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Volumn 3, Issue 7, 2002, Pages 517-530

Proneural genes and the specification of neural cell types

Author keywords

[No Author keywords available]

Indexed keywords

HELIX LOOP HELIX PROTEIN; TRANSCRIPTION FACTOR;

EID: 0036631456     PISSN: 14710048     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrn874     Document Type: Review
Times cited : (1228)

References (158)
  • 1
    • 0024007762 scopus 로고
    • From DNA to form: The achaete-scute complex
    • Ghysen, A. & Dambly-Chaudiere, C. From DNA to form: the achaete-scute complex. Genes Dev. 2, 495-501 (1988).
    • (1988) Genes Dev. , vol.2 , pp. 495-501
    • Ghysen, A.1    Dambly-Chaudiere, C.2
  • 2
    • 0018414898 scopus 로고
    • Genetic analysis of the achaete-scute system of Drosophila melanogaster
    • Garcia-Bellido, A. Genetic analysis of the achaete-scute system of Drosophila melanogaster. Genetics 91, 491-520 (1979).
    • (1979) Genetics , vol.91 , pp. 491-520
    • Garcia-Bellido, A.1
  • 3
    • 0024797651 scopus 로고
    • Molecular analysis of the asense gene, a member of the achaete-scute complex of Drosophila melanogaster, and its novel role in optic lobe development
    • Gonzalez, F. et al. Molecular analysis of the asense gene, a member of the achaete-scute complex of Drosophila melanogaster, and its novel role in optic lobe development. EMBO J. 8, 3553-3562 (1989).
    • (1989) EMBO J. , vol.8 , pp. 3553-3562
    • Gonzalez, F.1
  • 4
    • 0023669153 scopus 로고
    • The achaete-scute gene complex of D. melanogaster: Conserved domains in a subset of genes required for neurogenesis and their homology to myc
    • Villares, R. & Cabrera, C. V. The achaete-scute gene complex of D. melanogaster: conserved domains in a subset of genes required for neurogenesis and their homology to myc. Cell 50, 415-424 (1987). This paper was the first to report the molecular characterization of asc genes and to show that they share a domain that later became known as a bHLH domain.
    • (1987) Cell , vol.50 , pp. 415-424
    • Villares, R.1    Cabrera, C.V.2
  • 5
    • 0024378079 scopus 로고
    • Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence
    • Murre, C. et al. Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell 58, 537-544 (1989).
    • (1989) Cell , vol.58 , pp. 537-544
    • Murre, C.1
  • 6
    • 0024554495 scopus 로고
    • A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins
    • Murre, C., McCaw, P. S. & Baltimore, D. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell 56, 777-783 (1989). The bHLH class of transcription factors was first defined in this article. The properties of DNA binding and heterodimerization of bHLH domains were also first characterized here and in reference 5.
    • (1989) Cell , vol.56 , pp. 777-783
    • Murre, C.1    McCaw, P.S.2    Baltimore, D.3
  • 7
    • 0027233365 scopus 로고
    • Atonal is a proneural gene that directs chordotonal organ formation in the Drosophila peripheral nervous system
    • Jarman, A. P. et al. atonal is a proneural gene that directs chordotonal organ formation in the Drosophila peripheral nervous system. Cell 73, 1307-1321 (1993). This paper reports the isolation of the first known Drosophila proneural gene outside the asc complex, ato, and shows that asc and ato encode neuronal-subtype information.
    • (1993) Cell , vol.73 , pp. 1307-1321
    • Jarman, A.P.1
  • 8
    • 0034193571 scopus 로고    scopus 로고
    • Cato encodes a basic helix-lcop-helix transcription factor implicated in the correct differentiation of Drosophila sense organs
    • Goulding, S. E., White, N. M. & Jarman, A. P. cato encodes a basic helix-lcop-helix transcription factor implicated in the correct differentiation of Drosophila sense organs. Dev. Biol. 221, 120-131 (2000).
    • (2000) Dev. Biol. , vol.221 , pp. 120-131
    • Goulding, S.E.1    White, N.M.2    Jarman, A.P.3
  • 9
    • 0034023140 scopus 로고    scopus 로고
    • Amos, a proneural gene for Drosophila olfactory sense organs that is regulated by lozenge
    • Goulding, S. E., zur Lage, P. & Jarman, A.P. amos, a proneural gene for Drosophila olfactory sense organs that is regulated by lozenge. Neuron 25, 69-78 (2000).
    • (2000) Neuron , vol.25 , pp. 69-78
    • Goulding, S.E.1    Zur Lage, P.2    Jarman, A.P.3
  • 10
    • 0034026869 scopus 로고    scopus 로고
    • The proneural gene amos promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system
    • Huang, M. L., Hsu, C. H. & Chien, C. T. The proneural gene amos promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system. Neuron 25, 57-67 (2000).
    • (2000) Neuron , vol.25 , pp. 57-67
    • Huang, M.L.1    Hsu, C.H.2    Chien, C.T.3
  • 11
    • 0026694036 scopus 로고
    • Patterning of the Drosophila nervous system: The achaete-scute gene complex
    • Campuzano, S. & Modolell, J. Patterning of the Drosophila nervous system: the achaete-scute gene complex. Trends Genet 8, 202-208 (1992).
    • (1992) Trends Genet , vol.8 , pp. 202-208
    • Campuzano, S.1    Modolell, J.2
  • 12
    • 0028557131 scopus 로고
    • Genetic control of cell fate specification in Drosophila peripheral nervous system
    • Jan, Y. N. & Jan, L. Y. Genetic control of cell fate specification in Drosophila peripheral nervous system. Annu. Rev. Genet. 28, 373-393 (1994).
    • (1994) Annu. Rev. Genet. , vol.28 , pp. 373-393
    • Jan, Y.N.1    Jan, L.Y.2
  • 13
    • 0027274927 scopus 로고
    • Neural fate specification in Drosophila
    • Jimenez, F. & Modolell, J. Neural fate specification in Drosophila. Curr. Opin. Genet. Dev. 3, 626-632 (1993).
    • (1993) Curr. Opin. Genet. Dev. , vol.3 , pp. 626-632
    • Jimenez, F.1    Modolell, J.2
  • 14
    • 0033617522 scopus 로고    scopus 로고
    • Notch signaling: Cell fate control and signal integration in development
    • Artavanis-Tsakonas, S., Rand, M. D. & Lake, R. J. Notch signaling: cell fate control and signal integration in development. Science 284, 770-776 (1999).
    • (1999) Science , vol.284 , pp. 770-776
    • Artavanis-Tsakonas, S.1    Rand, M.D.2    Lake, R.J.3
  • 15
    • 0025348621 scopus 로고
    • Defective neuroblast commitment in mutants of the achaete-scute complex and adjacent genes of D. melanogaster
    • Jimenez, F. & Campos-Ortega, J. A. Defective neuroblast commitment in mutants of the achaete-scute complex and adjacent genes of D. melanogaster. Neuron 5, 81-89 (1990).
    • (1990) Neuron , vol.5 , pp. 81-89
    • Jimenez, F.1    Campos-Ortega, J.A.2
  • 16
    • 0034641745 scopus 로고    scopus 로고
    • A genomewide survey of basic helix-loop-helix factors in Drosophila
    • Moore, A.W. et al. A genomewide survey of basic helix-loop-helix factors in Drosophila. Proc. Natl Acad. Sci. USA 97, 10436-10441 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 10436-10441
    • Moore, A.W.1
  • 17
    • 0034967571 scopus 로고    scopus 로고
    • New members of the Drosophila Myc transcription factor subfamily revealed by a genome-wide examination for basic helix-loop-helix genes
    • Peyrefitte, S., Kahn, D. & Haenlin, M. New members of the Drosophila Myc transcription factor subfamily revealed by a genome-wide examination for basic helix-loop-helix genes. Mech. Dev. 104, 99-104 (2001).
    • (2001) Mech. Dev. , vol.104 , pp. 99-104
    • Peyrefitte, S.1    Kahn, D.2    Haenlin, M.3
  • 18
    • 0031045152 scopus 로고    scopus 로고
    • Basic helix-loop-helix genes in neural development
    • Lee, J. E. Basic helix-loop-helix genes in neural development. Curr. Opin. Neurobiol. 7, 13-20 (1997).
