Wound hypoxia and acidosis limit neutrophil bacterial killing mechanisms

Archives of Surgery

Volumn 132, Issue 9, 1997, Pages 991-996

  Allen, Daniel B ^c   Maguire, John J ^d   Mahdavian, Mani ^b   Wicke, Corinna ^b   Marcocci, Lucia ^d   Scheuenstuhl, Heinz ^b   Chang, Michael ^b   Le, Anh X ^b   Hopf, Harriet W ^a,b   Hunt, Thomas K ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDOSIS; ARTICLE; BACTERICIDAL ACTIVITY; HUMAN; HUMAN CELL; HYPOXIA; LEUKOCYTE METABOLISM; NEUTROPHIL; OXYGEN CONSUMPTION; OXYGEN TENSION; PRIORITY JOURNAL; RESPIRATORY BURST; WOUND HEALING;

EID: 15644382445     PISSN: 00040010     EISSN: None     Source Type: Journal    
DOI: 10.1001/archsurg.1997.01430330057009     Document Type: Article

References (30)

1. Haley RW, Culver DH, Morgan WM, White JW, Emori TG, Hooton TM. Identifying patients at high risk of surgical wound infection: a simple multivariate index of patient susceptibility and wound contamination. Am J Epidemiol. 1985;121: 206-215.
2. Sheffield C, Sessler D, Hopf H, et al. Centrally and locally mediated thermoregulatory responses alter subcutaneous oxygen tension. Wound Repair Regeneration. 1996;4:339-345.
3. Gottrup F, Firmin R, Rabkin J, Halliday BJ, Hunt TK. Directly measured tissue oxygen tension and arterial oxygen tension assess tissue perfusion. Crit Care Med. 1987;15:1030-1036.
4. Jonsson K, Jensen JA, Goodson WH, West JM, Hunt TK. Assessment of perfusion in postoperative patients using tissue oxygen measurements. Br J Surg. 1987;74:263-267.
5. Knighton DR, Halliday B, Hunt TK. Oxygen as an antibiotic: the effect of inspired oxygen on infection. Arch Surg. 1984;119:199-204.
6. Barbul A. Postoperative wound infection. In: Cameron J, ed. Current Surgical Therapy. 4th ed. St Louis, Mo: Mosby-Year Book lnc; 1992:960-990.
7. Jonsson K, Hunt TK, Mathes SJ. Oxygen as an isolated variable influences resistance to infection. Ann Surg. 1988;208:783-787.
8. Hopf HW, Hunt TK, West JM, et al. Wound tissue oxygen tension predicts the risk of wound infection in surgical patients. Arch Surg. 1997;132:997-1004.
9. Kurz A, Sessler D, Lenhardt, et al. Perioperative normothermia to reduce the incidence of surgical-wound infection and shorten hospitalization. N Engl J Med. 1996;334:1209-1215.
10. Babior BM. Oxygen-dependent microbial killing by phagocytes. N Engl J Med. 1978;198:659-668.
11. Klebanoff S. Oxygen metabolism and the toxic properties of phagocytes. Ann Intern Med. 1980;93:480-489.
12. Holmes B, Page A, Good R. Studies of the metabolic activity of leukocytes from patients with a genetic abnormality of phagocytic function. J Clin Invest. 1967; 46:1422-1432.
13. Babior B, Woodman R. Chronic granulomatous disease. Semin Hematol. 1990; 27:247-259.
14. Silver IA. Cellular microenvironment in healing and non-healing wounds. In: Hunt TK, Heppenstall RB, Pines E, eds. Soft and Hard Tissue Repair. New York, NY: Praeger Publishers; 1984:50-66.
15. Mader JT, Brown GL, Guckian JC, Wells CH, Reinarz JA. A mechanism for the amelioration by hyperbaric oxygen of experimental staphylococcal osteomyelitis in rabbits. J Infect Dis. 1980;142:915-922.
16. Niinikoski J, Jussila P, Vihersaari T. Radical mastectomy wound as a model for studies of human wound metabolism. Am J Surg. 1973;126:53-58.
17. Hunt T, Banda M, Silver I. Cell interactions in post-traumatic fibrosis. In: Evered D, Whelan J, eds. Fibrosis. London, England: Pitman Books Ltd; 1985;114:127-129.
18. Gabig TG, Bearman SI, Babior BM. Effects of oxygen tension and pH on the respiratory burst of human neutrophils. Blood. 1979;53:1133-1139.
19. Edwards S, Hallett M, Campbell A. Oxygen-radical production during inflammation may be limited by oxygen concentration. Biochem J. 1984;217:851-854.
20. 2 forming enzyme for oxygen. In: Rossi F, Patriarca P, eds. Biochemistry and Function of Phagocytes. New York, NY: Plenum Publishing Corp; 1980:351-360.
21. Metcalf J, Gallin J, Nauseef W, Root R. Laboratory Manual of Neutrophil Function. New York, NY: Raven Press; 1986.
22. Rotstein O, Fiegel V, Simmons R, Knighton D. The deleterious effect of reduced pH and hypoxia on neutrophil migration in vitro. J Surg Res. 1988;45:298-303.
23. James P, Grinberg O, Michaels G, Swartz H. Intraphagosomal oxygen in stimulated macrophages. J Cell Physiol. 1995;163:241-247.
24. Marhoffer W, Stein M, Maeser D, Federlin K. Impairment of polymorphonuclear leukocyte function and metabolic control of diabetes. Diabetes Care. 1992;15:256-260.
25. Wenisch C, Narzt E, Sessler D, et al. Mild intraoperative hypothermia reduces production of reactive oxygen intermediates by polymorphonuclear leukocytes. Anesth Analg. 1996;82:810-816.
26. Silver IA. Oxygen tension and epithelialization. In: Maibach HI, Rovee DT, eds. Epidermal Wound Healing. Chicago, III: Year Book Medical Publishers lnc; 1972:291-305.
27. Hopf H, West J, Hunt T. Clonidine increases tissue oxygen in patients with local tissue hypoxia in non-healing wounds. Wound Repair Regeneration. 1996;4:A129.
28. Jensen JA, Jonsson K, Goodson WH, Hunt TK, Roizen MF. Epinephrine lowers subcutaneous wound oxygen tension. Curr Surg. 1985;42:472-474.
29. West J, Hopf H, Sessler D, Hunt T. The effect of rapid postoperative rewarming on tissue oxygen. Wound Repair Regeneration. 1993;1:93. Abstract.
30. Roizen M, Hunt TK, Beaupre P, et al. The effect of α-adrenergic blockade on cardiac performance and tissue oxygen delivery during excision of pheochromocytoma. Surgery. 1983;94:941-945.