-
1
-
-
0042626242
-
SKN1 links C. Elegans mesendodermal specification to a conserved oxidative stress response
-
An JH, Blackwell TK (2003) SKN1 links C.elegans mesendodermal specification to a conserved oxidative stress response. Genes Dev 17:1882-1893.
-
(2003)
Genes Dev
, vol.17
, pp. 1882-1893
-
-
An, J.H.1
Blackwell, T.K.2
-
2
-
-
31344444419
-
Inhibition of DNA binding by differential sumoylation of heat shock factors
-
Anckar J, Hietakangas V, Denessiouk K et al. (2006) Inhibition of DNA binding by differential sumoylation of heat shock factors. Mol Cell Biol 26:955-964.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 955-964
-
-
Anckar, J.1
Hietakangas, V.2
Denessiouk, K.3
-
3
-
-
0024263748
-
MDA content in fast and slow-twitch skeletal muscle with intensity of exercise in a rat
-
Alessio HM, Goldfarb AH, Cutler RG (1988) MDA content in fast and slow-twitch skeletal muscle with intensity of exercise in a rat. Am J Physiol 255:C874-C877.
-
(1988)
Am J Physiol
, vol.255
, pp. C874-C877
-
-
Alessio, H.M.1
Goldfarb, A.H.2
Cutler, R.G.3
-
4
-
-
3442881380
-
Concentration of signal transduction protein exercise and insulin responses in rat extensor digitorum longus and soleus muscles
-
Atherton PJ, Higginson JM, Singh J et al. (2004) Concentration of signal transduction protein exercise and insulin responses in rat extensor digitorum longus and soleus muscles. Mol Cell Biochem 261:111-116.
-
(2004)
Mol Cell Biochem
, vol.261
, pp. 111-116
-
-
Atherton, P.J.1
Higginson, J.M.2
Singh, J.3
-
5
-
-
0025865317
-
The inducible transcription factor NF-γB: Regulation by distinct protein subunits
-
Baeuerle PA (1991) The inducible transcription factor NF-γB: regulation by distinct protein subunits. Biochem Biophys Acta 1072:63-80.
-
(1991)
Biochem Biophys Acta
, vol.1072
, pp. 63-80
-
-
Baeuerle, P.A.1
-
6
-
-
33845617675
-
Sensing the environment: Lesson from fungi
-
Bahn YS, Xue C, Idnum A et al. (2007) Sensing the environment: lesson from fungi. Nat Rev Microbiol 5:57-69.
-
(2007)
Nat Rev Microbiol
, vol.5
, pp. 57-69
-
-
Bahn, Y.S.1
Xue, C.2
Idnum, A.3
-
7
-
-
2942529192
-
Nuclear stress bodies: A heterochromatin affair?
-
Biamonti G (2004) Nuclear stress bodies: a heterochromatin affair?. Nat Rev Mol Cell Biol 5:493-498.
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 493-498
-
-
Biamonti, G.1
-
8
-
-
0033595011
-
Protein kinase B/AKT-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
-
Biggs WH, Meisenhelder J, Hunter T et al. (1999) Protein kinase B/AKT-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc Natl Acad Sci USA 96:7421-7426.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 7421-7426
-
-
Biggs, W.H.1
Meisenhelder, J.2
Hunter, T.3
-
9
-
-
35348972430
-
Genetic links between diet and lifespan: Shared mechanisms from yeast to humans
-
Bishop NA, Guarente L (2007a) Genetic links between diet and lifespan: shared mechanisms from yeast to humans. Nat Rev Genet 8:835-844.
-
(2007)
Nat Rev Genet
, vol.8
, pp. 835-844
-
-
Bishop, N.A.1
Guarente, L.2
-
10
-
-
34249891333
-
Two neurons mediate diet-restriction-induced longevity in C elegans
-
Bishop NA, Guarente L (2007b) Two neurons mediate diet-restriction-induced longevity in C elegans. Nature 447:545-549.
-
(2007)
Nature
, vol.447
, pp. 545-549
-
-
Bishop, N.A.1
Guarente, L.2
-
11
-
-
0037942739
-
Extended longevity in mice lacking the insulin receptor in adipose tissue
-
Bluher M, Khan BB, Kahn CR (2003) Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299:572-574.
-
(2003)
Science
, vol.299
, pp. 572-574
-
-
Bluher, M.1
Khan, B.B.2
Kahn, C.R.3
-
12
-
-
34247267098
-
Both the N-terminal loop and wing W2 of the forkhead domain of transcription factor FoxO4 are important for DNA binding
-
Boura E, Silhan J, Herman P et al. (2007) Both the N-terminal loop and wing W2 of the forkhead domain of transcription factor FoxO4 are important for DNA binding. J Biol Chem 282:8265-8275.
-
(2007)
J Biol Chem
, vol.282
, pp. 8265-8275
-
-
Boura, E.1
Silhan, J.2
Herman, P.3
-
13
-
-
0033582929
-
AKT promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor
-
Brunet A, Bonni A, Zigmond MJ et al. (1999) AKT promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell 96:857-868.
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
-
14
-
-
0037018148
-
14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport
-
Brunet A, Kanai F, Stehn J et al. (2002) 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport. J Cell Biol 156:817-828.
-
(2002)
J Cell Biol
, vol.156
, pp. 817-828
-
-
Brunet, A.1
Kanai, F.2
Stehn, J.3
-
15
-
-
12144290563
-
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
-
Brunet A, Sweeney LB, Sturgill JF et al. (2004) Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303:2011-2015.
-
(2004)
Science
, vol.303
, pp. 2011-2015
-
-
Brunet, A.1
Sweeney, L.B.2
Sturgill, J.F.3
-
16
-
-
0036629251
-
Cell cycle and death control: Long live forkheads
-
Burgering BM, Kops GJ (2002) Cell cycle and death control: long live forkheads. Trends Biochem Sci 27:352-360.
-
(2002)
Trends Biochem Sci
, vol.27
, pp. 352-360
-
-
Burgering, B.M.1
Kops, G.J.2
-
17
-
-
5444262078
-
IKKbeta/NF-kappaB activation causes severe muscle wasting in mice
-
Cai D, Frantz JD, Tawa NE et al. (2004) IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. Cell 119:285-298.
-
(2004)
Cell
, vol.119
, pp. 285-298
-
-
Cai, D.1
Frantz, J.D.2
Tawa, N.E.3
-
18
-
-
38349167559
-
Black tea polyphenols mimic insulin/insulin-like growth factor-1 signaling to the longevity factor FOXO1a
-
Cameron AR, Anton S, Melville L et al. (2008) Black tea polyphenols mimic insulin/insulin-like growth factor-1 signaling to the longevity factor FOXO1a. Aging Cell 7:69-77.
-
(2008)
Aging Cell
, vol.7
, pp. 69-77
-
-
Cameron, A.R.1
Anton, S.2
Melville, L.3
-
19
-
-
0035836698
-
An important function of nrf2 in combating oxidative stress: Detoxification of acetaminophen
-
Chan K, Han XD, Kan YW (2001) An important function of nrf2 in combating oxidative stress: detoxification of acetaminophen. Proc Natl Acad Sci USA 98:4611-4616.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 4611-4616
-
-
Chan, K.1
Han, X.D.2
Kan, Y.W.3
-
20
-
-
0036007313
-
Role of NRF2 in protection against hyperoxic lung injury in mice
-
Cho HY, Jedlicka AE, Reddy SP et al. (2002) Role of NRF2 in protection against hyperoxic lung injury in mice. Am J Respir Cell Mol Biol 26:175-182.
