Math1 is essential for genesis of cerebellar granule neurons

Nature

Volumn 390, Issue 6656, 1997, Pages 169-172

  Ben Arie, Nissim ^a   Bellen, Hugo J ^a   Armstrong, Dawna L ^a   McCall, Alanna E ^a   Gordadze, Polina R ^a   Guo, Qiuxia ^a   Matzuk, Martin M ^a   Zoghbi, Huda Y ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HELIX LOOP HELIX PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL TISSUE; ARTICLE; CEREBELLUM; EMBRYO; GENE; GRANULE CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; CEREBELLUM; GENE DELETION; GENE TARGETING; HELIX-LOOP-HELIX MOTIFS; MICE; NERVE TISSUE PROTEINS; NEURONS; RESPIRATION; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0030669218     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/36579     Document Type: Article

References (29)

1. Altman, J. & Bayer, S. A. in Development of the Cerebellar System: In Relation to its Evolution, Structure, and Functions (CRC Press, Boca Raton, Florida, 1996).
2. Akazawa, C., Ishibashi, M., Shimizu, C, Nakanishi, S. & Kageyama, R. A. Mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system. J. Biol. Chem. 270, 8730-8738 (1995).
3. Ben-Arie, N. et al. Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggest a conserved role in neurogenesis. Hum. Mol. Genet. 5, 1207-1216 (1996).
4. Jarman, A. P., Grau, Y., Jan, L. Y. & Jan, Y. N. atonal is a proneural gene that directs chordotonal organ formation in the Drosophila peripheral nervous system. Cell 73, 1307-1321 (1993).
5. Hatten, M. E. & Heintz, N. Mechanisms of neural patterning and specification in the developing cerebellum. Annu. Rev. Neurosci. 18, 385-408 (1995).
6. Hallonet, M. E. & Le Dourain, N. M. Tracing neuroepithelial cells of the mesencephalic and metencephalic alar plates during cerebellar ontogeny in quail-chick chimaeras. Eur. J. Neursci. 5, 1145-1155 (1993).
7. Hatten, M. E., Alder, J., Zimmerman, K. & Heintz, N. Genes involved in cerebellar cell specification and differentiation. Curr. Opin. Neurobiol. 7, 40-47 (1997).
8. Jarman, A. P., Sun, Y., Jan, L. Y. & Jan, Y. N. Role of the proneural gene, atonal, in formation of Drosophila chordotonal organs and photoreceptors. Development 121, 2019-2030 (1995).
9. Yang, X. W., Zhong, R. & Heintz, N. Granule cell specification in the developing mouse brain as defined by expression of the zinc finger transcription factor RU49. Development 122, 555-566 (1996).
10. Debus, E., Weber, K. & Osborn, M. Monoclonal antibodies specific for glial fibrillary acidic (GFA) protein and for each of the neurofilament triplet polypeptides. Differentiation 25, 193-203 (1983).
11. Tohyama, T. et al. Nestin expression in embryonic human neuroepithelium and in human neuroepithelial tumor cells. Lab. Invest. 66, 303-313 (1992).
12. Smeyne, R. J. & Goldowitz, D. Development and death of external granular layer cells in the weaver mouse cerebellum: a quantitative study. J. Neurosci. 9, 1608-1620 (1989).
13. Wood, K. A., Dipasquale, B. & Youle, R. J. In situ labeling of granule cells for apoptosis associated DNA fragmentation reveals different mechanisms of cell loss in developing cerebellum. Neuron 11, 621-632 (1993).
14. His, W. Die Entwicklung des menschlichen Rautenhirns vom Ende des ersten bis zum Beginn des dritten Monats. I. Verlängertes Mark. Abhandlung der königlicher sächsischen Gesellschaft der Wissenschaften, mathematische-physikalische Klasse 29, 1-74 (1891).
15. Heintz, N., Norman, D., Gao, W.-O. & Hatten, M. in genome Maps and Neurological Disorders (eds Davies, K. E. & Tilghman, S. M.) 19-45 (Cold Spring Harbor Laboratory Press, New York, 1993).
16. Mouse Genome Database 3.1 (Mouse Genome Informatics, The Jackson Laboratory, Bar Horbor, Maine (http://www.informatics.jax.org/), 1996).
17. Frontiers in Bioscience 2.6 (http://www.bioscience.org/knockout/knochome.html) (1997).
18. Goffinet, A. M. Events governing organization of postmigratory neurons: studies on brain development in normal and reeler mice. Brain Res. Rev. 7, 261-296 (1984).
19. Rezai, Z. & Yoon, C. H. Abnormal rte of granule cell migration in the cerebellum of weaver mutant mice. Dev. Biol. 29, 17-26 (1972).
20. Joyner, A. L. Engrailed, Wnt and Pax genes regulate midbrain-hindbrain development. Trends Genet. 12, 15-20 (1996).
21. McMahon, A. P. & Bradley, A. The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell 62, 1073-1085 (1990).
22. Thomas, K. R. & Capecchi, M. R. Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature 346, 845-850 (1990).
23. Thomas, K. R., Musci, T. S., Neumann, P. E. & Capecchi, M. R. Swaying is a mutant allele of the protooncogene Wnt-1. Cell 67, 969-976 (1991).
24. McMahon, A. P., Joyner, A. L., Bradley, A. & McMahon, J. A. The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1-mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum. Cell 69, 581-595 (1992).
25. Millen, K. J., Wurst, W., Herrup, K. & Joyner, A. L. Abnormal embryonic cerebellar development and patterning of postnatal foliation in two mouse Engrailed-2 mutants. Development 120, 695-706 (1994).
26. Wurst, W., Auerbach, A. B. & Joyner, A. L. Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum. Development 120, 2065-2075 (1994).
27. Guillemot, F. et al. Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons. Cell 75, 463-476 (1993).
28. Albrecht, U., Eichele, G., Helms, J. & Lu, H. in Visualization of Gene Expression Patterns by in situ Hybridization (ed. Daston, G. P.) 23-48 (CRC Press, Boca Raton, Florida, 1997).
29. Schaeren-Wiemers, N. & Gerfin-Moser, A. A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes. Histochemistry 100, 431-440 (1993).