-
1
-
-
0034680825
-
The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia
-
Agani FH, Pichiule P, Chavez JC, LaManna JC. (2000) The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia. J Biol Chem.; 275: 35863-7.
-
(2000)
J Biol Chem
, vol.275
, pp. 35863-35867
-
-
Agani, F.H.1
Pichiule, P.2
Chavez, J.C.3
LaManna, J.C.4
-
2
-
-
0033529173
-
2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase
-
2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase. Proc Natl Acad Sci USA.; 96: 7944-9.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 7944-7949
-
-
Archer, S.L.1
Reeve, H.L.2
Michelakis, E.3
Puttagunta, L.4
Waite, R.5
Nelson, D.P.6
Dinauer, M.C.7
Weir, E.K.8
-
3
-
-
0032900610
-
Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1
-
Bhattacharya S, Michels CL, Leung MK, Arany ZP, Kung AL, Livingston DM. (1999) Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes Dev.; 13: 64-75.
-
(1999)
Genes Dev
, vol.13
, pp. 64-75
-
-
Bhattacharya, S.1
Michels, C.L.2
Leung, M.K.3
Arany, Z.P.4
Kung, A.L.5
Livingston, D.M.6
-
4
-
-
0035847050
-
Role of exon 2-encoded beta-domain of the von Hippel-Lindau tumor suppressor protein. (2001)
-
Bonicalzi ME, Groulx I, de Paulsen N, Lee S. (2001) Role of exon 2-encoded beta-domain of the von Hippel-Lindau tumor suppressor protein. (2001) J Biol Chem.; 276: 1407-16.
-
(2001)
J Biol Chem
, vol.276
, pp. 1407-1416
-
-
Bonicalzi, M.E.1
Groulx, I.2
De Paulsen, N.3
Lee, S.4
-
5
-
-
0034255036
-
Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
-
Bruick RK. (2000) Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc Natl Acad Sci USA.; 97: 9082-7.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 9082-9087
-
-
Bruick, R.K.1
-
6
-
-
0035834409
-
A conserved family of prolyl-4-hydroxylases that modify HIF
-
Bruick RK, McKnight SL. (2001) A conserved family of prolyl-4- hydroxylases that modify HIF. Science.; 294: 1337-40.
-
(2001)
Science
, vol.294
, pp. 1337-1340
-
-
Bruick, R.K.1
McKnight, S.L.2
-
7
-
-
0036469146
-
Transcription. Oxygen sensing gets a second wind
-
Bruick RK, McKnight SL. (2002) Transcription. Oxygen sensing gets a second wind. Science.; 295: 807-8.
-
(2002)
Science
, vol.295
, pp. 807-808
-
-
Bruick, R.K.1
McKnight, S.L.2
-
8
-
-
0034899785
-
Transcription factors p53 and HIF-1alpha as targets of nitric oxide
-
Brüne B, von Knethen A, Sandau KB. (2001) Transcription factors p53 and HIF-1alpha as targets of nitric oxide. Cell Signal.; 13: 525-33.
-
(2001)
Cell Signal
, vol.13
, pp. 525-533
-
-
Brüne, B.1
Von Knethen, A.2
Sandau, K.B.3
-
9
-
-
0034100836
-
Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3)
-
Caniggia I, Mostachfi H, Winter J, Gassmann M, Lye SJ, Kuliszewski M, Post M. (2000) Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3). J Clin Invest.; 105: 577-87.
-
(2000)
J Clin Invest
, vol.105
, pp. 577-587
-
-
Caniggia, I.1
Mostachfi, H.2
Winter, J.3
Gassmann, M.4
Lye, S.J.5
Kuliszewski, M.6
Post, M.7
-
10
-
-
0032581277
-
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
-
Erratum in: Nature.; 395: 525
-
Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell P, Koch CJ, Ratcliffe P, Moons L, Jain RK, Collen D, Keshert E, Keshet E. (1998) Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature.; 394: 485-90. Erratum in: Nature.; 395: 525.
-
(1998)
Nature
, vol.394
, pp. 485-490
-
-
Carmeliet, P.1
Dor, Y.2
Herbert, J.M.3
Fukumura, D.4
Brusselmans, K.5
Dewerchin, M.6
Neeman, M.7
Bono, F.8
Abramovitch, R.9
Maxwell, P.10
Koch, C.J.11
Ratcliffe, P.12
Moons, L.13
Jain, R.K.14
Collen, D.15
Keshert, E.16
Keshet, E.17
-
11
-
-
0032578458
-
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
-
Chandel NS, Maltepe E, Goldwasser E, Mathieu CE, Simon MC, Schumacker PT. (1998) Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci USA.; 95: 11715-20.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 11715-11720
-
-
Chandel, N.S.1
Maltepe, E.2
Goldwasser, E.3
Mathieu, C.E.4
Simon, M.C.5
Schumacker, P.T.6
-
12
-
-
0142154635
-
Oxygen-dependent and -independent regulation of HIF-1alpha
-
Chun YS, Kim MS, Park JW. (2002) Oxygen-dependent and -independent regulation of HIF-1alpha. J Korean Med Sci.; 17: 581-8.
-
(2002)
J Korean Med Sci
, vol.17
, pp. 581-588
-
-
Chun, Y.S.1
Kim, M.S.2
Park, J.W.3
-
13
-
-
0032504165
-
Adrenomedullin gene expression is developmentally regulated and induced by hypoxia in rat ventricular cardiac myocytes
-
Cormier-Regard S, Nguyen SV, Claycomb WC. (1998) Adrenomedullin gene expression is developmentally regulated and induced by hypoxia in rat ventricular cardiac myocytes. J Biol Chem.; 273: 17787-92.
-
(1998)
J Biol Chem
, vol.273
, pp. 17787-17792
-
-
Cormier-Regard, S.1
Nguyen, S.V.2
Claycomb, W.C.3
-
14
-
-
0141643358
-
Hypoxia upregulates prolyl hydroxylase activity: A feedback mechanism that limits HIF-1 responses during reoxygenation
-
D'Angelo G, Duplan E, Boyer N, Vigne P, Frelin C. (2003) Hypoxia upregulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation. J Biol Chem.; 278: 38183-7.
-
(2003)
J Biol Chem
, vol.278
, pp. 38183-38187
-
-
D'Angelo, G.1
Duplan, E.2
Boyer, N.3
Vigne, P.4
Frelin, C.5
-
15
-
-
0346668332
-
NPAS2: A gas-responsive transcription factor
-
Dioum EM, Rutter J, Tuckerman JR, Gonzalez G, Gilles-Gonzalez MA, McKnight SL. (2002) NPAS2: a gas-responsive transcription factor. Science.; 298: 2385-7.
