Achaete-scute homolog 1 as a marker of poorly differentiated neuroendocrine carcinomas of different sites: A validation study using immunohistochemistry and quantitative real-time polymerase chain reaction on 335 cases

Human Pathology

Volumn 44, Issue 7, 2013, Pages 1391-1399

  La Rosa, Stefano ^a   Marando, Alessandro ^b   Gatti, Gaia ^c   Rapa, Ida ^c   Volante, Marco ^c   Papotti, Mauro ^c   Sessa, Fausto ^b,d   Capella, Carlo ^a,b  

^a OSPEDALE DI CIRCOLO   (Italy)

^b UNIVERSITY OF INSUBRIA   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

^d IRCCS MULTIMEDICA   (Italy)

Author keywords

Achaete scute homolog 1; ASH1; Neuroendocrine carcinoma; Neuroendocrine tumor

Indexed keywords

TRANSCRIPTION FACTOR MASH1;

ADULT; AGED; APPENDIX; ARTICLE; CANCER DIAGNOSIS; CANCER LOCALIZATION; CONTROLLED STUDY; EXTRAPULMONARY NEUROENDOCRINE CARCINOMA; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; ILEUM; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LUNG NEUROENDOCRINE CARCINOMA; MAJOR CLINICAL STUDY; MALE; MERKEL CELL TUMOR; NEUROENDOCRINE TUMOR; PANCREAS; POORLY DIFFERENTIATED NEUROENDOCRINE CARCINOMA; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RECTUM; SENSITIVITY AND SPECIFICITY; STOMACH; UPREGULATION; VALIDATION STUDY;

ADULT; AGED; AGED, 80 AND OVER; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CARCINOMA, NEUROENDOCRINE; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; REAL-TIME POLYMERASE CHAIN REACTION; REPRODUCIBILITY OF RESULTS; TUMOR MARKERS, BIOLOGICAL;

EID: 84879225333     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2012.11.013     Document Type: Article

References (27)

