinct adhesive sites on fibrinogen by related integrins on platelets and endothelial cells
16. Integrin αvβ3 differentially regulates adhesive and phagocytic functions of the fibronectin receptor α5β1
17. Human dermal microvascular endothelial cells use α5β1, as well as avb3, to interact with the major fibrinogen breakdown product E1
18. Human fibroblasts bind directly to fibrinogen at RGD sites through integrin αvβ3
19. Integrins: Emerging paradigms of signal transduction
20. Cooperative signaling by α5β1 and α4β1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin
21. PDGF induction of α2 integrin gene expression is mediated by protein kinase C-ζ
22. Fibrin and collagen differentially regulate human dermal microvascular endothelial cell integrins: Stabilization of αvβ3 mRNA by fibrin
23. Enhancement of the streptokinase-induced activation of human plasminogen by human fibrinogen and human fibrinogen fragment D1
24. An endothelial cell receptor for plasminogen and tissue plasminogen activator: Identity with annexin II
25. Interaction of plasminogen activator inhibitor (PAI-1) with vitronectin
26. Changes in procoagulant and fibrinolytic gene expression during bleomycin-induced lung injury in the mouse
27. Abnormalities in pathways of alveolar fibrin turnover among patients with interstitial lung disease
28. An immunohistochemical study of architectural remodeling and connective tissue synthesis in pulmonary fibrosis
29. Bleomycin-induced fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene
30. Loss of fibrinogen rescues mice from the pleiotropic effects of plasminogen deficiency
31. Factors that affect vessel reactivity and leukocyte emigration
32. Interleukin-8 and related chemotactic cytokines-CXC and CC chemokines
33. Chemotaxis for human monocytes by fibrinogen-derived peptides
34. CD1lb/CD18 mediates the neutrophil chemotactic activity of fibrin degradation product D domain
35. Adherence of neutrophils to cultured human microvascular endothelial cells. Stimulation by chemotactic peptides and lipid mediators and dependence upon the Mac-l, LFA-1, p150,95 glycoprotein family
36. Sialylated, fucosylated ligands for L-selectin expressed on leukocytes mediate tethering and rolling adhesions in physiologic flow conditions
37. CD11c/CD18 on neutrophils recognizes a domain at the N terminus of the A alpha chain of fibrinogen
38. Fibronectin and fibrinogen degradation products stimulate PMN-leukocyte and mast cell degranulation
39. The contribution of leukocyte proteases to fibrinolysis
40. Neutrophil proteases in plasminogen activation
41. Role of neutrophil membrane proteases in fibrin degradation
42. Neutrophil emigration, activation, and tissue damage
43. Oxygen-independent antimicrobial systems of phagocytosis
44. Oxygen metabolites from phagocytes
45. Modulation of polymorphonuclear leukocyte microbicidal activity and oxidative metabolism by fibrinogen degradation products D and E
46. Collagen and collagen peptide-induced chemotaxis of human blood monocytes
47. Chemotactic activity of elastin-derived peptides
48. Cryptic chemotactic activity of fibronectin for human monocytes resides in the 120 kDa fibroblastic cell-binding fragment
49. Thrombin immobilized to extra-cellular matrix is a potent mitogen for vascular smooth muscle cells: Nonenzymatic mode of action
50. Transforming growth factor type β induces monocyte chemotaxis and growth factor production
51. Human monocyte adherence: A primary effect of chemotactic factors on the monocyte to stimulate adherence to human endothelium
52. A unique recognition site mediates the interaction of fibrinogen with the leukocyte integrin Mac-1 (CD 11b/CD 18)
53. Evidence that exposure to fibrinogen or to antibodies directed against Mac-1 (CD11b/CD18; CR3) modulates human monocyte effector functions
54. Macrophages as destructive cells in host defense
55. FDP D-dimer induces the secretion of interleukin-1, urokinase-type plasminogen activator, and plasminogen activator inhibitor-2 in a human promonocytic leukemia cell line
56. Mac-1 (CDllb/CD18) and the urokinase receptor (CD87) form a functional unit on monocytic cells
57. Adherence-dependent increase in human monocyte PDGF(B) mRNA is associated with increases in c-fos, c-jun, and EGF2 mRNA
58. Signal transduction from the extracellular matrix
59. Macrophage involvement in wound repair, remodeling and fibrosis