-
(2002)
Science
, vol.298
, pp. 2385-2387
-
-
Dioum, E.M.1
Rutter, J.2
Tuckerman, J.R.3
Gonzalez, G.4
Gilles-Gonzalez, M.A.5
McKnight, S.L.6
-
16
-
-
0042388388
-
Carbon monoxide - A "new" gaseous modulator of gene expression
-
Dulak J, Jozkowicz A. (2003a) Carbon monoxide - a "new" gaseous modulator of gene expression. Acta Biochim Polon.; 50: 31-47.
-
(2003)
Acta Biochim Polon
, vol.50
, pp. 31-47
-
-
Dulak, J.1
Jozkowicz, A.2
-
17
-
-
0037297175
-
Regulation of vascular endothelial growth factor synthesis by nitric oxide: Facts and controversies
-
Dulak J, Jozkowicz A. (2003b) Regulation of vascular endothelial growth factor synthesis by nitric oxide: facts and controversies. Antioxid Redox Signal.; 5: 123-32.
-
(2003)
Antioxid Redox Signal
, vol.5
, pp. 123-132
-
-
Dulak, J.1
Jozkowicz, A.2
-
19
-
-
0343851651
-
Nitric oxide induces the synthesis of vascular endothelial growth factor by rat vascular smooth muscle cells
-
Dulak J, Józkowicz A, Dembinska-Kiec A, Guevara I, Zdzienicka A, Zmudzinska-Grochot D, Florek I, Wójtowicz A, Szuba A, Cooke JP. (2000) Nitric oxide induces the synthesis of vascular endothelial growth factor by rat vascular smooth muscle cells. Arterioscler Thromb Vasc Biol.; 20: 659-66.
-
(2000)
Arterioscler Thromb Vasc Biol
, vol.20
, pp. 659-666
-
-
Dulak, J.1
Józkowicz, A.2
Dembinska-Kiec, A.3
Guevara, I.4
Zdzienicka, A.5
Zmudzinska-Grochot, D.6
Florek, I.7
Wójtowicz, A.8
Szuba, A.9
Cooke, J.P.10
-
20
-
-
0036090780
-
Heme oxygenase activity modulates vascular endothelial growth factor synthesis in vascular smooth muscle cells
-
Dulak J, Jozkowicz A, Foresti R, Kasza A, Frick M, Huk I, Green CJ, Pachinger O, Weidinger F, Motterlini R. (2002) Heme oxygenase activity modulates vascular endothelial growth factor synthesis in vascular smooth muscle cells. Antioxid Redox Signal.; 4: 229-40.
-
(2002)
Antioxid Redox Signal
, vol.4
, pp. 229-240
-
-
Dulak, J.1
Jozkowicz, A.2
Foresti, R.3
Kasza, A.4
Frick, M.5
Huk, I.6
Green, C.J.7
Pachinger, O.8
Weidinger, F.9
Motterlini, R.10
-
21
-
-
0030611360
-
Characterization of the alpha1B-adrenergic receptor gene promoter region and hypoxia regulatory elements in vascular smooth muscle
-
Eckhart AD, Yang N, Xin X, Faber JE. (1997) Characterization of the alpha1B-adrenergic receptor gene promoter region and hypoxia regulatory elements in vascular smooth muscle. Proc Natl Acad Sci USA.; 94: 9487-92.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 9487-9492
-
-
Eckhart, A.D.1
Yang, N.2
Xin, X.3
Faber, J.E.4
-
22
-
-
0033118983
-
Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: Their stabilization and redox signal-induced interaction with CBP/p300
-
Ema M, Hirota K, Mimura J, Abe H, Yodoi J, Sogawa K, Poellinger L, Fujii-Kuriyama Y. (1999) Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300. EMBO J.; 18: 1905-14.
-
(1999)
EMBO J
, vol.18
, pp. 1905-1914
-
-
Ema, M.1
Hirota, K.2
Mimura, J.3
Abe, H.4
Yodoi, J.5
Sogawa, K.6
Poellinger, L.7
Fujii-Kuriyama, Y.8
-
23
-
-
17944375360
-
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ. (2001) C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell.; 107: 43-54.
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.1
Gleadle, J.M.2
McNeill, L.A.3
Hewitson, K.S.4
O'Rourke, J.5
Mole, D.R.6
Mukherji, M.7
Metzen, E.8
Wilson, M.I.9
Dhanda, A.10
Tian, Y.M.11
Masson, N.12
Hamilton, D.L.13
Jaakkola, P.14
Barstead, R.15
Hodgkin, J.16
Maxwell, P.H.17
Pugh, C.W.18
Schofield, C.J.19
Ratcliffe, P.J.20
more..
-
24
-
-
0033566693
-
Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2
-
Feldser D, Agani F, Iyer NV, Pak B, Ferreira G, Semenza GL. (1999) Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2. Cancer Res.; 59: 3915-8.
-
(1999)
Cancer Res
, vol.59
, pp. 3915-3918
-
-
Feldser, D.1
Agani, F.2
Iyer, N.V.3
Pak, B.4
Ferreira, G.5
Semenza, G.L.6
-
25
-
-
0028359320
-
Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: Similarities with the erythropoietin 3′ enhancer
-
Firth JD, Ebert BL, Pugh CW, Ratcliffe PJ. (1994) Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3′ enhancer. Proc Natl Acad Sci USA.; 91: 6496-500.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 6496-6500
-
-
Firth, J.D.1
Ebert, B.L.2
Pugh, C.W.3
Ratcliffe, P.J.4
-
26
-
-
0029761644
-
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
-
Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, Koos RD, Semenza GL. (1996) Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol.; 16: 4604-13.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4604-4613
-
-
Forsythe, J.A.1
Jiang, B.H.2
Iyer, N.V.3
Agani, F.4
Leung, S.W.5
Koos, R.D.6
Semenza, G.L.7
-
27
-
-
0030751493
-
Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes: Flt-1, but not Flk-1/KDR, is upregulated by hypoxia
-
Gerber H-P, Condorelli F, Park J, Ferrara N. (1997) Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes: Flt-1, but not Flk-1/KDR, is upregulated by hypoxia. J Biol Chem.; 272: 23659-67.
-
(1997)
J Biol Chem
, vol.272
, pp. 23659-23667
-
-
Gerber, H.-P.1
Condorelli, F.2
Park, J.3
Ferrara, N.4
-
28
-
-
0032192140
-
The complexity of p53 modulation: Emerging patterns from divergent signals
-
Giaccia AJ, Kastan MB. (1998) The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev.; 12: 2973-83.