-
(2002)
Am J Respir Cell Mol Biol
, vol.26
, pp. 175-182
-
-
Cho, H.Y.1
Jedlicka, A.E.2
Reddy, S.P.3
-
21
-
-
11444261268
-
Gene expression profiling of NRF2-mediated protection against oxidative injury
-
Cho HY, Reddy SP, Debiase A et al. (2005) Gene expression profiling of NRF2-mediated protection against oxidative injury. Free Radic Biol Med 38:325-343.
-
(2005)
Free Radic Biol Med
, vol.38
, pp. 325-343
-
-
Cho, H.Y.1
Reddy, S.P.2
Debiase, A.3
-
22
-
-
0032541032
-
Transcriptional activity of heat shock factor 1 at 37C is repressed through phosphorylation of two distinct residues by glycogen synthase kinase 3 and protein kinase Cγ and Cγ
-
Chu B, Zhong R, Soncin F et al. (1998) Transcriptional activity of heat shock factor 1 at 37C is repressed through phosphorylation of two distinct residues by glycogen synthase kinase 3 and protein kinase Cγ and Cγ. J Biol Chem 273:18640-18646.
-
(1998)
J Biol Chem
, vol.273
, pp. 18640-18646
-
-
Chu, B.1
Zhong, R.2
Soncin, F.3
-
23
-
-
0027270989
-
Co-crystal structure of the HNF-3/fork head DNA recognition motif resembles histone H5
-
Clark KL, Halay ED, Lai E et al. (1993) Co-crystal structure of the HNF-3/fork head DNA recognition motif resembles histone H5. Nature 364:412-420.
-
(1993)
Nature
, vol.364
, pp. 412-420
-
-
Clark, K.L.1
Halay, E.D.2
Lai, E.3
-
24
-
-
0025606431
-
Molecular cloning and expression of a hexameric Drosophila heat shock factor subject to negative regulation
-
Clos J, Westwood JT, Becker PB et al. (1990) Molecular cloning and expression of a hexameric Drosophila heat shock factor subject to negative regulation. Cell 63:1085-1097.
-
(1990)
Cell
, vol.63
, pp. 1085-1097
-
-
Clos, J.1
Westwood, J.T.2
Becker, P.B.3
-
25
-
-
34548499151
-
Exercise builds brain health: Key roles of growth factor cascades and inflammation
-
Cotman CW, Berchtold NC, Christie LA (2007) Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci 30:464-472.
-
(2007)
Trends Neurosci
, vol.30
, pp. 464-472
-
-
Cotman, C.W.1
Berchtold, N.C.2
Christie, L.A.3
-
26
-
-
3042750643
-
Silent information regulator 2 potentiates FoXo1-mediated transcription through its deacetylase activity
-
Daitoku H, Hatta M, Matsuzaki H et al. (2004) Silent information regulator 2 potentiates FoXo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci USA 101:10042-10047.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 10042-10047
-
-
Daitoku, H.1
Hatta, M.2
Matsuzaki, H.3
-
28
-
-
7044229640
-
Fatiguing exercise reduces DNA binding activity of NF-γB in skeletal muscle nuclei
-
Durham WJ, Li YP, Genken E et al. (2004) Fatiguing exercise reduces DNA binding activity of NF-γB in skeletal muscle nuclei. J Appl Physiol 97:1740-1745.
-
(2004)
J Appl Physiol
, vol.97
, pp. 1740-1745
-
-
Durham, W.J.1
Li, Y.P.2
Genken, E.3
-
29
-
-
0035985201
-
Human chromosomes 9, 12, and 15 contain the nucleation sites of stress-induced nuclear bodies
-
Denegri M, Moralli D, Rocchi M et al. (2002) Human chromosomes 9, 12, and 15 contain the nucleation sites of stress-induced nuclear bodies. Mol Biol Cell 13:2069-2079.
-
(2002)
Mol Biol Cell
, vol.13
, pp. 2069-2079
-
-
Denegri, M.1
Moralli, D.2
Rocchi, M.3
-
30
-
-
0037015035
-
Direct evidence that sulphydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
-
Dinkova-Kostova AT, Holtzclaw WD, Cole RN et al. (2002) Direct evidence that sulphydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci USA 99:11908-11913.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 11908-11913
-
-
Dinkova-Kostova, A.T.1
Holtzclaw, W.D.2
Cole, R.N.3
-
31
-
-
0242580872
-
Convergence of peroxisome proliferator-activated receptor gamma and FOXO1 signaling pathways
-
Dowell P, Otto TC, Adi S et al. (2003) Convergence of peroxisome proliferator-activated receptor gamma and FOXO1 signaling pathways. J Biol Chem 278:45485-45491.
-
(2003)
J Biol Chem
, vol.278
, pp. 45485-45491
-
-
Dowell, P.1
Otto, T.C.2
Adi, S.3
-
32
-
-
11244320393
-
FOXO transcription factor activation by oxidative stress mediated by small GTPase ral and JNK
-
Essers MA, Weijzen S, de Vries-Smits AM et al. (2004) FOXO transcription factor activation by oxidative stress mediated by small GTPase ral and JNK. EMBO J 23:4802-4812.
-
(2004)
EMBO J
, vol.23
, pp. 4802-4812
-
-
Essers, M.A.1
Weijzen, S.2
De Vries-Smits, A.M.3
-
33
-
-
18844382368
-
Functional interaction between beta-catenin and FOXO in oxidative stress signaling
-
Essers MA, de Vries-Smits LM, Barker N et al. (2005) Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science 308:1181-1184.
-
(2005)
Science
, vol.308
, pp. 1181-1184
-
-
Essers, M.A.1
De Vries-Smits, L.M.2
Barker, N.3
-
34
-
-
9144260619
-
HSF4 is required for normal cell growth and differentiation during mouse lens development
-
Fujimoto M, Izu H, Seki K et al. (2004) HSF4 is required for normal cell growth and differentiation during mouse lens development. EMBO J 23:4297-4306.
-
(2004)
EMBO J
, vol.23
, pp. 4297-4306
-
-
Fujimoto, M.1
Izu, H.2
Seki, K.3
-
35
-
-
0034661826
-
Identification of the differential distribution patterns of mRNA and consensus binding sequences for mouse DAF-16 homologues
-
Furuyama T, Nakazawa T, Nakano I et al. (2000) Identification of the differential distribution patterns of mRNA and consensus binding sequences for mouse DAF-16 homologues. Biochem J 349:629-634.
-
(2000)
Biochem J
, vol.349
, pp. 629-634
-
-
Furuyama, T.1
Nakazawa, T.2
Nakano, I.3
-
36
-
-
40549146580
-
Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: Not required, but its activity modulates the response
-
Giannakou ME, Goss M, Partridge L (2008) Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response. Aging Cell 7:187-198.
-
(2008)
Aging Cell
, vol.7
, pp. 187-198
-
-
Giannakou, M.E.1
Goss, M.2
Partridge, L.3
-
37
-
-
0042477712
-
FOXO transcription factors directly activate Bim gene expression and promote apoptosis in sympathetic neurons
-
Gilley J, Coffer PJ, Ham J (2003) FOXO transcription factors directly activate Bim gene expression and promote apoptosis in sympathetic neurons. J Cell Biol 162:613-622.
