Association Study of 25 Type 2 Diabetes Related Loci with Measures of Obesity in Indian Sib Pairs

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Gupta, Vipin ^a   Vinay, Donipadi Guru ^b   Sovio, Ulla ^c   Rafiq, Sajjad ^d   Kranthi Kumar, Madamchetty Venkata ^b   Janipalli, Charles Spurgeon ^b   Evans, David ^e   Mani, Kulathu Radha ^b   Sandeep, Madana Narasimha ^b   Taylor, Amy ^e   Kinra, Sanjay ^c   Sullivan, Ruth ^c   Bowen, Liza ^c   Timpson, Nicholas ^e   da Smith, Georgevey ^e   Dudbridge, Frank ^c   Prabhakaran, Dorairaj ^f   Ben Shlomo, Yoav ^e   Reddy, Kolli Srinath ^a   Ebrahim, Shah ^a,c   Chandak, Giriraj Ratan ^b   more..

^a PUBLIC HEALTH FOUNDATION OF INDIA   (India)

^b CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

^c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^d UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^e UNIVERSITY OF BRISTOL   (United Kingdom)

^f CENTRE FOR CHRONIC DISEASE CONTROL   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ADAM PROTEIN; CELL CYCLE PROTEIN; CHEMOKINE RECEPTOR CXCR4; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; DERMCIDIN; HEPATOCYTE NUCLEAR FACTOR 3BETA; NEUROGENIN 3; NOTCH2 RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; POTASSIUM CHANNEL KCNQ; TRANSCRIPTION FACTOR 7 LIKE 2; VASCULOTROPIN A;

ABCC8 GENE; ADAM30 GENE; ADULT; ARTICLE; BCL11A GENE; BODY FAT; BODY MASS; BODY WEIGHT; CDC123 GENE; CDKAL1 GENE; CDKN2A GENE; CDKN2B GENE; CXCR4 GENE; DCD GENE; ENERGY CONSUMPTION; FEMALE; FLJ3970 GENE; FOXA2 GENE; GCK GENE; GENE; GENE FUNCTION; GENE LOCUS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC TRAIT; GENETIC VARIABILITY; HHEX GENE; HUMAN; INDIA; INDIAN; KCNQ1 GENE; KCTD12 GENE; LGR5 GENE; LOC646279 GENE; MAJOR CLINICAL STUDY; MALE; NGN3 GENE; NON INSULIN DEPENDENT DIABETES MELLITUS; NOTCH2 GENE; OBESITY; PATHOPHYSIOLOGY; PHENOTYPE; PHYSICAL ACTIVITY; POPULATION RESEARCH; PPARG GENE; RISK ASSESSMENT; RISK FACTOR; SCORING SYSTEM; SIBLING; SINGLE NUCLEOTIDE POLYMORPHISM; SLC30A8 GENE; TCF2 GENE; TCF7L2 GENE; THADA GENE; TSPAN GENE; VALIDATION STUDY; VEGFA GENE; WAIST HIP RATIO; WFS1 GENE;

ADULT; AGED; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BODY MASS INDEX; BODY WEIGHT; DIABETES MELLITUS, TYPE 2; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HEPATOCYTE NUCLEAR FACTOR 3-BETA; HOMEODOMAIN PROTEINS; HUMANS; INDIA; MALE; NEOPLASM PROTEINS; NERVE TISSUE PROTEINS; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, CXCR4; SIBLINGS; TRANSCRIPTION FACTOR 7-LIKE 2 PROTEIN; TRANSCRIPTION FACTORS; TRANSIENTS AND MIGRANTS; WAIST-HIP RATIO;

EID: 84872583704     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0053944     Document Type: Article

References (41)

