RAS/ERK signaling controls proneural genetic programs in cortical development and gliomagenesis

Journal of Neuroscience

Volumn 34, Issue 6, 2014, Pages 2169-2190

  Li, Saiqun ^a,b   Mattar, Pierre ^a,b   Dixit, Rajiv ^a,b   Lawn, Samuel O ^a,b   Wilkinson, Grey ^a,b   Kinch, Cassandra ^a,b   Eisenstat, David ^c   Kurrasch, Deborah M ^a,b   Chan, Jennifer A ^a,b   Schuurmans, Carol ^a,b  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

BHLHtranscription factors; Glioma and glioneuronal tumors; Neurog2 and Ascl1; Neurogenesis versus gliogenesis; Proneural genetic switch; RAS ERK signaling

Indexed keywords

B RAF KINASE; MITOGEN ACTIVATED PROTEIN KINASE; NEUROGENIN 2; OLIGODENDROCYTE TRANSCRIPTION FACTOR 2; RAS PROTEIN; TRANSCRIPTION FACTOR MASH1; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR SOX2;

ADOLESCENT; ADULT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; ELECTROPORATION; EMBRYO; FEMALE; GLIOMA; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MOUSE; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SCORING SYSTEM; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING; YOUNG ADULT;

BHLH TRANSCRIPTION FACTORS; GLIOMA AND GLIONEURONAL TUMORS; NEUROG2 AND ASCL1; NEUROGENESIS VERSUS GLIOGENESIS; PRONEURAL GENETIC SWITCH; RAS/ERK SIGNALING;

ANIMALS; BRAIN NEOPLASMS; CEREBRAL CORTEX; FEMALE; GENES, RAS; GLIOMA; HEK293 CELLS; HUMANS; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, TRANSGENIC; NEURONS; PREGNANCY;

EID: 84893441872     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4077-13.2014     Document Type: Article

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