Proneural bHLH genes in development and disease

Current Topics in Developmental Biology

Volumn 110, Issue , 2014, Pages 75-127

  Huang, Carol ^a   Chan, Jennifer A ^b   Schuurmans, Carol ^c  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c ALBERTA CHILDREN S HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

Achaete scute; Ascl1; Atonal; Basic helix loop helix transcription factors; Cancer; Diabetes; Neurog1 2 3; Neuropsychiatric disorders; Peripheral and central nervous systems; Proneural genes

Indexed keywords

ASCL1 PROTEIN, MOUSE; ATOH1 PROTEIN, MOUSE; ATOH7 PROTEIN, MOUSE; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; DROSOPHILA PROTEIN; NERVE PROTEIN; NEUROG1 PROTEIN, HUMAN; NEUROG2 PROTEIN, HUMAN;

ANIMAL; CENTRAL NERVOUS SYSTEM; CYTOLOGY; DEVELOPMENTAL DISORDER; DIABETES MELLITUS; EMBRYOLOGY; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; INNER EAR; METABOLISM; NEOPLASM; NERVE CELL; NEUROLOGIC DISEASE; PHYSIOLOGY; RETINA; SPINAL GANGLION; VERTEBRATE;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CENTRAL NERVOUS SYSTEM; DEVELOPMENTAL DISABILITIES; DIABETES MELLITUS; DROSOPHILA PROTEINS; EAR, INNER; GANGLIA, SPINAL; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; NEOPLASMS; NERVE TISSUE PROTEINS; NERVOUS SYSTEM DISEASES; NEURONS; RETINA; VERTEBRATES;

EID: 84907683150     PISSN: 00702153     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-405943-6.00002-6     Document Type: Chapter

References (273)

1. Abematsu M., Kagawa T., Fukuda S., Inoue T., Takebayashi H., Komiya S., et al. Basic fibroblast growth factor endows dorsal telencephalic neural progenitors with the ability to differentiate into oligodendrocytes but not gamma-aminobutyric acidergic neurons. Journal of Neuroscience Research 2006, 83(5):731-743. 10.1002/jnr.20762.
2. Akazawa C., Ishibashi M., Shimizu C., Nakanishi S., Kageyama R. A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system. The Journal of Biological Chemistry 1995, 270(15):8730-8738.
3. Alexiades M.R., Cepko C.L. Subsets of retinal progenitors display temporally regulated and distinct biases in the fates of their progeny. Development 1997, 124(6):1119-1131.
4. Ali F., Hindley C., McDowell G., Deibler R., Jones A., Kirschner M., et al. Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis. Development 2011, 138(19):4267-4277. 10.1242/dev.067900.
5. Amiel J., Laudier B., Attie-Bitach T., Trang H., de Pontual L., Gener B., et al. Polyalanine expansion and frameshift mutations of the paired-like homeobox gene PHOX2B in congenital central hypoventilation syndrome. Nature Genetics 2003, 33(4):459-461. 10.1038/ng1130.
6. Anderson S.A., Eisenstat D.D., Shi L., Rubenstein J.L. Interneuron migration from basal forebrain to neocortex: Dependence on Dlx genes. Science 1997, 278(5337):474-476.
7. Anderson S.A., Kaznowski C.E., Horn C., Rubenstein J.L., McConnell S.K. Distinct origins of neocortical projection neurons and interneurons in vivo. Cerebral Cortex 2002, 12(7):702-709.
8. Anderson S.A., Marin O., Horn C., Jennings K., Rubenstein J.L. Distinct cortical migrations from the medial and lateral ganglionic eminences. Development 2001, 128(3):353-363.
9. Andersson E.K., Irvin D.K., Ahlsio J., Parmar M. Ngn2 and Nurr1 act in synergy to induce midbrain dopaminergic neurons from expanded neural stem and progenitor cells. Experimental Cell Research 2007, 313(6):1172-1180. 10.1016/j.yexcr.2006.12.014.
10. Andersson E., Jensen J.B., Parmar M., Guillemot F., Bjorklund A. Development of the mesencephalic dopaminergic neuron system is compromised in the absence of neurogenin 2. Development 2006, 133(3):507-516. 10.1242/dev.02224.
11. Anthwal N., Pelling M., Claxton S., Mellitzer G., Collin C., Kessaris N., et al. Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity. Disease Models & Mechanisms 2013, 6(5):1133-1145. 10.1242/dmm.011916.
12. Artavanis-Tsakonas S., Rand M.D., Lake R.J. Notch signaling: Cell fate control and signal integration in development. Science 1999, 284(5415):770-776.
13. Avolio F., Pfeifer A., Courtney M., Gjernes E., Ben-Othman N., Vieira A., et al. From pancreas morphogenesis to β-cell regeneration. Current Topics in Developmental Biology 2013, 106:217-238.
14. Axelrod F.B., Chelimsky G.G., Weese-Mayer D.E. Pediatric autonomic disorders. Pediatrics 2006, 118(1):309-321. 10.1542/peds.2005-3032.
15. Ayrault O., Zhao H., Zindy F., Qu C., Sherr C.J., Roussel M.F. Atoh1 inhibits neuronal differentiation and collaborates with Gli1 to generate medulloblastoma-initiating cells. Cancer Research 2010, 70(13):5618-5627. 10.1158/0008-5472.CAN-09-3740.
16. Aziz A., Liu Q.C., Dilworth F.J. Regulating a master regulator: Establishing tissue-specific gene expression in skeletal muscle. Epigenetics 2010, 5(8):691-695. 10.4161/epi.5.8.13045.
17. Battiste J., Helms A.W., Kim E.J., Savage T.K., Lagace D.C., Mandyam C.D., et al. Ascl1 defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord. Development 2007, 134(2):285-293. 10.1242/dev.02727.
18. Ben-Arie N., Bellen H.J., Armstrong D.L., McCall A.E., Gordadze P.R., Guo Q., et al. Math1 is essential for genesis of cerebellar granule neurons. Nature 1997, 390(6656):169-172. 10.1038/36579.
19. Ben-Othman N., Courtney M., Vieira A., Pfeifer A., Druelle N., Gjernes E., et al. From pancreatic islet formation to beta-cell regeneration. Diabetes Res Clin Pract. 2013 Feb 1, pii: S0168-8227(13)00014-4., [Epub ahead of print]. 10.1016/j.diabres.2013.01.013.
20. Bergstrom D.A., Penn B.H., Strand A., Perry R.L., Rudnicki M.A., Tapscott S.J. Promoter-specific regulation of MyoD binding and signal transduction cooperate to pattern gene expression. Molecular Cell 2002, 9(3):587-600.
21. Bermingham N.A., Hassan B.A., Price S.D., Vollrath M.A., Ben-Arie N., Eatock R.A., et al. Math1: An essential gene for the generation of inner ear hair cells. Science 1999, 284(5421):1837-1841.
22. Berninger B., Guillemot F., Gotz M. Directing neurotransmitter identity of neurones derived from expanded adult neural stem cells. The European Journal of Neuroscience 2007, 25(9):2581-2590. EJN5509 [pii]. 10.1111/j.1460-9568.2007.05509.x.
23. Bertrand N., Castro D.S., Guillemot F. Proneural genes and the specification of neural cell types. Nature Reviews. Neuroscience 2002, 3(7):517-530. 10.1038/nrn874.
24. Bielle F., Griveau A., Narboux-Neme N., Vigneau S., Sigrist M., Arber S., et al. Multiple origins of Cajal-Retzius cells at the borders of the developing pallium. Nature Neuroscience 2005, 8(8):1002-1012. nn1511 [pii]. 10.1038/nn1511.
25. Blais A., Tsikitis M., Acosta-Alvear D., Sharan R., Kluger Y., Dynlacht B.D. An initial blueprint for myogenic differentiation. Genes & Development 2005, 19(5):553-569.
26. Borges M., Linnoila R.I., van de Velde H.J., Chen H., Nelkin B.D., Mabry M., et al. An achaete-scute homologue essential for neuroendocrine differentiation in the lung. Nature 1997, 386(6627):852-855. 10.1038/386852a0.
27. Bossuyt W., De Geest N., Aerts S., Leenaerts I., Marynen P., Hassan B.A. The atonal proneural transcription factor links differentiation and tumor formation in Drosophila. PLoS Biology 2009, 7(2):e40. 10.1371/journal.pbio.1000040.
28. Bossuyt W., Kazanjian A., De Geest N., Van Kelst S., De Hertogh G., Geboes K., et al. Atonal homolog 1 is a tumor suppressor gene. PLoS Biology 2009, 7(2):e39. 10.1371/journal.pbio.1000039.
