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Volumn 19, Issue 2, 2005, Pages 282-294

Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells

Author keywords

Basic helix loop helix (bHLH); Development; Motor neuron; Neurogenin (Ngn); Olig; Oligodendrocyte

Indexed keywords

HELIX LOOP HELIX PROTEIN; OLIGODENDROCYTE TRANSCRIPTION FACTOR 2; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NGN2; UNCLASSIFIED DRUG;

EID: 12144271676     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1257105     Document Type: Article
Times cited : (182)

References (46)
  • 1
    • 0031891341 scopus 로고    scopus 로고
    • Regulation of neuronal specification in the zebrafish spinal cord by Delta function
    • Appel, B. and Eisen, J.S. 1998. Regulation of neuronal specification in the zebrafish spinal cord by Delta function. Development 125: 371-380.
    • (1998) Development , vol.125 , pp. 371-380
    • Appel, B.1    Eisen, J.S.2
  • 2
    • 0033180516 scopus 로고    scopus 로고
    • Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity
    • Arber, S., Han, B., Mendelsohn, M., Smith, M., Jessell, T.M., and Sockanathan, S. 1999. Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity. Neuron 23: 659-674.
    • (1999) Neuron , vol.23 , pp. 659-674
    • Arber, S.1    Han, B.2    Mendelsohn, M.3    Smith, M.4    Jessell, T.M.5    Sockanathan, S.6
  • 3
    • 0036631456 scopus 로고    scopus 로고
    • Proneural genes and the specification of neural cell types
    • Bertrand, N., Castro, D.S., and Guillemot, F. 2002. Proneural genes and the specification of neural cell types. Nat. Rev. Neurosci. 3: 517-530.
    • (2002) Nat. Rev. Neurosci. , vol.3 , pp. 517-530
    • Bertrand, N.1    Castro, D.S.2    Guillemot, F.3
  • 4
    • 0035252990 scopus 로고    scopus 로고
    • Specification of neuronal fates in the ventral neural tube
    • Briscoe, J. and Ericson, J. 2001. Specification of neuronal fates in the ventral neural tube. Curr. Opin. Neurobiol. 11: 43-49.
    • (2001) Curr. Opin. Neurobiol. , vol.11 , pp. 43-49
    • Briscoe, J.1    Ericson, J.2
  • 5
    • 0034640087 scopus 로고    scopus 로고
    • A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube
    • Briscoe, J., Pierani, A., Jessell, T.M., and Ericson, J. 2000. A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube. Cell 101: 435-445.
    • (2000) Cell , vol.101 , pp. 435-445
    • Briscoe, J.1    Pierani, A.2    Jessell, T.M.3    Ericson, J.4
  • 6
    • 0032965752 scopus 로고    scopus 로고
    • The roles of intrinsic and extrinsic cues and bHLH genes in the determination of retinal cell fates
    • Cepko, C.L. 1999. The roles of intrinsic and extrinsic cues and bHLH genes in the determination of retinal cell fates. Curr. Opin. Neurobiol. 9: 37-46.
    • (1999) Curr. Opin. Neurobiol. , vol.9 , pp. 37-46
    • Cepko, C.L.1
  • 7
    • 0026638915 scopus 로고
    • Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1
    • Ericson, J., Thor, S., Edlund, T., Jessell, T.M., and Yamada, T. 1992. Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1. Science 256: 1555-1560.
    • (1992) Science , vol.256 , pp. 1555-1560
    • Ericson, J.1    Thor, S.2    Edlund, T.3    Jessell, T.M.4    Yamada, T.5
  • 9
    • 0034051923 scopus 로고    scopus 로고
    • Generation of neurons by transient expression of neural bHLH proteins in mammalian cells
    • Farah, M.H., Olson, J.M., Sucic, H.B., Hume, R.I., Tapscott, S.J., and Turner, D.L. 2000. Generation of neurons by transient expression of neural bHLH proteins in mammalian cells. Development 127: 693-702.
    • (2000) Development , vol.127 , pp. 693-702
    • Farah, M.H.1    Olson, J.M.2    Sucic, H.B.3    Hume, R.I.4    Tapscott, S.J.5    Turner, D.L.6
  • 10
    • 0027437850 scopus 로고
    • Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2
    • Gyuris, J., Golemis, E., Chertkov, H., and Brent, R. 1993. Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2. Cell 75: 791-803.
