Constitutive achaete-scute homologue-1 promotes airway dysplasia and lung neuroendocrine tumors in transgenic mice

Cancer Research

Volumn 60, Issue 15, 2000, Pages 4005-4009

  Linnoila, R I ^a   Zhao, B ^a   DeMayo, J L ^a   Nelkin, B D ^a   Baylin, S B ^a   DeMayo, F J ^a   Ball, D W ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RNA; TRANSCRIPTION FACTOR;

AIRWAY; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DYSPLASIA; IMMUNOHISTOCHEMISTRY; LUNG TUMOR; METAPLASIA; MOUSE; NEUROENDOCRINE TUMOR; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, POLYOMAVIRUS TRANSFORMING; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BRONCHI; CARCINOMA, NON-SMALL-CELL LUNG; CELL DIFFERENTIATION; CELL DIVISION; COCARCINOGENESIS; DNA-BINDING PROTEINS; EPITHELIAL CELLS; FEMALE; HUMANS; HYPERPLASIA; LUNG; LUNG NEOPLASMS; METAPLASIA; MICE; MICE, INBRED ICR; MICE, TRANSGENIC; NEUROENDOCRINE TUMORS; NEUROSECRETORY SYSTEMS; RABBITS; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0033885165     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Autocrine loops, signal transduction, and cell cycle abnormalities in the molecular biology of lung cancer
2. Impact of neuroendocrine differentiation in non-small cell lung cancer
3. An achaete-scute homologue essential for neuroendocrine differentiation in the lung
4. Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons
5. Distinct subpopulations of enteric neuronal progenitors defined by time of development, sympathoadrenal lineage markers and Mash-1-dependence
6. Mash1 promotes neuronal differentiation in the retina
7. Requirement of the MASH-1 transcription factor for neuroendocrine differentiation of thyroid C cells
8. Correct coordination of neuronal differentiation events in ventral forebrain requires the bHLH factor MASH1
9. Identification of a human achaete-scute homolog highly expressed in neuroendocrine tumors
10. Cloning and characterization of the mouse Clara cell specific 10 kDa protein gene: Comparison of the 5'-flanking region with the human rat and rabbit gene
11. Manipulating the mouse embryo
12. Cyclin-dependent kinase inhibitor expression in pulmonary Clara cells transformed with SV40 large T antigen in transgenic mice
13. Neuroendocrine differentiation in endocrine and nonendocrine lung carcinomas
14. Immunohistochemical localization of mouse Clara cell 10-KD protein using antibodies raised against the recombinant protein
15. Cis-Acting elements involved in the regulation of mouse Clara cell-specific 10 kDa protein gene
16. Repopulation of denuded tracheas by Clara cells isolated from the lungs of rabbits
17. Embryonic mouse lung epithelial progenitor cells co-express immunohistochemical markers of diverse mature cell lineages, J, Histochem
18. The SV40 large T antigen and adenovirus Ela oncoproteins interact with distinct isoforms of the transcriptional co-activator, p300
19. Transition from SCLC to NSCLC phenotype is accompanied by an increased TRE-binding activity and recruitment of specific AP-1 proteins
20. Calcitonin driven v-Ha-ras induces multilineage pulmonary epithelial hyperplasias and neoplasms
21. Histochemical characterization of non-neuroendocrine tumors and neuroendocrine cell hyperplasia induced in hamster lung by 4-(methylnitro-samino)-1-(3-pyridyl)-1-butanone with or without hyperoxia