29. Bower R.J., Adkins J.C. Ondine's curse and neurocristopathy. Clinical Pediatrics (Phila) 1980, 19(10):665-668.
30. Bray S., Furriols M. Notch pathway: Making sense of suppressor of hairless. Current Biology 2001, 11(6):R217-R221.
31. Brill M.S., Ninkovic J., Winpenny E., Hodge R.D., Ozen I., Yang R., et al. Adult generation of glutamatergic olfactory bulb interneurons. Nature Neuroscience 2009, 12(12):1524-1533. 10.1038/nn.2416.
32. Britz O., Mattar P., Nguyen L., Langevin L.M., Zimmer C., Alam S., et al. A role for proneural genes in the maturation of cortical progenitor cells. Cerebral Cortex 2006, 16(Suppl. 1):i138-i151. 16/suppl_1/i138 [pii]. 10.1093/cercor/bhj168.
33. Brockschmidt A., Todt U., Ryu S., Hoischen A., Landwehr C., Birnbaum S., et al. Severe mental retardation with breathing abnormalities (Pitt-Hopkins syndrome) is caused by haploinsufficiency of the neuronal bHLH transcription factor TCF4. Human Molecular Genetics 2007, 16(12):1488-1494. 10.1093/hmg/ddm099.
34. Brown N.L., Kanekar S., Vetter M.L., Tucker P.K., Gemza D.L., Glaser T. Math5 encodes a murine basic helix-loop-helix transcription factor expressed during early stages of retinal neurogenesis. Development 1998, 125(23):4821-4833.
35. Brown N.L., Patel S., Brzezinski J., Glaser T. Math5 is required for retinal ganglion cell and optic nerve formation. Development 2001, 128(13):2497-2508.
36. Brzezinski J.A., Brown N.L., Tanikawa A., Bush R.A., Sieving P.A., Vitaterna M.H., et al. Loss of circadian photoentrainment and abnormal retinal electrophysiology in Math5 mutant mice. Investigative Ophthalmology & Visual Science 2005, 46(7):2540-2551. 10.1167/iovs.04-1123.
37. Brzezinski J.A., Prasov L., Glaser T. Math5 defines the ganglion cell competence state in a subpopulation of retinal progenitor cells exiting the cell cycle. Developmental Biology 2012, 365(2):395-413. 10.1016/j.ydbio.2012.03.006.
38. Cabrera C.V., Alonso M.C. Transcriptional activation by heterodimers of the achaete-scute and daughterless gene products of Drosophila. The EMBO Journal 1991, 10(10):2965-2973.
39. Caiazzo M., Dell'Anno M.T., Dvoretskova E., Lazarevic D., Taverna S., Leo D., et al. Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature 2011, 476(7359):224-227. 10.1038/nature10284.
40. Calegari F., Haubensak W., Haffner C., Huttner W.B. Selective lengthening of the cell cycle in the neurogenic subpopulation of neural progenitor cells during mouse brain development. The Journal of Neuroscience 2005, 25(28):6533-6538. 10.1523/JNEUROSCI.0778-05.2005.
41. Calegari F., Huttner W.B. An inhibition of cyclin-dependent kinases that lengthens, but does not arrest, neuroepithelial cell cycle induces premature neurogenesis. Journal of Cell Science 2003, 116(Pt 24):4947-4955. 10.1242/jcs.00825.
42. Campuzano S., Modolell J. Patterning of the Drosophila nervous system: The achaete-scute gene complex. Trends in Genetics 1992, 8(6):202-208.
43. Cao Y., Kumar R.M., Penn B.H., Berkes C.A., Kooperberg C., Boyer L.A., et al. Global and gene-specific analyses show distinct roles for Myod and Myog at a common set of promoters. The EMBO Journal 2006, 25(3):502-511.
44. Casarosa S., Fode C., Guillemot F. Mash1 regulates neurogenesis in the ventral telencephalon. Development 1999, 126(3):525-534.
45. Castro D.S., Martynoga B., Parras C., Ramesh V., Pacary E., Johnston C., et al. A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets. Genes & Development 2011, 25(9):930-945. 25/9/930 [pii]. 10.1101/gad.627811.
46. Castro D.S., Skowronska-Krawczyk D., Armant O., Donaldson I.J., Parras C., Hunt C., et al. Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif. Developmental Cell 2006, 11(6):831-844. S1534-5807(06)00458-8 [pii]. 10.1016/j.devcel.2006.10.006.
47. Cau E., Gradwohl G., Fode C., Guillemot F. Mash1 activates a cascade of bHLH regulators in olfactory neuron progenitors. Development 1997, 124(8):1611-1621.
48. Caviness V.S., Takahashi T., Nowakowski R.S. Numbers, time and neocortical neuronogenesis: A general developmental and evolutionary model. Trends in Neurosciences 1995, 18(9):379-383.
49. Chavali S., Mahajan A., Tabassum R., Dwivedi O.P., Chauhan G., Ghosh S., et al. Association of variants in genes involved in pancreatic beta-cell development and function with type 2 diabetes in North Indians. Journal of Human Genetics 2011, 56(10):695-700.
50. Chien C.T., Hsiao C.D., Jan L.Y., Jan Y.N. Neuronal type information encoded in the basic-helix-loop-helix domain of proneural genes. Proceedings of the National Academy of Sciences of the United States of America 1996, 93(23):13239-13244.
51. Cortina G., Smart C.N., Farmer D.G., Bhuta S., Treem W.R., Hill I.D., et al. Enteroendocrine cell dysgenesis and malabsorption, a histopathologic and immunohistochemical characterization. Human Pathology 2007, 38(4):570-580.
52. Cuschieri A., Bannister L.H. The development of the olfactory mucosa in the mouse: Light microscopy. Journal of Anatomy 1975, 119(Pt 2):277-286.
53. Davis R.L., Turner D.L. Vertebrate hairy and enhancer of split related proteins: Transcriptional repressors regulating cellular differentiation and embryonic patterning. Oncogene 2001, 20(58):8342-8357. 10.1038/sj.onc.1205094.
54. Dehay C., Kennedy H. Cell-cycle control and cortical development. Nature Reviews. Neuroscience 2007, 8(6):438-450. 10.1038/nrn2097.
55. del Bosque-Plata L., Lin J., Horikawa Y., Schwarz P.E., Cox N.J., Iwasaki N., et al. Mutations in the coding region of the neurogenin 3 gene (NEUROG3) are not a common cause of maturity-onset diabetes of the young in Japanese subjects. Diabetes 2001, 50(3):694-696.
56. Demelash A., Rudrabhatla P., Pant H.C., Wang X., Amin N.D., McWhite C.D., et al. Achaete-scute homologue-1 (ASH1) stimulates migration of lung cancer cells through Cdk5/p35 pathway. Molecular Biology of the Cell 2012, 23(15):2856-2866. 10.1091/mbc.E10-12-1010.
57. de Pontual L., Nepote V., Attie-Bitach T., Al Halabiah H., Trang H., Elghouzzi V., et al. Noradrenergic neuronal development is impaired by mutation of the proneural HASH-1 gene in congenital central hypoventilation syndrome (Ondine's curse). Human Molecular Genetics 2003, 12(23):3173-3180. 10.1093/hmg/ddg339.
58. Dixit R., Tachibana N., Touahri Y., Zinyk D., Logan C., Schuurmans C. Gene expression is dynamically regulated in retinal progenitor cells prior to and during overt cellular differentiation. Gene Expression Patterns 2013, 14(1):42-54.
59. Dixit R., Wilkinson G., Li S., Cancino G., Shaker T., Adnani L., et al. Neurog1 and Neurog2 control two waves of neuronal differentiation in the piriform cortex. The Journal of Neuroscience 2014, 34(2):539-553.
60. Dixit R., Zimmer C., Waclaw R.R., Mattar P., Shaker T., Kovach C., et al. Ascl1 participates in Cajal-Retzius cell development in the neocortex. Cerebral Cortex 2011, 21(11):2599-2611. 10.1093/cercor/bhr046.
61. Edghill E.L., Minton J.A., Groves C.J., Flanagan S.E., Patch A.M., Rubio-Cabezas O., et al. Sequencing of candidate genes selected by beta cell experts in monogenic diabetes of unknown aetiology. Journal of the Pancreas 2010, 11(1):14-17.
62. Ellenberger T., Fass D., Arnaud M., Harrison S.C. Crystal structure of transcription factor E47: E-box recognition by a basic region helix-loop-helix dimer. Genes & Development 1994, 8(8):970-980.
63. Englund C., Kowalczyk T., Daza R.A., Dagan A., Lau C., Rose M.F., et al. Unipolar brush cells of the cerebellum are produced in the rhombic lip and migrate through developing white matter. The Journal of Neuroscience 2006, 26(36):9184-9195. 10.1523/JNEUROSCI.1610-06.2006.