    • (1993) Cell , vol.75 , pp. 791-803
    • Gyuris, J.1    Golemis, E.2    Chertkov, H.3    Brent, R.4
  • 11
    • 84924926133 scopus 로고
    • A series of normal stages in the development of chick embryo
    • Hamburger, V. and Hamilton, H. 1951. A series of normal stages in the development of chick embryo. J. Morphol. 88: 49-92.
    • (1951) J. Morphol. , vol.88 , pp. 49-92
    • Hamburger, V.1    Hamilton, H.2
  • 12
    • 0025034673 scopus 로고
    • Two distinct transcription factors that bind the immunoglobulin enhancer microE5/κ 2 motif
    • Henthorn, P., Kiledjian, M., and Kadesch, T. 1990. Two distinct transcription factors that bind the immunoglobulin enhancer microE5/κ 2 motif. Science 247: 467-470.
    • (1990) Science , vol.247 , pp. 467-470
    • Henthorn, P.1    Kiledjian, M.2    Kadesch, T.3
  • 13
    • 0026512017 scopus 로고
    • HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors
    • Hu, J.S., Olson, E.N., and Kingston, R.E. 1992. HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors. Mol. Cell. Biol. 12: 1031-1042.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 1031-1042
    • Hu, J.S.1    Olson, E.N.2    Kingston, R.E.3
  • 14
    • 0040914505 scopus 로고    scopus 로고
    • 'Shocking' developments in chick embryology: Electroporation and in ovo gene expression
    • Itasaki, N., Bel-Vialar, S., and Krumlauf, R. 1999. 'Shocking' developments in chick embryology: Electroporation and in ovo gene expression. Nat. Cell Biol. 1: E203-E207.
    • (1999) Nat. Cell Biol. , vol.1
    • Itasaki, N.1    Bel-Vialar, S.2    Krumlauf, R.3
  • 15
    • 0034303585 scopus 로고    scopus 로고
    • Neuronal specification in the spinal cord: Inductive signals and transcriptional codes
    • Jessell, T.M. 2000. Neuronal specification in the spinal cord: Inductive signals and transcriptional codes. Nat. Rev. Genet. 1: 20-29.
    • (2000) Nat. Rev. Genet. , vol.1 , pp. 20-29
    • Jessell, T.M.1
  • 16
    • 0038386025 scopus 로고    scopus 로고
    • Synchronization of neurogenesis and motor neuron specification by direct coupling of bHLH and homeodomain transcription factors
    • Lee, S.K. and Pfaff, S.L. 2003. Synchronization of neurogenesis and motor neuron specification by direct coupling of bHLH and homeodomain transcription factors. Neuron 38: 731-745.
    • (2003) Neuron , vol.38 , pp. 731-745
    • Lee, S.K.1    Pfaff, S.L.2
  • 17
    • 0032230311 scopus 로고    scopus 로고
    • Identification of critical residues for heterodimerization within the ligand-binding domain of retinoid X receptor
    • Lee, S.K., Na, S.Y., Kim, H.J., Soh, J., Choi, H.S., and Lee, J.W. 1998. Identification of critical residues for heterodimerization within the ligand-binding domain of retinoid X receptor. Mol. Endocrinol. 12: 325-332.
    • (1998) Mol. Endocrinol. , vol.12 , pp. 325-332
    • Lee, S.K.1    Na, S.Y.2    Kim, H.J.3    Soh, J.4    Choi, H.S.5    Lee, J.W.6
  • 18
    • 4243150837 scopus 로고    scopus 로고
    • Analysis of embryonic motoneuron gene regulation: Derepression of general activators function in concert with enhancer factors
    • Lee, S.K., Jurata, L.W., Funahashi, J., Ruiz, E.C., and Pfaff, S.L. 2004. Analysis of embryonic motoneuron gene regulation: Derepression of general activators function in concert with enhancer factors. Development 131: 3295-3306.