-
(1998)
Genes Dev
, vol.12
, pp. 2973-2983
-
-
Giaccia, A.J.1
Kastan, M.B.2
-
29
-
-
0028844810
-
Diphenylene iodonium inhibits the induction of erythropoietin and other mammalian genes by hypoxia. Implications for the mechanism of oxygen sensing
-
Gleadle JM, Ebert BL, Ratcliffe PJ. (1995) Diphenylene iodonium inhibits the induction of erythropoietin and other mammalian genes by hypoxia. Implications for the mechanism of oxygen sensing. Eur J Biochem.; 234: 92-9.
-
(1995)
Eur J Biochem
, vol.234
, pp. 92-99
-
-
Gleadle, J.M.1
Ebert, B.L.2
Ratcliffe, P.J.3
-
30
-
-
0031016301
-
Induction of hypoxia-inducible factor-1, erythropoietin, vascular endothelial growth factor, and glucose transporter-1 by hypoxia: Evidence against a regulatory role for Src kinase
-
Gleadle JM, Ratcliffe PJ. (1997) Induction of hypoxia-inducible factor-1, erythropoietin, vascular endothelial growth factor, and glucose transporter-1 by hypoxia: evidence against a regulatory role for Src kinase. Blood.; 89: 503-9.
-
(1997)
Blood
, vol.89
, pp. 503-509
-
-
Gleadle, J.M.1
Ratcliffe, P.J.2
-
31
-
-
0035816732
-
Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: Role of the p22(phox)-containing NADPH oxidase
-
Gorlach A, Diebold I, Schini-Kerth VB, Berchner-Pfannschmidt U, Roth U, Brandes RP, Kietzmann T, Busse R. (2001) Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: Role of the p22(phox)-containing NADPH oxidase. Circ Res.; 89: 47-54.
-
(2001)
Circ Res
, vol.89
, pp. 47-54
-
-
Gorlach, A.1
Diebold, I.2
Schini-Kerth, V.B.3
Berchner-Pfannschmidt, U.4
Roth, U.5
Brandes, R.P.6
Kietzmann, T.7
Busse, R.8
-
32
-
-
0034629304
-
Identification of alternative spliced variants of human hypoxia-inducible factor-1alpha
-
Gothie E, Richard DE, Berra E, Pages G, Pouyssegur J. (2000) Identification of alternative spliced variants of human hypoxia-inducible factor-1alpha. J Biol Chem.; 275: 6922-7.
-
(2000)
J Biol Chem
, vol.275
, pp. 6922-6927
-
-
Gothie, E.1
Richard, D.E.2
Berra, E.3
Pages, G.4
Pouyssegur, J.5
-
33
-
-
4444272652
-
Gene transfer of CuZn superoxide dismutase enhances the synthesis of vascular endothelial growth factor
-
in press
-
Grzenkowicz-Wydra J, Cisowski J, Nakonieczna J, Zarȩbski A, Udilova N, Nohl H, Józkowicz A, Podhajska A, Dulak J. (2004) Gene transfer of CuZn superoxide dismutase enhances the synthesis of vascular endothelial growth factor. Mol Cell Biochem.; in press.
-
(2004)
Mol Cell Biochem
-
-
Grzenkowicz-Wydra, J.1
Cisowski, J.2
Nakonieczna, J.3
Zarȩbski, A.4
Udilova, N.5
Nohl, H.6
Józkowicz, A.7
Podhajska, A.8
Dulak, J.9
-
34
-
-
0035793584
-
Molecular mechanism of hypoxia-inducible factor 1alpha-p300 interaction. A leucine-rich interface regulated by a single cysteine
-
Gu J, Milligan J, Huang LE. (2001) Molecular mechanism of hypoxia-inducible factor 1alpha-p300 interaction. A leucine-rich interface regulated by a single cysteine. J Biol Chem.; 276: 3550-4.
-
(2001)
J Biol Chem
, vol.276
, pp. 3550-3554
-
-
Gu, J.1
Milligan, J.2
Huang, L.E.3
-
35
-
-
0035651033
-
Dissecting hypoxia-dependent and hypoxia-independent steps in the HIF-1alpha activation cascade: Implications for HIF-1alpha gene therapy
-
Hofer T, Desbaillets I, Hopfl G, Gassmann M, Wenger RH. (2001) Dissecting hypoxia-dependent and hypoxia-independent steps in the HIF-1alpha activation cascade: implications for HIF-1alpha gene therapy. FASEB J.; 15: 2715-7.
-
(2001)
FASEB J
, vol.15
, pp. 2715-2717
-
-
Hofer, T.1
Desbaillets, I.2
Hopfl, G.3
Gassmann, M.4
Wenger, R.H.5
-
36
-
-
0032576971
-
Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand
-
Hu J, Discher DJ, Bishopric NH, Webster KA. (1998) Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand. Biochem Biophys Res Commun.; 245: 894-9.
-
(1998)
Biochem Biophys Res Commun
, vol.245
, pp. 894-899
-
-
Hu, J.1
Discher, D.J.2
Bishopric, N.H.3
Webster, K.A.4
-
37
-
-
0031028158
-
Erythropoietin gene regulation depends on heme-dependent oxygen sensing and assembly of interacting transcription factors
-
Huang LE, Ho V, Arany Z, Krainc D, Galson D, Tendler D, Livingston DM, Bunn HF. (1997) Erythropoietin gene regulation depends on heme-dependent oxygen sensing and assembly of interacting transcription factors. Kidney Int.; 51: 548-52.
-
(1997)
Kidney Int
, vol.51
, pp. 548-552
-
-
Huang, L.E.1
Ho, V.2
Arany, Z.3
Krainc, D.4
Galson, D.5
Tendler, D.6
Livingston, D.M.7
Bunn, H.F.8
-
39
-
-
0033605676
-
Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling
-
Huang LE, Willmore WG, Gu J, Goldberg MA, Bunn HF. (1999) Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling. J Biol Chem.; 274: 9038-44.
-
(1999)
J Biol Chem
, vol.274
, pp. 9038-9044
-
-
Huang, L.E.1
Willmore, W.G.2
Gu, J.3
Goldberg, M.A.4
Bunn, H.F.5
-
40
-
-
0035917313
-
2 sensing
-
2 sensing. Science.; 292: 464-8.
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
Kaelin Jr., W.G.10
-
41
-
-
15444342958
-
2 homeostasis by hypoxia-inducible factor 1 alpha
-
2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev.; 12: 149-62.
-
(1998)
Genes Dev
, vol.12
, pp. 149-162
-
-
Iyer, N.V.1
Kotch, L.E.2
Agani, F.3
Leung, S.W.4
Laughner, E.5
Wenger, R.H.6
Gassmann, M.7
Gearhart, J.D.8
Lawler, A.M.9
Yu, A.Y.10
Semenza, G.L.11
-
42
-
-
0035917808
-
2-regulated prolyl hydroxylation
-
2-regulated prolyl hydroxylation. Science.; 292: 468-72.