64. Feng L., Xie Z.H., Ding Q., Xie X., Libby R.T., Gan L. MATH5 controls the acquisition of multiple retinal cell fates. Molecular Brain 2010, 3:36. 10.1186/1756-6606-3-36.
65. Flora A., Garcia J.J., Thaller C., Zoghbi H.Y. The E-protein Tcf4 interacts with Math1 to regulate differentiation of a specific subset of neuronal progenitors. Proceedings of the National Academy of Sciences of the United States of America 2007, 104(39):15382-15387. 0707456104 [pii]. 10.1073/pnas.0707456104.
66. Flora A., Klisch T.J., Schuster G., Zoghbi H.Y. Deletion of Atoh1 disrupts Sonic Hedgehog signaling in the developing cerebellum and prevents medulloblastoma. Science 2009, 326(5958):1424-1427. 10.1126/science.1181453.
67. Fode C., Gradwohl G., Morin X., Dierich A., LeMeur M., Goridis C., et al. The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons. Neuron 1998, 20(3):483-494.
68. Fode C., Ma Q., Casarosa S., Ang S.L., Anderson D.J., Guillemot F. A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons. Genes & Development 2000, 14(1):67-80.
69. Forrest M.P., Waite A.J., Martin-Rendon E., Blake D.J. Knockdown of human TCF4 affects multiple signaling pathways involved in cell survival, epithelial to mesenchymal transition and neuronal differentiation. PLoS One 2013, 8(8):e73169. 10.1371/journal.pone.0073169.
70. Gabay L., Lowell S., Rubin L.L., Anderson D.J. Deregulation of dorsoventral patterning by FGF confers trilineage differentiation capacity on CNS stem cells in vitro. Neuron 2003, 40(3):485-499. S0896627303006378 [pii].
71. Galichet C., Guillemot F., Parras C.M. Neurogenin 2 has an essential role in development of the dentate gyrus. Development 2008, 135(11):2031-2041. 10.1242/dev.015115.
72. Garcia-Bellido A. Genetic analysis of the achaete-scute system of Drosophila melanogaster. Genetics 1979, 91(3):491-520.
73. Ge W., He F., Kim K.J., Blanchi B., Coskun V., Nguyen L., et al. Coupling of cell migration with neurogenesis by proneural bHLH factors. Proceedings of the National Academy of Sciences of the United States of America 2006, 103(5):1319-1324.
74. Geoffroy C.G., Critchley J.A., Castro D.S., Ramelli S., Barraclough C., Descombes P., et al. Engineering of dominant active basic helix-loop-helix proteins that are resistant to negative regulation by postnatal central nervous system antineurogenic cues. Stem Cells 2009, 27(4):847-856. 10.1002/stem.17.
75. Ghysen A., Dambly-Chaudiere C. From DNA to form: The achaete-scute complex. Genes & Development 1988, 2(5):495-501.
76. Gibson P., Tong Y., Robinson G., Thompson M.C., Currle D.S., Eden C., et al. Subtypes of medulloblastoma have distinct developmental origins. Nature 2010, 468(7327):1095-1099. 10.1038/nature09587.
77. Gilbertson R.J., Ellison D.W. The origins of medulloblastoma subtypes. Annual Review of Pathology 2008, 3:341-365. 10.1146/annurev.pathmechdis.3.121806.151518.
78. Gohlke J.M., Armant O., Parham F.M., Smith M.V., Zimmer C., Castro D.S., et al. Characterization of the proneural gene regulatory network during mouse telencephalon development. BMC Biology 2008, 6:15. 1741-7007-6-15 [pii]. 10.1186/1741-7007-6-15.
79. Golbabapour S., Majid N.A., Hassandarvish P., Hajrezaie M., Abdulla M.A., Hadi A.H. Gene silencing and polycomb group proteins: An overview of their structure, mechanisms and phylogenetics. OMICS 2013, 17(6):283-296. 10.1089/omi.2012.0105.
80. Gonzalez-Quevedo R., Lee Y., Poss K.D., Wilkinson D.G. Neuronal regulation of the spatial patterning of neurogenesis. Developmental Cell 2010, 18(1):136-147. S1534-5807(09)00490-0 [pii]. 10.1016/j.devcel.2009.11.010.
81. Goulding S.E., White N.M., Jarman A.P. cato encodes a basic helix-loop-helix transcription factor implicated in the correct differentiation of Drosophila sense organs. Developmental Biology 2000, 221(1):120-131. 10.1006/dbio.2000.9677.
82. Goulding S.E., zur Lage P., Jarman A.P. amos, a proneural gene for Drosophila olfactory sense organs that is regulated by lozenge. Neuron 2000, 25(1):69-78.
83. Gradwohl G., Dierich A., LeMeur M., Guillemot F. neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proceedings of the National Academy of Sciences of the United States of America 2000, 97(4):1607-1611.
84. Gradwohl G., Fode C., Guillemot F. Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors. Developmental Biology 1996, 180(1):227-241.
85. Grbavec D., Stifani S. Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif. Biochemical and Biophysical Research Communications 1996, 223(3):701-705. 10.1006/bbrc.1996.0959.
86. Grimaldi P., Parras C., Guillemot F., Rossi F., Wassef M. Origins and control of the differentiation of inhibitory interneurons and glia in the cerebellum. Developmental Biology 2009, 328(2):422-433. 10.1016/j.ydbio.2009.02.008.
87. Gu G., Dubauskaite J., Melton D.A. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 2002, 129(10):2447-2457.
88. Guillemot F., Joyner A.L. Dynamic expression of the murine Achaete-Scute homologue Mash-1 in the developing nervous system. Mechanisms of Development 1993, 42(3):171-185.
89. Guillemot F., Lo L.C., Johnson J.E., Auerbach A., Anderson D.J., Joyner A.L. Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons. Cell 1993, 75(3):463-476.
90. Gupta V., Vinay D.G., Sovio U., Rafiq S., Kranthi Kumar M.V., Janipalli C.S., et al. Association study of 25 type 2 diabetes related Loci with measures of obesity in Indian sib pairs. PLoS One 2013, 8(1):e53944.
91. Habener J.F., Kemp D.M., Thomas M.K. Minireview: Transcriptional regulation in pancreatic development. Endocrinology 2005, 146(3):1025-1034. 10.1210/en.2004-1576.
92. Hack M.A., Sugimori M., Lundberg C., Nakafuku M., Gotz M. Regionalization and fate specification in neurospheres: The role of Olig2 and Pax6. Molecular and Cellular Neurosciences 2004, 25(4):664-678. S1044743103003956 [pii]. 10.1016/j.mcn.2003.12.012.
93. Hand R., Bortone D., Mattar P., Nguyen L., Heng J.I., Guerrier S., et al. Phosphorylation of Neurogenin2 specifies the migration properties and the dendritic morphology of pyramidal neurons in the neocortex. Neuron 2005, 48(1):45-62.
94. Hand R., Polleux F. Neurogenin2 regulates the initial axon guidance of cortical pyramidal neurons projecting medially to the corpus callosum. Neural Development 2011, 6:30. 10.1186/1749-8104-6-30.
95. Helms A.W., Gowan K., Abney A., Savage T., Johnson J.E. Overexpression of MATH1 disrupts the coordination of neural differentiation in cerebellum development. Molecular and Cellular Neurosciences 2001, 17(4):671-682. 10.1006/mcne.2000.0969.
96. Heng J.I., Nguyen L., Castro D.S., Zimmer C., Wildner H., Armant O., et al. Neurogenin 2 controls cortical neuron migration through regulation of Rnd2. Nature 2008, 455(7209):114-118. nature07198 [pii]. 10.1038/nature07198.
97. Henke R.M., Meredith D.M., Borromeo M.D., Savage T.K., Johnson J.E. Ascl1 and Neurog2 form novel complexes and regulate Delta-like3 (Dll3) expression in the neural tube. Developmental Biology 2009, 328(2):529-540. 10.1016/j.ydbio.2009.01.007.
98. Hester M.E., Murtha M.J., Song S., Rao M., Miranda C.J., Meyer K., et al. Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes. Molecular Therapy 2011, 19(10):1905-1912. 10.1038/mt.2011.135.
99. Hindley C., Ali F., McDowell G., Cheng K., Jones A., Guillemot F., et al. Post-translational modification of Ngn2 differentially affects transcription of distinct targets to regulate the balance between progenitor maintenance and differentiation. Development 2012, 139(10):1718-1723. 10.1242/dev.077552.
100. Hiroshima K., Iyoda A., Shida T., Shibuya K., Iizasa T., Kishi H., et al. Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: A morphological, immunohistochemical, and molecular analysis. Modern Pathology 2006, 19(10):1358-1368. 10.1038/modpathol.3800659.
101. Hirsch M.R., Tiveron M.C., Guillemot F., Brunet J.F., Goridis C. Control of noradrenergic differentiation and Phox2a expression by MASH1 in the central and peripheral nervous system. Development 1998, 125(4):599-608.