    • (1997) Curr. Opin. Neurobiol. , vol.7 , pp. 13-20
    • Lee, J.E.1
  • 19
    • 0033572713 scopus 로고    scopus 로고
    • Vertebrate bHLH genes and the determination of neuronal fates
    • Guillemot, F. Vertebrate bHLH genes and the determination of neuronal fates. Exp. Cell Res. 253, 357-364 (1999).
    • (1999) Exp. Cell Res. , vol.253 , pp. 357-364
    • Guillemot, F.1
  • 20
    • 0033883069 scopus 로고    scopus 로고
    • Doing the MATH: Is the mouse a good model for fly development?
    • Hassan, B. A. & Bellen, H. J. Doing the MATH: is the mouse a good model for fly development? Genes Dev. 14, 1852-1865 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 1852-1865
    • Hassan, B.A.1    Bellen, H.J.2
  • 21
    • 0025766486 scopus 로고
    • Transcriptional activation by heterodimers of the achaete-scute and daughterless gene products of Drosophila
    • Cabrera, C.V. & Alonso, M. C. Transcriptional activation by heterodimers of the achaete-scute and daughterless gene products of Drosophila. EMBO J. 10, 2965-2973 (1991).
    • (1991) EMBO J. , vol.10 , pp. 2965-2973
    • Cabrera, C.V.1    Alonso, M.C.2
  • 22
    • 0026539165 scopus 로고
    • DNA binding and transcriptional regulatory activity of mammalian achaete-scute homologous (MASH) proteins revealed by interaction with a muscle-specific enhancer
    • Johnson, J. E. et al. DNA binding and transcriptional regulatory activity of mammalian achaete-scute homologous (MASH) proteins revealed by interaction with a muscle-specific enhancer. Proc. Natl Acad. Sci. USA 89, 3595-3600 (1992).
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 3595-3600
    • Johnson, J.E.1
  • 23
    • 0033980393 scopus 로고    scopus 로고
    • Helix-loop-helix proteins: Regulators of transcription in eucaryotic organisms
    • Massari, M. E. & Murre, C. Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol. Cell. Biol. 20, 429-440 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 429-440
    • Massari, M.E.1    Murre, C.2
  • 24
    • 0028329080 scopus 로고
    • Crystal structure of transcription factor E47: E-box recognition by a basic region helix-toop-helix dimer
    • Ellenberger, T. et al. Crystal structure of transcription factor E47: E-box recognition by a basic region helix-toop-helix dimer. Genes Dev. 8, 970-980 (1994).
    • (1994) Genes Dev. , vol.8 , pp. 970-980
    • Ellenberger, T.1
  • 25
    • 0027910469 scopus 로고
    • Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain
    • Ferre-D'Amare, A. R. et al. Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain. Nature 363, 33-45 (1993).
    • (1993) Nature , vol.363 , pp. 33-45
    • Ferre-D'Amare, A.R.1
  • 26
    • 0028215362 scopus 로고
    • Crystal structure of MyoD bHLH domain-DNA complex: Perspectives on DNA recognition and implications for transcriptional activation
    • Ma, P. C. et al. Crystal structure of MyoD bHLH domain-DNA complex: perspectives on DNA recognition and implications for transcriptional activation. Cell 77, 451-459 (1994).
    • (1994) Cell , vol.77 , pp. 451-459
    • Ma, P.C.1
  • 27
    • 0035924698 scopus 로고    scopus 로고
    • Emc, a negative HLH regulator with multiple functions in Drosophila development
    • Campuzano, S. Emc, a negative HLH regulator with multiple functions in Drosophila development. Oncogene 20, 8299-8307 (2001).
    • (2001) Oncogene , vol.20 , pp. 8299-8307
    • Campuzano, S.1
  • 28
    • 0035924694 scopus 로고    scopus 로고
    • 1d and development
    • Yokota, Y. 1d and development. Oncogene 20, 8290-8298 (2001).
    • (2001) Oncogene , vol.20 , pp. 8290-8298
    • Yokota, Y.1
  • 29
    • 85047699421 scopus 로고    scopus 로고
    • Vertebrate hairy and Enhancer of split related proteins: Transcriptional repressors regulating cellular differentiation and embryonic patterning
    • Davis, R. L. & Turner, D. L. Vertebrate hairy and Enhancer of split related proteins: transcriptional repressors regulating cellular differentiation and embryonic patterning. Oncogene 20, 8342-8357 (2001).
    • (2001) Oncogene , vol.20 , pp. 8342-8357
    • Davis, R.L.1    Turner, D.L.2
  • 30
    • 0030727631 scopus 로고    scopus 로고
    • Helix-loop-helix factors in growth and differentiation of the vertebrate nervous system
    • Kageyama, R. & Nakanishi, S. Helix-loop-helix factors in growth and differentiation of the vertebrate nervous system. Curr. Opin. Genet. Dev. 7, 659-665 (1997).
    • (1997) Curr. Opin. Genet. Dev. , vol.7 , pp. 659-665
    • Kageyama, R.1    Nakanishi, S.2
  • 31
    • 0030974127 scopus 로고    scopus 로고
    • Conservation of the Drosophila lateral inhibition pathway in human lung cancer: A hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression
    • Chen, H. et al. Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression. Proc. Natl Acad. Sci. USA 94, 5355-5360 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 5355-5360
    • Chen, H.1
  • 32
    • 0028171511 scopus 로고
    • Hairy function as a DNA-binding helix-loop-helix repressor of Drosophila sensory organ formation
    • Ohsako, S. et al. Hairy function as a DNA-binding helix-loop-helix repressor of Drosophila sensory organ formation. Genes Dev. 8, 2743-2755 (1994).
    • (1994) Genes Dev. , vol.8 , pp. 2743-2755
    • Ohsako, S.1
  • 33
    • 0028034321 scopus 로고
    • Negative regulation of proneural gene activity: Hairy is a direct transcriptional repressor of achaete
    • Van Doren, M. et al. Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete. Genes Dev. 8, 2729-2742 (1994).
    • (1994) Genes Dev. , vol.8 , pp. 2729-2742
    • Van Doren, M.1
  • 34
    • 0029822418 scopus 로고    scopus 로고
    • Neuronal type information encoded in the basic-hefix-loop-hetix domain of proneural genes
    • Chien, C. T. et al. Neuronal type information encoded in the basic-hefix-loop-hetix domain of proneural genes. Proc. Natl Acad. Sci. USA 93, 13239-13244 (1996). By analysing the properties of chimeric genes of ato and sc, this paper provided the first indication that the specificity of proneural gene function might depend on interactions with cofactors.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 13239-13244
    • Chien, C.T.1
  • 35
    • 0035855786 scopus 로고    scopus 로고
    • Combinatorial roles of Olig2 and Neurogenin2 in the coordinated induction of pan-neuronal and subtype-specific properties of motoneurons
    • Mizuguchi, R. et al. Combinatorial roles of Olig2 and Neurogenin2 in the coordinated induction of pan-neuronal and subtype-specific properties of motoneurons. Neuron 31, 757-771 (2001).
    • (2001) Neuron , vol.31 , pp. 757-771
    • Mizuguchi, R.1
  • 36
    • 0035855795 scopus 로고    scopus 로고
    • Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2
    • Novitch, B. G., Chen, A. I. & Jessell, T. M. Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2. Neuron 31, 773-789 (2001).
    • (2001) Neuron , vol.31 , pp. 773-789
    • Novitch, B.G.1    Chen, A.I.2    Jessell, T.M.3
  • 37
    • 0032703604 scopus 로고    scopus 로고
    • Activation of Xenopus genes required for lateral inhibition and neuronal differentiation during primary neurogenesis
    • Koyano-Nakagawa, N., Wettstein, D. & Kintner, C. Activation of Xenopus genes required for lateral inhibition and neuronal differentiation during primary neurogenesis. Mol. Cell. Neurosci. 14, 327-339 (1999).