1. G. Rindi, R. Arnold, and F.T. Bosman Nomenclature and classification of neuroendocrine neoplasms of the digestive system F.T. Bosman, F. Carneiro, R.H. Hruban, WHO classification of tumours of the digestive system 2010 IARC Press Lyon, France 13 14
2. E. Solcia, G. Klöppel, and L.H. Sobin Histological typing of endocrine tumours. WHO International Histological Classification of Tumours 2nd ed 2000 Springer Berlin, Germany
3. T.M. Lanigan, S.K. DeRaad, and A.F. Russo Requirement of the mASH-1 transcription factor for neuroendocrine differentiation of thyroid C cells J Neurobiol 34 1998 126 134
4. K. Huber, B. Bruhl, F. Guillemot, E.N. Olson, U. Ernsberger, and K. Unsicker Development of chromaffin cells depends on MASH1 function Development 129 2002 4729 4738
5. M. Borges, R.I. Linnoila, and H.J. van de Velde An achaete-scute homologue essential for neuroendocrine differentiation in the lung Nature 386 1997 852 855
6. H. Kokubu, T. Ohtsuka, and R. Kageyama Mash1 is required for neuroendocrine cell development in the glandular stomach Genes Cells 13 2008 41 51
7. D.W. Ball Achaete-scute homolog-1 and Notch in lung neuroendocrine development and cancer Cancer Lett 204 2004 159 169
8. S.X. Jiang, T. Kameya, and H. Asamura hASH1 expression is closely correlated with endocrine phenotype and differentiation extent in pulmonary neuroendocrine tumors Mod Pathol 17 2004 222 229
9. T. Shida, M. Furuya, and T. Nikaido Aberrant expression of human achaete-scute homologue gene 1 in the gastrointestinal neuroendocrine carcinomas Clin Cancer Res 11 2005 450 458
10. T. Shida, M. Furuya, and T. Kishimoto The expression of NeuroD and MASH1 in the gastroenteropancreatic neuroendocrine tumors Mod Pathol 21 2008 1363 1370
11. I. Rapa, P. Ceppi, and E. Bollito Human ASH1 expression in prostate cancer with neuroendocrine differentiation Mod Pathol 21 2008 700 707
12. S. La Rosa, E. Rigoli, S. Uccella, A.M. Chiaravalli, and C. Capella CDX2 as a marker of intestinal EC-cells and related well-differentiated endocrine tumors Virchows Arch 445 2004 248 254
13. S. La Rosa, A.M. Chiaravalli, C. Placidi, N. Papanikolaou, M. Cerati, and C. Capella TTF1 expression in normal lung neuroendocrine cells and related tumors. Immunohistochemical study comparing two different monoclonal antibodies Virchows Arch 457 2010 497 507
14. S. La Rosa, A. Marando, D. Furlan, N. Sahnane, and C. Capella Colorectal poorly differentiated neuroendocrine carcinomas and mixed adenoneuroendocrine carcinomas: insights into the diagnostic immunophenotype, assessment of methylation profile, and search for prognostic markers Am J Surg Pathol 36 2012 601 611
15. S. La Rosa, F. Inzani, and A. Vanoli Histologic characterization and improved prognostic evaluation of 209 gastric neuroendocrine neoplasms Hum Pathol 42 2011 1373 1384
16. P. Ceppi, M. Volante, and S. Saviozzi Squamous cell carcinoma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase Cancer 107 2006 1589 1596
17. S.K. Lau, D.J. Luthringer, and R.N. Eisen Thyroid transcription factor-1: review Appl Immunohistochem Mol Morphol 10 2002 97 102
18. M. Barbareschi, C. Roldo, and G. Zamboni CDX-2 homeobox gene product expression in neuroendocrine tumors: its role as a marker of intestinal neuroendocrine tumors Am J Surg Pathol 28 2004 1169 1176
19. L.A. Erickson, B. Papouchado, H. Dimashkieh, S. Zhang, N. Nakamura, and R.V. Lloyd Cdx2 as a marker for neuroendocrine tumors of unknown primary sites Endocr Pathol 15 2004 247 252
20. A.M. Schmitt, F. Riniker, and M. Anlauf Islet 1 (Isl1) expression is a reliable marker for pancreatic endocrine tumors and their metastases Am J Surg Pathol 32 2008 420 425
21. I. Koo, R.B. Mertens, J.M. Mirocha, H.L. Wang, and D. Dhall Value of Islet 1 and PAX8 in identifying metastatic neuroendocrine tumors of pancreatic origin Mod Pathol 25 2012 893 901
22. J.S. Lewis, E. Duncavage, and P.W. Klonowski Oral cavity neuroendocrine carcinoma: a comparison study with cutaneous Merkel cell carcinoma and other mucosal head and neck neuroendocrine carcinomas Oral Surg Oral Med Oral Pathol Oral Radiol Endod 110 2010 209 217
23. D.W. Ball, C.G. Azzoli, and S.B. Baylin Identification of a human achaete-scute homolog highly expressed in neuroendocrine tumors Proc Natl Acad Sci USA 90 1993 5648 5652
24. K. Hiroshima, A. Iyoda, and T. Shida Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: a morphological, immunohistochemical, and molecular analysis Mod Pathol 19 2006 1358 1368
25. J. Ralston, L. Chiriboga, and D. Nonaka MASH1: a useful marker in differentiating pulmonary small cell carcinoma from Merkel cell carcinoma Mod Pathol 21 2008 1357 1362
26. J.H. Leonard, A.L. Cook, and M. van Gele Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma Int J Cancer 101 2002 103 110
27. B. Cordes, M.D. Williams, and Y. Tirado Molecular and phenotypic analysis of poorly differentiated sinonasal neoplasms: an integrated approach for early diagnosis and classification Hum Pathol 40 2009 283 292