102. Ho B.C., Epping E., Wang K., Andreasen N.C., Librant A., Wassink T.H. Basic helix-loop-helix transcription factor NEUROG1 and schizophrenia: Effects on illness susceptibility, MRI brain morphometry and cognitive abilities. Schizophrenia Research 2008, 106(2-3):192-199. 10.1016/j.schres.2008.08.009.
103. Horton S., Meredith A., Richardson J.A., Johnson J.E. Correct coordination of neuronal differentiation events in ventral forebrain requires the bHLH factor MASH1. Molecular and Cellular Neurosciences 1999, 14(4-5):355-369. S1044-7431(99)90791-1 [pii]. 10.1006/mcne.1999.0791.
104. Hu J.S., Olson E.N., Kingston R.E. HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors. Molecular and Cellular Biology 1992, 12(3):1031-1042.
105. Huang M.L., Hsu C.H., Chien C.T. The proneural gene amos promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system. Neuron 2000, 25(1):57-67.
106. Ide M., Yamada K., Toyota T., Iwayama Y., Ishitsuka Y., Minabe Y., et al. Genetic association analyses of PHOX2B and ASCL1 in neuropsychiatric disorders: Evidence for association of ASCL1 with Parkinson's disease. Human Genetics 2005, 117(6):520-527. 10.1007/s00439-005-1342-8.
107. Imamura O., Satoh Y., Endo S., Takishima K. Analysis of extracellular signal-regulated kinase 2 function in neural stem/progenitor cells via nervous system-specific gene disruption. Stem Cells 2008, 26(12):3247-3256. 2008-0578 [pii]. 10.1634/stemcells.2008-0578.
108. Imayoshi I., Isomura A., Harima Y., Kawaguchi K., Kori H., Miyachi H., et al. Oscillatory control of factors determining multipotency and fate in mouse neural progenitors. Science 2013, 342(6163):1203-1208. 10.1126/science.1242366.
109. Imayoshi I., Shimogori T., Ohtsuka T., Kageyama R. Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline. Development 2008, 135(15):2531-2541. 10.1242/dev.021535.
110. Izumikawa M., Minoda R., Kawamoto K., Abrashkin K.A., Swiderski D.L., Dolan D.F., et al. Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals. Nature Medicine 2005, 11(3):271-276. 10.1038/nm1193.
111. Jarman A.P., Grau Y., Jan L.Y., Jan Y.N. atonal is a proneural gene that directs chordotonal organ formation in the Drosophila peripheral nervous system. Cell 1993, 73(7):1307-1321.
112. Jarman A.P., Grell E.H., Ackerman L., Jan L.Y., Jan Y.N. Atonal is the proneural gene for Drosophila photoreceptors. Nature 1994, 369(6479):398-400. 10.1038/369398a0.
113. Jarman A.P., Sun Y., Jan L.Y., Jan Y.N. Role of the proneural gene, atonal, in formation of Drosophila chordotonal organs and photoreceptors. Development 1995, 121(7):2019-2030.
114. Jenny M., Uhl C., Roche C., Duluc I., Guillermin V., Guillemot F., et al. Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium. The EMBO Journal 2002, 21(23):6338-6347.
115. Jensen J., Heller R.S., Funder-Nielsen T., Pedersen E.E., Lindsell C., Weinmaster G., et al. Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: A role for the notch pathway in repression of premature differentiation. Diabetes 2000, 49(2):163-176.
116. Jeon S.J., Fujioka M., Kim S.C., Edge A.S. Notch signaling alters sensory or neuronal cell fate specification of inner ear stem cells. The Journal of Neuroscience 2011, 31(23):8351-8358. 10.1523/JNEUROSCI.6366-10.2011.
117. Jhaveri D., Sen A., Reddy G.V., Rodrigues V. Sense organ identity in the Drosophila antenna is specified by the expression of the proneural gene atonal. Mechanisms of Development 2000, 99(1-2):101-111.
118. Jiang T., Collins B.J., Jin N., Watkins D.N., Brock M.V., Matsui W., et al. Achaete-scute complex homologue 1 regulates tumor-initiating capacity in human small cell lung cancer. Cancer Research 2009, 69(3):845-854. 10.1158/0008-5472.CAN-08-2762.
119. Jiang S.X., Kameya T., Asamura H., Umezawa A., Sato Y., Shinada J., et al. hASH1 expression is closely correlated with endocrine phenotype and differentiation extent in pulmonary neuroendocrine tumors. Modern Pathology 2004, 17(2):222-229. 10.1038/modpathol.3800038.
120. Johansson K.A., Dursun U., Jordan N., Gu G., Beermann F., Gradwohl G., et al. Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types. Developmental Cell 2007, 12(3):457-465.
121. Johnson J.E., Birren S.J., Anderson D.J. Two rat homologues of Drosophila achaete-scute specifically expressed in neuronal precursors. Nature 1990, 346(6287):858-861. 10.1038/346858a0.
122. Ju B.G., Solum D., Song E.J., Lee K.J., Rose D.W., Glass C.K., et al. Activating the PARP-1 sensor component of the groucho/TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway. Cell 2004, 119(6):815-829. S0092867404010931 [pii]. 10.1016/j.cell.2004.11.017.
123. Kageyama R., Ohtsuka T., Kobayashi T. The Hes gene family: Repressors and oscillators that orchestrate embryogenesis. Development 2007, 134(7):1243-1251. dev.000786 [pii]. 10.1242/dev.000786.
124. Kanadia R.N., Cepko C.L. Alternative splicing produces high levels of noncoding isoforms of bHLH transcription factors during development. Genes & Development 2010, 24(3):229-234. 10.1101/gad.1847110.
125. Kang P., Lee H.K., Glasgow S.M., Finley M., Donti T., Gaber Z.B., et al. Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Neuron 2012, 74(1):79-94. 10.1016/j.neuron.2012.01.024.
126. Kataoka A., Shimogori T. Fgf8 controls regional identity in the developing thalamus. Development 2008, 135(17):2873-2881. 10.1242/dev.021618.
127. Kazanjian A., Noah T., Brown D., Burkart J., Shroyer N.F. Atonal homolog 1 is required for growth and differentiation effects of notch/gamma-secretase inhibitors on normal and cancerous intestinal epithelial cells. Gastroenterology 2010, 139(3):918-928. 928 e911-916. 10.1053/j.gastro.2010.05.081.
128. Kele J., Simplicio N., Ferri A.L., Mira H., Guillemot F., Arenas E., et al. Neurogenin 2 is required for the development of ventral midbrain dopaminergic neurons. Development 2006, 133(3):495-505.
129. Kendler K.S., Myers J.M., O'Neill F.A., Martin R., Murphy B., MacLean C.J., et al. Clinical features of schizophrenia and linkage to chromosomes 5q, 6p, 8p, and 10p in the Irish Study of High-Density Schizophrenia Families. The American Journal of Psychiatry 2000, 157(3):402-408.
130. Kim E.J., Battiste J., Nakagawa Y., Johnson J.E. Ascl1 (Mash1) lineage cells contribute to discrete cell populations in CNS architecture. Molecular and Cellular Neurosciences 2008, 38(4):595-606. 10.1016/j.mcn.2008.05.008.
131. Kim T.H., Shivdasani R.A. Genetic evidence that intestinal Notch functions vary regionally and operate through a common mechanism of Math1 repression. The Journal of Biological Chemistry 2011, 286(13):11427-11433. 10.1074/jbc.M110.188797.
132. Kim S.H., Warram J.H., Krolewski A.S., Doria A. Mutation screening of the neurogenin-3 gene in autosomal dominant diabetes. The Journal of Clinical Endocrinology and Metabolism 2001, 86(5):2320-2322.
133. Kishi Y., Fujii Y., Hirabayashi Y., Gotoh Y. HMGA regulates the global chromatin state and neurogenic potential in neocortical precursor cells. Nature Neuroscience 2012, 10.1038/nn.3165.
134. Kool M., Koster J., Bunt J., Hasselt N.E., Lakeman A., van Sluis P., et al. Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features. PLoS One 2008, 3(8):e3088. 10.1371/journal.pone.0003088.
135. Kovach C., Dixit R., Li S., Mattar P., Wilkinson G., Elsen G.E., et al. Neurog2 simultaneously activates and represses alternative gene expression programs in the developing neocortex. Cerebral Cortex 2013, 23(8):1884-1900. 10.1093/cercor/bhs176.
136. La Rosa S., Marando A., Gatti G., Rapa I., Volante M., Papotti M., et al. Achaete-scute homolog 1 as a marker of poorly differentiated neuroendocrine carcinomas of different sites: A validation study using immunohistochemistry and quantitative real-time polymerase chain reaction on 335 cases. Human Pathology 2013, 44(7):1391-1399. 10.1016/j.humpath.2012.11.013.