    • (1999) Mol. Cell. Neurosci. , vol.14 , pp. 327-339
    • Koyano-Nakagawa, N.1    Wettstein, D.2    Kintner, C.3
  • 38
    • 0027239898 scopus 로고
    • The regulation and function of the helix-loop-helix gene, asense, in Drosophila neural precursors
    • Jarman, A. P. et al. The regulation and function of the helix-loop-helix gene, asense, in Drosophila neural precursors. Development 119, 19-29 (1993).
    • (1993) Development , vol.119 , pp. 19-29
    • Jarman, A.P.1
  • 39
    • 0027245640 scopus 로고
    • Asense, a member of the Drosophila achaete-scute complex, is a proneural and neural differentiation gene
    • Dominguez, M. & Campuzano, S. asense, a member of the Drosophila achaete-scute complex, is a proneural and neural differentiation gene. EMBO J. 12, 2049-2060 (1993).
    • (1993) EMBO J. , vol.12 , pp. 2049-2060
    • Dominguez, M.1    Campuzano, S.2
  • 40
    • 0025145260 scopus 로고
    • Competence to develop sensory organs is temporally and spatially regulated in Drosophila epidermal primordia
    • Rodriguez, I. et al. Competence to develop sensory organs is temporally and spatially regulated in Drosophila epidermal primordia. EMBO J. 9, 3583-3592 (1990).
    • (1990) EMBO J. , vol.9 , pp. 3583-3592
    • Rodriguez, I.1
  • 41
    • 0028275740 scopus 로고
    • Atonal is the proneural gene for Drosophila photoreceptors
    • Jarman, A. P. et al, atonal is the proneural gene for Drosophila photoreceptors. Nature 369, 398-400 (1994).
    • (1994) Nature , vol.369 , pp. 398-400
    • Jarman, A.P.1
  • 42
    • 0033697450 scopus 로고    scopus 로고
    • Atonal regulates neurite arborization but does not act as a proneural gene in the Drosophila brain
    • Hassan, B. A. et al. atonal regulates neurite arborization but does not act as a proneural gene in the Drosophila brain. Neuron 25, 549-561 (2000).
    • (2000) Neuron , vol.25 , pp. 549-561
    • Hassan, B.A.1
  • 43
    • 0033027914 scopus 로고    scopus 로고
    • Mash1 regulates neurogenesis in the ventral telencephalon
    • Casarosa, S., Fode, C. & Guillemot, F. Mash1 regulates neurogenesis in the ventral telencephalon. Development 126, 525-534 (1999). References 43 and 46 first showed the importance of proneural gene activity for the development of the vertebrate CNS.
    • (1999) Development , vol.126 , pp. 525-534
    • Casarosa, S.1    Fode, C.2    Guillemot, F.3
  • 44
    • 0036333010 scopus 로고    scopus 로고
    • Mash1 and Ngn1 control distinct steps of determination and differentiation in the olfactory sensory neuron lineage
    • Cau, E., Casarosa, S. & Guillemot, F. Mash1 and Ngn1 control distinct steps of determination and differentiation in the olfactory sensory neuron lineage. Development 129, 1871-1880 (2002).
    • (2002) Development , vol.129 , pp. 1871-1880
    • Cau, E.1    Casarosa, S.2    Guillemot, F.3
  • 45
    • 0027420712 scopus 로고
    • Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons
    • Guillemot, F. et al. Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons. Cell 75, 463-476 (1993). The first demonstration by gene knockout in the mouse of the role of a proneural gene in vertebrate neurogenesis.
    • (1993) Cell , vol.75 , pp. 463-476
    • Guillemot, F.1
  • 46
    • 0032702817 scopus 로고    scopus 로고
    • Correct coordination of neuronal differentiation events in ventral forebrain requires the bHLH factor MASH 1
    • Horton, S. et al. Correct coordination of neuronal differentiation events in ventral forebrain requires the bHLH factor MASH 1. Mol. Cell. Neurosci. 14, 355-369 (1999).
    • (1999) Mol. Cell. Neurosci. , vol.14 , pp. 355-369
    • Horton, S.1
  • 47
    • 0032033009 scopus 로고    scopus 로고
    • The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons
    • Fode, C. et al. The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons. Neuron 20, 483-494 (1998).
    • (1998) Neuron , vol.20 , pp. 483-494
    • Fode, C.1
  • 48
    • 0032032016 scopus 로고    scopus 로고
    • Neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia
    • Ma, Q. et al. neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia. Neuron 20, 469-482 (1998).
    • (1998) Neuron , vol.20 , pp. 469-482
    • Ma, Q.1
  • 49
    • 0033166408 scopus 로고    scopus 로고
    • Neurogenin1 and neurogenin2 control two distinct waves of neurogenesis in developing dorsal root ganglia
    • Ma, Q. et al. Neurogenin1 and neurogenin2 control two distinct waves of neurogenesis in developing dorsal root ganglia. Genes Dev. 13, 1717-1728 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 1717-1728
    • Ma, Q.1
  • 50
    • 0035797449 scopus 로고    scopus 로고
    • Crossregulation between neurogenin2 and pathways specifying neuronal identity in the spinal cord
    • Scardigli, R. et al. Crossregulation between neurogenin2 and pathways specifying neuronal identity in the spinal cord. Neuron 31, 203-217 (2001).
    • (2001) Neuron , vol.31 , pp. 203-217
    • Scardigli, R.1
  • 51
    • 0033967842 scopus 로고    scopus 로고
    • A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons
    • Fode, C. et al. A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons. Genes Dev. 14, 67-80 (2000). This paper and reference 59 showed that proneural genes are involved in the specification of neuronal Identity in the forebrain and spinal cord, respectively, and that distinct neuroepithelial domains of proneural gene expression are established through crass-inhibition.
    • (2000) Genes Dev , vol.14 , pp. 67-80
    • Fode, C.1
  • 52
    • 0032959276 scopus 로고    scopus 로고
    • NeuroD regulates multiple functions in the developing neural retina in rodent
    • Morrow, E. M. et al. NeuroD regulates multiple functions in the developing neural retina in rodent. Development 126, 23-36 (1999).
    • (1999) Development , vol.126 , pp. 23-36
    • Morrow, E.M.1
  • 53
    • 0034676035 scopus 로고    scopus 로고
    • Mammalian achaete-scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system
    • Tomita, K. et al. Mammalian achaete-scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system. EMBO J. 19, 5460-5472 (2000). References 53 and 68 provide genetic evidence that neural bHLH genes act in a redundant manner to promote neurogenesis and inhibit gliogenesis in the CNS.
    • (2000) EMBO J. , vol.19 , pp. 5460-5472
    • Tomita, K.1
  • 54
    • 0030680997 scopus 로고    scopus 로고
    • The activity of neurogenin1 is controlled by local cues in the zebrafish embryo
    • Blader, P. et al.The activity of neurogenin1 is controlled by local cues in the zebrafish embryo. Development 124, 4557-4569 (1997).
    • (1997) Development , vol.124 , pp. 4557-4569
    • Blader, P.1
  • 55
    • 0003073157 scopus 로고    scopus 로고
    • Identification of neurogenin, a vertebrate neuronal determination gene
    • Ma, Q., Kintner, C. & Anderson, D. J. Identification of neurogenin, a vertebrate neuronal determination gene. Cell 87, 43-52 (1996). The first evidence that Ngn genes can ectopically activate neuronal differentiation and interact with Notch signalling, and thus have the characteristics of proneural genes.
    • (1996) Cell , vol.87 , pp. 43-52
    • Ma, Q.1    Kintner, C.2    Anderson, D.J.3
  • 56
    • 0030669218 scopus 로고    scopus 로고
    • Math1 is essential for genesis of cerebellar granule neurons
    • Ben-Arie, N. et al. Math1 is essential for genesis of cerebellar granule neurons. Nature 390, 169-172 (1997).
    • (1997) Nature , vol.390 , pp. 169-172
    • Ben-Arie, N.1
  • 57
    • 0033546004 scopus 로고    scopus 로고
    • Math1: An essential gene for the generation of inner ear hair cells
    • Bermingham, N. A. et al. Math1: an essential gene for the generation of inner ear hair cells. Science 284, 1837-1841 (1999).