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
Kriegsheim, A.V.7
Hebestreit, H.F.8
Mukherji, M.9
Schofield, C.J.10
Maxwell, P.H.11
Pugh, C.W.12
Ratcliffe, P.J.13
-
43
-
-
0029944965
-
Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1
-
Jiang BH, Rue E, Wang GL, Roe R, Semenza GL. (1996a) Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J Biol Chem.; 271: 17771-8.
-
(1996)
J Biol Chem
, vol.271
, pp. 17771-17778
-
-
Jiang, B.H.1
Rue, E.2
Wang, G.L.3
Roe, R.4
Semenza, G.L.5
-
45
-
-
0034869434
-
Genetic augmentation of nitric oxide synthase increases the vascular generation of VEGF
-
Jozkowicz A, Cooke JP, Guevara I, Huk I, Funovics P, Pachinger O, Weidinger F, Dulak J. (2001) Genetic augmentation of nitric oxide synthase increases the vascular generation of VEGF. Cardiovasc Res.; 51: 773-83.
-
(2001)
Cardiovasc Res
, vol.51
, pp. 773-783
-
-
Jozkowicz, A.1
Cooke, J.P.2
Guevara, I.3
Huk, I.4
Funovics, P.5
Pachinger, O.6
Weidinger, F.7
Dulak, J.8
-
46
-
-
1642531778
-
Heme oxygenase and angiogenic activity of endothelial cells: Stimulation by carbon monoxide and inhibition by tin protoporphyrin-IX
-
Jozkowicz A, Huk I, Nigisch A, Weigel G, Dietrich W, Motterlini R, Dulak J. (2003) Heme oxygenase and angiogenic activity of endothelial cells: stimulation by carbon monoxide and inhibition by tin protoporphyrin-IX. Antioxid Redox Signal.; 5: 155-62.
-
(2003)
Antioxid Redox Signal
, vol.5
, pp. 155-162
-
-
Jozkowicz, A.1
Huk, I.2
Nigisch, A.3
Weigel, G.4
Dietrich, W.5
Motterlini, R.6
Dulak, J.7
-
47
-
-
0347356253
-
Opposite effects of prostaglandin-J(2) on VEGF in normoxia and hypoxia: Role of HIF-1
-
Jozkowicz A, Nigisch A, Wȩgrzyn J, Weigel G, Huk I, Dulak J. (2004) Opposite effects of prostaglandin-J(2) on VEGF in normoxia and hypoxia: role of HIF-1. Biochem Biophys Res Commun.; 314: 31-38.
-
(2004)
Biochem Biophys Res Commun
, vol.314
, pp. 31-38
-
-
Jozkowicz, A.1
Nigisch, A.2
Wȩgrzyn, J.3
Weigel, G.4
Huk, I.5
Dulak, J.6
-
48
-
-
0030914648
-
Activation of hypoxia-inducible factor 1alpha: Posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor
-
Kallio PJ, Pongratz I, Gradin K, McGuire J, Poellinger L. (1997) Activation of hypoxia-inducible factor 1alpha: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor. Proc Natl Acad Sci USA.; 94: 5667-72.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 5667-5672
-
-
Kallio, P.J.1
Pongratz, I.2
Gradin, K.3
McGuire, J.4
Poellinger, L.5
-
49
-
-
0032538797
-
Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha
-
Kallio PJ, Okamoto K, O'Brien S, Carrero P, Makino Y, Tanaka H, Poellinger L. (1998) Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha. EMBO J.; 17: 6573-86.
-
(1998)
EMBO J
, vol.17
, pp. 6573-6586
-
-
Kallio, P.J.1
Okamoto, K.2
O'Brien, S.3
Carrero, P.4
Makino, Y.5
Tanaka, H.6
Poellinger, L.7
-
50
-
-
0033525830
-
Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway
-
Kallio PJ, Wilson WJ, O'Brien S, Makino Y, Poellinger L. (1999) Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway. J Biol Chem.; 274: 6519-25.
-
(1999)
J Biol Chem
, vol.274
, pp. 6519-6525
-
-
Kallio, P.J.1
Wilson, W.J.2
O'Brien, S.3
Makino, Y.4
Poellinger, L.5
-
51
-
-
1642453685
-
Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling
-
Kasuno K, Takabuchi S, Fukuda K, Kizaka-Kondoh S, Yodoi J, Adachi T, Semenza GL, Hirota K. (2004) Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling. J Biol Chem.; 279: 2550-8.
-
(2004)
J Biol Chem
, vol.279
, pp. 2550-2558
-
-
Kasuno, K.1
Takabuchi, S.2
Fukuda, K.3
Kizaka-Kondoh, S.4
Yodoi, J.5
Adachi, T.6
Semenza, G.L.7
Hirota, K.8
-
52
-
-
0037088576
-
Heat induction of the unphosphorylated form of hypoxia-inducible factor-1alpha is dependent on heat shock protein-90 activity
-
Katschinski DM, Le L, Heinrich D, Wagner KF, Hofer T, Schindler SG, Wenger RH. (2002) Heat induction of the unphosphorylated form of hypoxia-inducible factor-1alpha is dependent on heat shock protein-90 activity. J Biol Chem.; 277: 9262-7.
-
(2002)
J Biol Chem
, vol.277
, pp. 9262-9267
-
-
Katschinski, D.M.1
Le, L.2
Heinrich, D.3
Wagner, K.F.4
Hofer, T.5
Schindler, S.G.6
Wenger, R.H.7
-
53
-
-
0032795850
-
Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes
-
Kietzmann T, Roth U, Jungermann K. (1999) Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes. Blood.; 94: 4177-85.
-
(1999)
Blood
, vol.94
, pp. 4177-4185
-
-
Kietzmann, T.1
Roth, U.2
Jungermann, K.3
-
54
-
-
0013199207
-
Early expression of myocardial HIF-1alpha in response to mechanical stresses: Regulation by stretch-activated channels and the phosphatidylinositol 3-kinase signaling pathway
-
Kim CH, Cho YS, Chun YS, Park JW, Kim MS. (2002) Early expression of myocardial HIF-1alpha in response to mechanical stresses: regulation by stretch-activated channels and the phosphatidylinositol 3-kinase signaling pathway. Circ Res.; 90: E25-33.
-
(2002)
Circ Res
, vol.90
-
-
Kim, C.H.1
Cho, Y.S.2
Chun, Y.S.3
Park, J.W.4
Kim, M.S.5
-
55
-
-
0033975850
-
Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: Control of hypoxia-inducible factor-1 activity by nitric oxide
-
Kimura H, Weisz A, Kurashima Y, Hashimoto K, Ogura T, D'Acquisto F, Addeo R, Makuuchi M, Esumi H. (2000) Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide. Blood.; 95: 189-97.