137. Lassiter R.N., Stark M.R., Zhao T., Zhou C. Signaling mechanisms controlling cranial placode neurogenesis and delamination. Developmental Biology 2013, 389(1):39-49. 10.1016/j.ydbio.2013.11.025.
138. Le T.T., Wroblewski E., Patel S., Riesenberg A.N., Brown N.L. Math5 is required for both early retinal neuron differentiation and cell cycle progression. Developmental Biology 2006, 295(2):764-778. 10.1016/j.ydbio.2006.03.055.
139. Lee S., Cuvillier J.M., Lee B., Shen R., Lee J.W., Lee S.K. Fusion protein Isl1-Lhx3 specifies motor neuron fate by inducing motor neuron genes and concomitantly suppressing the interneuron programs. Proceedings of the National Academy of Sciences of the United States of America 2012, 109(9):3383-3388. 10.1073/pnas.1114515109.
140. Lee C.S., De Leon D.D., Kaestner K.H., Stoffers D.A. Regeneration of pancreatic islets after partial pancreatectomy in mice does not involve the reactivation of neurogenin-3. Diabetes 2006, 55(2):269-272.
141. Lee S., Lee B., Lee J.W., Lee S.K. Retinoid signaling and neurogenin2 function are coupled for the specification of spinal motor neurons through a chromatin modifier CBP. Neuron 2009, 62(5):641-654. 10.1016/j.neuron.2009.04.025.
142. Lee S.K., Lee B., Ruiz E.C., Pfaff S.L. Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells. Genes & Development 2005, 19(2):282-294. 10.1101/gad.1257105.
143. Lee C.S., Perreault N., Brestelli J.E., Kaestner K.H. Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity. Genes & Development 2002, 16(12):1488-1497.
144. Lee S.K., Pfaff S.L. Synchronization of neurogenesis and motor neuron specification by direct coupling of bHLH and homeodomain transcription factors. Neuron 2003, 38(5):731-745.
145. Leonard J.H., Cook A.L., Van Gele M., Boyle G.M., Inglis K.J., Speleman F., et al. Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma. International Journal Cancer. Journal International du Cancer 2002, 101(2):103-110. 10.1002/ijc.10554.
146. Leow C.C., Romero M.S., Ross S., Polakis P., Gao W.Q. Hath1, down-regulated in colon adenocarcinomas, inhibits proliferation and tumorigenesis of colon cancer cells. Cancer Research 2004, 64(17):6050-6057. 10.1158/0008-5472.CAN-04-0290.
147. Li S., Mattar P., Dixit R., Lawn S.O., Wilkinson G., Kinch C., et al. RAS/ERK signaling functions as a proneural lineage switch in cortical development and gliomagenesis. Journal of Neuroscience 2014, 34(6):2169-2190. 10.1523/JNEUROSCI.4077-13.2014.
148. Li S., Mattar P., Zinyk D., Singh K., Chaturvedi C.P., Kovach C., et al. GSK3 temporally regulates neurogenin 2 proneural activity in the neocortex. The Journal of Neuroscience 2012, 32(23):7791-7805. 10.1523/JNEUROSCI.1309-12.2012.
149. Linnoila R.I., Zhao B., DeMayo J.L., Nelkin B.D., Baylin S.B., DeMayo F.J., et al. Constitutive achaete-scute homologue-1 promotes airway dysplasia and lung neuroendocrine tumors in transgenic mice. Cancer Research 2000, 60(15):4005-4009.
150. Liu X., Li F., Stubblefield E.A., Blanchard B., Richards T.L., Larson G.A., et al. Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells. Cell Research 2012, 22(2):321-332. 10.1038/cr.2011.181.
151. Liu W., Mo Z., Xiang M. The Ath5 proneural genes function upstream of Brn3 POU domain transcription factor genes to promote retinal ganglion cell development. Proceedings of the National Academy of Sciences of the United States of America 2001, 98(4):1649-1654. 10.1073/pnas.98.4.1649.
152. Lluis F., Ballestar E., Suelves M., Esteller M., Munoz-Canoves P. E47 phosphorylation by p38 MAPK promotes MyoD/E47 association and muscle-specific gene transcription. The EMBO Journal 2005, 24(5):974-984.
153. Lo L., Dormand E., Greenwood A., Anderson D.J. Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells. Development 2002, 129(7):1553-1567.
154. Lo L.C., Johnson J.E., Wuenschell C.W., Saito T., Anderson D.J. Mammalian achaete-scute homolog 1 is transiently expressed by spatially restricted subsets of early neuroepithelial and neural crest cells. Genes & Development 1991, 5(9):1524-1537.
155. Long J.E., Cobos I., Potter G.B., Rubenstein J.L. Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways. Cerebral Cortex 2009, 19(Suppl 1):i96-i106. 10.1093/cercor/bhp045.
156. Lukaszewicz A., Savatier P., Cortay V., Kennedy H., Dehay C. Contrasting effects of basic fibroblast growth factor and neurotrophin 3 on cell cycle kinetics of mouse cortical stem cells. The Journal of Neuroscience 2002, 22(15):6610-6622. 20026666 22/15/6610 [pii].
157. Ma Q., Chen Z., del Barco Barrantes I., de la Pompa J.L., Anderson D.J. Neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia. Neuron 1998, 20(3):469-482.
158. Ma Q., Fode C., Guillemot F., Anderson D.J. Neurogenin1 and neurogenin2 control two distinct waves of neurogenesis in developing dorsal root ganglia. Genes & Development 1999, 13(13):1717-1728.
159. Ma Q., Kintner C., Anderson D.J. Identification of neurogenin, a vertebrate neuronal determination gene. Cell 1996, 87(1):43-52.
160. Ma Y.C., Song M.R., Park J.P., Henry Ho H.Y., Hu L., Kurtev M.V., et al. Regulation of motor neuron specification by phosphorylation of neurogenin 2. Neuron 2008, 58(1):65-77. S0896-6273(08)00132-3 [pii]. 10.1016/j.neuron.2008.01.037.
161. Machold R., Fishell G. Math1 is expressed in temporally discrete pools of cerebellar rhombic-lip neural progenitors. Neuron 2005, 48(1):17-24. 10.1016/j.neuron.2005.08.028.
162. Malecki M.T., Jhala U.S., Antonellis A., Fields L., Doria A., Orban T., et al. Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus. Nature Genetics 1999, 23(3):323-328.
163. Mao C.A., Wang S.W., Pan P., Klein W.H. Rewiring the retinal ganglion cell gene regulatory network: Neurod1 promotes retinal ganglion cell fate in the absence of Math5. Development 2008, 135(20):3379-3388. 10.1242/dev.024612.
164. Marro S., Pang Z.P., Yang N., Tsai M.C., Qu K., Chang H.Y., et al. Direct lineage conversion of terminally differentiated hepatocytes to functional neurons. Cell Stem Cell 2011, 9(4):374-382. 10.1016/j.stem.2011.09.002.
165. Mattar P., Britz O., Johannes C., Nieto M., Ma L., Rebeyka A., et al. A screen for downstream effectors of Neurogenin2 in the embryonic neocortex. Developmental Biology 2004, 273(2):373-389. S0012-1606(04)00429-4 [pii]. 10.1016/j.ydbio.2004.06.013.
166. Mattar P., Langevin L.M., Markham K., Klenin N., Shivji S., Zinyk D., et al. Basic helix-loop-helix transcription factors cooperate to specify a cortical projection neuron identity. Molecular and Cellular Biology 2008, 28(5):1456-1469. MCB.01510-07 [pii]. 10.1128/MCB.01510-07.
167. Matter-Sadzinski L., Matter J.M., Ong M.T., Hernandez J., Ballivet M. Specification of neurotransmitter receptor identity in developing retina: The chick ATH5 promoter integrates the positive and negative effects of several bHLH proteins. Development 2001, 128(2):217-231.
168. Matter-Sadzinski L., Puzianowska-Kuznicka M., Hernandez J., Ballivet M., Matter J.M. A bHLH transcriptional network regulating the specification of retinal ganglion cells. Development 2005, 132(17):3907-3921. 10.1242/dev.01960.
169. Mazzoni E.O., Mahony S., Closser M., Morrison C.A., Nedelec S., Williams D.J., et al. Synergistic binding of transcription factors to cell-specific enhancers programs motor neuron identity. Nature Neuroscience 2013, 16(9):1219-1227. 10.1038/nn.3467.
170. McNay D.E., Pelling M., Claxton S., Guillemot F., Ang S.L. Mash1 is required for generic and subtype differentiation of hypothalamic neuroendocrine cells. Molecular Endocrinology 2006, 20(7):1623-1632. 10.1210/me.2005-0518.
