Directing neurotransmitter identity of neurones derived from expanded adult neural stem cells

European Journal of Neuroscience

Volumn 25, Issue 9, 2007, Pages 2581-2590

  Berninger, Benedikt ^a,b   Guillemot, François ^c   Götz, Magdalena ^a,b  

^a UNIVERSITY OF MUNICH   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

Adult neurogenesis; Cell fate; Mouse; Neurogenic; Repair; Synapse formation

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; GLUTAMIC ACID; NEUROGENIN 2; NEUROTRANSMITTER; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MASH1; TRANSCRIPTION FACTOR T BET; TRANSCRIPTION FACTOR TBR1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NERVE CELL; NEURAL STEM CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROGENY; PROTEIN EXPRESSION; PROTEIN FUNCTION; SUBVENTRICULAR ZONE; TELENCEPHALON; TRANSCRIPTION INITIATION; UPREGULATION;

ADULT STEM CELLS; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL LINEAGE; CELL SEPARATION; CELLS, CULTURED; DNA-BINDING PROTEINS; EXCITATORY AMINO ACID ANTAGONISTS; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLUTAMIC ACID; MICE; MICE, INBRED C57BL; NERVE TISSUE PROTEINS; NEURONS; NEUROTRANSMITTER AGENTS; PHENOTYPE; SPHEROIDS, CELLULAR; TELENCEPHALON; TRANS-ACTIVATION (GENETICS);

EID: 34250004608     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2007.05509.x     Document Type: Article

References (45)