-
(2003)
J Cell Biol
, vol.162
, pp. 613-622
-
-
Gilley, J.1
Coffer, P.J.2
Ham, J.3
-
39
-
-
34250326302
-
The emerging role of FOXO transcription factors in pancreatic γ cells
-
Glauser DA, Schlegel W (2007) The emerging role of FOXO transcription factors in pancreatic γ cells. J Endocrinol 193:195-207.
-
(2007)
J Endocrinol
, vol.193
, pp. 195-207
-
-
Glauser, D.A.1
Schlegel, W.2
-
40
-
-
0036234459
-
Missing pieces in the NF-kappaB puzzle
-
Ghosh S, Karin M (2002) Missing pieces in the NF-kappaB puzzle. Cell 109:S81-S96.
-
(2002)
Cell
, vol.109
, pp. S81-S96
-
-
Ghosh, S.1
Karin, M.2
-
41
-
-
23844540597
-
Decreasing xanthine oxidase mediated oxidative stress prevents useful cellular adaptations to exercise in rats
-
Gomez-Cabrera MC, Borras C, Pallardó FV et al. (2005) Decreasing xanthine oxidase mediated oxidative stress prevents useful cellular adaptations to exercise in rats. J Physiol 567:113-120.
-
(2005)
J Physiol
, vol.567
, pp. 113-120
-
-
Gomez-Cabrera, M.C.1
Borras, C.2
Pallardó, F.V.3
-
42
-
-
33750736364
-
Oxidative stress in marathon runners: Interest of antioxidant supplementation
-
Gomez-Cabrera MC, Martinez A, Santangelo G et al. (2006) Oxidative stress in marathon runners: interest of antioxidant supplementation. Br J Nutr 96:S31-S33.
-
(2006)
Br J Nutr
, vol.96
, pp. S31-S33
-
-
Gomez-Cabrera, M.C.1
Martinez, A.2
Santangelo, G.3
-
43
-
-
0029039963
-
A heat shock-responsive domain of human HSF1 that regulates transcription activation domain function
-
Green M, Schultz TJ, Sullivan EK et al. (1995) A heat shock-responsive domain of human HSF1 that regulates transcription activation domain function. Mol Cell Biol 15:3354-3362.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 3354-3362
-
-
Green, M.1
Schultz, T.J.2
Sullivan, E.K.3
-
44
-
-
27844497945
-
FOXO transcription factors at the interface between longevity and tumor suppression
-
Greer EL, Brunet A (2005) FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 24:7410-7425.
-
(2005)
Oncogene
, vol.24
, pp. 7410-7425
-
-
Greer, E.L.1
Brunet, A.2
-
45
-
-
26944487335
-
Translation elongation factor 1a is essential for regulation of the actin cytoskeleton and cell morphology
-
Gross SR, Kinzy TG (2005) Translation elongation factor 1a is essential for regulation of the actin cytoskeleton and cell morphology. Nat Struct Mol Biol 12:772-778.
-
(2005)
Nat Struct Mol Biol
, vol.12
, pp. 772-778
-
-
Gross, S.R.1
Kinzy, T.G.2
-
47
-
-
18244384703
-
Analysis of phosphorylation of human heat shock factor 1 in cells experiencing stress
-
Guettouche T, Boellmann F, Lane WS et al. (2005) Analysis of phosphorylation of human heat shock factor 1 in cells experiencing stress. BMC Biochem 6:4.
-
(2005)
BMC Biochem
, vol.6
, pp. 4
-
-
Guettouche, T.1
Boellmann, F.2
Lane, W.S.3
-
48
-
-
33947379500
-
Protective effect of sulforaphane against dopaminergic cell death
-
Han JM, Lee YJ, Lee SY et al. (2007) Protective effect of sulforaphane against dopaminergic cell death. J Pharmacol Exp Ther 321:249-256.
-
(2007)
J Pharmacol Exp Ther
, vol.321
, pp. 249-256
-
-
Han, J.M.1
Lee, Y.J.2
Lee, S.Y.3
-
49
-
-
40149105890
-
A role for autophagy in the extension of lifespan by dietary restriction in C.elegans
-
Hansen M, Chandra A, Mitic LL et al. (2008) A role for autophagy in the extension of lifespan by dietary restriction in C.elegans. PLoS Genet 4:e24.
-
(2008)
PLoS Genet
, vol.4
, pp. e24
-
-
Hansen, M.1
Chandra, A.2
Mitic, L.L.3
-
50
-
-
33646351055
-
Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass
-
Hashimoto N, Kido Y, Uchida T et al. (2006) Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass. Nat Genet 38:589-593.
-
(2006)
Nat Genet
, vol.38
, pp. 589-593
-
-
Hashimoto, N.1
Kido, Y.2
Uchida, T.3
-
51
-
-
34548239152
-
Physical activity and public health: Updated recommendation for adults from the American College of Sports Medicine and the American Heart Association
-
Haskell WL, Lee IM, Pate RR et al. (2007) Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Med Sci Sports Exerc 39:1423-1434.
-
(2007)
Med Sci Sports Exerc
, vol.39
, pp. 1423-1434
-
-
Haskell, W.L.1
Lee, I.M.2
Pate, R.R.3
-
52
-
-
38849199203
-
Shared principles in NF-γB Signaling
-
Hayden MS, Ghosh S (2008) Shared principles in NF-γB Signaling. Cell 132:344-362.
-
(2008)
Cell
, vol.132
, pp. 344-362
-
-
Hayden, M.S.1
Ghosh, S.2
-
53
-
-
0035877643
-
Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation
-
He CH, Gong P, Hu B et al. (2001) Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation. J Biol Chem 276:20858-20865.
-
(2001)
J Biol Chem
, vol.276
, pp. 20858-20865
-
-
He, C.H.1
Gong, P.2
Hu, B.3
-
54
-
-
0042818001
-
Elevated expression of heat shock factor 2A stimulates HSF1-induced transcription during stress
-
He H, Soncin F, Grammatikakis N et al. (2003) Elevated expression of heat shock factor 2A stimulates HSF1-induced transcription during stress. J Biol Chem 278:35465-35475.
-
(2003)
J Biol Chem
, vol.278
, pp. 35465-35475
-
-
He, H.1
Soncin, F.2
Grammatikakis, N.3
-
55
-
-
0037385213
-
Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1
-
Hietakangas V, Ahlskog JK, Jakobsson AM et al. (2003) Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1. Mol Cell Biol 23:2953-2968.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 2953-2968
-
-
Hietakangas, V.1
Ahlskog, J.K.2
Jakobsson, A.M.3
-
56
-
-
33746111834
-
Induction of quinone reductase NQO1 by resveratrol in human K562 cells involves the antioxidant response element ARE and is accompanied by nuclear translocation of transcription factor Nrf2
-
Hsieh TC, Lu X, Wang Z et al. (2006) Induction of quinone reductase NQO1 by resveratrol in human K562 cells involves the antioxidant response element ARE and is accompanied by nuclear translocation of transcription factor Nrf2. Med Chem 3:275-285.
-
(2006)
Med Chem
, vol.3
, pp. 275-285
-
-
Hsieh, T.C.1
Lu, X.2
Wang, Z.3
-
57
-
-
25444492611
-
Regulation of IkappaB kinase and NF-kappaB in contracting adult rat skeletal muscle
-
Ho RC, Hirshman MF, Li Y et al. (2005) Regulation of IkappaB kinase and NF-kappaB in contracting adult rat skeletal muscle. Am J Physiol Cell Physiol 289:C794-C801.
