Evidence suggestive of a locus on chromosome 5q31 contributing to susceptibility for schizophrenia in German and Israeli families by multipoint affected sib-pair linkage analysis

Molecular Psychiatry

Volumn 2, Issue 2, 1997, Pages 156-160

  Schwab, S G ^a   Eckstein, G N ^a   Hallmayer, J ^b   Lerer, B ^c   Albus, M ^d   Borrmann, M ^d   Lichtermann, D ^e   Ertl, M A ^f   Maier, W ^a   Wildenauer, D B ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^d KLINIKUM MÜNCHEN OST   (Germany)

^e NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^f UNIVERSITY OF MUNICH   (Germany)

Author keywords

Affected sib pair analysis; Chromosome 5; Lod score analysis; Schizophrenia

Indexed keywords

ARTICLE; CHROMOSOME 5Q; GENE LOCUS; GENETIC LINKAGE; GENETIC MODEL; GENETIC SUSCEPTIBILITY; HUMAN; MAJOR CLINICAL STUDY; MARKER GENE; PEDIGREE ANALYSIS; PRIORITY JOURNAL; SCHIZOPHRENIA; SIBLING;

EID: 8244226000     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000263     Document Type: Article

References (30)

1. Gottesman II. Schizophrenia Genesis: The Origin of Madness. WH Freeman: New York, 1991.
2. Pulver AE, Lasseter VK, Kasch L, Wolniec P, Nestadt G, Blouin J-L, Kimberland M, Babb R, Vourlis S, Chen H, Lalioti M, Morris MA, Karayiorgou M, Ott J, Meyers D, Antonarakis SE, Housman D, Kazazian HH. Schizophrenia: a genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes. Am J Genet Neuropsychiatr Genet 1995; 60: 252-260.
3. Straub RE, MacLean CJ, O'Neill FA, Burke J, Murphy B, Duke F, Shinkwin R, Webb BT, Zhang J, Walsh D, Kendler KS. A potential vulnerability locus for schizophrenia on chromosome 6p24-22: evidence for genetic heterogeneity. Nature Genet 1995; 11: 287-293.
4. Kendler SK, MacLean CJ, O'Neill FA, Burke J, Murphy B, Duke F, Shinkwin R, Easter SM, Webb BT, Zhang J, Walsh D, Straub ER. Evidence for a schizophrenia locus on chromosome 8p in the Irish study of high-density schizophrenia families. Am J Psychiatry 1996; 153: 1534-1540.
5. Risch N. Linkage strategies for genetically complex traits. I. Multilocus models. Am J Hum Genet 1990; 46: 229-241.
6. Risch N, Merikangas K. The future of genetic studies of complex diseases. Science 1996; 273: 1516-1517.
7. Hallmayer J, Maier W, Ackenheil M, Ertl MA, Schmidt S, Minges J, Lichtermann D, Wildenauer D. Evidence against linkage of schizophrenia to chromosome 5q11-q13 markers in systematically ascertained families. Biol Psychiatry 1992; 31: 83-94.
8. Maier W, Schmidt F, Schwab SG, Hallmayer J, Minges J, Ackenheil M, Lichtermann D, Wildenauer DB. Lack of linkage between schizophrenia and markers at the telomeric end of the pseudoautosomal region of the sex chromosomes. Biol Psychiatry 1995; 37: 344-347.
9. Wildenauer DB, Schwab SG, Eckstein G, Zill P, Hoenig S, Hallmayer J, Albus M, Borrmann M, Ebstein RP, Lichtermann D, Lerer B, Risch N, Maier W. Searching for susceptibility genes in schizophrenia by affected sib pair analysis: evidence for loci in 22q, 5q, 6p. Am J Hum Genet 1995; 57 (Suppl): 176 (Abstract).
10. Straub RE, MacLean CJ, O'Neill FO, Walsh D, Kendler KS. Support for a schizophrenia vulnerability locus in region 5q21-q31 in Irish pedigrees. Mol Psychiatry 1997; 2: 148-155.
11. Hallmayer J, Maier W, Schwab S, Ertl MA, Minges J, Ackenheil M, Lichtermann D, Wildenauer DB. No evidence of linkage between the dopamine D2 receptor gene and schizophrenia. Psychiatry Res 1994; 53: 203-215.