    • (1999) Science , vol.284 , pp. 1837-1841
    • Bermingham, N.A.1
  • 58
    • 0034983567 scopus 로고    scopus 로고
    • Proprioceptor pathway development is dependent on Math1
    • Bermingham, N. A. et al. Proprioceptor pathway development is dependent on Math1. Neuron 30, 411-422 (2001).
    • (2001) Neuron , vol.30 , pp. 411-422
    • Bermingham, N.A.1
  • 59
    • 0035797454 scopus 로고    scopus 로고
    • Crossinhibitory activities of Ngn1 and Math1 allow specification of distinct dorsal interneurons
    • Gowan, K. et al. Crossinhibitory activities of Ngn1 and Math1 allow specification of distinct dorsal interneurons. Neuron 31, 219-232 (2001).
    • (2001) Neuron , vol.31 , pp. 219-232
    • Gowan, K.1
  • 60
    • 0034926798 scopus 로고    scopus 로고
    • Math5 is required for retinal ganglion cell and optic nerve formation
    • Brown, N. L. et al. Math5 is required for retinal ganglion cell and optic nerve formation. Development 128, 2497-2508 (2001).
    • (2001) Development , vol.128 , pp. 2497-2508
    • Brown, N.L.1
  • 61
    • 0034972475 scopus 로고    scopus 로고
    • Retinal ganglion cell genesis requires lakritz, a zebrafish atonal homolog
    • Kay, J. N. et al. Retinal ganglion cell genesis requires lakritz, a zebrafish atonal homolog. Neuron 30, 725-736 (2001).
    • (2001) Neuron , vol.30 , pp. 725-736
    • Kay, J.N.1
  • 62
    • 0035187880 scopus 로고    scopus 로고
    • Requirement for math5 in the development of retinal ganglion cells
    • Wang, S. W. et al. Requirement for math5 in the development of retinal ganglion cells. Genes Dev. 15, 24-29 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 24-29
    • Wang, S.W.1
  • 63
    • 0030780416 scopus 로고    scopus 로고
    • Xath5 participates in a network of bHLH genes in the developing Xenopus retina
    • Kanekar, S. et al. Xath5 participates in a network of bHLH genes in the developing Xenopus retina. Neuron 19, 981-994 (1997).
    • (1997) Neuron , vol.19 , pp. 981-994
    • Kanekar, S.1
  • 64
    • 0035144456 scopus 로고    scopus 로고
    • Specification of neurotransmitter receptor identity in developing retina: The chick ATH5 promoter integrates the positive and negative effects of several bHLH proteins
    • Matter-Sadzinski, L. et al. Specification of neurotransmitter receptor identity in developing retina: the chick ATH5 promoter integrates the positive and negative effects of several bHLH proteins. Development 128, 217-231 (2001).
    • (2001) Development , vol.128 , pp. 217-231
    • Matter-Sadzinski, L.1
  • 65
    • 0031194049 scopus 로고    scopus 로고
    • XATH-1, a vertebrate homolog of Drosophila atonal, induces a neuronal differentiation within ectodermal progenitors
    • Kim, P. et al. XATH-1, a vertebrate homolog of Drosophila atonal, induces a neuronal differentiation within ectodermal progenitors. Dev. Biol. 187, 1-12 (1997).
    • (1997) Dev. Biol. , vol.187 , pp. 1-12
    • Kim, P.1
  • 66
    • 0034023488 scopus 로고    scopus 로고
    • Functional conservation of atonal and Math1 in the CNS and PNS
    • Ben-Arie, N. et al. Functional conservation of atonal and Math1 in the CNS and PNS. Development 127, 1039-1048 (2000).
    • (2000) Development , vol.127 , pp. 1039-1048
    • Ben-Arie, N.1
  • 67
    • 0029616735 scopus 로고
    • The cellular function of MASH1 in autonomic neurogenesis
    • Sommer, L. et al. The cellular function of MASH1 in autonomic neurogenesis. Neuron 15, 1245-1258 (1995).
    • (1995) Neuron , vol.15 , pp. 1245-1258
    • Sommer, L.1
  • 68
    • 0035102110 scopus 로고    scopus 로고
    • Neural bHLH genes control the neuronal versus glial fate decision in cortical progenitors
    • Nieto, M. et al. Neural bHLH genes control the neuronal versus glial fate decision in cortical progenitors. Neuron 29, 401-413 (2001).
    • (2001) Neuron , vol.29 , pp. 401-413
    • Nieto, M.1
  • 69
    • 0028099362 scopus 로고
    • XASH genes promote neurogenesis in Xenopus embryos
    • Ferreiro, B. et al. XASH genes promote neurogenesis in Xenopus embryos. Development 120, 3649-3655 (1994).
    • (1994) Development , vol.120 , pp. 3649-3655
    • Ferreiro, B.1
  • 70
    • 0036333195 scopus 로고    scopus 로고
    • Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells
    • Lo, L. et al. Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells. Development 129, 1553-1567 (2002).
    • (2002) Development , vol.129 , pp. 1553-1567
    • Lo, L.1
  • 71
    • 0028306459 scopus 로고
    • Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate
    • Turner, D. L. & Weintraub, H. Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate. Genes Dev. 8, 1434-1447 (1994).
    • (1994) Genes Dev. , vol.8 , pp. 1434-1447
    • Turner, D.L.1    Weintraub, H.2
  • 72
    • 0030018563 scopus 로고    scopus 로고
    • Sensitivity of proneural genes to lateral inhibition affects the pattern of primary neurons in Xenopus embryos
    • Chitnis, A. & Kintner, C. Sensitivity of proneural genes to lateral inhibition affects the pattern of primary neurons in Xenopus embryos. Development 122, 2295-2301 (1996).
    • (1996) Development , vol.122 , pp. 2295-2301
    • Chitnis, A.1    Kintner, C.2
  • 73
    • 0030901471 scopus 로고    scopus 로고
    • cash4, a novel achaete-scute homolog induced by Hensen's node during generation of the posterior nervous system
    • Henrique, D. et al. cash4, a novel achaete-scute homolog induced by Hensen's node during generation of the posterior nervous system. Genes Dev. 11, 603-615 (1997).
    • (1997) Genes Dev. , vol.11 , pp. 603-615
    • Henrique, D.1
  • 74
    • 0032242705 scopus 로고    scopus 로고
    • Notch signalling and the control of cell fate choices in vertebrates
    • Lewis, J. Notch signalling and the control of cell fate choices in vertebrates. Semin. Cell Dev. Biol. 9, 583-589 (1998).
    • (1998) Semin. Cell Dev. Biol. , vol.9 , pp. 583-589
    • Lewis, J.1
  • 75
    • 0034067695 scopus 로고    scopus 로고
    • Determination of vertebrate retinal progenitor cell fate by the Notch pathway and basic helix-loop-helix transcription factors
    • Perron, M. & Harris, W. A. Determination of vertebrate retinal progenitor cell fate by the Notch pathway and basic helix-loop-helix transcription factors. Cell. Mol. Life Sci. 57, 215-223 (2000).
    • (2000) Cell. Mol. Life Sci. , vol.57 , pp. 215-223
    • Perron, M.1    Harris, W.A.2
  • 76
    • 0030044345 scopus 로고    scopus 로고
    • Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila
    • Heitzler, P. et al. Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila. Devebpment 122, 161-171 (1996).
    • (1996) Devebpment , vol.122 , pp. 161-171
    • Heitzler, P.1
  • 77
    • 0028178791 scopus 로고
    • The basic-hefix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes
    • Hinz, U., Giebel, B. & Campos-Ortega, J. A. The basic-hefix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes. Cell 76, 77-87 (1994).
    • (1994) Cell , vol.76 , pp. 77-87
    • Hinz, U.1    Giebel, B.2    Campos-Ortega, J.A.3
  • 78
    • 0028061455 scopus 로고
    • Lateral inhibition mediated by the Drosophila neurogenic gene delta is enhanced by proneural proteins
    • Kunisch, M., Haenlin, M. & Campos-Ortega, J. A. Lateral inhibition mediated by the Drosophila neurogenic gene delta is enhanced by proneural proteins. Proc. Natl Acad. Sci. USA 91, 10139-10143 (1994).