-
(2005)
Am J Physiol Cell Physiol
, vol.289
, pp. C794-C801
-
-
Ho, R.C.1
Hirshman, M.F.2
Li, Y.3
-
58
-
-
33750448661
-
Transcriptional regulation via the NF-kappaB signaling module
-
Hoffmann A, Natoli G, Ghosh G (2006) Transcriptional regulation via the NF-kappaB signaling module. Oncogene 25:6706-6716.
-
(2006)
Oncogene
, vol.25
, pp. 6706-6716
-
-
Hoffmann, A.1
Natoli, G.2
Ghosh, G.3
-
59
-
-
0034631756
-
Superoxide dismutase gene expression in skeletal muscle: Fiber-specific effect of age
-
Hollander J, Bejma J, Ookawara T et al. (2000) Superoxide dismutase gene expression in skeletal muscle: fiber-specific effect of age. Mech Ageing Dev 116:33-45.
-
(2000)
Mech Ageing Dev
, vol.116
, pp. 33-45
-
-
Hollander, J.1
Bejma, J.2
Ookawara, T.3
-
60
-
-
0034950434
-
Superoxide dismutase gene expression is activated by a single bout of exercise
-
Hollander J, Fiebig R, Ookawara T et al. (2001) Superoxide dismutase gene expression is activated by a single bout of exercise. Pflug Arch (Eur J Physiol) 442:426-434.
-
(2001)
Pflug Arch (Eur J Physiol)
, vol.442
, pp. 426-434
-
-
Hollander, J.1
Fiebig, R.2
Ookawara, T.3
-
61
-
-
17844386323
-
Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1
-
Holmberg CI, Hietakangas V, Mikhailov A et al. (2001) Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1. EMBO J 20:3800-3810.
-
(2001)
EMBO J
, vol.20
, pp. 3800-3810
-
-
Holmberg, C.I.1
Hietakangas, V.2
Mikhailov, A.3
-
62
-
-
84911893354
-
IGF-1 receptor regulates lifespan and oxidative stress resistance in mice
-
Holzenberg M, Dupont J, Ducos B et al. (2003) IGF-1 receptor regulates lifespan and oxidative stress resistance in mice. Nature 421:182-187.
-
(2003)
Nature
, vol.421
, pp. 182-187
-
-
Holzenberg, M.1
Dupont, J.2
Ducos, B.3
-
63
-
-
0035955662
-
Regulation of heat shock factor 1 by stress-induced SUMO-1 modification
-
Hong Y, Rogers R, Matunis MJ et al. (2001) Regulation of heat shock factor 1 by stress-induced SUMO-1 modification. J Biol Chem 276:40263-40267.
-
(2001)
J Biol Chem
, vol.276
, pp. 40263-40267
-
-
Hong, Y.1
Rogers, R.2
Matunis, M.J.3
-
64
-
-
11144317940
-
Disruption of either the Nfkb1 or the Bcl3 gene inhibits skeletal muscle atrophy
-
Hunter RB, Kandarian SC (2004) Disruption of either the Nfkb1 or the Bcl3 gene inhibits skeletal muscle atrophy. J Clin Invest 114:1504-1511.
-
(2004)
J Clin Invest
, vol.114
, pp. 1504-1511
-
-
Hunter, R.B.1
Kandarian, S.C.2
-
65
-
-
0031577292
-
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
-
Itoh K, Chiba T, Takahashi S, Ishii T et al. (1997) An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun 236:313-322.
-
(1997)
Biochem Biophys Res Commun
, vol.236
, pp. 313-322
-
-
Itoh, K.1
Chiba, T.2
Takahashi, S.3
Ishii, T.4
-
66
-
-
20444438012
-
Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells
-
Jeong WS, Keum YS, Chen C et al. (2005) Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells. J Biochem Mol Biol 38:167-176.
-
(2005)
J Biochem Mol Biol
, vol.38
, pp. 167-176
-
-
Jeong, W.S.1
Keum, Y.S.2
Chen, C.3
-
67
-
-
0031452176
-
HSF1 transcription factor concentrates in nuclear foci during heat shock: Relationship with transcription sites
-
Jolly C, Morimoto RI, Robert-Nicoud M et al. (1997) HSF1 transcription factor concentrates in nuclear foci during heat shock: relationship with transcription sites. J Cell Sci 110:2935-2941.
-
(1997)
J Cell Sci
, vol.110
, pp. 2935-2941
-
-
Jolly, C.1
Morimoto, R.I.2
Robert-Nicoud, M.3
-
68
-
-
0033536006
-
Rapid and reversible relocalization of heat shock factor 1 within seconds to nuclear stress granules
-
Jolly C, Usson Y, Morimoto RI (1999) Rapid and reversible relocalization of heat shock factor 1 within seconds to nuclear stress granules. Proc Natl Acad Sci USA 96:6769-6774.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 6769-6774
-
-
Jolly, C.1
Usson, Y.2
Morimoto, R.I.3
-
69
-
-
0037018158
-
In vivo binding of active heat shock transcription factor 1 to human chromosome 9 heterochromatin during stress
-
Jolly C, Konecny L, Grady DL et al. (2002) In vivo binding of active heat shock transcription factor 1 to human chromosome 9 heterochromatin during stress. J Cell Biol 156:775-781.
-
(2002)
J Cell Biol
, vol.156
, pp. 775-781
-
-
Jolly, C.1
Konecny, L.2
Grady, D.L.3
-
70
-
-
0347432388
-
Stress-induced transcription of satellite III repeats
-
Jolly C, Metz A, Govin J et al. (2004) Stress-induced transcription of satellite III repeats. J Cell Biol 164:25-33.
-
(2004)
J Cell Biol
, vol.164
, pp. 25-33
-
-
Jolly, C.1
Metz, A.2
Govin, J.3
-
71
-
-
34447328075
-
Up-regulation of aldose reductase expression mediated by phosphatidylinositol 3-kinase/AKT and Nrf2 is involved in the protective effect of curcumin against oxidative damage
-
Kang ES, Woo IS, Kim HJ et al. (2007) Up-regulation of aldose reductase expression mediated by phosphatidylinositol 3-kinase/AKT and Nrf2 is involved in the protective effect of curcumin against oxidative damage. Free Radic Biol Med 43:535-545.
-
(2007)
Free Radic Biol Med
, vol.43
, pp. 535-545
-
-
Kang, E.S.1
Woo, I.S.2
Kim, H.J.3
-
72
-
-
0034752461
-
Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription
-
Katob Y, Itoh K, Yoshida E et al. (2001) Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription. Genes Cells 6:857-868.
-
(2001)
Genes Cells
, vol.6
, pp. 857-868
-
-
Katob, Y.1
Itoh, K.2
Yoshida, E.3
-
73
-
-
33847050801
-
Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
-
Kensler TW, Wakabayashi N, Biswal S (2007) Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 47:89-116.
-
(2007)
Annu Rev Pharmacol Toxicol
, vol.47
, pp. 89-116
-
-
Kensler, T.W.1
Wakabayashi, N.2
Biswal, S.3
-
74
-
-
16844366162
-
Polo-like kinase phosphorylates heat shock transcription factor 1 and mediates its nuclear translocation during heat stress
-
Kim SA, Yoon JH, Lee SH et al. (2005) Polo-like kinase phosphorylates heat shock transcription factor 1 and mediates its nuclear translocation during heat stress. J Biol Chem 280:12653-12657.