12. Maier W, Schwab S, Hallmayer J, Ertl MA, Minges J, Ackenheil M, Lichtermann D, Wildenauer D. Absence of linkage between schizophrenia and the dopamine D4 receptor gene. Psychiatry Res 1994; 53: 77-96.
13. Grandy DK, Zhou Q-Y, Allen L, Litt R, Magenis RE, Civelli O, Litt M. A human D1 dopamine receptor gene is located on chromosome 5 at q35.1 and identifies an EcoRI RFLP. Am J Hum Genet 1990; 47: 828-834.
14. Risch N. Linkage strategies for genetically complex traits. II. The power of affected relative pairs. Am J Hum Genet 1990; 46: 229-241.
15. Schwab SG, Albus M, Hallmayer J, Honig S, Borrmann M, Lichtermann D, Epstein RP, Ackenheil M, Lerer B, Risch N, Maier W, Wildenauer DB. Evaluation of a susceptibility gene for schizophrenia on chromosome 6p by multipoint affected sib-pair linkage analysis. Nature Genet 1995; 11: 325-327.
16. Daly MJ, Lander ES. The importance of being independent: sib pair analysis in diabetes. Nature Genet 1996; 14: 131-132.
17. Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet 1995; 11: 241-247.
18. Sherrington R, Brynjolfsson J, Petursson H, Potter M, Dudleston K, Barraclongh B, Wasmuth J, Dobles M, Gurling H. Localization of a susceptibility locus for schizophrenia on chromosome 5. Nature 1988; 336: 164-167.
19. Silverman JM, Greenberg DA, Altstiel LD, Siever LJ, Mohs RC, Smith CJ, Zhou G, Hollander TE, Yang X-P, Kedache M, Li G, Zaccario ML, Davis KL. Evidence of a locus for schizophrenia and related disorders on the short arm of chromosome 5 in a large pedigree. Am J Med Genet (Neuropsych Gen) 1996; 67: 162-171.
20. Spitzer RL, Endicott J, Robins E. Research Diagnostic Criteria for a Selected Group of Functional Disorders. New York State Psychiatric Institute: New York, 1978.
21. Fyer A, Endicott J, Mannuzza S, Klein DF. Schedule for Affective Disorders and Schizophrenia-Lifetime Version (SADS-LA). New York State Psychiatric Institute: New York, 1985.
22. Spitzer RL, Williams JB. Structured Clinical Interview for DSM-III Diagnoses-Personality Disorders. New York State Psychiatric Institute: New York, 1985.
23. Leckman JF, Sholomskas D, Thompson D, Belanger A, Weissmann MM. Best estimate of lifetime psychiatric diagnosis. Arch Gen Psychiatr 1982; 39: 879-883.
24. Gyapay G, Morissette J, Vignal A, Dib C, Fizames C, Millasseau P, Marc S, Bernardi G, Lathrop M, Weissenbach J. The 1993-94 Genethon human genetic linkage map. Nature Genet 1994; 7: 246-339.
25. Cottingham RW, Idury RM, Schäffer AA. Faster sequential genetic linkage computations. Am J Hum Genet 1993; 53: 252-263.
26. Schäffer AA, Gupta SK, Shriram K, Cottingham RW. Avoiding recomputation in linkage analysis. Hum Hered 1994; 44: 225-237.
27. Lathrop GM, Lalouel JM. Easy calculation of lod scores and genetic risk on small computers. Am J Hum Genet 1984; 36: 460-465.
28. Knapp M, Seuchter SA, Baur MP. Linkage analysis in nuclear families. 1: Optimality criteria for affected sib-pair tests. Hum Hered 1994; 44: 37-43.
29. Knapp M, Seuchter SA, Baur MP. Linkage anlaysis in nuclear families. 2: Relationship between affected sib-pair tests and lod score analysis. Hum Hered 1994; 44: 44-51.
30. Collins A, Teague J, Lio P, Morton NE. The genetic location database. www.// cedar.genetics.soton.ac.uk/pub lic_html/