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 10139-10143
    • Kunisch, M.1    Haenlin, M.2    Campos-Ortega, J.A.3
  • 79
    • 0032128198 scopus 로고    scopus 로고
    • Proneural gene self-stimulation in neural precursors: An essential mechanism for sense organ development that is regulated by Notch signaling
    • Culi, J. & Modolell, J. Proneural gene self-stimulation in neural precursors: an essential mechanism for sense organ development that is regulated by Notch signaling. Genes Dev. 12, 2036-2047 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 2036-2047
    • Culi, J.1    Modolell, J.2
  • 80
    • 0036469897 scopus 로고    scopus 로고
    • Neurogenesis in embryos and in adult neural stem cells
    • Kintner, C. Neurogenesis in embryos and in adult neural stem cells. J. Neurosci. 22, 639-643 (2002).
    • (2002) J. Neurosci. , vol.22 , pp. 639-643
    • Kintner, C.1
  • 81
    • 0028325108 scopus 로고
    • Daughterless is essential for neuronal precursor differentiation but not for initiation of neuronal precursor formation in Drosophila embryo
    • Vaessin, H. et al. daughterless is essential for neuronal precursor differentiation but not for initiation of neuronal precursor formation in Drosophila embryo. Development 120, 935-945 (1994).
    • (1994) Development , vol.120 , pp. 935-945
    • Vaessin, H.1
  • 82
    • 0034604339 scopus 로고    scopus 로고
    • Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila
    • Nolo, R., Abbott, L. A. & Bellen, H. J. Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila. Cell 102, 349-362 (2000).
    • (2000) Cell , vol.102 , pp. 349-362
    • Nolo, R.1    Abbott, L.A.2    Bellen, H.J.3
  • 83
    • 0032510040 scopus 로고    scopus 로고
    • XCoe2, a transcription factor of the Col/Olf-1/ EBF family involved in the specification of primary neurons in Xenopus
    • Dubois, L. et al. XCoe2, a transcription factor of the Col/Olf-1/ EBF family involved in the specification of primary neurons in Xenopus. Curr. Biol. 8, 199-209 (1998).
    • (1998) Curr. Biol. , vol.8 , pp. 199-209
    • Dubois, L.1
  • 84
    • 0033913972 scopus 로고    scopus 로고
    • The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation
    • Bae, S. et al. The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation. Development 127, 2933-2943 (2000).
    • (2000) Development , vol.127 , pp. 2933-2943
    • Bae, S.1
  • 85
    • 0033757060 scopus 로고    scopus 로고
    • Hes6 acts in a positive feedback loop with the neurogenins to promote neuronal differentiation
    • Koyano-Nakagawa, N. et al. Hes6 acts in a positive feedback loop with the neurogenins to promote neuronal differentiation. Development 127, 4203-4216 (2000).
    • (2000) Development , vol.127 , pp. 4203-4216
    • Koyano-Nakagawa, N.1
  • 86
    • 0030478206 scopus 로고    scopus 로고
    • X-MyT1, a Xenopus C2HC-type zinc finger protein with a regulatory function in neuronal differentiation
    • Bellefroid, E. J. et al. X-MyT1, a Xenopus C2HC-type zinc finger protein with a regulatory function in neuronal differentiation. Cell 87, 1191-1202 (1996).
    • (1996) Cell , vol.87 , pp. 1191-1202
    • Bellefroid, E.J.1
  • 87
    • 3543099114 scopus 로고    scopus 로고
    • Transcriptional regulation of atonal during development of the Drosophila peripheral nervous system
    • Sun, Y., Jan, L. Y. & Jan, Y. N. Transcriptional regulation of atonal during development of the Drosophila peripheral nervous system. Development 125, 3731-3740 (1998).
    • (1998) Development , vol.125 , pp. 3731-3740
    • Sun, Y.1    Jan, L.Y.2    Jan, Y.N.3
  • 88
    • 0027058411 scopus 로고
    • Spatial regulation of proneural gene activity: Auto- And cross-activation of achaete is antagonized by extramacrochaetae
    • Van Doren, M. et al. Spatial regulation of proneural gene activity: auto-and cross-activation of achaete is antagonized by extramacrochaetae. Genes Dev. 6, 2592-2605 (1992).
    • (1992) Genes Dev. , vol.6 , pp. 2592-2605
    • Van Doren, M.1
  • 89
    • 0034029614 scopus 로고    scopus 로고
    • Autoregulation and multiple enhancers control Math1 expression in the developing nervous system
    • Helms, A. W. et al. Autoregulation and multiple enhancers control Math1 expression in the developing nervous system. Development 127, 1185-1196 (2000).
    • (2000) Development , vol.127 , pp. 1185-1196
    • Helms, A.W.1
  • 90
    • 0035146601 scopus 로고    scopus 로고
    • The EGF receptor and N signalling pathways act antagonistically in Drosophila mesothorax bristle patterning
    • Culi, J., Martin-Blanco, E: & Modolell, J. The EGF receptor and N signalling pathways act antagonistically in Drosophila mesothorax bristle patterning. Development 128, 299-308 (2001).
    • (2001) Development , vol.128 , pp. 299-308
    • Culi, J.1    Martin-Blanco, E.2    Modolell, J.3
  • 91
    • 0029791173 scopus 로고    scopus 로고
    • Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis
    • Ben-Arie, N. et al. Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis. Hum. Mol. Genet. 5, 1207-1216 (1996).
    • (1996) Hum. Mol. Genet. , vol.5 , pp. 1207-1216
    • Ben-Arie, N.1
  • 92
    • 0030601949 scopus 로고    scopus 로고
    • Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors
    • Gradwohl, G., Fode, C. & Guillemot, F. Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors. Dev. Biol. 180, 227-241 (1996).
    • (1996) Dev. Biol. , vol.180 , pp. 227-241
    • Gradwohl, G.1    Fode, C.2    Guillemot, F.3
  • 93
    • 0025761636 scopus 로고
    • Proneural clusters of achaete-scute expression and the generation of sensory organs in the Drosophila imaginal wing disc
    • Cubas, P. et al. Proneural clusters of achaete-scute expression and the generation of sensory organs in the Drosophila imaginal wing disc. Genes Dev. 5, 996-1008 (1991).
    • (1991) Genes Dev. , vol.5 , pp. 996-1008
    • Cubas, P.1
  • 94
    • 0025730207 scopus 로고
    • Regulation of achaete-scute gene expression and sensory organ pattern formation in the Drosophila wing
    • Skeath, J. B. & Carroll, S. B. Regulation of achaete-scute gene expression and sensory organ pattern formation in the Drosophila wing. Genes Dev. 5, 984-995 (1991).
    • (1991) Genes Dev. , vol.5 , pp. 984-995
    • Skeath, J.B.1    Carroll, S.B.2
  • 95
    • 0027141207 scopus 로고
    • HLH proteins, fly neurogenesis, and vertebrate myogenesis
    • Jan, Y. N. & Jan, L. Y. HLH proteins, fly neurogenesis, and vertebrate myogenesis. Cell 75, 827-630 (1993).
    • (1993) Cell , vol.75 , pp. 827-1630
    • Jan, Y.N.1    Jan, L.Y.2
  • 96
    • 0027738464 scopus 로고
    • The MyoD family and myogenesis: Redundancy, networks, and thresholds
    • Weintraub, H. The MyoD family and myogenesis: redundancy, networks, and thresholds. Cell 75, 1241-1244 (1993).
    • (1993) Cell , vol.75 , pp. 1241-1244
    • Weintraub, H.1
  • 97
    • 0034051923 scopus 로고    scopus 로고
    • Generation of neurons by transient expression of neural bHLH proteins in mammalian cells
    • Farah, M. H. et al. Generation of neurons by transient expression of neural bHLH proteins in mammalian cells. Development 127, 693-702 (2000).
    • (2000) Development , vol.127 , pp. 693-702
    • Farah, M.H.1
  • 98
    • 0029068316 scopus 로고
    • Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein
    • Lee, J. E. et al. Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science 268, 836-844 (1995). This paper reported, for the first time, that ectopic expression in Xenopus embryos of a neural bHLH gene, NeuroD, is sufficient to drive the differentiation of ectoderm cells into neurons.
