Induction of human neuronal cells by defined transcription factors

Nature

Volumn 476, Issue 7359, 2011, Pages 220-223

  Pang, Zhiping P ^a   Yang, Nan ^a   Vierbuchen, Thomas ^a   Ostermeier, Austin ^a   Fuentes, Daniel R ^a   Yang, Troy Q ^a   Citri, Ami ^a   Sebastiano, Vittorio ^a   Marro, Samuele ^a   Südhof, Thomas C ^a   Wernig, Marius ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROGENIC DIFFERENTIATION FACTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR BRN2; TRANSCRIPTION FACTOR MASH1; TRANSCRIPTION FACTOR MYT1L; UNCLASSIFIED DRUG;

ACTION POTENTIAL; BRAIN CELL; CELL STRAIN IN; CELL STRUCTURE; COCULTURE; DOWN REGULATION; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LETTER; NERVE CELL; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; SOMATIC CELL; TRANSGENE;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; CELL LINE; CELLS, CULTURED; CEREBRAL CORTEX; COCULTURE TECHNIQUES; DNA-BINDING PROTEINS; ELECTRIC CONDUCTIVITY; FIBROBLASTS; HUMANS; MEMBRANE POTENTIALS; MICE; NERVE TISSUE PROTEINS; NEURONS; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELLS; POU DOMAIN FACTORS; REGENERATIVE MEDICINE; SYNAPSES; TRANSCRIPTION FACTORS; TRANSGENES;

EID: 79960854285     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature10202     Document Type: Letter

References (27)

1. Blau, H.M. et al. Plasticityofthe differentiated state. Science230, 758-766 (1985).
2. Gurdon, J. B. From nuclear transfer to nuclear reprogramming: the reversal of cell differentiation. Annu. Rev. Cell Dev. Biol. 22, 1-22 (2006)
3. Heins, N. et al. Glial cells generate neurons: the roleof the transcription factor Pax6. Nature Neurosci. 5, 308-315 (2002). (Pubitemid 34279810)
4. Ieda, M. et al. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 142, 375-386 (2010).
5. Shen, C.-N., Slack, J. M. W. & Tosh, D. Molecular basis of transdifferentiation of pancreas to liver. Nature Cell Biol. 2, 879-887 (2000).
6. Tada, M., Takahama, Y., Abe, K., Nakatsuji,N.&Tada,T.Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells. Curr. Biol. 11, 1553-1558 (2001). (Pubitemid 32931020)
7. Takahashi, K. et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872 (2007). (Pubitemid 350138099)
8. Wilmut, I., Schnieke, A. E., McWhir, J., Kind, A. J. & Campbell, K. H. Viable offspring derived from fetal and adult mammalian cells. Nature 385, 810-813 (1997). (Pubitemid 27106068)
9. Xie, H., Ye, M., Feng, R. & Graf, T. Stepwise reprogramming of B cells into macrophages. Cell 117, 663-676 (2004). (Pubitemid 38692531)
10. Zhou, Q., Brown, J., Kanarek, A., Rajagopal,J. & Melton, D. A. Invivo reprogramming of adult pancreatic exocrine cells to b-cells. Nature 455, 627-632 (2008).
11. Graf, T. & Enver, T. Forcing cells to change lineages. Nature 462, 587-594 (2009).
12. Zhou, Q. & Melton, D. A. Extreme makeover: converting one cell into another. Cell Stem Cell 3, 382-388 (2008).
13. Vierbuchen, T. et al. Direct conversion of fibroblasts to functional neurons by defined factors. Nature 463, 1035-1041 (2010).
14. Hansen, D. V., Lui, J. H., Parker, P. R. & Kriegstein, A. R. Neurogenic radial glia in the outer subventricular zone of human neocortex. Nature 464, 554-561 (2010).
15. Kriegstein, A., Noctor, S. & Martinez-Cerdeno, V. Patterns of neural stem and progenitor cell division may underlie evolutionary cortical expansion. Nature Rev. Neurosci. 7, 883-890 (2006). (Pubitemid 44624180)
16. Zhang, X. et al. Pax6 is a human neuroectoderm cell fate determinant. Cell Stem Cell 7, 90-100 (2010).
17. Bottenstein, J. E. & Sato, G. H. Growth ofa rat neuroblastoma cell line in serum-free supplemented medium. Proc. Natl Acad. Sci. USA 76, 514-517 (1979). (Pubitemid 9106659)
18. Guo, G. et al. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev. Cell 18, 675-685 (2010).
19. Johnson, M. A., Weick, J. P., Pearce, R. A. & Zhang, S. C. Functional neural development from human embryonic stem cells: accelerated synaptic activity via astrocyte coculture. J. Neurosci. 27, 3069-3077 (2007). (Pubitemid 46474121)
20. Wu, H. et al. Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines. Proc. Natl Acad. Sci. USA 104, 13821-13826 (2007). (Pubitemid 350003404)
21. Koch, P., Opitz, T., Steinbeck, J. A., Ladewig, J. & Brustle, O. A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration. Proc. Natl Acad. Sci. USA 106, 3225-3230 (2009).
22. Marchetto, M. C. et al. A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell 143, 527-539 (2010).
23. Hu, B. Y. et al. Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proc. Natl Acad. Sci. USA 107, 4335-4340 (2010).
24. Xu, Y. et al. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc. Natl Acad. Sci. USA 107, 8129-8134 (2010).
25. Maximov, A., Pang, Z. P., Tervo, D. G. & Sudhof, T. C. Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation. J. Neurosci. Methods 161, 75-87 (2007). (Pubitemid 46349250)
26. Wong, C. C. et al. Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage. Nature Biotechnol. 28, 1115-1121 (2010).
27. Somers, A. et al. Generation of transgene-free lung disease-specific human induced pluripotent stem cells usinga single excisable lentiviral stem cell cassette. Stem Cells 28, 1728-1740 (2010).