    • (2004) Development , vol.131 , pp. 3295-3306
    • Lee, S.K.1    Jurata, L.W.2    Funahashi, J.3    Ruiz, E.C.4    Pfaff, S.L.5
  • 19
    • 0347915722 scopus 로고    scopus 로고
    • Olig genes are expressed in a heterogeneous population of precursor cells in the developing spinal cord
    • Liu, Y. and Rao, M.S. 2004. Olig genes are expressed in a heterogeneous population of precursor cells in the developing spinal cord. Glia 45: 67-74.
    • (2004) Glia , vol.45 , pp. 67-74
    • Liu, Y.1    Rao, M.S.2
  • 20
    • 0033767315 scopus 로고    scopus 로고
    • Sonic hedgehog-Regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system
    • Lu, Q.R., Yuk, D., Alberta, J.A., Zhu, Z., Pawlitzky, I., Chan, J., McMahon, A.P., Stiles, C.D., and Rowitch, D.H. 2000. Sonic hedgehog-Regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron 25: 317-329.
    • (2000) Neuron , vol.25 , pp. 317-329
    • Lu, Q.R.1    Yuk, D.2    Alberta, J.A.3    Zhu, Z.4    Pawlitzky, I.5    Chan, J.6    McMahon, A.P.7    Stiles, C.D.8    Rowitch, D.H.9
  • 21
    • 0037023529 scopus 로고    scopus 로고
    • Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection
    • Lu, Q.R., Sun, T., Zhu, Z., Ma, N., Garcia, M., Stiles, C.D., and Rowitch, D.H. 2002. Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Cell 109: 75-86.
    • (2002) Cell , vol.109 , pp. 75-86
    • Lu, Q.R.1    Sun, T.2    Zhu, Z.3    Ma, N.4    Garcia, M.5    Stiles, C.D.6    Rowitch, D.H.7
  • 22
    • 0035929332 scopus 로고    scopus 로고
    • Cracking the transcriptional code for cell specification in the neural tube
    • Marquardt, T. and Pfaff, S.L. 2001. Cracking the transcriptional code for cell specification in the neural tube. Cell 106: 651-654.
    • (2001) Cell , vol.106 , pp. 651-654
    • Marquardt, T.1    Pfaff, S.L.2
  • 23
    • 0028858680 scopus 로고
    • Constructing the cerebral cortex: Neurogenesis and fate determination
    • McConnell, S.K. 1995. Constructing the cerebral cortex: Neurogenesis and fate determination. Neuron 15: 761-768.
    • (1995) Neuron , vol.15 , pp. 761-768
    • McConnell, S.K.1
  • 24
    • 0035855786 scopus 로고    scopus 로고
    • Combinatorial roles of olig2 and neurogenin2 in the coordinated induction of pan-neuronal and subtype-specific properties of motoneurons
    • Mizuguchi, R., Sugimori, M., Takebayashi, H., Kosako, H., Nagao, M., Yoshida, S., Nabeshima, Y., Shimamura, K., and Nakafuku, M. 2001. Combinatorial roles of olig2 and neurogenin2 in the coordinated induction of pan-neuronal and subtype-specific properties of motoneurons. Neuron 31: 757-771.
    • (2001) Neuron , vol.31 , pp. 757-771
    • Mizuguchi, R.1    Sugimori, M.2    Takebayashi, H.3    Kosako, H.4    Nagao, M.5    Yoshida, S.6    Nabeshima, Y.7    Shimamura, K.8    Nakafuku, M.9
  • 25
    • 0035937415 scopus 로고    scopus 로고
    • Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube
    • Muhr, J., Andersson, E., Persson, M., and Jessell, T.M. 2001. Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube. Cell 104: 861-873.
    • (2001) Cell , vol.104 , pp. 861-873
    • Muhr, J.1    Andersson, E.2    Persson, M.3    Jessell, T.M.4
  • 26
    • 0033935341 scopus 로고    scopus 로고
    • Misexpression of genes in brain vesicles by in ovo electroporation
    • Nakamura, H., Watanabe, Y., and Funahashi, J. 2000. Misexpression of genes in brain vesicles by in ovo electroporation. Dev. Growth Differ. 42: 199-201.