1. Alvarez-Buylla, A., Herrera, D.G. Wichterle, H. (2000) The subventricular zone: source of neuronal precursors for brain repair. Prog. Brain Res., 127, 1 11.
2. Berninger, B., Hack, M.A. Götz, M. (2006) Neural stem cells: on where they hide, in which disguise, and how we may lure them out. Handb. Exp. Pharmacol., 174, 319 360.
3. Bertrand, N., Castro, D.S. Guillemot, F. (2002) Proneural genes and the specification of neural cell types. Nat. Rev. Neurosci., 3, 517 530.
4. Buffo, A., Vosko, M.R., Erturk, D., Hamann, G.F., Jucker, M., Rowitch, D. Götz, M. (2005) Expression pattern of the transcription factor Olig2 in response to brain injuries: implications for neuronal repair. Proc. Natl Acad. Sci. U.S.A., 102, 18 183 18 188.
5. Casarosa, S., Fode, C. Guillemot, F. (1999) Mash1 regulates neurogenesis in the ventral telencephalon. Development, 126, 525 534.
6. Doetsch, F., Caille, I., Lim, D.A., Garcia-Verdugo, J.M. Alvarez-Buylla, A. (1999) Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell, 97, 703 716.
7. Doetsch, F., Petreanu, L., Caille, I., Garcia-Verdugo, J.M. Alvarez-Buylla, A. (2002) EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells. Neuron, 36, 1021 1034.
8. Edwards, F.A., Konnerth, A. Sakmann, B. (1990) Quantal analysis of inhibitory synaptic transmission in the dentate gyrus of rat hippocampal slices: a patch-clamp study. J. Physiol., 430, 213 249.
9. Englund, C., Fink, A., Lau, C., Pham, D., Daza, R.A.M., Bulfone, A., Kowalczyk, T. Hevner, R.F. (2005) Pax6, Tbr2 and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex. J. Neurosci., 25, 247 251.
10. Falk, A., Holmstrom, N., Carlen, M., Cassidy, R., Lundberg, C. Frisen, J. (2002) Gene delivery to adult neural stem cells. Exp. Cell Res., 279, 34 39.
11. Fitzsimonds, R.M., Song, H.J. Poo, M.-M. (1997) Propagation of activity-dependent synaptic depression in simple neural networks. Nature, 388, 439 448.
12. Fode, C., Ma, Q., Casarosa, S., Ang, S.L., Anderson, D.J. Guillemot, F. (2000) A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons. Genes Dev., 14, 67 80.
13. Gabay, L., Lowell, S., Rubin, L.L. Anderson, D.J. (2003) Deregulation of dorsoventral patterning by FGF confers trilineage differentiation capacity on CNS stem cells in vitro. Neuron, 40, 485 499.
14. Gage, F.H. (2000) Mammalian neural stem cells. Science, 287, 1433 1438.
15. Guillemot, F. (2005) Cellular and molecular control of neurogenesis in the mammalian telencephalon. Curr. Opin. Cell Biol., 17, 639 647.
16. Guillemot, F., Molnár, Z., Tarabykin, V. Stoykova, A. (2006) Molecular mechanisms of cortical differentiation. Eur. J. Neurosci., 23, 857 868.
17. Hack, M.A., Sugimori, M., Lundberg, C., Nakafuku, M. Götz, M. (2004) Regionalization and fate specification in neurospheres: the role of Olig2 and Pax6. Mol. Cell. Neurosci., 25, 664 678.
18. Hack, M.A., Saghatelyan, A., de Chevigny, A., Pfeifer, A., Ashery-Padan, R., Lledo, P.M. Götz, M. (2005) Neuronal fate determinants of adult olfactory bulb neurogenesis. Nat. Neurosci., 8, 865 872.
19. Hand, R., Bortone, D., Mattar, P., Nguyen, L., Heng, J.I., Guerrier, S., Boutt, E., Peters, E., Barnes, A.P., Parras, C., Schuurmans, C., Guillemot, F. Polleux, F. (2005) Phosphorylation of Neurogenin2 specifies the migration properties and the dendritic morphology of pyramidal neurons in the neocortex. Neuron, 48, 45 62.
20. Hartfuss, E., Galli, R., Heins, N. Götz, M. (2001) Characterization of CNS precursor subtypes and radial glia. Dev. Biol., 229, 15 30.
21. Hatakeyama, J., Tomita, K., Inoue, T. Kageyama, R. (2001) Roles of homeobox and bHLH genes in specification of a retinal cell type. Development, 128, 1313 1322.
22. Hevner, R.F., Shi, L., Justice, N., Hsueh, Y.-P., Sheng, M., Smiga, S., Bulfone, A., Goffinet, A.M., Campagnoni, A.T. Rubenstein, J.L.R. (2001) Tbr1 regulates differentiation of the preplate and layer 6. Neuron, 29, 353 366.
23. Hofstetter, C.P., Holmstrom, N.A., Lilja, J.A., Schweinhardt, P., Hao, J., Spenger, C., Wiesenfeld-Hallin, Z., Kurpad, S.N., Frisen, J. Olson, L. (2005) Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome. Nat. Neurosci., 8, 346 353.
24. Horn, R. Marty, A. (1988) Muscarinic activation of ionic currents measured by a new whole-cell recording method. J. Gen. Physiol., 92, 145 159.