171. Mizuguchi R., Kriks S., Cordes R., Gossler A., Ma Q., Goulding M. Ascl1 and Gsh1/2 control inhibitory and excitatory cell fate in spinal sensory interneurons. Nature Neuroscience 2006, 9(6):770-778. 10.1038/nn1706.
172. Mizuguchi R., Sugimori M., Takebayashi H., Kosako H., Nagao M., Yoshida S., et al. Combinatorial roles of olig2 and neurogenin2 in the coordinated induction of pan-neuronal and subtype-specific properties of motoneurons. Neuron 2001, 31(5):757-771.
173. Mu X., Fu X., Sun H., Beremand P.D., Thomas T.L., Klein W.H. A gene network downstream of transcription factor Math5 regulates retinal progenitor cell competence and ganglion cell fate. Developmental Biology 2005, 280(2):467-481. 10.1016/j.ydbio.2005.01.028.
174. Murre C., Bain G., van Dijk M.A., Engel I., Furnari B.A., Massari M.E., et al. Structure and function of helix-loop-helix proteins. Biochimica et Biophysica Acta 1994, 1218(2):129-135.
175. Murre C., McCaw P.S., Vaessin H., Caudy M., Jan L.Y., Jan Y.N., et al. Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell 1989, 58(3):537-544. 0092-8674(89)90434-0 [pii].
176. Naya F.J., Huang H.P., Qiu Y., Mutoh H., DeMayo F.J., Leiter A.B., et al. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes & Development 1997, 11(18):2323-2334.
177. Nieto M., Schuurmans C., Britz O., Guillemot F. Neural bHLH genes control the neuronal versus glial fate decision in cortical progenitors. Neuron 2001, 29(2):401-413. S0896-6273(01)00214-8 [pii].
178. Nocerino V., Colombo C., Bonfanti R., Iafusco D., Barbetti F. Mutations in IAPP and NEUROG3 genes are not a common cause of permanent neonatal/infancy/childhood-onset diabetes. Diabetic Medicine 2009, 26(6):660-661.
179. Northcott P.A., Korshunov A., Witt H., Hielscher T., Eberhart C.G., Mack S., et al. Medulloblastoma comprises four distinct molecular variants. Journal of Clinical Oncology 2011, 29(11):1408-1414. 10.1200/JCO.2009.27.4324.
180. Novitch B.G., Chen A.I., Jessell T.M. Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2. Neuron 2001, 31(5):773-789.
181. Ochiai W., Nakatani S., Takahara T., Kainuma M., Masaoka M., Minobe S., et al. Periventricular notch activation and asymmetric Ngn2 and Tbr2 expression in pair-generated neocortical daughter cells. Molecular and Cellular Neurosciences 2009, 40(2):225-233. S1044-7431(08)00275-3 [pii]. 10.1016/j.mcn.2008.10.007.
182. Onoguchi M., Hirabayashi Y., Koseki H., Gotoh Y. A noncoding RNA regulates the neurogenin1 gene locus during mouse neocortical development. Proceedings of the National Academy of Sciences of the United States of America 2012, 109(42):16939-16944. 10.1073/pnas.1202956109.
183. Osada H., Tatematsu Y., Yatabe Y., Horio Y., Takahashi T. ASH1 gene is a specific therapeutic target for lung cancers with neuroendocrine features. Cancer Research 2005, 65(23):10680-10685. 10.1158/0008-5472.CAN-05-1404.
184. Ozen I., Galichet C., Watts C., Parras C., Guillemot F., Raineteau O. Proliferating neuronal progenitors in the postnatal hippocampus transiently express the proneural gene Ngn2. The European Journal of Neuroscience 2007, 25(9):2591-2603. 10.1111/j.1460-9568.2007.05541.x.
185. Pang Z.P., Yang N., Vierbuchen T., Ostermeier A., Fuentes D.R., Yang T.Q., et al. Induction of human neuronal cells by defined transcription factors. Nature 2011, 476(7359):220-223. 10.1038/nature10202.
186. Park C.H., Kang J.S., Shin Y.H., Chang M.Y., Chung S., Koh H.C., et al. Acquisition of in vitro and in vivo functionality of Nurr1-induced dopamine neurons. The FASEB Journal 2006, 20(14):2553-2555. 10.1096/fj.06-6159fje.
187. Parras C.M., Galli R., Britz O., Soares S., Galichet C., Battiste J., et al. Mash1 specifies neurons and oligodendrocytes in the postnatal brain. The EMBO Journal 2004, 23(22):4495-4505. 7600447 [pii]. 10.1038/sj.emboj.7600447.
188. Parras C.M., Hunt C., Sugimori M., Nakafuku M., Rowitch D., Guillemot F. The proneural gene Mash1 specifies an early population of telencephalic oligodendrocytes. The Journal of Neuroscience 2007, 27(16):4233-4242. 27/16/4233 [pii]. 10.1523/JNEUROSCI.0126-07.2007.
189. Parras C.M., Schuurmans C., Scardigli R., Kim J., Anderson D.J., Guillemot F. Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity. Genes & Development 2002, 16(3):324-338. 10.1101/gad.940902.
190. Pattyn A., Goridis C., Brunet J.F. Specification of the central noradrenergic phenotype by the homeobox gene Phox2b. Molecular and Cellular Neurosciences 2000, 15(3):235-243. 10.1006/mcne.1999.0826.
191. Peignon G., Durand A., Cacheux W., Ayrault O., Terris B., Laurent-Puig P., et al. Complex interplay between beta-catenin signalling and Notch effectors in intestinal tumorigenesis. Gut 2011, 60(2):166-176. 10.1136/gut.2009.204719.
192. Pelling M., Anthwal N., McNay D., Gradwohl G., Leiter A.B., Guillemot F., et al. Differential requirements for neurogenin 3 in the development of POMC and NPY neurons in the hypothalamus. Developmental Biology 2011, 349(2):406-416. 10.1016/j.ydbio.2010.11.007.
193. Penn B.H., Bergstrom D.A., Dilworth F.J., Bengal E., Tapscott S.J. A MyoD-generated feed-forward circuit temporally patterns gene expression during skeletal muscle differentiation. Genes & Development 2004, 18(19):2348-2353.
194. Perez S.E., Rebelo S., Anderson D.J. Early specification of sensory neuron fate revealed by expression and function of neurogenins in the chick embryo. Development 1999, 126(8):1715-1728.
195. Perrin F.E., Boniface G., Serguera C., Lonjon N., Serre A., Prieto M., et al. Grafted human embryonic progenitors expressing neurogenin-2 stimulate axonal sprouting and improve motor recovery after severe spinal cord injury. PLoS One 2010, 5(12):e15914. 10.1371/journal.pone.0015914.
196. Pfisterer U., Kirkeby A., Torper O., Wood J., Nelander J., Dufour A., et al. Direct conversion of human fibroblasts to dopaminergic neurons. Proceedings of the National Academy of Sciences of the United States of America 2011, 108(25):10343-10348. 10.1073/pnas.1105135108.
197. Phillips H.S., Kharbanda S., Chen R., Forrest W.F., Soriano R.H., Wu T.D., et al. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 2006, 9(3):157-173. S1535-6108(06)00056-0 [pii]. 10.1016/j.ccr.2006.02.019.
198. Pinney S.E., Oliver-Krasinski J., Ernst L., Hughes N., Patel P., Stoffers D.A., et al. Neonatal diabetes and congenital malabsorptive diarrhea attributable to a novel mutation in the human neurogenin-3 gene coding sequence. The Journal of Clinical Endocrinology and Metabolism 2011, 96(7):1960-1965.
199. Poitras L., Ghanem N., Hatch G., Ekker M. The proneural determinant MASH1 regulates forebrain Dlx1/2 expression through the I12b intergenic enhancer. Development 2007, 134(9):1755-1765. dev.02845 [pii]. 10.1242/dev.02845.
200. Powell L.M., Jarman A.P. Context dependence of proneural bHLH proteins. Current Opinion in Genetics & Development 2008, 18(5):411-417. S0959-437X(08)00091-9 [pii]. 10.1016/j.gde.2008.07.012.
201. Prasov L., Brown N.L., Glaser T. A critical analysis of Atoh7 (Math5) mRNA splicing in the developing mouse retina. PLoS One 2010, 5(8):e12315. 10.1371/journal.pone.0012315.
202. Prasov L., Glaser T. Pushing the envelope of retinal ganglion cell genesis: Context dependent function of Math5 (Atoh7). Developmental Biology 2012, 368(2):214-230. 10.1016/j.ydbio.2012.05.005.
203. Prasov L., Masud T., Khaliq S., Mehdi S.Q., Abid A., Oliver E.R., et al. ATOH7 mutations cause autosomal recessive persistent hyperplasia of the primary vitreous. Human Molecular Genetics 2012, 21(16):3681-3694. 10.1093/hmg/dds197.
