Deletion of Atoh1 disrupts sonic hedgehog signaling in the developing cerebellum and prevents medulloblastoma

Science

Volumn 326, Issue 5958, 2009, Pages 1424-1427

  Flora, Adriano ^a   Klisch, Tiemo J ^a   Schuster, Gabriele ^a   Zoghbi, Huda Y ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATOH1 PROTEIN; PROTEIN; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

ACOUSTIC WAVE; BIOLOGICAL DEVELOPMENT; CYTOLOGY; MUTATION; NERVOUS SYSTEM; RODENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN DEVELOPMENT; CARCINOGENESIS; CEREBELLUM; CONTROLLED STUDY; GENE DELETION; HUMAN; MEDULLOBLASTOMA; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CEREBELLAR NEOPLASMS; CEREBELLUM; DOWN-REGULATION; GENE DELETION; GENE KNOCK-IN TECHNIQUES; HEDGEHOG PROTEINS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MEDULLOBLASTOMA; MICE; NERVE TISSUE PROTEINS; NEURONS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

ERINACEIDAE;

EID: 71549138077     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1181453     Document Type: Article

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24. We thank H.-T. Chao, X. Liu, and R. Atkinson for experimental support and V. Brandt for helping in editing the manuscript. We thank H. Bellen, G. Dotti, M. B. Bhattacharjee, E. Battaglioli, J. Neul, and members of the Zoghbi lab for critical reading of the manuscript. The confocal microscopy was supported by the Intellectual and Developmental Disabilities Research Center at Baylor College of Medicine (5 P30 HD024064). H.Y.Z. is an investigator and T.J.K. is a postdoctoral research associate with the Howard Hughes Medical Institute.