-
(2000)
Blood
, vol.95
, pp. 189-197
-
-
Kimura, H.1
Weisz, A.2
Kurashima, Y.3
Hashimoto, K.4
Ogura, T.5
D'Acquisto, F.6
Addeo, R.7
Makuuchi, M.8
Esumi, H.9
-
56
-
-
0035910429
-
Identification of hypoxia-inducible factor 1 ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide
-
Kimura H, Weisz A, Ogura T, Hitomi Y, Kurashima Y, Hashimoto K, D'Acquisto F, Makuuchi M, Esumi H. (2001) Identification of hypoxia-inducible factor 1 ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide. J Biol Chem.; 276: 2292-8.
-
(2001)
J Biol Chem
, vol.276
, pp. 2292-2298
-
-
Kimura, H.1
Weisz, A.2
Ogura, T.3
Hitomi, Y.4
Kurashima, Y.5
Hashimoto, K.6
D'Acquisto, F.7
Makuuchi, M.8
Esumi, H.9
-
57
-
-
0036150703
-
Hypoxia-inducible factor-1alpha/vascular endothelial growth factor pathway for adventitial vasa vasorum formation in hypertensive rat aorta
-
Kuwahara F, Kai H, Tokuda K, Shibata R, Kusaba K, Tahara N, Niiyama H, Nagata T, Imaizumi T. (2002) Hypoxia-inducible factor-1alpha/vascular endothelial growth factor pathway for adventitial vasa vasorum formation in hypertensive rat aorta. Hypertension.; 39: 46-50.
-
(2002)
Hypertension
, vol.39
, pp. 46-50
-
-
Kuwahara, F.1
Kai, H.2
Tokuda, K.3
Shibata, R.4
Kusaba, K.5
Tahara, N.6
Niiyama, H.7
Nagata, T.8
Imaizumi, T.9
-
58
-
-
0036469038
-
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
-
Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML. (2002a) Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science.; 295: 858-61.
-
(2002)
Science
, vol.295
, pp. 858-861
-
-
Lando, D.1
Peet, D.J.2
Whelan, D.A.3
Gorman, J.J.4
Whitelaw, M.L.5
-
59
-
-
0037097861
-
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
-
Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, Bruick RK. (2002b) FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev.; 16: 1466-71.
-
(2002)
Genes Dev
, vol.16
, pp. 1466-1471
-
-
Lando, D.1
Peet, D.J.2
Gorman, J.J.3
Whelan, D.A.4
Whitelaw, M.L.5
Bruick, R.K.6
-
60
-
-
0031041377
-
Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia
-
Lee PJ, Jiang BH, Chin BY, Iyer NV, Alam J, Semenza GL, Choi AM. (1997) Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia. J Biol Chem.; 272: 5375-81.
-
(1997)
J Biol Chem
, vol.272
, pp. 5375-5381
-
-
Lee, P.J.1
Jiang, B.H.2
Chin, B.Y.3
Iyer, N.V.4
Alam, J.5
Semenza, G.L.6
Choi, A.M.7
-
61
-
-
0032736054
-
Molecular cloning and chromosomal localization of the human CITED2 gene encoding p35srj/Mrg1
-
Leung MK, Jones T, Michels CL, Livingston DM, Bhattacharya S. (1999) Molecular cloning and chromosomal localization of the human CITED2 gene encoding p35srj/Mrg1. Genomics.; 61: 307-13.
-
(1999)
Genomics
, vol.61
, pp. 307-313
-
-
Leung, M.K.1
Jones, T.2
Michels, C.L.3
Livingston, D.M.4
Bhattacharya, S.5
-
62
-
-
0032511014
-
Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5′ enhancer
-
Liu Y, Christou H, Morita T, Laughner E, Semenza GL, Kourembanas S. (1998) Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5′ enhancer. J Biol Chem.; 273: 15257-62.
-
(1998)
J Biol Chem
, vol.273
, pp. 15257-15262
-
-
Liu, Y.1
Christou, H.2
Morita, T.3
Laughner, E.4
Semenza, G.L.5
Kourembanas, S.6
-
63
-
-
0000655498
-
Identification of a hypoxia response element in the transferrin receptor gene
-
Lok CN, Ponka P. (1999) Identification of a hypoxia response element in the transferrin receptor gene. J Biol Chem.; 274: 24147-52.
-
(1999)
J Biol Chem
, vol.274
, pp. 24147-24152
-
-
Lok, C.N.1
Ponka, P.2
-
64
-
-
0037133736
-
Identification of an additional hypoxia responsive element in the glyceraldehyde-3-phosphate dehydrogenase gene promoter
-
Lu S, Gu X, Hoestje S, Epner DE. (2002) Identification of an additional hypoxia responsive element in the glyceraldehyde-3-phosphate dehydrogenase gene promoter. Biochim Biophys Acta.; 1574: 152-6.
-
(2002)
Biochim Biophys Acta
, vol.1574
, pp. 152-156
-
-
Lu, S.1
Gu, X.2
Hoestje, S.3
Epner, D.E.4
-
65
-
-
0035969508
-
Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression
-
Makino Y, Cao R, Svensson K, Bertilsson G, Asman M, Tanaka H, Cao Y, Berkenstam A, Poellinger L. (2001) Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature.; 414: 550-4.
-
(2001)
Nature
, vol.414
, pp. 550-554
-
-
Makino, Y.1
Cao, R.2
Svensson, K.3
Bertilsson, G.4
Asman, M.5
Tanaka, H.6
Cao, Y.7
Berkenstam, A.8
Poellinger, L.9
-
66
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, Ratcliffe PJ. (1999) The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature.; 399: 271-5.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
67
-
-
0028786601
-
A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter
-
Melillo G, Musso T, Sica A, Taylor LS, Cox GW, Varesio L. (1995) A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter. J Exp Med.; 182: 1683-93.
-
(1995)
J Exp Med
, vol.182
, pp. 1683-1693
-
-
Melillo, G.1
Musso, T.2
Sica, A.3
Taylor, L.S.4
Cox, G.W.5
Varesio, L.6
-
68
-
-
0037386143
-
Intracellular localisation of human HIF-1 alpha hydroxylases: Implications for oxygen sensing
-
Metzen E, Berchner-Pfannschmidt U, Stengel P, Marxsen JH, Stolze I, Klinger M, Huang WQ, Wotzlaw C, Hellwig-Burgel T, Jelkmann W, Acker H, Fandrey J. (2003a) Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing. J Cell Sci.; 116: 1319-26.
