Combinatorial roles of Olig2 and Neurogenin2 in the coordinated induction of pan-neuronal and subtype-specific properties of motoneurons

Neuron

Volumn 31, Issue 5, 2001, Pages 757-771

  Mizuguchi, Rumiko ^a   Sugimori, Michiya ^a   Takebayashi, Hirohide ^b   Kosako, Hidetaka ^a   Nagao, Motoshi ^a   Yoshida, Shosei ^b   Nabeshima, Yo Ichi ^b   Shimamura, Kenji ^a   Nakafuku, Masato ^a,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HELIX LOOP HELIX PROTEIN; HOMEODOMAIN PROTEIN; OLIGODENDROCYTE TRANSCRIPTION FACTOR 2; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NEUROGENIN2; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL SPECIFICITY; CELL TYPE; CHICK EMBRYO; CONTROLLED STUDY; EMBRYO; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NEURAL TUBE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; RAT; REGULATORY MECHANISM; SPINAL CORD MOTONEURON; STEM CELL; VENTRAL ROOT;

EID: 0035855786     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(01)00413-5     Document Type: Article

References (58)

1. The determination of the neuronal phenotype
2. Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity
3. The activity of neurogenin1 is controlled by local cues in the zebrafish embryo
4. Specification of neuronal fates in the ventral neural tube
5. Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling
6. A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube
7. PAX2 is expressed in multiple spinal cord interneurons, including a population of EN1+ interneurons that require PAX6 for their development
8. Neuronal type information encoded in the basic-helix-loop-helix domain of proneural genes
9. The phox2b transcription factor coordinately regulates neuronal cell cycle exit and identity
10. Progression from extrinsic to intrinsic signaling in cell fate specification: A view from the nervous system
11. Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling
12. A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons
13. Vertebrate bHLH genes and the determination of neuronal fates
14. Doing the MATH: Is the mouse a good model for fly development?
15. Roles of homeobox and bHLH genes in specification of a retinal cell type
16. Progenitors of dorsal commissural interneurons are defined by MATH1 expression
17. The specificity of proneural genes in determining Drosophila sense organ identity
18. Neuronal specification in the spinal cord: Inductive signals and transcriptional codes
19. Migratory paths of neurons and glia in the embryonic chick spinal cord
20. The basic helix-loop-helix protein family: Comparative genomics and phylogenetic analysis
21. Mammalian achaete-scute homolog 1 is transiently expressed by spatially restricted subsets of early neuroepithelial and neural crest cells
22. MASH1 maintains competence for BMP2-induced neuronal differentiation in post-migratory neural crest cells
23. Specification of neurotransmitter identity by Phox2 proteins in neural crest stem cells
24. Sonic hedgehog-regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system
25. Identification of neurogenin, a vertebrate neuronal determination gene
26. Pax3 and Pax7 are expressed in commissural neurons and restrict ventral neuronal identity in the spinal cord
27. Pax6 defines the di-mesencephalic boundary by repressing En1 and Pax2
28. Evx1 is a postmitotic determinant of V0 interneuron identity in the spinal cord
29. Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube
30. Neural bHLH genes control the neuronal versus glial fate decision in cortical progenitors
31. Pax-6 is involved in the specification of hindbrain motor neuron subtype
32. Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis
33. Control of hindbrain motor neuron differentiation by the homeobox gene Phox2b
34. Early specification of sensory neuron fate revealed by expression and function of neurogenins in the chick embryo
35. X-ngnr-1 and Xath3 promote ectopic expression of sensory neuron markers in the neurula ectoderm and have distinct inducing properties in the retina
36. Determination of neuroepithelial cell fate: Induction of the oligodendrocyte lineage by ventral midline cells and sonic hedgehog
37. Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS development
38. Oligodendrocyte lineage and the motor neuron connection
39. Ventral neural patterning by Nkx homeobox genes: Nkx6.1 controls somatic motor neuron and ventral interneuron fates
40. Cross regulation between Neurogenin2 and pathways specifying progenitor identity in the spinal cord
41. Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system
42. LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons
43. Inductive interactions direct early regionalization of the mouse forebrain
44. Neurogenin2 expression in ventral and dorsal spinal neural tube progenitor cells is regulated by distinct enhancers
45. Neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS
46. The Phox2 homeodomain proteins are sufficient to promote the development of sympathetic neurons
47. Pax6 modulates the dorsoventral patterning of the mammalian telencephalon
48. Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms
49. Dynamic expression of basic helix-loop-helix Olig family members: Implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3
50. Specification of motor neuron identity by the MNR2 homeodomain protein
51. Developmental changes in unique cell surface antigens of chick embryo spinal motoneurons and ganglion cells
52. Active suppression of interneuron programs within developing motor neurons revealed by analysis of homeodomain factor HB9
53. Transcription factors Mash-1 and Prox-1 delineate early steps in differentiation of neural stem cells in the developing central nervous system
54. Inhibition of floor plate differentiation by Pax3: Evidence from ectopic expression in transgenic mice
55. Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes
56. Differential expression of LIM homeobox genes among motor neuron subpopulations in the developing chick brain stem
57. Drosophila atonal controls photoreceptor R8-specific properties and modulates both receptor tyrosine kinase and Hedgehog signalling
58. Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors