Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals

Nature Medicine

Volumn 11, Issue 3, 2005, Pages 271-276

  Izumikawa, Masahiko ^a,b   Minoda, Ryosei ^a,c   Kawamoto, Kohei ^b   Abrashkin, Karen A ^a   Swiderski, Donald L ^a   Dolan, David F ^a   Brough, Douglas E ^d   Raphael, Yehoash ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b KANSAI MEDICAL UNIVERSITY   (Japan)

^c KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^d GENVEC INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HELIX LOOP HELIX PROTEIN; TRANSCRIPTION FACTOR;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATOH1 GENE; AUDITORY SYSTEM; CELL DIFFERENTIATION; CELL LOSS; CELL MATURATION; CELL REGENERATION; CONTROLLED STUDY; CORTI ORGAN; GENE; GENE THERAPY; HAIR CELL; HEARING IMPAIRMENT; INFECTION; MATH1 GENE; NONHUMAN; OTOTOXICITY; PERCEPTION DEAFNESS; PHENOTYPE; PRIORITY JOURNAL; SENSORY NERVE CELL;

ADENOVIRIDAE; ANIMALS; COCHLEA; DNA-BINDING PROTEINS; ETHACRYNIC ACID; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE THERAPY; GUINEA PIGS; HAIR CELLS; HEARING LOSS, SENSORINEURAL; HELIX-LOOP-HELIX MOTIFS; KANAMYCIN; NERVE REGENERATION; NERVE TISSUE PROTEINS; TRANSCRIPTION FACTORS;

EID: 16244411316     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1193     Document Type: Article

References (24)

1. Fekete, D.M. Cell fate specification in the inner ear. Current Opin. Neurobiol. 6, 533-541 (1996).
2. Fekete, D.M. Making sense of making hair cells. Trends Neurosci. 23, 386 (2000).
3. Torres, M. & Giraldez, F. The development of the vertebrate inner ear. Mech. Dev. 71, 5-21 (1998).
4. Bermingham, N.A. et al. Math 1: an essential gene for the generation of inner ear hair cells. Science 284, 1837-1841 (1999).
5. Chen, P., Johnson, J.E., Zoghbi, H.Y. & Segil, N. The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination. Development 129, 2495-2505 (2002).
6. Shou, J., Zheng, J.L. & Gao, W.Q. Robust generation of new hair cells in the mature mammalian inner ear by adenoviral expression of Math1. Mol. Cell Neurosci. 23, 169-179 (2003).
7. Kawamoto, K., Ishimoto, S., Minoda, R., Brough, D.E. & Raphael, Y. Math1 gene transfer generates new cochlear hair cells in mature guinea pigs in vivo. J. Neurosci. 23, 4395-4400 (2003).
8. Hasson, T., Heintzelman, M.B., Santos-Sacchi, J., Corey, D.P. & Mooseker, M.S. Expression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1B. Proc. Nat. Acad. Sci. USA 92, 9815-9819 (1995).
9. Woods, C., Montcouquiol, M. & Kelley, M.W. Mathl regulates development of the sensory epithelium in the mammalian cochlea. Nat. Neurosci. 7, 1310-1318 (2004).
10. Greenwood, D.D. Critical bandwidth and the frequency coordinates of the basiiar membrane. J. Acoust. Soc. Am. 33, 1344-1356 (1961).
11. Dallos, P. & Harris, D. Properties of auditory nerve responses in absence of outer hair cells. J. Neurophysiol. 41, 365-383 (1978).
12. Teas, D.C. & Nielsen, D.W. Interaural attenuation versus frequency for guinea pig and chinchilla CM response. J. Acoust. Soc. Am. 58, 1066-1072 (1975).
13. Zheng, J.L. & Gao, W.Q. Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears. Nat. Neurosci. 3, 580-586 (2000).
14. Cotanche, D.A., Messana, E.P. & Ofsie, M.S. Migration of hyaline cells into the chick basiiar papilla during severe noise damage. Hear. Res. 91, 148-159 (1995).
15. Li, H., Liu, H. & Heller, S. Pluripotent stem cells from the adult mouse inner ear, Nat. Med. 9, 1293-1299 (2003).
16. Turner, C.W., Gantz, B.J., Vidal, C., Behrens, A. & Henry, B.A. Speech recognition in noise for cochlear implant listeners: benefits of residual acoustic hearing. J. Acoust. Soc. Am. 115, 1729-1735 (2004).
17. Ishimoto, S., Kawamoto, K., Kanzaki S. & Raphael, Y. Gene transfer into supporting cells of the organ of Corti. Hear. Res. 173, 187-197 (2002).
18. Brough, D.E. et al. Activation of transgene expression by early region 4 is responsible for a high level of persistent transgene expression from adenovirus vectors in vivo. J. Virol. 71, 9206-9213 (1997).
19. Yamasoba, T. & Dolan, D.F. Chronic strychnine administration into the cochlea potentiates permanent threshold shift following noise exposure. Hear. Res. 112, 13-20 (1997).
20. Davis, H. Principles of electric response audiometry. Ann. Otol. Rhinol. Laryngol. 85 Suppl 28, 1-96 (1976).
21. Raphael, Y. & Altschuler, R.A. Reorganization of cytoskeletal and junctional proteins during cochlear hair cell degeneration. Cell Motil. Cytoskeleton 18, 215-227 (1991).
22. Raphael, Y. Reorganization of the chick basilar papilla after acoustic trauma. J. Comp. Neurol. 330, 521-532 (1993).
23. Beyer, L. A. et al. Hair cells in the inner ear of the pirouette and shaker 2 mutant mice. J. Neurocytol. 29, 227-240 (2000).
24. Yagi, M. et al. Spiral ganglion neurons are protected from degeneration by GDNF gene therapy. J. Assoc. Res. Otolaryngol. 1, 315-325 (2000).