-
(2003)
J Cell Sci
, vol.116
, pp. 1319-1326
-
-
Metzen, E.1
Berchner-Pfannschmidt, U.2
Stengel, P.3
Marxsen, J.H.4
Stolze, I.5
Klinger, M.6
Huang, W.Q.7
Wotzlaw, C.8
Hellwig-Burgel, T.9
Jelkmann, W.10
Acker, H.11
Fandrey, J.12
-
69
-
-
0042469448
-
Nitric oxide impairs normoxic degradation of HIF-1{alpha} by inhibition of prolyl hydroxylases
-
Hetzen E, Zhou J, Jelkmann W, Fandrey J, Brune B. (2003b) Nitric oxide impairs normoxic degradation of HIF-1{alpha} by inhibition of prolyl hydroxylases. Mol Biol Cell.; 14: 3470-81.
-
(2003)
Mol Biol Cell
, vol.14
, pp. 3470-3481
-
-
Hetzen, E.1
Zhou, J.2
Jelkmann, W.3
Fandrey, J.4
Brune, B.5
-
70
-
-
0036830469
-
Regulation of gene expression by oxygen: NF-kappaB and HIF-1, two extremes
-
Michiels C, Minet E, Mottet D, Raes M. (2002) Regulation of gene expression by oxygen: NF-kappaB and HIF-1, two extremes. Free Radic Biol Med.; 33: 1231-42.
-
(2002)
Free Radic Biol Med
, vol.33
, pp. 1231-1242
-
-
Michiels, C.1
Minet, E.2
Mottet, D.3
Raes, M.4
-
71
-
-
0034647742
-
Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency
-
Mukhopadhyay CK, Mazumder B, Fox PL. (2000) Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency. J Biol Chem.; 275: 21048-54.
-
(2000)
J Biol Chem
, vol.275
, pp. 21048-21054
-
-
Mukhopadhyay, C.K.1
Mazumder, B.2
Fox, P.L.3
-
72
-
-
0041562752
-
Regulation of hypoxia inducible factor-1 by nitric oxide in contrast to hypoxia in microvascular endothelium
-
Natarajan R, Fisher BJ, Fowler AA 3rd. (2003) Regulation of hypoxia inducible factor-1 by nitric oxide in contrast to hypoxia in microvascular endothelium. FEBS Lett.; 549: 99-104.
-
(2003)
FEBS Lett
, vol.549
, pp. 99-104
-
-
Natarajan, R.1
Fisher, B.J.2
Fowler III, A.A.3
-
73
-
-
0028859483
-
2-responsive sequences on the tyrosine hydroxylase gene
-
2-responsive sequences on the tyrosine hydroxylase gene. J Biol Chem.; 270: 23774-9.
-
(1995)
J Biol Chem
, vol.270
, pp. 23774-23779
-
-
Norris, M.L.1
Millhorn, D.E.2
-
74
-
-
0029858079
-
Identification of hypoxically inducible mRNAs in HeLa cells using differential-display PCR. Role of hypoxia-inducible factor-1
-
O'Rourke JF, Pugh CW, Bartlett SM, Ratcliffe PJ. (1996) Identification of hypoxically inducible mRNAs in HeLa cells using differential-display PCR. Role of hypoxia-inducible factor-1. Eur J Biochem.; 241: 403-10.
-
(1996)
Eur J Biochem
, vol.241
, pp. 403-410
-
-
O'Rourke, J.F.1
Pugh, C.W.2
Bartlett, S.M.3
Ratcliffe, P.J.4
-
75
-
-
0036391915
-
Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors
-
Oehme F, Ellinghaus P, Kolkhof P, Smith TJ, Ramakrishnan S, Hutter J, Schramm M, Flamme I. (2002) Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors. Biochem Biophys Res Commun.; 296: 343-9.
-
(2002)
Biochem Biophys Res Commun
, vol.296
, pp. 343-349
-
-
Oehme, F.1
Ellinghaus, P.2
Kolkhof, P.3
Smith, T.J.4
Ramakrishnan, S.5
Hutter, J.6
Schramm, M.7
Flamme, I.8
-
76
-
-
0037073695
-
Induction of hypoxia-inducible factor-1alpha by transcriptional and translational mechanisms
-
Page EL, Robitaille GA, Pouyssegur J, Richard DE. (2002) Induction of hypoxia-inducible factor-1alpha by transcriptional and translational mechanisms. J Biol Chem.; 277: 48403-9.
-
(2002)
J Biol Chem
, vol.277
, pp. 48403-48409
-
-
Page, E.L.1
Robitaille, G.A.2
Pouyssegur, J.3
Richard, D.E.4
-
78
-
-
0030937718
-
Activation of hypoxia-inducible factor-1; definition of regulatory domains within the alpha subunit
-
Pugh CW, O'Rourke JF, Nagao M, Gleadle JM, Ratcliffe PJ. (1997) Activation of hypoxia-inducible factor-1; definition of regulatory domains within the alpha subunit. J Biol Chem.; 272: 11205-14.
-
(1997)
J Biol Chem
, vol.272
, pp. 11205-11214
-
-
Pugh, C.W.1
O'Rourke, J.F.2
Nagao, M.3
Gleadle, J.M.4
Ratcliffe, P.J.5
-
79
-
-
0033954247
-
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha
-
Ravi R, Mookerjee B, Bhujwalla ZM, Sutter CH, Artemov D, Zeng Q, Dillehay LE, Madan A, Semenza GL, Bedi A. (2000) Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev.; 14: 34-44.
-
(2000)
Genes Dev
, vol.14
, pp. 34-44
-
-
Ravi, R.1
Mookerjee, B.2
Bhujwalla, Z.M.3
Sutter, C.H.4
Artemov, D.5
Zeng, Q.6
Dillehay, L.E.7
Madan, A.8
Semenza, G.L.9
Bedi, A.10
-
80
-
-
0030200110
-
PEST sequences and regulation by proteolysis
-
Rechsteiner M, Rogers SW. (1996) PEST sequences and regulation by proteolysis. Trends Biochem Sci.; 21: 267-71.
-
(1996)
Trends Biochem Sci
, vol.21
, pp. 267-271
-
-
Rechsteiner, M.1
Rogers, S.W.2
-
81
-
-
0032725554
-
p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1
-
Richard DE, Berra E, Gothie E, Roux D, Pouyssegur J. (1999) p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1. J Biol Chem.; 274: 32631-7.
-
(1999)
J Biol Chem
, vol.274
, pp. 32631-32637
-
-
Richard, D.E.1
Berra, E.2
Gothie, E.3
Roux, D.4
Pouyssegur, J.5
-
82
-
-
0034282388
-
Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells
-
Richard DE, Berra E, Pouyssegur J. (2000) Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells. J Biol Chem.; 275: 26765-71.
-
(2000)
J Biol Chem
, vol.275
, pp. 26765-26771
-
-
Richard, D.E.1
Berra, E.2
Pouyssegur, J.3
-
83
-
-
0030792094
-
Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1
-
Rolfs A, Kvietikova I, Gassmann M, Wenger RH. (1997) Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1. J Biol Chem.; 272: 20055-62.