-
(2005)
J Biol Chem
, vol.280
, pp. 12653-12657
-
-
Kim, S.A.1
Yoon, J.H.2
Lee, S.H.3
-
75
-
-
22744452215
-
Food restriction, evolution and ageing
-
Kirkwood TB, Shanley DP (2005) Food restriction, evolution and ageing. Mech Ageing Dev 126:1011-1016.
-
(2005)
Mech Ageing Dev
, vol.126
, pp. 1011-1016
-
-
Kirkwood, T.B.1
Shanley, D.P.2
-
76
-
-
0036950665
-
The forkhead transcription factor FoXo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth
-
Kitamura T, Nakae J, Kitamura Y et al. (2002) The forkhead transcription factor FoXo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest 110:1839-1847.
-
(2002)
J Clin Invest
, vol.110
, pp. 1839-1847
-
-
Kitamura, T.1
Nakae, J.2
Kitamura, Y.3
-
77
-
-
0030988941
-
Repression of the heat shock factor 1 transcriptional activation domain is modulated by constitutive phosphorylation
-
Kline MP, Morimoto RI (1997) Repression of the heat shock factor 1 transcriptional activation domain is modulated by constitutive phosphorylation. Mol Cell Biol 17:2107-2115.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 2107-2115
-
-
Kline, M.P.1
Morimoto, R.I.2
-
78
-
-
0029804194
-
Repression of heat shock factor 1 activity at control temperature by phosphorylation
-
Knauf U, Newton EM, Kyriakis J et al. (1996) Repression of heat shock factor 1 activity at control temperature by phosphorylation. Genes Dev 10:2782-2793.
-
(1996)
Genes Dev
, vol.10
, pp. 2782-2793
-
-
Knauf, U.1
Newton, E.M.2
Kyriakis, J.3
-
79
-
-
3543008924
-
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
-
Kobayashi A, Kang MI, Okawa H et al. (2004) Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol 24:7130-7139.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 7130-7139
-
-
Kobayashi, A.1
Kang, M.I.2
Okawa, H.3
-
80
-
-
14044254798
-
Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation
-
Kobayashi M, Yamamoto M (2005) Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation. Antioxid Redox Signal 7:385-394.
-
(2005)
Antioxid Redox Signal
, vol.7
, pp. 385-394
-
-
Kobayashi, M.1
Yamamoto, M.2
-
81
-
-
34247558673
-
Delay of photoreceptor degeneration in tubby mouse by sulforaphane
-
Kong L, Tanito M, Huang Z, Li F et al. (2007) Delay of photoreceptor degeneration in tubby mouse by sulforaphane. J Neurochem 101:1041-1052.
-
(2007)
J Neurochem
, vol.101
, pp. 1041-1052
-
-
Kong, L.1
Tanito, M.2
Huang, Z.3
Li, F.4
-
82
-
-
0037136563
-
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
-
Kops GJ, Dansen TB, Polderman PE et al. (2002) Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 419:316-321.
-
(2002)
Nature
, vol.419
, pp. 316-321
-
-
Kops, G.J.1
Dansen, T.B.2
Polderman, P.E.3
-
83
-
-
0842304134
-
Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult
-
Kraft AD, Johnson DA, Johnson JA (2004) Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult. J Neurosci 24:1101-1112.
-
(2004)
J Neurosci
, vol.24
, pp. 1101-1112
-
-
Kraft, A.D.1
Johnson, D.A.2
Johnson, J.A.3
-
84
-
-
34447632877
-
Exercise, MAPK, and NF-γB signaling in skeletal muscle
-
Kramer HF, Goodyear LJ (2007) Exercise, MAPK, and NF-γB signaling in skeletal muscle. J Appl Physiol 103:388-395.
-
(2007)
J Appl Physiol
, vol.103
, pp. 388-395
-
-
Kramer, H.F.1
Goodyear, L.J.2
-
85
-
-
0036084783
-
Heat shock proteins: Modifying factors in physiological stress responses and acquired thermotolerance
-
Kregel KC (2002) Heat shock proteins: modifying factors in physiological stress responses and acquired thermotolerance. J Appl Physiol 92:2177-2186.
-
(2002)
J Appl Physiol
, vol.92
, pp. 2177-2186
-
-
Kregel, K.C.1
-
86
-
-
15544377794
-
Molecular and evolutionary basis of the cellular stress response
-
Kultz D (2005) Molecular and evolutionary basis of the cellular stress response. Annu Rev Physiol 67:225-257.
-
(2005)
Annu Rev Physiol
, vol.67
, pp. 225-257
-
-
Kultz, D.1
-
87
-
-
0037424262
-
Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival
-
Kwak MK, Wakabayashi N, Itoh K et al. (2003) Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival. J Biol Chem 278:8135-8145.
-
(2003)
J Biol Chem
, vol.278
, pp. 8135-8145
-
-
Kwak, M.K.1
Wakabayashi, N.2
Itoh, K.3
-
88
-
-
0038146898
-
Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis
-
Lee JM, Calkins MJ, Chan K et al. (2003a) Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis. J Biol Chem 278:12029-12038.
-
(2003)
J Biol Chem
, vol.278
, pp. 12029-12038
-
-
Lee, J.M.1
Calkins, M.J.2
Chan, K.3
-
89
-
-
0141621061
-
NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary cortical neurons
-
Lee JM, Shih AY, Murphy TH et al. (2003b) NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary cortical neurons. J Biol Chem 278:37948-37956.
-
(2003)
J Biol Chem
, vol.278
, pp. 37948-37956
-
-
Lee, J.M.1
Shih, A.Y.2
Murphy, T.H.3
-
90
-
-
0031032934
-
Adaptation of glutathione antioxidant system to endurance training are tissue and muscle fiber specific
-
Leeuwenburgh C, Hollander J, Leichtweis M et al. (1997) Adaptation of glutathione antioxidant system to endurance training are tissue and muscle fiber specific. Am J Physiol 272:R363-R369.
-
(1997)
Am J Physiol
, vol.272
, pp. R363-R369
-
-
Leeuwenburgh, C.1
Hollander, J.2
Leichtweis, M.3
-
91
-
-
33646934067
-
A conservedMST-FOXO signaling pathway mediates oxidative-stress responses and extends lifespan
-
Lehtinen MK, Yuan Z, Boaq PR et al. (2006) A conservedMST-FOXO signaling pathway mediates oxidative-stress responses and extends lifespan. Cell 125:987-1001.
-
(2006)
Cell
, vol.125
, pp. 987-1001
-
-
Lehtinen, M.K.1
Yuan, Z.2
Boaq, P.R.3
-
92
-
-
0345447590
-
Tissue-specific activities of C. Elegans DAF-16 in the regulation of lifespan
-
Libina N, Berman JR, Kenyon C (2003) Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Cell 115:489-502.
-
(2003)
Cell
, vol.115
, pp. 489-502
-
-
Libina, N.1
Berman, J.R.2
Kenyon, C.3
-
93
-
-
0022555843
-
The heat shock response
-
Lindquist S (1986) The heat shock response. Annu Rev Biochem 55:1151-1191.
-
(1986)
Annu Rev Biochem
, vol.55
, pp. 1151-1191
-
-
Lindquist, S.1
-
95
-
-
1542335553
-
Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/AKT pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol
-
Martin D, Rojo AI, Salinas M et al. (2004) Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/AKT pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol. J Biol Chem 279:8919-8929.