    • (1995) Science , vol.268 , pp. 836-844
    • Lee, J.E.1
  • 99
    • 0034681192 scopus 로고    scopus 로고
    • Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy
    • Liu, M. et al. Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy. Proc. Natl Acad. Sci. USA 97, 865-870 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 865-870
    • Liu, M.1
  • 100
    • 0033165994 scopus 로고    scopus 로고
    • NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus
    • Miyata, T. Maeda, T. & Lee, J. E. NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus. Genes Dev. 13, 1647-1652 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 1647-1652
    • Miyata, T.1    Maeda, T.2    Lee, J.E.3
  • 101
    • 0035370246 scopus 로고    scopus 로고
    • NeuroD2 is necessary for development and survival of central nervous system neurons
    • Olson, J. M. et al. NeuroD2 is necessary for development and survival of central nervous system neurons. Dev. Biol. 234, 174-187 (2001).
    • (2001) Dev. Biol. , vol.234 , pp. 174-187
    • Olson, J.M.1
  • 102
    • 0034657665 scopus 로고    scopus 로고
    • Neuronal basic helix-loop-helix proteins (NEX and BETA2/NeuroD) regulate terminal granule cell differentiation in the hippocampus
    • Schwab, M. H. et al. Neuronal basic helix-loop-helix proteins (NEX and BETA2/NeuroD) regulate terminal granule cell differentiation in the hippocampus. J. Neurosci. 20, 3714-3724 (2000).
    • (2000) J. Neurosci. , vol.20 , pp. 3714-3724
    • Schwab, M.H.1
  • 103
    • 0033593056 scopus 로고    scopus 로고
    • X-ngnr-1 and Xath3 promote ectopic expression of sensory neuron markers in the neurula ectoderm and have distinct inducing properties in the retina
    • Perron, M. et al. X-ngnr-1 and Xath3 promote ectopic expression of sensory neuron markers in the neurula ectoderm and have distinct inducing properties in the retina. Proc. Natl Acad. Sci. USA 96, 14996-15001 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 14996-15001
    • Perron, M.1
  • 104
    • 0033996527 scopus 로고    scopus 로고
    • Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3
    • Huang, H. P. et al. Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3. Mol. Cell. Biol. 20, 3292-3307 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 3292-3307
    • Huang, H.P.1
  • 105
    • 0031034468 scopus 로고    scopus 로고
    • Two domains of MyoD mediate transcriptional activation of genes in repressive chromatin: A mechanism for lineage determination in myogenesis
    • Gerber, A. N. et al. Two domains of MyoD mediate transcriptional activation of genes in repressive chromatin: a mechanism for lineage determination in myogenesis. Genes Dev. 11, 435-450 (1997).
    • (1997) Genes Dev. , vol.11 , pp. 435-450
    • Gerber, A.N.1
  • 106
    • 0035499887 scopus 로고    scopus 로고
    • The development of neural stem cells
    • Temple, S. The development of neural stem cells. Nature 414, 112-117 (2001).
    • (2001) Nature , vol.414 , pp. 112-117
    • Temple, S.1
  • 107
    • 0035046195 scopus 로고    scopus 로고
    • A turn of the helix: Preventing the glial fate
    • Vetter, M. A turn of the helix: preventing the glial fate. Neuron 29, 559-562 (2001).
    • (2001) Neuron , vol.29 , pp. 559-562
    • Vetter, M.1
  • 108
    • 0033852532 scopus 로고    scopus 로고
    • Misexpression of basic helix-loop-helix genes in the murine cerebral cortex affects cell fate choices and neuronal survival
    • Cai, L., Morrow, E. M. & Cepko, C. L. Misexpression of basic helix-loop-helix genes in the murine cerebral cortex affects cell fate choices and neuronal survival. Development 127, 3021-3030 (2000).
    • (2000) Development , vol.127 , pp. 3021-3030
    • Cai, L.1    Morrow, E.M.2    Cepko, C.L.3
  • 109
    • 0036336928 scopus 로고    scopus 로고
    • Math3 and NeuroD regulate amacrine cell fate specification in the retina
    • Inoue, T. et al. Math3 and NeuroD regulate amacrine cell fate specification in the retina. Development 129, 831-842 (2002).
    • (2002) Development , vol.129 , pp. 831-842
    • Inoue, T.1
  • 110
    • 0035855802 scopus 로고    scopus 로고
    • Ventral neurogenesis and the neuron-glial switch
    • Kessaris, N., Pringle, N. & Richardson, W. D. Ventral neurogenesis and the neuron-glial switch. Neuron 31, 677-680 (2001).
    • (2001) Neuron , vol.31 , pp. 677-680
    • Kessaris, N.1    Pringle, N.2    Richardson, W.D.3
  • 111
    • 0035855787 scopus 로고    scopus 로고
    • The bHLH transcription factor Olig2 promotes oligodendrocyte differentiation in collaboration with Nkx2.2
    • Zhou, Q., Choi, G. & Anderson, D. J. The bHLH transcription factor Olig2 promotes oligodendrocyte differentiation in collaboration with Nkx2.2. Neuron 31, 791-807 (2001).
    • (2001) Neuron , vol.31 , pp. 791-807
    • Zhou, Q.1    Choi, G.2    Anderson, D.J.3
  • 112
    • 0035830503 scopus 로고    scopus 로고
    • Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms
    • Sun, Y. et al. Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms. Cell 104, 365-376 (2001). Reported the unexpected finding that Ngn1 promotes neurogenesis and inhibits astrocytic differentiation by independent mechanisms: the activation of transcription and direct interference with gliogenic signalling pathways, respectively.
    • (2001) Cell , vol.104 , pp. 365-376
    • Sun, Y.1
  • 113
    • 0033574767 scopus 로고    scopus 로고
    • Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300
    • Nakashima, K. et al. Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300. Science 284, 479-482 (1999).
    • (1999) Science , vol.284 , pp. 479-482
    • Nakashima, K.1
  • 114
    • 0035480007 scopus 로고    scopus 로고
    • Hematopoietic development: A balancing act
    • Cantor, A. B. & Orkin, S. H. Hematopoietic development: a balancing act. Curr. Opin. Genet. Dev. 11, 513-519 (2001).
    • (2001) Curr. Opin. Genet. Dev. , vol.11 , pp. 513-519
    • Cantor, A.B.1    Orkin, S.H.2
  • 115
    • 0033854551 scopus 로고    scopus 로고
    • Basic helix-loop-helix proteins and the timing of oligodendrocyte differentiation
    • Kondo, T. & Raff, M. Basic helix-loop-helix proteins and the timing of oligodendrocyte differentiation. Development 127, 2989-2998 (2000).
    • (2000) Development , vol.127 , pp. 2989-2998
    • Kondo, T.1    Raff, M.2
  • 116
    • 0035052390 scopus 로고    scopus 로고
    • A role for the helix-loop-helix protein Id2 in the control of oligodendrocyte development
    • Wang, S. et al. A role for the helix-loop-helix protein Id2 in the control of oligodendrocyte development. Neuron 29, 603-614 (2001).
    • (2001) Neuron , vol.29 , pp. 603-614
    • Wang, S.1
  • 117
    • 0033593304 scopus 로고    scopus 로고
    • Progression from extrinsic to intrinsic signaling in cell fate specification: A view from the nervous system
    • Edlund, T. & Jessell, T. M. Progression from extrinsic to intrinsic signaling in cell fate specification: a view from the nervous system. Cell 96, 211-224 (1999).
    • (1999) Cell , vol.96 , pp. 211-224
    • Edlund, T.1    Jessell, T.M.2
  • 119
    • 0032521448 scopus 로고    scopus 로고
    • The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells
    • Mutoh, H. et al. The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells. Genes Dev. 12, 820-830 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 820-830
    • Mutoh, H.1
  • 120
    • 0032474776 scopus 로고    scopus 로고
    • Wingless and Notch regulate cell-cycle arrest in the developing Drosophila wing
    • Johnston, L. A. & Edgar, B. A. Wingless and Notch regulate cell-cycle arrest in the developing Drosophila wing. Nature 394, 82-84 (1998).