-
(1997)
J Biol Chem
, vol.272
, pp. 20055-20062
-
-
Rolfs, A.1
Kvietikova, I.2
Gassmann, M.3
Wenger, R.H.4
-
84
-
-
0035919479
-
Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors
-
Rutter J, Reick M, Wu LC, McKnight SL. (2001) Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors. Science.; 293: 510-4.
-
(2001)
Science
, vol.293
, pp. 510-514
-
-
Rutter, J.1
Reick, M.2
Wu, L.C.3
McKnight, S.L.4
-
85
-
-
0030961006
-
Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
-
Salceda S, Caro J. (1997) Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem.; 272: 22642-7.
-
(1997)
J Biol Chem
, vol.272
, pp. 22642-22647
-
-
Salceda, S.1
Caro, J.2
-
86
-
-
0035864361
-
Accumulation of HIF-1alpha under the influence of nitric oxide
-
Sandau KB, Fandrey J, Brune B. (2001a) Accumulation of HIF-1alpha under the influence of nitric oxide. Blood.; 97: 1009-15.
-
(2001)
Blood
, vol.97
, pp. 1009-1015
-
-
Sandau, K.B.1
Fandrey, J.2
Brune, B.3
-
87
-
-
0035955663
-
Regulation of the hypoxia-inducible factor 1alpha by the inflammatory mediators nitric oxide and tumor necrosis factor-alpha in contrast to desferroxamine and phenylarsine oxide
-
Sandau KB, Zhou J, Kietzmann T, Brune B. (2001b) Regulation of the hypoxia-inducible factor 1alpha by the inflammatory mediators nitric oxide and tumor necrosis factor-alpha in contrast to desferroxamine and phenylarsine oxide. J Biol Chem.; 276: 39805-11.
-
(2001)
J Biol Chem
, vol.276
, pp. 39805-39811
-
-
Sandau, K.B.1
Zhou, J.2
Kietzmann, T.3
Brune, B.4
-
88
-
-
4644291365
-
p53 and HIF-1: Transcription factors communicating at multiple levels
-
Abstract Book, Berlin, poster No. 17
-
Schmid T, Callapina M, Zhou J, Brune B. (2003) p53 and HIF-1: transcription factors communicating at multiple levels. Oxygen and the Cell, Abstract Book, Berlin, poster No. 17.
-
(2003)
Oxygen and the Cell
-
-
Schmid, T.1
Callapina, M.2
Zhou, J.3
Brune, B.4
-
90
-
-
0034663989
-
HIF-1 and human disease: One highly involved factor
-
Semenza GL. (2000a) HIF-1 and human disease: one highly involved factor. Genes Dev.; 14: 1983-91.
-
(2000)
Genes Dev
, vol.14
, pp. 1983-1991
-
-
Semenza, G.L.1
-
91
-
-
0034006016
-
HIF-1: Mediator of physiological and pathophysiological responses to hypoxia
-
Semenza GL. (2000b) HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol.; 88: 1474-80.
-
(2000)
J Appl Physiol
, vol.88
, pp. 1474-1480
-
-
Semenza, G.L.1
-
92
-
-
0033991530
-
Expression of hypoxia-inducible factor 1: Mechanisms and consequences
-
Semenza GL. (2000c) Expression of hypoxia-inducible factor 1: mechanisms and consequences. Biochem Pharmacol.; 59: 47-53.
-
(2000)
Biochem Pharmacol
, vol.59
, pp. 47-53
-
-
Semenza, G.L.1
-
93
-
-
0035812772
-
HIF-1, O(2), and the 3 PHDs: How animal cells signal hypoxia to the nucleus
-
Semenza GL. (2001) HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell.; 107: 1-3.
-
(2001)
Cell
, vol.107
, pp. 1-3
-
-
Semenza, G.L.1
-
94
-
-
0028068606
-
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
-
Semenza GL, Roth PH, Fang HM, Wang GL. (1994) Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J Biol Chem.; 269: 23757-63.
-
(1994)
J Biol Chem
, vol.269
, pp. 23757-23763
-
-
Semenza, G.L.1
Roth, P.H.2
Fang, H.M.3
Wang, G.L.4
-
95
-
-
0030460724
-
Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
-
Semenza GL, Jiang BH, Leung SW, Passantino R, Concordet JP, Maire P, Giallongo A. (1996) Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J Biol Chem.; 271: 32529-37.
-
(1996)
J Biol Chem
, vol.271
, pp. 32529-32537
-
-
Semenza, G.L.1
Jiang, B.H.2
Leung, S.W.3
Passantino, R.4
Concordet, J.P.5
Maire, P.6
Giallongo, A.7
-
96
-
-
0032560504
-
Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia
-
Sogawa K, Numayama-Tsuruta K, Ema M, Abe M, Abe H, Fujii-Kuriyama Y. (1998) Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia. Proc Natl Acad Sci USA.; 95: 7368-73.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 7368-7373
-
-
Sogawa, K.1
Numayama-Tsuruta, K.2
Ema, M.3
Abe, M.4
Abe, H.5
Fujii-Kuriyama, Y.6
-
97
-
-
0035884701
-
HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors
-
Sowter HM, Ratcliffe PJ, Watson P, Greenberg AH, Harris AL. (2001) HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res.; 61: 6669-73.
-
(2001)
Cancer Res
, vol.61
, pp. 6669-6673
-
-
Sowter, H.M.1
Ratcliffe, P.J.2
Watson, P.3
Greenberg, A.H.4
Harris, A.L.5
-
98
-
-
0033588021
-
Transferrin receptor induction by hypoxia: HIF-1-mediated transcriptional activation and cell-specific posttranscriptional regulation
-
Tacchini L, Bianchi L, Bernelli-Zazzera A, Cairo G. (1999) Transferrin receptor induction by hypoxia: HIF-1-mediated transcriptional activation and cell-specific posttranscriptional regulation. J Biol Chem.; 274: 24142-6.
-
(1999)
J Biol Chem
, vol.274
, pp. 24142-24146
-
-
Tacchini, L.1
Bianchi, L.2
Bernelli-Zazzera, A.3
Cairo, G.4
-
99
-
-
0034640269
-
Hypoxic induction of prolyl 4-hydroxylase alpha (I) in cultured cells
-
Takahashi Y, Takahashi S, Shiga Y, Yoshimi T, Miura T. (2000) Hypoxic induction of prolyl 4-hydroxylase alpha (I) in cultured cells. J Biol Chem.; 275: 14139-46.