-
(2004)
J Biol Chem
, vol.279
, pp. 8919-8929
-
-
Martin, D.1
Rojo, A.I.2
Salinas, M.3
-
96
-
-
0036483748
-
Exercise and skeletal muscle ageing: Cellular and molecular mechanisms
-
McArdle A, Vasilaki A, Jackson M (2002) Exercise and skeletal muscle ageing: cellular and molecular mechanisms. Ageing Res Dev 1:79-93.
-
(2002)
Ageing Res Dev
, vol.1
, pp. 79-93
-
-
McArdle, A.1
Vasilaki, A.2
Jackson, M.3
-
97
-
-
40549127471
-
Drosophila lifespan control by dietary restriction independent of insulin-like signaling
-
Min KJ, Yamamoto R, Buch S et al. (2008) Drosophila lifespan control by dietary restriction independent of insulin-like signaling. Aging Cell 7:199-206.
-
(2008)
Aging Cell
, vol.7
, pp. 199-206
-
-
Min, K.J.1
Yamamoto, R.2
Buch, S.3
-
98
-
-
0034575085
-
Longevity and aging: Beneficial effects of exposure to mild stress
-
Minois N (2000) Longevity and aging: beneficial effects of exposure to mild stress. Biogerontology 1:15-29.
-
(2000)
Biogerontology
, vol.1
, pp. 15-29
-
-
Minois, N.1
-
99
-
-
0028061444
-
Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the γ-globin locus control region
-
Moi P, Chan K, Asunis I et al. (1994) Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the γ-globin locus control region. Proc Natl Acad Sci USA 91:9926-9930.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 9926-9930
-
-
Moi, P.1
Chan, K.2
Asunis, I.3
-
100
-
-
1342264308
-
Mammalian SIRT1 represses forkhead transcription factors
-
Motta MC, Divecha N, Lemieux M et al. (2004) Mammalian SIRT1 represses forkhead transcription factors. Cell 116:551-563.
-
(2004)
Cell
, vol.116
, pp. 551-563
-
-
Motta, M.C.1
Divecha, N.2
Lemieux, M.3
-
101
-
-
2342518844
-
Diverse and specific gene expression responses to stresses in cultured human cells
-
Murray JI, Whitfield ML, Trinklein ND et al. (2004) Diverse and specific gene expression responses to stresses in cultured human cells. Mol Biol Cell 15:2361-2374.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 2361-2374
-
-
Murray, J.I.1
Whitfield, M.L.2
Trinklein, N.D.3
-
102
-
-
0037036377
-
Activation of Maf/AP-1 repressor Bach2 by oxidative stress promotes apoptosis and its interaction with promyelocytic leukemia nuclear bodies
-
Muto A, Tashiro S, Tsuchiya H et al. (2002) Activation of Maf/AP-1 repressor Bach2 by oxidative stress promotes apoptosis and its interaction with promyelocytic leukemia nuclear bodies. J Biol Chem 277:20724-20733.
-
(2002)
J Biol Chem
, vol.277
, pp. 20724-20733
-
-
Muto, A.1
Tashiro, S.2
Tsuchiya, H.3
-
103
-
-
33644646401
-
Chemoprotection by sulforaphane: Keep one eye beyond Keap1
-
Myzak MC, Dashwood RH (2006) Chemoprotection by sulforaphane: keep one eye beyond Keap1. Cancer Lett 233:208-218.
-
(2006)
Cancer Lett
, vol.233
, pp. 208-218
-
-
Myzak, M.C.1
Dashwood, R.H.2
-
104
-
-
0036787607
-
Regulation of insulin action and pancreatic betacell function by mutated alleles of the gene encoding forkhead transcription factor FoXo1
-
Nakae J, Biggs WH 3rd, Kitamura T et al. (2002) Regulation of insulin action and pancreatic betacell function by mutated alleles of the gene encoding forkhead transcription factor FoXo1. Nat Genet 32:245-253.
-
(2002)
Nat Genet
, vol.32
, pp. 245-253
-
-
Nakae, J.1
Biggs, W.H.2
Kitamura, T.3
-
105
-
-
0031032550
-
HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator
-
Nakai A, Tanabe M, Kawazoe Y et al. (1997) HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator. Mol Cell Biol 17:469-481.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 469-481
-
-
Nakai, A.1
Tanabe, M.2
Kawazoe, Y.3
-
106
-
-
0031617024
-
Eukaryotic translation elongation factor 1 alpha: Structure, expression, functions, and possible role in aminoacyl-t-RNA channeling
-
Negrutskii BS, El'skaya AV (1998) Eukaryotic translation elongation factor 1 alpha: structure, expression, functions, and possible role in aminoacyl-t-RNA channeling. Prog Nucleic Acid Res Mol Biol 60:47-78.
-
(1998)
Prog Nucleic Acid Res Mol Biol
, vol.60
, pp. 47-78
-
-
Negrutskii, B.S.1
El'Skaya, A.V.2
-
107
-
-
3142570440
-
The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress
-
Nguyen T, Yang CS, Pickett CB (2004) The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress. Free Radic Biol Med 37:433-441.
-
(2004)
Free Radic Biol Med
, vol.37
, pp. 433-441
-
-
Nguyen, T.1
Yang, C.S.2
Pickett, C.B.3
-
108
-
-
34147149523
-
Heat shock factor 2 (HSF2) contributes to inducible expression of hsp genes through interplay with HSF1
-
Ostling P, Biork JK, Ross-Mattjus P et al. (2007) Heat shock factor 2 (HSF2) contributes to inducible expression of hsp genes through interplay with HSF1. J Biol Chem 282:7077-7086.
-
(2007)
J Biol Chem
, vol.282
, pp. 7077-7086
-
-
Ostling, P.1
Biork, J.K.2
Ross-Mattjus, P.3
-
109
-
-
0028588049
-
Translational control during heat shock
-
Panniers R (1994) Translational control during heat shock. Biochemie 76:737-747.
-
(1994)
Biochemie
, vol.76
, pp. 737-747
-
-
Panniers, R.1
-
110
-
-
40649108843
-
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction
-
Pearson KJ, Lewis KN, Price NL et al. (2008) Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc Natl Acad Sci USA 105:2325-2330.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 2325-2330
-
-
Pearson, K.J.1
Lewis, K.N.2
Price, N.L.3
-
111
-
-
17744372861
-
Roles of the heat shock transcription factors in regulation of the heat shock response and beyond
-
Pirkalla L, Nykanen P, Sistonen L (2001) Roles of the heat shock transcription factors in regulation of the heat shock response and beyond. FASEB J 15:1118-1131.
-
(2001)
FASEB J
, vol.15
, pp. 1118-1131
-
-
Pirkalla, L.1
Nykanen, P.2
Sistonen, L.3
-
112
-
-
0038362751
-
AKT activation promotes degradation of tuberin and FOXO3a via the proteasome
-
Plas DR, Thompson CB (2003) AKT activation promotes degradation of tuberin and FOXO3a via the proteasome. J Biol Chem 278:12361-12366.
-
(2003)
J Biol Chem
, vol.278
, pp. 12361-12366
-
-
Plas, D.R.1
Thompson, C.B.2
-
113
-
-
0027452754
-
Regulation of heat shock factor trimer formation: Role of a conserved leucine zipper
-
Rabindran SK, Haroun RI, Clos J et al. (1993) Regulation of heat shock factor trimer formation: role of a conserved leucine zipper. Science 259:230-234.