1. Abelson P, Kennedy D, (2004) The obesity epidemic. Science 304: 1413.
2. Haslam DW, James WP, (2005) Obesity. Lancet 366: 1197-209.
3. Gregg EW, Cadwell BL, Cheng YJ, Cowie CC, Williams DE, et al. (2004) Trends in the prevalence and ratio of diagnosed to undiagnosed diabetes according to obesitylevels in the U.S. Diabetes Care. 27(12): 2806-12.
4. Boffetta P, McLerran D, Chen Y, Inoue M, Sinha R, et al. (2011) Body mass index and diabetes in Asia: a cross-sectional pooled analysis of 900,000 individuals in the Asia cohort consortium. PLoS One 2011 6(6): e19930.
5. Yoon KH, Lee JH, Kim JW, Cho JH, Choi YH, et al. (2006) Epidemic obesity and type 2 diabetes in Asia. Lancet 368(9548): 1681-8.
6. Kahn SE, Hull RL, Utzschneider KM, (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444(7121): 840-6.
7. Freathy RM, Timpson NJ, Lawlor DA, Pouta A, Ben-Shlomo Y, et al. (2008) Common variation in the FTO gene alters diabetes-related metabolic traits to extent expected, given its effect on BMI. Diabetes 57;1419-1426.
8. Freathy RM, Bennett AJ, Ring SM, Shields B, Groves CJ, et al. (2009) Type 2 diabetes risk alleles are associated with reduced size at birth.Diabetes. 58(6): 1428-33.
9. Altshuler D, Hirschhorn JN, Klannemark M, Lindgren CM, Vohl MC, et al. (2000) The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 26: 76-80.
10. Aulchenko YS, Pullen J, Kloosterman WP, Yazdanpanah M, Hofman A, et al. (2007) LPIN2 is associated with type 2 diabetes, glucose metabolism, and body composition. Diabetes 56: 3020-3026.
11. Taylor AE, Sandeep MN, Janipalli CS, Giambartolomei C, Evans DM, et al. (2011) Associations of FTO and MC4R variants with obesity traits in Indians and the role of rural/urban environment as a possible effect modifier. Journal of Obesity doi:10.1155/2011/307542.
12. Ramya K, Radha V, Ghosh S, Majumder PP, Mohan V, (2011) Genetic variations in the FTO gene are associated with type 2 diabetes and obesity in south Indians (CURES-79). Diabetes Technol Ther. 13(1): 33-42.
13. Tabassum R, Mahendran Y, Dwivedi OP, Chauhan G, Ghosh S, et al. (2012) Common Variants of IL6, LEPR, and PBEF1 Are Associated With Obesity in Indian Children. Diabetes DOI: 10.2337/db11-1501.
14. Been LF, Nath SK, Ralhan SK, Wander GS, Mehra NK, et al. (2010) Replication of association between a common variant near melanocortin-4 receptor gene and obesity-related traits in Asian Sikhs. Obesity (Silver Spring) 18(2): 425-9.
15. Janipalli CS, Kumar MV, Vinay DG, Sandeep MN, Bhaskar S, et al. (2012) Analysis of 32 common susceptibility genetic variants and their combined effect in predicting risk of type 2 diabetes and related traits in Indians. Diabet Med. 29(1): 121-7.
16. Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, et al. (2010) Meta-analysis identifies 13 new loci associated with waist hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genetics 42(11): 949-60.
17. Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, et al. (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nature Genetics 42(11): 937-48.
18. Li S, Zhao JH, Luan J, Langenberg C, Luben RN, et al. (2011) Genetic predisposition to obesity leads to increased risk of type 2 diabetes. Diabetologia (4): 776-82.
19. Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, et al. (2010) Twelve T2D susceptibility loci identified through large-scale association analysis. Nature Genetics 42(7): 579-589.
20. Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, et al. (2010) New genetic loci implicated in fasting glucose homeostasis and their impact on T2D risk. Nature Genetics 42(2): 105-116.
21. Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, et al. (2012) Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet. doi: 10.1038/ng.2385.
22. Wang X, Ding X, Su S, Spector TD, Mangino M, et al. (2009) Heritability of insulin sensitivity and lipid profile depend on BMI: evidence for gene-obesity interaction. Diabetologia 52(12): 2578-84.
23. Kooner JS, Saleheen D, Sim X, Sehmi J, Zhang W, et al. (2011) Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat Genet. 43(10): 984-9.
24. Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, et al. (2009) Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet. 5(6): e1000508.
25. Gupta V, Vinay DG, Rafiq S, Kranthikumar MV, Janipalli CS, et al. (2012) Association analysis of31 common polymorphisms with type 2 diabetes andits related traits inIndian sib pairs. Diabetologia 55(2): 349-57.
26. Ebrahim S, Kinra S, Bowen L, Andersen E, Ben-Shlomo Y, et al. (2010) The effect of rural-to-urban migration on obesity and diabetes in India: a cross-sectional study. PLoS Medicine 7(4): e1000268.
27. WHO Expert Consultation, (2004) Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 363(9403): 157-63.
28. Durnin JV, Womersley J, (1974) Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. Br J Nutr 32(1): 77-97.
29. Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, et al. (2007) A genome-wide association study of T2D in Finns detects multiple susceptibility variants. Science 316: 1341-1345.
30. Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, et al. (2008) Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 40(5): 638-45.
31. Purcell S, Cherny SS, Sham PC, (2003) Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19(1): 149-150.
32. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, et al. (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81(3): 559-575.
33. Fulker DW, Cherny SS, Sham PC, Hewitt JK, (1996) Combined linkage and association sib-pair analysis for quantitative traits. Am J Hum Genet 64(1): 259-267.
34. Timpson NJ, Emmett PM, Frayling TM, Rogers I, Hattersley AT, et al. (2008) The fat mass- and obesity-associated locus and dietary intake in children. Am J Clin Nutr. 88(4): 971-8.
35. Benjamini Y, Hochberg Y, (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. Journal of the Royal Statistical Society B57: 289-300.
36. Pecioska S, Zillikens MC, Henneman P, Snijders PJ, Oostra BA, et al. (2010) Association between type 2 diabetes loci and measures of fatness. PLoS One 5(1): e8541.
37. Zhao J, Bradfield JP, Zhang H, Annaiah K, Wang K, et al. (2010) Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE asa locus influencing pediatric BMI. Diabetes 59(3): 751-5.
38. Puigserver P, Rodgers JT, (2006) Foxa2, a novel transcriptional regulator of insulin sensitivity. Nature Medicine 12: 38-39.
39. Tabassum R, Chavali S, Dwivedi OP, Tandon N, Bharadwaj D, (2008) Genetic variants of FOXA2: risk of type 2 diabetes and effect on metabolic traits in North Indians. J Hum Genet 53(11-12): 957-65.
40. Laird NM and Lange C (2006) Family-based designs in the age of large-scale gene-association studies. Nature Review Genetics 7, 385-394.
41. Bowen L, Ebrahim S, De Stavola B, Ness A, Kinra S, et al. (2011) Dietary intake and rural-urban migration in India: a cross-sectional study. PLoS One 6(6): e14822.