-
(2000)
J Biol Chem
, vol.275
, pp. 14139-14146
-
-
Takahashi, Y.1
Takahashi, S.2
Shiga, Y.3
Yoshimi, T.4
Miura, T.5
-
100
-
-
0035880239
-
Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain
-
Vaux EC, Metzen E, Yeates KM, Ratcliffe PJ. (2001) Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain. Blood.; 98: 296-302.
-
(2001)
Blood
, vol.98
, pp. 296-302
-
-
Vaux, E.C.1
Metzen, E.2
Yeates, K.M.3
Ratcliffe, P.J.4
-
101
-
-
0027136260
-
Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: Implications for models of hypoxia signal transduction
-
Wang GL, Semenza GL. (1993) Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction. Blood.; 82: 3610-5.
-
(1993)
Blood
, vol.82
, pp. 3610-3615
-
-
Wang, G.L.1
Semenza, G.L.2
-
102
-
-
0029051439
-
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
-
Wang GL, Jiang BH, Rue EA, Semenza GL. (1995a) Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA.; 92: 5510-4.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 5510-5514
-
-
Wang, G.L.1
Jiang, B.H.2
Rue, E.A.3
Semenza, G.L.4
-
103
-
-
0028785860
-
Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1
-
Wang GL, Jiang BH, Semenza GL. (1995b) Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1. Biochem Biophys Res Commun.; 216: 669-75.
-
(1995)
Biochem Biophys Res Commun
, vol.216
, pp. 669-675
-
-
Wang, G.L.1
Jiang, B.H.2
Semenza, G.L.3
-
104
-
-
0035984138
-
HIF-1alpha-prolyl hydroxylase: Molecular target of nitric oxide in the hypoxic signal transduction pathway
-
Wang F, Sekine H, Kikuchi Y, Takasaki C, Miura C, Heiwa O, Shuin T, Fujii-Kuriyama Y, Sogawa K. (2002) HIF-1alpha-prolyl hydroxylase: molecular target of nitric oxide in the hypoxic signal transduction pathway. Biochem Biophys Res Commun.; 295: 657-62.
-
(2002)
Biochem Biophys Res Commun
, vol.295
, pp. 657-662
-
-
Wang, F.1
Sekine, H.2
Kikuchi, Y.3
Takasaki, C.4
Miura, C.5
Heiwa, O.6
Shuin, T.7
Fujii-Kuriyama, Y.8
Sogawa, K.9
-
105
-
-
0032079558
-
Oxygen-regulated erythropoietin gene expression is dependent on a CpG methylation-free hypoxia-inducible factor-1 DNA-binding site
-
Wenger RH, Kvietikova I, Rolfs A, Camenisch G, Gassmann M. (1998) Oxygen-regulated erythropoietin gene expression is dependent on a CpG methylation-free hypoxia-inducible factor-1 DNA-binding site. Eur J Biochem.; 253: 771-7.
-
(1998)
Eur J Biochem
, vol.253
, pp. 771-777
-
-
Wenger, R.H.1
Kvietikova, I.2
Rolfs, A.3
Camenisch, G.4
Gassmann, M.5
-
106
-
-
0036320934
-
2- regulated gene expression
-
2-regulated gene expression. FASEB J.; 16: 1151-62.
-
(2002)
FASEB J
, vol.16
, pp. 1151-1162
-
-
Wenger, R.H.1
-
107
-
-
0030583293
-
In vivo expression of mRNAs encoding hypoxia-inducible factor 1
-
Wiener CM, Booth G, Semenza GL. (1996) In vivo expression of mRNAs encoding hypoxia-inducible factor 1. Biochem Biophys Res Commun.; 225: 485-8.
-
(1996)
Biochem Biophys Res Commun
, vol.225
, pp. 485-488
-
-
Wiener, C.M.1
Booth, G.2
Semenza, G.L.3
-
108
-
-
0034671307
-
Hypoxia-inducible expression of tumor-associated carbonic anhydrases
-
Wykoff CC, Beasley NJ, Watson PH, Turner KJ, Pastorek J, Sibtain A, Wilson GD, Turley H, Talks KL, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL. (2000) Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Cancer Res.; 60: 7075-83.
-
(2000)
Cancer Res
, vol.60
, pp. 7075-7083
-
-
Wykoff, C.C.1
Beasley, N.J.2
Watson, P.H.3
Turner, K.J.4
Pastorek, J.5
Sibtain, A.6
Wilson, G.D.7
Turley, H.8
Talks, K.L.9
Maxwell, P.H.10
Pugh, C.W.11
Ratcliffe, P.J.12
Harris, A.L.13
-
109
-
-
0031753986
-
Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung
-
Yu AY, Frid MG, Shimoda LA, Wiener CM, Stenmark K, Semenza GL. (1998) Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung. Am J Physiol.; 275: L818-26.
-
(1998)
Am J Physiol
, vol.275
-
-
Yu, A.Y.1
Frid, M.G.2
Shimoda, L.A.3
Wiener, C.M.4
Stenmark, K.5
Semenza, G.L.6
-
110
-
-
0033104847
-
Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha
-
Yu AY, Shimoda LA, Iyer NV, Huso DL, Sun X, McWilliams R, Beaty T, Sham JS, Wiener CM, Sylvester JT, Semenza GL. (1999) Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha. J Clin Invest.; 103: 691-6.
-
(1999)
J Clin Invest
, vol.103
, pp. 691-696
-
-
Yu, A.Y.1
Shimoda, L.A.2
Iyer, N.V.3
Huso, D.L.4
Sun, X.5
McWilliams, R.6
Beaty, T.7
Sham, J.S.8
Wiener, C.M.9
Sylvester, J.T.10
Semenza, G.L.11
-
111
-
-
0034654174
-
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
-
Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu MM, Simons JW, Semenza GL. (2000) Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res.; 60: 1541-5.
-
(2000)
Cancer Res
, vol.60
, pp. 1541-1545
-
-
Zhong, H.1
Chiles, K.2
Feldser, D.3
Laughner, E.4
Hanrahan, C.5
Georgescu, M.M.6
Simons, J.W.7
Semenza, G.L.8
-
112
-
-
0034050050
-
Loss of PTEN facilitates HIF-1-mediated gene expression
-
Zundel W, Schindler C, Haas-Kogan D, Koong A, Kaper F, Chen E, Gottschalk AR, Ryan HE, Johnson RS, Jefferson AB, Stokoe D, Giaccia AJ. (2000) Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev.; 14: 391-6.
-
(2000)
Genes Dev
, vol.14
, pp. 391-396
-
-
Zundel, W.1
Schindler, C.2
Haas-Kogan, D.3
Koong, A.4
Kaper, F.5
Chen, E.6
Gottschalk, A.R.7
Ryan, H.E.8
Johnson, R.S.9
Jefferson, A.B.10
Stokoe, D.11
Giaccia, A.J.12
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