    • (1998) Nature , vol.394 , pp. 82-84
    • Johnston, L.A.1    Edgar, B.A.2
  • 121
    • 0034048795 scopus 로고    scopus 로고
    • The pan-neural bHLH proteins DEADPAN and ASENSE regulate mitotic activity and cdk inhibitor dacapo expression in the Drosophila larval optic lobes
    • Wallace, K., Liu, T. H. & Vaessin, H. The pan-neural bHLH proteins DEADPAN and ASENSE regulate mitotic activity and cdk inhibitor dacapo expression in the Drosophila larval optic lobes. Genesis 26, 77-85 (2000).
    • (2000) Genesis , vol.26 , pp. 77-85
    • Wallace, K.1    Liu, T.H.2    Vaessin, H.3
  • 122
    • 0032144227 scopus 로고    scopus 로고
    • The specificity of proneural genes in determining Drosophila sense organ identity
    • Jarman, A. P. & Ahmed, I. The specificity of proneural genes in determining Drosophila sense organ identity. Mech. Dev. 76, 117-125 (1998).
    • (1998) Mech. Dev. , vol.76 , pp. 117-125
    • Jarman, A.P.1    Ahmed, I.2
  • 123
    • 0029850583 scopus 로고    scopus 로고
    • Control of neural precursor specification by proneural proteins in the CNS of Drosophila
    • Parras, C. et al. Control of neural precursor specification by proneural proteins in the CNS of Drosophila. EMBO J. 15, 6394-6399 (1996).
    • (1996) EMBO J. , vol.15 , pp. 6394-6399
    • Parras, C.1
  • 124
    • 0030250858 scopus 로고    scopus 로고
    • The achaete-scute complex proneural genes contribute to neural precursor specification in the Drosophila CNS
    • Skeath, J. B. & Doe, C. Q. The achaete-scute complex proneural genes contribute to neural precursor specification in the Drosophila CNS. Curr. Biol. 6, 1146-1152 (1996).
    • (1996) Curr. Biol. , vol.6 , pp. 1146-1152
    • Skeath, J.B.1    Doe, C.Q.2
  • 125
    • 0025733588 scopus 로고
    • Transformation of sensory organ identity by ectopic expression of Cut in Drosophila
    • Blochlinger, K., Jan, L. Y. & Jan, Y. N. Transformation of sensory organ identity by ectopic expression of Cut in Drosophila. Genes Dev. 5, 1124-1135 (1991).
    • (1991) Genes Dev. , vol.5 , pp. 1124-1135
    • Blochlinger, K.1    Jan, L.Y.2    Jan, Y.N.3
  • 126
    • 0026766680 scopus 로고
    • Acquisition of myogenic specificity by replacement of three amino acid residues from MyoD into E12
    • Davis, R. L. & Weintraub, H. Acquisition of myogenic specificity by replacement of three amino acid residues from MyoD into E12. Science 256, 1027-1030 (1992).
    • (1992) Science , vol.256 , pp. 1027-1030
    • Davis, R.L.1    Weintraub, H.2
  • 127
    • 0033738258 scopus 로고    scopus 로고
    • Sense organ identity in the Drosophila antenna is specified by the expression of the proneural gene atonal
    • Jhaveri, D. et al. Sense organ identity in the Drosophila antenna is specified by the expression of the proneural gene atonal. Mech. Dev. 99, 101-111 (2000).
    • (2000) Mech. Dev. , vol.99 , pp. 101-111
    • Jhaveri, D.1
  • 128
    • 0033637996 scopus 로고    scopus 로고
    • Interactions between chip and the achaete/scute-daughterless heterodimers are required for pannier-driven proneural patterning
    • Ramain, P. et al. Interactions between chip and the achaete/scute-daughterless heterodimers are required for pannier-driven proneural patterning. Mol. Cell 6, 781-790 (2000). Shows that the spatially restricted activation of an enhancer by Achaete-Scute proteins depends on interaction with a region-specific cofactor, Pannier.
    • (2000) Mol. Cell , vol.6 , pp. 781-790
    • Ramain, P.1
  • 129
    • 0033006185 scopus 로고    scopus 로고
    • Transcriptional control of neurotransmitter phenotype
    • Goridis, C. & Brunet, J. F. Transcriptional control of neurotransmitter phenotype. Curr. Opin. Neurobiol. 9, 47-53 (1999).
    • (1999) Curr. Opin. Neurobiol. , vol.9 , pp. 47-53
    • Goridis, C.1    Brunet, J.F.2
  • 130
    • 0031910150 scopus 로고    scopus 로고
    • Control of noradrenergic differentation and Phox2a expression by MASH1 in the central and peripheral nervous system
    • Hirsch, M. R. et al. Control of noradrenergic differentation and Phox2a expression by MASH1 in the central and peripheral nervous system. Development 125, 599-608 (1998).
    • (1998) Development , vol.125 , pp. 599-608
    • Hirsch, M.R.1
  • 131
    • 0031908025 scopus 로고    scopus 로고
    • MASH1 activates expression of the paired homeodomain transcription factor Phox2a, and couples pan-neuronal and subtype-specific components of autonomic neuronal identity
    • Lo, L., Tiveron, M. C. & Anderson, D. J. MASH1 activates expression of the paired homeodomain transcription factor Phox2a, and couples pan-neuronal and subtype-specific components of autonomic neuronal identity. Development 125, 609-520 (1998). References 130 and 131 show by complementary LOF and GOF approaches that Mash1 is a determinant of noradrenergic neuron identity.
    • (1998) Development , vol.125 , pp. 609-1520
    • Lo, L.1    Tiveron, M.C.2    Anderson, D.J.3
  • 132
    • 0033609337 scopus 로고    scopus 로고
    • The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives
    • Pattyn, A. et al. The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives. Nature 399, 356-370 (1999).
    • (1999) Nature , vol.399 , pp. 356-370
    • Pattyn, A.1
  • 133
    • 0036634851 scopus 로고    scopus 로고
    • Specification of catecholaminergic and serotonergic neurons
    • Goridis, C. & Rohrer, H. Specification of catecholaminergic and serotonergic neurons. Nature Rev. Neurosci. 3, 531-541 (2002).
    • (2002) Nature Rev. Neurosci. , vol.3 , pp. 531-541
    • Goridis, C.1    Rohrer, H.2
  • 134
    • 0034034865 scopus 로고    scopus 로고
    • Specification of the central noradrenergic phenotype by the homeobox gene Phox2b
    • Pattyn, A., Goridis, C. & Brunet, J. F. Specification of the central noradrenergic phenotype by the homeobox gene Phox2b. Mol. Cell. Neurosci. 15, 235-243 (2000). This paper and reference 70 provide evidence that Mash1 and Ngns are involved in the specification of distinct neuronal subtypes, and that their specificity Is dictated to different degrees by the cellular context.
    • (2000) Mol. Cell. Neurosci. , vol.15 , pp. 235-243
    • Pattyn, A.1    Goridis, C.2    Brunet, J.F.3
  • 135
    • 0036467664 scopus 로고    scopus 로고
    • Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity
    • Parras, C. M. et al. Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity. Genes Dev. 16, 324-338 (2002).
    • (2002) Genes Dev. , vol.16 , pp. 324-338
    • Parras, C.M.1
  • 136
    • 0032960888 scopus 로고    scopus 로고
    • Early specification of sensory neuron fate revealed by expression and function of neurogenins in the chick embryo
    • Perez, S. E., Rebelo, S. & Anderson, D. J. Early specification of sensory neuron fate revealed by expression and function of neurogenins in the chick embryo. Development 126, 1715-1728 (1999).
    • (1999) Development , vol.126 , pp. 1715-1728
    • Perez, S.E.1    Rebelo, S.2    Anderson, D.J.3
  • 137
    • 0032965752 scopus 로고    scopus 로고
    • The roles of intrinsic and extrinsic cues and bHLH genes in the determination of retinal cell fates
    • Cepko, C. L. The roles of intrinsic and extrinsic cues and bHLH genes in the determination of retinal cell fates. Curr. Opin. Neurobiol. 9, 37-46 (1999).