    • (2000) Dev. Growth Differ. , vol.42 , pp. 199-201
    • Nakamura, H.1    Watanabe, Y.2    Funahashi, J.3
  • 27
    • 0034471262 scopus 로고    scopus 로고
    • ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis
    • Norton, J.D. 2000. ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis. J. Cell Sci. 113: 3897-3905.
    • (2000) J. Cell Sci. , vol.113 , pp. 3897-3905
    • Norton, J.D.1
  • 28
    • 0035855795 scopus 로고    scopus 로고
    • Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2
    • Novitch, B.G., Chen, A.I., and Jessell, T.M. 2001. Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2. Neuron 31: 773-789.
    • (2001) Neuron , vol.31 , pp. 773-789
    • Novitch, B.G.1    Chen, A.I.2    Jessell, T.M.3
  • 29
    • 0141862010 scopus 로고    scopus 로고
    • A requirement for retinoic acid-mediated transcriptional activation in ventral neural patterning and motor neuron specificatior
    • Novitch, B.G., Wichterle, H., Jessell, T.M., and Sockanathan, S. 2003. A requirement for retinoic acid-mediated transcriptional activation in ventral neural patterning and motor neuron specificatior. Neuron 40: 81-95.
    • (2003) Neuron , vol.40 , pp. 81-95
    • Novitch, B.G.1    Wichterle, H.2    Jessell, T.M.3    Sockanathan, S.4
  • 30
    • 0041508452 scopus 로고    scopus 로고
    • Delta-Notch signaling regulates oligodendrocyte specification
    • Park, H.C. and Appel, B. 2003. Delta-Notch signaling regulates oligodendrocyte specification. Development 130: 3747-3755.
    • (2003) Development , vol.130 , pp. 3747-3755
    • Park, H.C.1    Appel, B.2
  • 31
    • 12144284478 scopus 로고    scopus 로고
    • Spatial and temporal regulation of ventral spinal cord precursor specification by Hedgehog signaling
    • Park, H.C., Shin, J., and Appel, B. 2004. Spatial and temporal regulation of ventral spinal cord precursor specification by Hedgehog signaling. Development 131: 5959-5969.
    • (2004) Development , vol.131 , pp. 5959-5969
    • Park, H.C.1    Shin, J.2    Appel, B.3
  • 32
    • 0034914553 scopus 로고    scopus 로고
    • Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor
    • Qi, Y., Cai, J., Wu, Y., Wu, R., Lee, J., Fu, H., Rao, M., Sussel, L., Rubenstein, J., and Qiu, M. 2001. Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor. Development 128: 2723-2733.
    • (2001) Development , vol.128 , pp. 2723-2733
    • Qi, Y.1    Cai, J.2    Wu, Y.3    Wu, R.4    Lee, J.5    Fu, H.6    Rao, M.7    Sussel, L.8    Rubenstein, J.9    Qiu, M.10
  • 35
    • 4644223417 scopus 로고    scopus 로고
    • Interactions between ID and OLIG proteins mediate the inhibitory effects of BMP4 on oligodendroglial differentiation
    • Samanta, J. and Kessler, J.A. 2004. Interactions between ID and OLIG proteins mediate the inhibitory effects of BMP4 on oligodendroglial differentiation. Development 131: 4131-4142.
    • (2004) Development , vol.131 , pp. 4131-4142
    • Samanta, J.1    Kessler, J.A.2
  • 36
    • 0035797449 scopus 로고    scopus 로고
    • Crossregulation between Neurogenin2 and pathways specifying neuronal identity in the spinal cord
    • Scardigli, R., Schuurmans, C., Gradwohl, G., and Guillemot, F. 2001. Crossregulation between Neurogenin2 and pathways specifying neuronal identity in the spinal cord. Neuron 31: 203-217.
    • (2001) Neuron , vol.31 , pp. 203-217
    • Scardigli, R.1    Schuurmans, C.2    Gradwohl, G.3    Guillemot, F.4
  • 37
    • 0035830503 scopus 로고    scopus 로고
    • Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms
    • Sun, Y., Nadal-Vicens, M., Misono, S., Lin, M.Z., Zubiaga, A., Hua, X., Fan, G., and Greenberg, M.E. 2001. Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms. Cell 104: 365-376.