204. Prasov L., Nagy M., Rudolph D.D., Glaser T. Math5 (Atoh7) gene dosage limits retinal ganglion cell genesis. Neuroreport 2012, 23(10):631-634. 10.1097/WNR.0b013e328355f260.
205. Rapa I., Volante M., Migliore C., Farsetti A., Berruti A., Vittorio Scagliotti G., et al. Human ASH-1 promotes neuroendocrine differentiation in androgen deprivation conditions and interferes with androgen responsiveness in prostate cancer cells. Prostate 2013, 73(11):1241-1249. 10.1002/pros.22679.
206. Rheinbay E., Suva M.L., Gillespie S.M., Wakimoto H., Patel A.P., Shahid M., et al. An aberrant transcription factor network essential for Wnt signaling and stem cell maintenance in glioblastoma. Cell Reports 2013, 3(5):1567-1579. 10.1016/j.celrep.2013.04.021.
207. Ribes V., Stutzmann F., Bianchetti L., Guillemot F., Dolle P., Le Roux I. Combinatorial signalling controls Neurogenin2 expression at the onset of spinal neurogenesis. Developmental Biology 2008, 321(2):470-481. 10.1016/j.ydbio.2008.06.003.
208. Rose M.F., Ren J., Ahmad K.A., Chao H.T., Klisch T.J., Flora A., et al. Math1 is essential for the development of hindbrain neurons critical for perinatal breathing. Neuron 2009, 64(3):341-354. 10.1016/j.neuron.2009.10.023.
209. Rousseau A., Nutt C.L., Betensky R.A., Iafrate A.J., Han M., Ligon K.L., et al. Expression of oligodendroglial and astrocytic lineage markers in diffuse gliomas: Use of YKL-40, ApoE, ASCL1, and NKX2-2. Journal of Neuropathology and Experimental Neurology 2006, 65(12):1149-1156. 10.1097/01.jnen.0000248543.90304.2b.
210. Roybon L., Hjalt T., Christophersen N.S., Li J.Y., Brundin P. Effects on differentiation of embryonic ventral midbrain progenitors by Lmx1a, Msx1, Ngn2, and Pitx3. The Journal of Neuroscience 2008, 28(14):3644-3656. 10.1523/JNEUROSCI.0311-08.2008.
211. Rubio-Cabezas O., Jensen J.N., Hodgson M.I., Codner E., Ellard S., Serup P., et al. Permanent neonatal diabetes and enteric anendocrinosis associated with biallelic mutations in NEUROG3. Diabetes 2011, 60(4):1349-1353.
212. Russo L., Iafusco D., Brescianini S., Nocerino V., Bizzarri C., Toni S., et al. Permanent diabetes during the first year of life: Multiple gene screening in 54 patients. Diabetologia 2011, 54(7):1693-1701.
213. Salomoni P., Calegari F. Cell cycle control of mammalian neural stem cells: Putting a speed limit on G1. Trends in Cell Biology 2010, 20(5):233-243. 10.1016/j.tcb.2010.01.006.
214. Salsano E., Pollo B., Eoli M., Giordana M.T., Finocchiaro G. Expression of MATH1, a marker of cerebellar granule cell progenitors, identifies different medulloblastoma sub-types. Neuroscience Letters 2004, 370(2-3):180-185. 10.1016/j.neulet.2004.08.053.
215. Scardigli R., Schuurmans C., Gradwohl G., Guillemot F. Crossregulation between Neurogenin2 and pathways specifying neuronal identity in the spinal cord. Neuron 2001, 31(2):203-217. S0896-6273(01)00358-0 [pii].
216. Schroder J.C., Lassig A.K., Galetzka D., Peters A., Castle J.C., Diederich S., et al. A boy with homozygous microdeletion of NEUROG1 presents with a congenital cranial dysinnervation disorder [Moebius syndrome variant]. Behavioral and Brain Functions 2013, 9:7. 10.1186/1744-9081-9-7.
217. Schuller U., Heine V.M., Mao J., Kho A.T., Dillon A.K., Han Y.G., et al. Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell 2008, 14(2):123-134. 10.1016/j.ccr.2008.07.005.
218. Schuurmans C., Armant O., Nieto M., Stenman J.M., Britz O., Klenin N., et al. Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways. The EMBO Journal 2004, 23(14):2892-2902.
219. Schwab S.G., Eckstein G.N., Hallmayer J., Lerer B., Albus M., Borrmann M., et al. Evidence suggestive of a locus on chromosome 5q31 contributing to susceptibility for schizophrenia in German and Israeli families by multipoint affected sib-pair linkage analysis. Molecular Psychiatry 1997, 2(2):156-160.
220. Schwab S.G., Wildenauer D.B. Genetics of psychiatric disorders in the GWAS era: An update on schizophrenia. European Archives of Psychiatry and Clinical Neuroscience 2013, 263(Suppl. 2):S147-S154. 10.1007/s00406-013-0450-z.
221. Seo S., Lim J.W., Yellajoshyula D., Chang L.W., Kroll K.L. Neurogenin and NeuroD direct transcriptional targets and their regulatory enhancers. The EMBO Journal 2007, 26(24):5093-5108. 7601923 [pii]. 10.1038/sj.emboj.
222. Seo S., Richardson G.A., Kroll K.L. The SWI/SNF chromatin remodeling protein Brg1 is required for vertebrate neurogenesis and mediates transactivation of Ngn and NeuroD. Development 2005, 132(1):105-115.
223. Shaker T., Dennis D., Kurrasch D.M., Schuurmans C. Neurog1 and Neurog2 coordinately regulate development of the olfactory system. Neural Development 2012, 7(1):28. 10.1186/1749-8104-7-28.
224. Shimojo H., Ohtsuka T., Kageyama R. Oscillations in notch signaling regulate maintenance of neural progenitors. Neuron 2008, 58(1):52-64. S0896-6273(08)00166-9 [pii]. 10.1016/j.neuron.2008.02.014.
225. Shroyer N.F., Helmrath M.A., Wang V.Y., Antalffy B., Henning S.J., Zoghbi H.Y. Intestine-specific ablation of mouse atonal homolog 1 (Math1) reveals a role in cellular homeostasis. Gastroenterology 2007, 132(7):2478-2488. 10.1053/j.gastro.2007.03.047.
226. Shroyer N.F., Wallis D., Venken K.J., Bellen H.J., Zoghbi H.Y. Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation. Genes & Development 2005, 19(20):2412-2417. 10.1101/gad.1353905.
227. Skeath J.B., Carroll S.B. The achaete-scute complex: Generation of cellular pattern and fate within the Drosophila nervous system. The FASEB Journal 1994, 8(10):714-721.
228. Skipper M., Lewis J. Getting to the guts of enteroendocrine differentiation. Nature Genetics 2000, 24(1):3-4.
229. Skol A.D., Young K.A., Tsuang D.W., Faraone S.V., Haverstock S.L., Bingham S., et al. Modest evidence for linkage and possible confirmation of association between NOTCH4 and schizophrenia in a large Veterans Affairs Cooperative Study sample. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 2003, 118B(1):8-15. 10.1002/ajmg.b.10055.
230. Skowronska-Krawczyk D., Ballivet M., Dynlacht B.D., Matter J.M. Highly specific interactions between bHLH transcription factors and chromatin during retina development. Development 2004, 131(18):4447-4454.
231. Skowronska-Krawczyk D., Chiodini F., Ebeling M., Alliod C., Kundzewicz A., Castro D., et al. Conserved regulatory sequences in Atoh7 mediate non-conserved regulatory responses in retina ontogenesis. Development 2009, 136(22):3767-3777. 10.1242/dev.033449.
232. Somasundaram K., Reddy S.P., Vinnakota K., Britto R., Subbarayan M., Nambiar S., et al. Upregulation of ASCL1 and inhibition of Notch signaling pathway characterize progressive astrocytoma. Oncogene 2005, 24(47):7073-7083. 10.1038/sj.onc.1208865.
233. Sommer L., Ma Q., Anderson D.J. Neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS. Molecular and Cellular Neurosciences 1996, 8(4):221-241.
234. Soosaar A., Chiaramello A., Zuber M.X., Neuman T. Expression of basic-helix-loop-helix transcription factor ME2 during brain development and in the regions of neuronal plasticity in the adult brain. Brain Research. Molecular Brain Research 1994, 25(1-2):176-180.
235. Stolt C.C., Lommes P., Sock E., Chaboissier M.C., Schedl A., Wegner M. The Sox9 transcription factor determines glial fate choice in the developing spinal cord. Genes & Development 2003, 17(13):1677-1689. 10.1101/gad.259003.
236. Sugimori M., Nagao M., Parras C.M., Nakatani H., Lebel M., Guillemot F., et al. Ascl1 is required for oligodendrocyte development in the spinal cord. Development 2008, 135(7):1271-1281. dev.015370 [pii]. 10.1242/dev.015370.