    • (1999) Curr. Opin. Neurobiol. , vol.9 , pp. 37-46
    • Cepko, C.L.1
  • 138
    • 0035035408 scopus 로고    scopus 로고
    • Roles of homeobox and bHLH genes in specification of a retinal cell type
    • Hatakeyama, J. et al. Roles of homeobox and bHLH genes in specification of a retinal cell type. Development 128, 1313-1322 (2001).
    • (2001) Development , vol.128 , pp. 1313-1322
    • Hatakeyama, J.1
  • 139
    • 0033767315 scopus 로고    scopus 로고
    • Sonic hedgehog - Regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system
    • Lu, Q. R. et al. Sonic hedgehog - regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron 25, 317-329 (2000).
    • (2000) Neuron , vol.25 , pp. 317-329
    • Lu, Q.R.1
  • 140
    • 0033746627 scopus 로고    scopus 로고
    • Dynamic expression of basic helix-loop-helix Olig family members: Implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3
    • Takebayashi, H. et al. Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3. Mech. Dev. 99, 143-148 (2000).
    • (2000) Mech. Dev. , vol.99 , pp. 143-148
    • Takebayashi, H.1
  • 141
    • 0034724344 scopus 로고    scopus 로고
    • The t(14;21)(q11.2;q22) chromosomal translocation associated withT-cell acute lymphoblastic leukemia activates the BHLHB1 gene
    • Wang, J. et al. The t(14;21)(q11.2;q22) chromosomal translocation associated withT-cell acute lymphoblastic leukemia activates the BHLHB1 gene. Proc. Natl Acad. Sci. USA 97, 3497-3502 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 3497-3502
    • Wang, J.1
  • 142
    • 0033764232 scopus 로고    scopus 로고
    • Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors
    • Zhou, Q., Wang, S. & Anderson, D. J. Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. Neuron 25, 331-343 (2000).
    • (2000) Neuron , vol.25 , pp. 331-343
    • Zhou, Q.1    Wang, S.2    Anderson, D.J.3
  • 143
    • 0035908998 scopus 로고    scopus 로고
    • Olig bHLH proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tube
    • Sun, T. et al. Olig bHLH proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tube. Curr. Biol. 11, 1413-1420 (2001).
    • (2001) Curr. Biol. , vol.11 , pp. 1413-1420
    • Sun, T.1
  • 144
    • 0037023529 scopus 로고    scopus 로고
    • Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte conneclion
    • Lu, Q. R. et al. Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte conneclion. Cell 109, 75-86 (2002).
    • (2002) Cell , vol.109 , pp. 75-86
    • Lu, Q.R.1
  • 145
    • 0037023492 scopus 로고    scopus 로고
    • The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification
    • Zhou, Q. & Anderson, D. J. The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification. Cell 109, 61-73 (2002).
    • (2002) Cell , vol.109 , pp. 61-73
    • Zhou, Q.1    Anderson, D.J.2
  • 146
    • 0033636521 scopus 로고    scopus 로고
    • Timing of CNS cell generation: A programmed sequence of neuron and glial cell production from isolated murine cortical stem cells
    • Qian, X. et al. Timing of CNS cell generation: a programmed sequence of neuron and glial cell production from isolated murine cortical stem cells. Neuron 28, 69-80 (2000).
    • (2000) Neuron , vol.28 , pp. 69-80
    • Qian, X.1
  • 147
    • 0031172193 scopus 로고    scopus 로고
    • MASH1 maintains competence for BMP2-induced neuronal differentiation in post-migratory neural crest cells
    • Lo, L., Sommer, L. & Anderson, D. J. MASH1 maintains competence for BMP2-induced neuronal differentiation in post-migratory neural crest cells. Curr. Biol. 7, 440-450 (1997).
    • (1997) Curr. Biol. , vol.7 , pp. 440-450
    • Lo, L.1    Sommer, L.2    Anderson, D.J.3
  • 148
    • 0035894847 scopus 로고    scopus 로고
    • Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells
    • Shingo, T. et al. Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells. J. Neurosci. 21, 9733-9743 (2001).
    • (2001) J. Neurosci. , vol.21 , pp. 9733-9743
    • Shingo, T.1
  • 149
    • 0030448423 scopus 로고    scopus 로고
    • Single factors direct the differentetion of stem cells from the fetal and adult central nervous system
    • Johe, K. K. et al. Single factors direct the differentetion of stem cells from the fetal and adult central nervous system. Genes Dev. 10, 3129-3140 (1996).
    • (1996) Genes Dev. , vol.10 , pp. 3129-3140
    • Johe, K.K.1
  • 150
    • 14344284361 scopus 로고    scopus 로고
    • BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis
    • Nakashima, K. et al. BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis. Proc. Natl Acad. Sci. USA 98, 5868-5873 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 5868-5873
    • Nakashima, K.1
  • 151
    • 0033366337 scopus 로고    scopus 로고
    • BMPs inhibit neurogenesis by a mechanism involving degradation of a transcription factor
    • Shou, J., Rim, P. C. & Calof, A. L. BMPs inhibit neurogenesis by a mechanism involving degradation of a transcription factor. Nature Neurosci. 2, 339-345 (1999).
    • (1999) Nature Neurosci. , vol.2 , pp. 339-345
    • Shou, J.1    Rim, P.C.2    Calof, A.L.3
  • 152
    • 0035545819 scopus 로고    scopus 로고
    • Neuronal potential and lineage determination by neural stem cells
    • Morrison, S. J. Neuronal potential and lineage determination by neural stem cells. Curr. Opin. Cell Biol. 13, 666-672 (2001).
    • (2001) Curr. Opin. Cell Biol. , vol.13 , pp. 666-672
    • Morrison, S.J.1
  • 153
    • 0035139022 scopus 로고    scopus 로고
    • Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate
    • Tanigaki, K. et al. Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate. Neuron 29, 45-55 (2001).
    • (2001) Neuron , vol.29 , pp. 45-55
    • Tanigaki, K.1
  • 154
    • 0035038390 scopus 로고    scopus 로고
    • Stem cells and pattern formation in the nervous system: The possible versus the actual
    • Anderson, D. J. Stem cells and pattern formation in the nervous system: the possible versus the actual. Neuron 30, 19-35 (2001).
    • (2001) Neuron , vol.30 , pp. 19-35
    • Anderson, D.J.1
  • 155
    • 0028131542 scopus 로고
    • Direct downstream targets of proneural activators in the imaginal disc include genes involved in lateral inhibitory signaling
    • Singson, A., Leviten, M. W., Bang, A. G., Hua, X. H. & Posakony, J. W. Direct downstream targets of proneural activators in the imaginal disc include genes involved in lateral inhibitory signaling. Genes Dev. 8, 2058-2071 (1994).
    • (1994) Genes Dev. , vol.8 , pp. 2058-2071
    • Singson, A.1    Leviten, M.W.2    Bang, A.G.3    Hua, X.H.4    Posakony, J.W.5
  • 156
    • 0032510953 scopus 로고    scopus 로고
    • Functional properties of the neuronal nicotinic acetylcholine receptor β3 promoter in the developing central nervous system
    • Roztocil, T., Matter-Sadzinski, L., Gomez, M., Ballivet, M. & Matter, J. M. Functional properties of the neuronal nicotinic acetylcholine receptor β3 promoter in the developing central nervous system. J. Biol. Chem. 273, 15131-15137 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 15131-15137
    • Roztocil, T.1    Matter-Sadzinski, L.2    Gomez, M.3    Ballivet, M.4    Matter, J.M.5
  • 157
    • 0030613544 scopus 로고    scopus 로고
    • NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene
    • Poulin, G., Turgeon, B. & Drouin, J. NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene. Mol. Cell. Biol. 17, 6673-6682 (1997).
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 6673-6682
    • Poulin, G.1    Turgeon, B.2    Drouin, J.3
  • 158
    • 0028941181 scopus 로고
    • Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor
    • Naya, F. J., Stellrecht, C. M. & Tsai, M. J. Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. Genes Dev. 9, 1009-1019 (1995).
    • (1995) Genes Dev. , vol.9 , pp. 1009-1019
    • Naya, F.J.1    Stellrecht, C.M.2    Tsai, M.J.3


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