25. Johansson, C.B., Svensson, M., Wallstedt, L., Janson, A.M. Frisen, J. (1999a) Neural stem cells in the adult human brain. Exp. Cell Res., 253, 733 736.
26. Johansson, C.B., Momma, S., Clarke, D.L., Risling, M., Lendahl, U. Frisen, J. (1999b) Identification of a neural stem cell in the adult mammalian central nervous system. Cell, 96, 25 34.
27. Lindvall, O., Kokaia, Z. Martinez-Serrano, A. (2004) Stem cell therapy for human neurodegenerative disorders - how to make it work. Nat. Med., 10 (Suppl. S42 S50.
28. Luskin, M.B. (1998) Neuroblasts of the postnatal mammalian forebrain: their phenotype and fate. J. Neurobiol., 36, 221 233.
29. Magavi, S.S., Leavitt, B.R. Macklis, J.D. (2000) Induction of neurogenesis in the neocortex of adult mice. Nature, 405, 951 955.
30. Mattar, P., Britz, O., Johannes, C., Nieto, M., Ma, L., Rebeyka, A., Klenin, N., Polleux, F., Guillemot, F. Schuurmans, C. (2004) A screen for downstream effectors of Neurogenin2 in the embryonic neocortex. Dev. Biol., 273, 373 389.
31. Merkle, F.T., Tramontin, A.D., Garcia-Verdugo, J.M. Alvarez-Buylla, A. (2004) Radial glia give rise to adult neural stem cells in the subventricular zone. Proc. Natl. Acad. Sci. U.S.A., 101, 17528 17532.
32. Moe, M.C., Varghese, M., Danilov, A.I., Westerlund, U., Ramm-Pettersen, J., Brundin, L., Svensson, M., Berg-Johnsen, J. Langmoen, I.A. (2005) Multipotent progenitor cells from the adult human brain: neurophysiological differentiation to mature neurons. Brain, 128, 2189 2199.
33. Morshead, C.M., Reynolds, B.A., Craig, C.G., McBurney, M.W., Staines, W.A., Morassutti, D., Weiss, S. van der Kooy, D. (1994) Neural stem cells in the adult mammalian forebrain: a relatively quiescent subpopulation of subependymal cells. Neuron, 13, 1071 1082.
34. Nguyen, L., Besson, A., Heng, J.I., Schuurmans, C., Teboul, L., Parras, C., Philpott, A., Roberts, J.M. Guillemot, F. (2006) p27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex. Genes Dev., 20, 1511 1524.
35. Parmar, M., Sjoberg, A., Bjorklund, A. Kokaia, Z. (2003) Phenotypic and molecular identity of cells in the adult subventricular zone in vivo and after expansion in vitro. Mol. Cell. Neurosci., 24, 741 752.
36. Parras, C.M., Schuurmans, C., Scardigli, R., Kim, J., Anderson, D.J. Guillemot, F. (2002) Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity. Genes Dev., 16, 324 338.
37. Parras, C.M., Galli, R., Britz, O., Soares, S., Galichet, C., Battiste, J., Johnson, J.E., Nakafuku, M., Vescovi, A. Guillemot, F. (2004) Mash1 specifies neurons and oligodendrocytes in the postnatal brain. EMBO J., 23, 4495 4505.
38. Rae, J., Cooper, K., Gates, P. Watsky, M. (1991) Low access resistance perforated patch recordings using amphotericin B. J. Neurosci. Meth., 37, 15 26.
39. Scheffler, B., Walton, N.M., Lin, D.D., Goetz, A.K., Enikolopov, G., Roper, S.N. Steindler, D.A. (2005) Phenotypic and functional characterization of adult brain neuropoiesis. Proc. Natl Acad. Sci. U.S.A., 102, 9353 9358.
40. Schinder, A.F., Berninger, B. Poo, M.-M. (2000) Postsynaptic target specificity of neurotrophin-induced presynaptic potentiation. Neuron, 25, 151 163.
41. Schuurmans, C., Armant, O., Nieto, M., Stenman, J.M., Britz, O., Klenin, N., Brown, C., Langevin, L.M., Seibt, J., Tang, H., Cunningham, J.M., Dyck, R., Walsh, C., Campbell, K., Polleux, F. Guillemot, F. (2004) Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways. EMBO J., 23, 2892 2902.
42. Song, H.J., Stevens, C.F. Gage, F.H. (2002) Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons. Nat. Neurosci., 5, 438 445.
43. Varoqueaux, F., Aramuni, G., Rawson, R.L., Mohrmann, R., Missler, M., Gottmann, K., Zhang, W., Südhof, T.C. Brose, N. (2006) Neuroligins determine synapse maturation and function. Neuron, 51, 741 754.
44. Westerlund, U., Svensson, M., Moe, M.C., Varghese, M., Gustavsson, B., Wallstedt, L., Berg-Johnsen, J. Langmoen, I.A. (2005) Endoscopically harvested stem cells: a putative method in future autotransplantation. Neurosurgery, 57, 779 784.
45. Zhu, J.J. (2000) Maturation of layer 5 pyramidal neurons: amplifying salient layer 1 and layer 4 inputs by Ca2+ action potentials in adult rat tuft dendrites. J. Physiol., 526, 571 587.