Math5 (Atoh7) gene dosage limits retinal ganglion cell genesis

NeuroReport

Volumn 23, Issue 10, 2012, Pages 631-634

  Prasov, Lev ^a   Nagy, Melinda ^a   Rudolph, Dellaney D ^a   Glaser, Tom ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

apoptosis; Atoh7; culling; genome wide association studies; glaucoma; Math5; neurogenesis; optic disc area; optic nerve; retinal ganglion cell

Indexed keywords

BASIC HELIX LOOL HELIX TRANSCRIPTION FACTOR MATH5; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL MATURATION; CONTROLLED STUDY; GENE DOSAGE; MOUSE; NERVE CELL; NERVE FIBER; NONHUMAN; OPTIC DISK; OPTIC NERVE; PRIORITY JOURNAL; RETINA GANGLION CELL; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; GENE DOSAGE; MICE; MICE, 129 STRAIN; MICE, CONGENIC; MICE, INBRED C57BL; NERVE TISSUE PROTEINS; NEUROGENESIS; RETINAL GANGLION CELLS;

EID: 84862178710     PISSN: 09594965     EISSN: 1473558X     Source Type: Journal    
DOI: 10.1097/WNR.0b013e328355f260     Document Type: Article

References (25)

1. Williams RW, Strom RC, Rice DS, Goldowitz D. Genetic and environmental control of variation in retinal ganglion cell number in mice. J Neurosci 1996; 16:7193-7205.
2. Strom RC,Williams RW. Cell production and cell death in the generation of variation in neuron number. J Neurosci 1998; 18:9948-9953.
3. Macgregor S, Hewitt AW, Hysi PG, Ruddle JB, Medland SE, Henders AK, et al. Genome-wide association identifies ATOH7 as a major gene determining human optic disc size. Hum Mol Genet 2010; 19:2716-2724.
4. Ramdas WD, van Koolwijk LM, Ikram MK, Jansonius NM, de Jong PT, Bergen AA, et al. A genome-wide association study of optic disc parameters. PLoS Genet 2010; 6:e1000978.
5. Khor CC, Ramdas WD, Vithana EN, Cornes BK, Sim X, Tay WT, et al. Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area. Hum Mol Genet 2011; 20:1864-1872.
6. Drager UC. Birth dates of retinal ganglion cells giving rise to the crossed and uncrossed optic projections in the mouse. Proc R Soc Lond B Biol Sci 1985; 224:57-77.
7. Young RW. Cell differentiation in the retina of the mouse. Anat Rec 1985; 212:199-205.
8. Provis JM, van Driel D, Billson FA, Russell P. Human fetal optic nerve: Overproduction and elimination of retinal axons during development. J Comp Neurol 1985; 238:92-100.
9. Farah MH, Easter SS Jr. Cell birth and death in the mouse retinal ganglion cell layer. J Comp Neurol 2005; 489:120-134.
10. O'Leary DD, Fawcett JW, Cowan WM. Topographic targeting errors in the retinocollicular projection and their elimination by selective ganglion cell death. J Neurosci 1986; 6:3692-3705.
11. Young RW. Cell death during differentiation of the retina in the mouse. J Comp Neurol 1984; 229:362-373.
12. Brown NL, Kanekar S, Vetter ML, Tucker PK, Gemza DL, Glaser T. Math5 encodes a murine basic helix-loop-helix transcription factor expressed during early stages of retinal neurogenesis. Development 1998; 125: 4821-4833.
13. Brown NL, Patel S, Brzezinski J, Glaser T. Math5 is required for retinal ganglion cell and optic nerve formation. Development 2001; 128:2497-2508.
14. Wang SW, Kim BS, Ding K,Wang H, Sun D, Johnson RL, et al. Requirement for math5 in the development of retinal ganglion cells. Genes Dev 2001; 15:24-29.
15. Ghiasvand NM, Rudolph DD, Mashayekhi M, Brzezinski JA, Goldman D, Glaser T. Deletion of a remote enhancer near ATOH7 disrupts retinal neurogenesis, causing NCRNA disease. Nat Neurosci 2011; 14:578-586.
16. Khan K, Logan CV, McKibbin M, Sheridan E, Elcioglu NH, Yenice O, et al. Next generation sequencing identifies mutations in Atonal homolog 7 (ATOH7) in families with global eye developmental defects. Hum Mol Genet 2011; 21:776-783.
17. Prasov L, Masud T, Khaliq S, Mehdi SQ, Abid A, Oliver ER, et al. ATOH7 mutations cause autosomal recessive persistent hyperplasia of the primary vitreous. Hum Mol Genet 2012; (In press).
18. Chen JH,Wang D, Huang C, Zheng Y, Chen H, Pang CP, et al. Interactive effects of ATOH7 and RFTN1 in association with adult-onset primary open angle glaucoma. Invest Ophthalmol Vis Sci 2012; 53:779-785.
19. Fan BJ, Wang DY, Pasquale LR, Haines JL, Wiggs JL. Genetic variants associated with optic nerve vertical cup-to-disc ratio are risk factors for primary open angle glaucoma in a US Caucasian population. Invest Ophthalmol Vis Sci 2011; 52:1788-1792.
20. Brzezinski JA, Prasov L, Glaser T. Math5 defines the ganglion cell competence state in a subpopulation of retinal progenitor cells exiting the cell cycle. Dev Biol 2012; 365:395-413.
21. Lin B,Wang SW, Masland RH. Retinal ganglion cell type, size, and spacing can be specified independent of homotypic dendritic contacts. Neuron 2004; 43:475-485.
22. Williams RW, Strom RC, Goldowitz D. Natural variation in neuron number in mice is linked to a major quantitative trait locus on Chr 11. J Neurosci 1998; 18:138-146.
23. Prasov L, Glaser T. Pushing the envelope of ganglion cell fate: Context dependent function of Math5 (Atoh7). Dev Biol 2012. DOI:10.1016/j.ydbio.2012.05. 005.
24. Harwerth RS, Quigley HA. Visual field defects and retinal ganglion cell losses in patients with glaucoma. Arch Ophthalmol 2006; 124:853-859.
25. Cecconi F, Alvarez-Bolado G, Meyer BI, Roth KA, Gruss P. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell 1998; 94:727-737.