237. Sun Y., Nadal-Vicens M., Misono S., Lin M.Z., Zubiaga A., Hua X., et al. Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms. Cell 2001, 104(3):365-376.
238. Tamamaki N., Fujimori K.E., Takauji R. Origin and route of tangentially migrating neurons in the developing neocortical intermediate zone. The Journal of Neuroscience 1997, 17(21):8313-8323.
239. Tapscott S.J. The circuitry of a master switch: Myod and the regulation of skeletal muscle gene transcription. Development 2005, 132(12):2685-2695.
240. Taylor M.D., Northcott P.A., Korshunov A., Remke M., Cho Y.J., Clifford S.C., et al. Molecular subgroups of medulloblastoma: The current consensus. Acta Neuropathologica 2012, 123(4):465-472. 10.1007/s00401-011-0922-z.
241. Theka I., Caiazzo M., Dvoretskova E., Leo D., Ungaro F., Curreli S., et al. Rapid generation of functional dopaminergic neurons from human induced pluripotent stem cells through a single-step procedure using cell lineage transcription factors. Stem Cells Translational Medicine 2013, 2(6):473-479. 10.5966/sctm.2012-0133.
242. Tomita K., Moriyoshi K., Nakanishi S., Guillemot F., Kageyama R. Mammalian achaete-scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system. The EMBO Journal 2000, 19(20):5460-5472.
243. Turner D.L., Cepko C.L. A common progenitor for neurons and glia persists in rat retina late in development. Nature 1987, 328(6126):131-136.
244. Ueno T., Ito J., Hoshikawa S., Ohori Y., Fujiwara S., Yamamoto S., et al. The identification of transcriptional targets of Ascl1 in oligodendrocyte development. Glia 2012, 60(10):1495-1505. 10.1002/glia.22369.
245. VanDussen K.L., Samuelson L.C. Mouse atonal homolog 1 directs intestinal progenitors to secretory cell rather than absorptive cell fate. Developmental Biology 2010, 346(2):215-223. 10.1016/j.ydbio.2010.07.026.
246. Van Hoof D., D'Amour K.A., German M.S. Derivation of insulin-producing cells from human embryonic stem cells. Stem Cell Research 2009, 3:73-87.
247. Vierbuchen T., Ostermeier A., Pang Z.P., Kokubu Y., Sudhof T.C., Wernig M. Direct conversion of fibroblasts to functional neurons by defined factors. Nature 2010, 463(7284):1035-1041. 10.1038/nature08797.
248. Villares R., Cabrera C.V. The achaete-scute gene complex of D. melanogaster: Conserved domains in a subset of genes required for neurogenesis and their homology to myc. Cell 1987, 50(3):415-424.
249. Wallace V.A. Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum. Current Biology 1999, 9(8):445-448.
250. Wang J., Cortina G., Wu S.V., Tran R., Cho J.H., Tsai M.J., et al. Mutant neurogenin-3 in congenital malabsorptive diarrhea. The New England Journal of Medicine 2006, 355(3):270-280.
251. Wang X.Y., Dakir el H., Naizhen X., Jensen-Taubman S.M., DeMayo F.J., Linnoila R.I. Achaete-scute homolog-1 linked to remodeling and preneoplasia of pulmonary epithelium. Laboratory Investigation 2007, 87(6):527-539. 10.1038/labinvest.3700552.
252. Wang S., Jensen J.N., Seymour P.A., Hsu W., Dor Y., Sander M., et al. Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proceedings of the National Academy of Sciences of the United States of America 2009, 106(24):9715-9720.
253. Wang X.Y., Jensen-Taubman S.M., Keefe K.M., Yang D., Linnoila R.I. Achaete-scute complex homolog-1 promotes DNA repair in the lung carcinogenesis through matrix metalloproteinase-7 and O(6)-methylguanine-DNA methyltransferase. PLoS One 2012, 7(12):e52832. 10.1371/journal.pone.0052832.
254. Wang S.W., Kim B.S., Ding K., Wang H., Sun D., Johnson R.L., et al. Requirement for math5 in the development of retinal ganglion cells. Genes & Development 2001, 15(1):24-29.
255. Wang V.Y., Rose M.F., Zoghbi H.Y. Math1 expression redefines the rhombic lip derivatives and reveals novel lineages within the brainstem and cerebellum. Neuron 2005, 48(1):31-43. 10.1016/j.neuron.2005.08.024.
256. Wapinski O.L., Vierbuchen T., Qu K., Lee Q.Y., Chanda S., Fuentes D.R., et al. Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons. Cell 2013, 155(3):621-635. 10.1016/j.cell.2013.09.028.
257. Wawersik S., Purcell P., Maas R.L. Pax6 and the genetic control of early eye development. Results and Problems in Cell Differentiation 2000, 31:15-36.
258. Wechsler-Reya R.J., Scott M.P. Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron 1999, 22(1):103-114.
259. Wee R., Castrucci A.M., Provencio I., Gan L., Van Gelder R.N. Loss of photic entrainment and altered free-running circadian rhythms in math5-/- mice. The Journal of Neuroscience 2002, 22(23):10427-10433.
260. Weese-Mayer D.E., Berry-Kravis E.M., Zhou L., Maher B.S., Silvestri J.M., Curran M.E., et al. Idiopathic congenital central hypoventilation syndrome: Analysis of genes pertinent to early autonomic nervous system embryologic development and identification of mutations in PHOX2b. American Journal of Medical Genetics. Part A 2003, 123A(3):267-278. 10.1002/ajmg.a.20527.
261. Wetts R., Serbedzija G.N., Fraser S.E. Cell lineage analysis reveals multipotent precursors in the ciliary margin of the frog retina. Developmental Biology 1989, 136(1):254-263.
262. Wildner H., Das Gupta R., Brohl D., Heppenstall P.A., Zeilhofer H.U., Birchmeier C. Genome-wide expression analysis of Ptf1a- and Ascl1-deficient mice reveals new markers for distinct dorsal horn interneuron populations contributing to nociceptive reflex plasticity. The Journal of Neuroscience 2013, 33(17):7299-7307. 10.1523/JNEUROSCI.0491-13.2013.
263. Wildner H., Muller T., Cho S.H., Brohl D., Cepko C.L., Guillemot F., et al. dILA neurons in the dorsal spinal cord are the product of terminal and non-terminal asymmetric progenitor cell divisions, and require Mash1 for their development. Development 2006, 133(11):2105-2113. 10.1242/dev.02345.
264. Wilkinson G., Dennis D., Schuurmans C. Proneural genes in neocortical development. Neuroscience 2013, 253:256-273. 10.1016/j.neuroscience.2013.08.029.
265. Winpenny E., Lebel-Potter M., Fernandez M.E., Brill M.S., Gotz M., Guillemot F., et al. Sequential generation of olfactory bulb glutamatergic neurons by Neurog2-expressing precursor cells. Neural Development 2011, 6:12. 10.1186/1749-8104-6-12.
266. Xu X., D'Hoker J., Stange G., Bonne S., De Leu N., Xiao X., et al. Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell 2008, 132(2):197-207.
267. Yang Q., Bermingham N.A., Finegold M.J., Zoghbi H.Y. Requirement of Math1 for secretory cell lineage commitment in the mouse intestine. Science 2001, 294(5549):2155-2158. 10.1126/science.1065718.
268. Yang Z.J., Ellis T., Markant S.L., Read T.A., Kessler J.D., Bourboulas M., et al. Medulloblastoma can be initiated by deletion of patched in lineage-restricted progenitors or stem cells. Cancer Cell 2008, 14(2):135-145. 10.1016/j.ccr.2008.07.003.
269. Yao J., Sun X., Wang Y., Xu G., Qian J. Math5 promotes retinal ganglion cell expression patterns in retinal progenitor cells. Molecular Vision 2007, 13:1066-1072.
270. Yokoi N., Kanamori M., Horikawa Y., Takeda J., Sanke T., Furuta H., et al. Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects. Diabetes 2006, 55(8):2379-2386.
271. Yoo A.S., Sun A.X., Li L., Shcheglovitov A., Portmann T., Li Y., et al. MicroRNA-mediated conversion of human fibroblasts to neurons. Nature 2011, 476(7359):228-231. 10.1038/nature10323.
272. Zaharieva I., Georgieva L., Nikolov I., Kirov G., Owen M.J., O'Donovan M.C., et al. Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping. BMC Psychiatry 2008, 8:11. 10.1186/1471-244X-8-11.
273. Zhao J., He H., Zhou K., Ren Y., Shi Z., Wu Z., et al. Neuronal transcription factors induce conversion of human glioma cells to neurons and inhibit tumorigenesis. PLoS One 2012, 7(7):e41506. 10.1371/journal.pone.0041506.