-
(1993)
Science
, vol.259
, pp. 230-234
-
-
Rabindran, S.K.1
Haroun, R.I.2
Clos, J.3
-
114
-
-
0032774977
-
The effect of exercise training on oxidative damage of lipids, proteins and DNA in rat skeletal muscle: Evidence for beneficial outcomes
-
Radak Z, Kaneko T, Tahara S et al. (1999) The effect of exercise training on oxidative damage of lipids, proteins and DNA in rat skeletal muscle: evidence for beneficial outcomes. Free Radic Biol Med 27:69-74.
-
(1999)
Free Radic Biol Med
, vol.27
, pp. 69-74
-
-
Radak, Z.1
Kaneko, T.2
Tahara, S.3
-
115
-
-
0035241612
-
Regular exercise improves cognitive function and decreases oxidative damage in rat brain
-
Radak Z, Kaneko T, Tahara H et al. (2001) Regular exercise improves cognitive function and decreases oxidative damage in rat brain. Neurochem Int 38:17-23.
-
(2001)
Neurochem Int
, vol.38
, pp. 17-23
-
-
Radak, Z.1
Kaneko, T.2
Tahara, H.3
-
116
-
-
20044379872
-
Exercise and hormesis: Oxidative stress-related adaptation for successful aging
-
Radak Z, Chung HY, Goto S (2005) Exercise and hormesis: oxidative stress-related adaptation for successful aging. Biogerontology 6:71-75.
-
(2005)
Biogerontology
, vol.6
, pp. 71-75
-
-
Radak, Z.1
Chung, H.Y.2
Goto, S.3
-
117
-
-
0030949494
-
Function and regulation of heat shock factor 2 during mouse embryogenesis
-
Rallu M, Loones M, Lallemand Y et al. (1997) Function and regulation of heat shock factor 2 during mouse embryogenesis. Proc Natl Acad Sci USA 94:2392-2397.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 2392-2397
-
-
Rallu, M.1
Loones, M.2
Lallemand, Y.3
-
118
-
-
0035853157
-
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
-
Ramos-Gomez M, Kwak MK, Dolan PM et al. (2001) Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci USA 98:3410-3415.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 3410-3415
-
-
Ramos-Gomez, M.1
Kwak, M.K.2
Dolan, P.M.3
-
119
-
-
4043079846
-
Aging intervention, prevention and therapy through hormesis
-
Rattan SIS (2004) Aging intervention, prevention and therapy through hormesis. J Gerontol Biol Sci 59A:705-709.
-
(2004)
J Gerontol Biol Sci
, vol.59 A
, pp. 705-709
-
-
Rattan, S.I.S.1
-
120
-
-
0035868368
-
Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targeting
-
Rena G, Prescott AR, Guo S et al. (2001) Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targeting. Biochem J 354:605-612.
-
(2001)
Biochem J
, vol.354
, pp. 605-612
-
-
Rena, G.1
Prescott, A.R.2
Guo, S.3
-
121
-
-
0036566003
-
Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion
-
Rena G, Woods YL, Prescott AR et al. (2002) Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion. EMBO J 21:2263-2271.
-
(2002)
EMBO J
, vol.21
, pp. 2263-2271
-
-
Rena, G.1
Woods, Y.L.2
Prescott, A.R.3
-
122
-
-
34250561475
-
A new puffing pattern induced by temperature shock and DNP in Drosophila
-
Ritossa F (1962) A new puffing pattern induced by temperature shock and DNP in Drosophila. Experimentia 18:571-573.
-
(1962)
Experimentia
, vol.18
, pp. 571-573
-
-
Ritossa, F.1
-
123
-
-
48749085399
-
Resveratrol protects primary rat hepatocytes against oxidative stress damage. Activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes
-
Rubiolo JA, Mithieux G, Vega FV (2008) Resveratrol protects primary rat hepatocytes against oxidative stress damage. Activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes. Eur J Pharmacol 591:66-72.
-
(2008)
Eur J Pharmacol
, vol.591
, pp. 66-72
-
-
Rubiolo, J.A.1
Mithieux, G.2
Vega, F.V.3
-
124
-
-
33645324024
-
RNA-mediated response to heat shock in mammalian cells
-
Shamovsky I, Ivannikov M, Kandel ES et al. (2006) RNA-mediated response to heat shock in mammalian cells. Nature 440:556-560.
-
(2006)
Nature
, vol.440
, pp. 556-560
-
-
Shamovsky, I.1
Ivannikov, M.2
Kandel, E.S.3
-
125
-
-
43249125196
-
New insights into the mechanism of heat shock response activation
-
Shamovsky I, Nudler E (2008) New insights into the mechanism of heat shock response activation. Cell Mol Life Sci 65:855-861.
-
(2008)
Cell Mol Life Sci
, vol.65
, pp. 855-861
-
-
Shamovsky, I.1
Nudler, E.2
-
126
-
-
41749102898
-
Inhibition of PI3K/AKT and MEK/ERK pathways act synergistically to enhance antiangiogenic effects of EGCG through activation of FOXO transcription factor
-
Shankar S, Chen Q, Srivastava RK (2008) Inhibition of PI3K/AKT and MEK/ERK pathways act synergistically to enhance antiangiogenic effects of EGCG through activation of FOXO transcription factor. J Mol Signal 20:3-7.
-
(2008)
J Mol Signal
, vol.20
, pp. 3-7
-
-
Shankar, S.1
Chen, Q.2
Srivastava, R.K.3
-
127
-
-
28844501753
-
Regulation of Nrf2, NF-kappaB, and AP-1 signaling pathways by chemopreventive agents
-
Shen G, Jeong WS, Hu R, Kong AN (2005) Regulation of Nrf2, NF-kappaB, and AP-1 signaling pathways by chemopreventive agents. Antioxid Redox Signal 7:1648-1663.
-
(2005)
Antioxid Redox Signal
, vol.7
, pp. 1648-1663
-
-
Shen, G.1
Jeong, W.S.2
Hu, R.3
Kong, A.N.4
-
128
-
-
17944378526
-
Activation by IKKγ of a second evolutionary conserved, NF-γB signaling pathway
-
Senftlenben U, Cao Y, Xiao G et al. (2001) Activation by IKKγ of a second evolutionary conserved, NF-γB signaling pathway. Science 293:1495-1499.
-
(2001)
Science
, vol.293
, pp. 1495-1499
-
-
Senftlenben, U.1
Cao, Y.2
Xiao, G.3
-
130
-
-
18644378321
-
Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene
-
Sun J, Hoshino H, Takaku K et al. (2002) Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene. EMBO J 21:5216-5224.
-
(2002)
EMBO J
, vol.21
, pp. 5216-5224
-
-
Sun, J.1
Hoshino, H.2
Takaku, K.3
-
131
-
-
0142166328
-
Cancer chemoprevention with dietary phytochemicals
-
Surh YJ (2003) Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 3:768-780.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 768-780
-
-
Surh, Y.J.1
-
132
-
-
0033600816
-
The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative slicing
-
Tanabe M, Sasai N, Nagata K et al. (1999) The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative slicing. J Biol Chem 274:27845-27856.
-
(1999)
J Biol Chem
, vol.274
, pp. 27845-27856
-
-
Tanabe, M.1
Sasai, N.2
Nagata, K.3
-
133
-
-
34247282872
-
Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin
-
Tanigawa S, Fujii M, Hou DX (2007) Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin. Free Radic Biol Med 42:1690-1703.
-
(2007)
Free Radic Biol Med
, vol.42
, pp. 1690-1703
-
-
Tanigawa, S.1
Fujii, M.2
Hou, D.X.3
-
134
-
-
0037106099
-
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray
-
Thimmulappa RK, Mai KH, Srisuma S et al. (2002) Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res 62:5196-5203.