60. Fibronectin and fibrin(ogen) provide a provisional matrix for epidermal cell migration during wound reepithelialization
61. Induction of tenascin in healing wounds
62. Distinctive integrin expression in the newly forming epidermis during wound healing in humans
63. Fibrinogen clears from epidermal and blood vessel matrix prior to healing of chronic wounds
64. Human wound repair. I. Epidermal regeneration
65. Fibronectin matrix deposition and fibronectin receptor expression in healing and normal skin
66. Expression of integrins and basement membrane components by wound keratinocytes
67. Regulation of extracellular matrix proteins and integrin cell substratum adhesion receptors on epithelium during cutaneous human wound healing in vivo
68. Reepithelialization of normal human excisional wounds is associated with a switch from αvβ5 to αvβ6 integrins
69. The activity of collagenase-1 is required for keratinocyte migration on a type I collagen matrix
70. Affinity of integrins for damaged extracellular matrix: αvβ3 binds to denatured collagen type I through RGD sites
71. Expression of β1, β3, β4, and β5 integrins by human epidermal keratinocytes and non-differentiating keratinocytes
72. TGF-β1 stimulates expression of keratinocyte integrins during re-epithelialization of cutaneous wounds
73. Fibrin(ogen) is an anti-adhesive for human keratinocytes: A possible mechanism for fibrin eschar slough during wound repair
74. Adult human keratinocytes migrating over nonviable dermal collagen produce collagenolytic enzymes that degrade type I and type IV collagen
75. Urokinase- and tissuetype plasminogen activators in kerafinocytes during wound reepithelilaization in vivo
76. Proteinases and tissue remodeling
77. Role of Platelet-derived growth factor in vivo
78. Transforming growth factor-β (TGF-β)
79. Induction of fibroblast chemotaxis by fibronectin. Location of the chemotactic region to a 140,000 molecular weight nongelatin binding fragment
80. Aα and Bβ chains of fibrinogen stimulate proliferation of human fibroblasts
81. Extracellular matrix alters PDGF regulation of fibroblast integrins
82. Proteoglycans and hyaluronan in morphogenesis and differentiation
83. Binding of basic fibroblast growth factor to fibrinogen and fibrin
84. Platelet-derived growth factor and inflammatory cytokines have differential effects on the expression of integrins α1β1 and α5β1 by human dermal fibroblasts in vitro
85. Mesenchymal cell activation is the rate limiting step of granulation tissue induction
86. Distinct populations of stromal cells express collagenase-3 (MMP- 13) and collagenase- 1 (MMP- 1) in chronic ulcers but not in normally healing wounds
87. Role of plasminogen, plasmin, and plasminogen activators in the migration of fibroblasts into plasma clots
88. Temporal relationships of F-actin bundle formation, collagen and fibronectin matrix assembly, and fibronectin receptor expression to wound contraction
89. In vitro fibroplasia: Matrix contraction, cell growth, and collagen production of fibroblasts cultured in fibrin gels
90. Angiogenesis
91. Angiogenic factors
92. Vascular permeability factor, an endothelial cell mitogen related to PDGF
93. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
94. PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF β-receptors
95. Wound repair: Lessons for tissue engineering
96. VEGFs, receptors and angiogenesis
97. The angiopoietins: Yin and Yang in angiogenesis
98. Role of platelets and fibrin in the healing sequence: An in vivo study of angiogenesis and collagen synthesis
99. Is the formation of fibrin a necessary event for the initiation of angiogenic response in the chick chorioallantoic membrane?
100. Fibrin containing gels induce angiogenesis. Implications for tumor stroma generation and wound healing
101. A novel, microcarrier-based in vitro assay for rapid and reliable quantification of three-dimensional cell migration and angiogenesis
102. The configuration of fibrin clots determines capillary morphogenesis and endothelial cell migration
103. Requirement of vascular integrin αvβ3 for angiogenesis
104. Integrin β1- and β3-mediated endothelial cell migration is triggered through distinct signaling mechanisms
105. Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
106. Thrombospondin 1 synthesis and function in wound repair
107. Wound fluid from chronic leg ulcers contains elevated levels of metalloproteinases MMP-2 and MMP-9
108. Fibronectin profiles in normal and chronic wound fluid