Int6/eIF3e silencing promotes functional blood vessel outgrowth and enhances wound healing by upregulating hypoxia-induced factor 2α expression

Circulation

Volumn 122, Issue 9, 2010, Pages 910-919

  Chen, Li ^a   Endler, Alexander ^a,b   Uchida, Kazuyo ^a   Horiguchi, Shin Ichiro ^c   Morizane, Yoshihito ^a   Iijima, Osamu ^a   Toi, Masakazu ^d   Shibasaki, Futoshi ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b TONGJI UNIVERSITY   (China)

^c TOKYO METROPOLITAN KOMAGOME HOSPITAL   (Japan)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

angiogenesis; hypoxia; molecular biology; signal transduction; siRNA

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANGIOGENIC FACTOR; CD31 ANTIGEN; HYPOXIA INDUCIBLE FACTOR 2ALPHA; INITIATION FACTOR 3; INITIATION FACTOR 3E; PROTEIN INT6; SMALL INTERFERING RNA; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; ACTIN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; HIF1A PROTEIN, MOUSE; HYPOXIA INDUCIBLE FACTOR 1ALPHA;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL; FEMALE; FIBROBLAST; GENE SILENCING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; SUBCUTANEOUS TISSUE; UPREGULATION; WOUND HEALING; 3T3 CELL LINE; ANIMAL; BAGG ALBINO MOUSE; BREAST TUMOR; C57BL MOUSE; FEEDBACK SYSTEM; GENETICS; HELA CELL LINE; ISCHEMIA; METABOLISM; MUTANT MOUSE STRAIN; NUDE MOUSE; PATHOPHYSIOLOGY; PHYSIOLOGY; PROMOTER REGION; TRANSPLANTATION; VASCULARIZATION;

ACTINS; ANIMALS; ANTIGENS, CD31; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BREAST NEOPLASMS; EUKARYOTIC INITIATION FACTOR-3; FEEDBACK, PHYSIOLOGICAL; FEMALE; FIBROBLASTS; HELA CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; ISCHEMIA; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICE, NUDE; NEOVASCULARIZATION, PHYSIOLOGIC; NIH 3T3 CELLS; PROMOTER REGIONS, GENETIC; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SUBCUTANEOUS TISSUE; WOUND HEALING;

EID: 77956355633     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.109.931931     Document Type: Article

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