    • (2001) Cell , vol.104 , pp. 365-376
    • Sun, Y.1    Nadal-Vicens, M.2    Misono, S.3    Lin, M.Z.4    Zubiaga, A.5    Hua, X.6    Fan, G.7    Greenberg, M.E.8
  • 38
    • 0142182059 scopus 로고    scopus 로고
    • Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex
    • Sun, T., Dong, H., Wu, L., Kane, M., Rowitch, D.H., and Stiles, C.D. 2003. Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex. J. Neurosci. 23: 9547-9556.
    • (2003) J. Neurosci. , vol.23 , pp. 9547-9556
    • Sun, T.1    Dong, H.2    Wu, L.3    Kane, M.4    Rowitch, D.H.5    Stiles, C.D.6
  • 39
    • 0029860502 scopus 로고    scopus 로고
    • Diversity and pattern in the developing spinal cord
    • Tanabe, Y. and Jessell, T.M. 1996. Diversity and pattern in the developing spinal cord. Science 274: 1115-1122.
    • (1996) Science , vol.274 , pp. 1115-1122
    • Tanabe, Y.1    Jessell, T.M.2
  • 40
    • 0032475837 scopus 로고    scopus 로고
    • Specification of motor neuron identity by the MNR2 homeodomain protein
    • Tanabe, Y., William, C., and Jessell, T.M. 1998. Specification of motor neuron identity by the MNR2 homeodomain protein. Cell 95: 67-80.
    • (1998) Cell , vol.95 , pp. 67-80
    • Tanabe, Y.1    William, C.2    Jessell, T.M.3
  • 41
    • 0033179908 scopus 로고    scopus 로고
    • Active suppression of interneuron programs within developing motor neurons revealed by analysis of homeodomain factor HB9
    • Thaler, J., Harrison, K., Sharma, K., Lettieri, K., Kehrl, J., and Pfaff, S.L. 1999. Active suppression of interneuron programs within developing motor neurons revealed by analysis of homeodomain factor HB9. Neuron 23: 675-687.
    • (1999) Neuron , vol.23 , pp. 675-687
    • Thaler, J.1    Harrison, K.2    Sharma, K.3    Lettieri, K.4    Kehrl, J.5    Pfaff, S.L.6
  • 42
    • 0037178783 scopus 로고    scopus 로고
    • LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions
    • Thaler, J.P., Lee, S.K., Jurata, L.W., Gill, G.N., and Pfaff, S.L. 2002. LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions. Cell 110: 237-249.
    • (2002) Cell , vol.110 , pp. 237-249
    • Thaler, J.P.1    Lee, S.K.2    Jurata, L.W.3    Gill, G.N.4    Pfaff, S.L.5
  • 43
    • 0028306459 scopus 로고
    • Expression of achaetcscute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate
    • Turner, D.L. and Weintraub, H. 1994. Expression of achaetcscute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate. Genes & Dev. 8: 1434-1447.
    • (1994) Genes & Dev. , vol.8 , pp. 1434-1447
    • Turner, D.L.1    Weintraub, H.2
  • 44
    • 0037023492 scopus 로고    scopus 로고
    • The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification
    • Zhou, Q. and Anderson, D.J. 2002. The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification. Cell 109: 61-73.
    • (2002) Cell , vol.109 , pp. 61-73
    • Zhou, Q.1    Anderson, D.J.2
  • 45
    • 0033764232 scopus 로고    scopus 로고
    • Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors
    • Zhou, Q., Wang, S., and Anderson, D.J. 2000. Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. Neuron 25: 331-343.
    • (2000) Neuron , vol.25 , pp. 331-343
    • Zhou, Q.1    Wang, S.2    Anderson, D.J.3
  • 46
    • 0035855787 scopus 로고    scopus 로고
    • The bHLH transcription factor Olig2 promotes oligodendrocyte differentiation in collaboration with Nkx2.2
    • Zhou, Q., Choi, G., and Anderson, D.J. 2001. The bHLH transcription factor Olig2 promotes oligodendrocyte differentiation in collaboration with Nkx2.2. Neuron 31: 791-807.
    • (2001) Neuron , vol.31 , pp. 791-807
    • Zhou, Q.1    Choi, G.2    Anderson, D.J.3


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