-
(2002)
Cancer Res
, vol.62
, pp. 5196-5203
-
-
Thimmulappa, R.K.1
Mai, K.H.2
Srisuma, S.3
-
135
-
-
0035826271
-
Increased dosage of Sir-2 gene extends lifespan in Caenorhabditis elegans
-
Tissembaum HA, Guarente L (2001) Increased dosage of Sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410:227-230.
-
(2001)
Nature
, vol.410
, pp. 227-230
-
-
Tissembaum, H.A.1
Guarente, L.2
-
136
-
-
0037134040
-
DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein
-
Tran H, Brunet A, Grenier JM et al. (2002) DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science 296:530-534.
-
(2002)
Science
, vol.296
, pp. 530-534
-
-
Tran, H.1
Brunet, A.2
Grenier, J.M.3
-
137
-
-
0344530503
-
Insulin inhibition of transcription stimulated by forkhead protein FOXO1 is not solely due to nuclear exclusion
-
Tsai WC, Bhattacharyya N, Han LY et al. (2003) Insulin inhibition of transcription stimulated by forkhead protein FOXO1 is not solely due to nuclear exclusion. Endocrinology 144:5615-5622.
-
(2003)
Endocrinology
, vol.144
, pp. 5615-5622
-
-
Tsai, W.C.1
Bhattacharyya, N.2
Han, L.Y.3
-
138
-
-
40849118472
-
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. Elegans
-
Tullet JMA, Hertweck M, An JH et al. (2008) Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 132:1025-1038.
-
(2008)
Cell
, vol.132
, pp. 1025-1038
-
-
Tullet, J.M.A.1
Hertweck, M.2
An, J.H.3
-
139
-
-
13244287966
-
Regulation of FOXO activity by CBP/p300-mediated acetylation
-
van der Heide L, Smidt MP (2005) Regulation of FOXO activity by CBP/p300-mediated acetylation. Trends Biochem Sci 30:81-86.
-
(2005)
Trends Biochem Sci
, vol.30
, pp. 81-86
-
-
Van Der Heide, L.1
Smidt, M.P.2
-
140
-
-
33749188883
-
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP
-
van der Host A, de Vries-Smits AM, Brenkman AB et al. (2006) FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP. Nat Cell Biol 10:1064-1073.
-
(2006)
Nat Cell Biol
, vol.10
, pp. 1064-1073
-
-
Van Der Host, A.1
De Vries-Smits, A.M.2
Brenkman, A.B.3
-
141
-
-
34249281690
-
Stressing the role of FOXO proteins in lifespan and disease
-
van der Horst A, Burgering BM (2007) Stressing the role of FOXO proteins in lifespan and disease. Nat Rev Mol Cell Biol 8:440-450.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 440-450
-
-
Van Der Horst, A.1
Burgering, B.M.2
-
142
-
-
0032542213
-
Nrf2 and Nrf1 in association with Jun. Proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes
-
Venugopal R, Jaiswal AK (1998) Nrf2 and Nrf1 in association with Jun. proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes. Oncogene 17:3145-3156.
-
(1998)
Oncogene
, vol.17
, pp. 3145-3156
-
-
Venugopal, R.1
Jaiswal, A.K.2
-
143
-
-
25444442080
-
Triple layer control: Phosphorylation, acetylation and ubiquitination of FOXO proteins
-
Vogt PK, Jiang H, Aoki M (2005) Triple layer control: phosphorylation, acetylation and ubiquitination of FOXO proteins. Cell Cycle 4:908-913.
-
(2005)
Cell Cycle
, vol.4
, pp. 908-913
-
-
Vogt, P.K.1
Jiang, H.2
Aoki, M.3
-
144
-
-
3542991477
-
On mechanisms that control heat shock transcription factor activity in metazoan cells
-
Voellmy R (2004) On mechanisms that control heat shock transcription factor activity in metazoan cells. Cell Stress Chaperones 9:122-133.
-
(2004)
Cell Stress Chaperones
, vol.9
, pp. 122-133
-
-
Voellmy, R.1
-
145
-
-
0242329881
-
Keap1-null mutation leads to post-natal lethality due to constitutive Nrf2 activation
-
Wakabayashi N, Itoh K, Wakabayashi J et al. (2003) Keap1-null mutation leads to post-natal lethality due to constitutive Nrf2 activation. Nat Genet 35:238-245.
-
(2003)
Nat Genet
, vol.35
, pp. 238-245
-
-
Wakabayashi, N.1
Itoh, K.2
Wakabayashi, J.3
-
146
-
-
0041468990
-
Regulation of molecular chaperons gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmatic sequestration of heat shock factor 1
-
Wang X, Grammatikakis N, Siganou A et al. (2003) Regulation of molecular chaperons gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmatic sequestration of heat shock factor 1. Mol Cell Biol 23:6013-6026.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 6013-6026
-
-
Wang, X.1
Grammatikakis, N.2
Siganou, A.3
-
147
-
-
10344252829
-
Interactions between extracellular signal regulated protein kinase 1(ERK1), 14-3-3 epsilon and heat shock factor 1 during stress
-
Wang X, Grammatikakis N, Siganou A et al. (2004) Interactions between extracellular signal regulated protein kinase 1(ERK1), 14-3-3 epsilon and heat shock factor 1 during stress. J Biol Chem 279:49460-49469.
-
(2004)
J Biol Chem
, vol.279
, pp. 49460-49469
-
-
Wang, X.1
Grammatikakis, N.2
Siganou, A.3
-
148
-
-
17044408768
-
JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling
-
Wang MC, Bohmann D, Jasper H (2005) JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell 121:115-125.
-
(2005)
Cell
, vol.121
, pp. 115-125
-
-
Wang, M.C.1
Bohmann, D.2
Jasper, H.3
-
149
-
-
0022379715
-
Morphological study of the mammalian stress response: Characterization of changes in cytoplasmic organelles, cytoskeleton, and nucleoli, and appearance of intranuclear actin filaments in rat fibroblasts after heat-shock treatment
-
Welch WJ, Suhan JP (1985) Morphological study of the mammalian stress response: characterization of changes in cytoplasmic organelles, cytoskeleton, and nucleoli, and appearance of intranuclear actin filaments in rat fibroblasts after heat-shock treatment. J Cell Biol 101:1198-1211.
-
(1985)
J Cell Biol
, vol.101
, pp. 1198-1211
-
-
Welch, W.J.1
Suhan, J.P.2
-
150
-
-
25844466597
-
Heat shock response modulators as therapeutic tools for disease of protein conformation
-
Westerheid SD, Morimoto RI (2005) Heat shock response modulators as therapeutic tools for disease of protein conformation. J Biol Chem 280:33097-33100.
-
(2005)
J Biol Chem
, vol.280
, pp. 33097-33100
-
-
Westerheid, S.D.1
Morimoto, R.I.2
-
151
-
-
0029564954
-
Heat shock transcription factors: Structure and regulation
-
Wu C (1995) Heat shock transcription factors: structure and regulation. Annu Rev Cell Dev Biol 11:441-469.
-
(1995)
Annu Rev Cell Dev Biol
, vol.11
, pp. 441-469
-
-
Wu, C.1
-
152
-
-
33646179260
-
Upregulation of heme oxygenase-1 by epigallocatechin-3-gallate via the phosphatidylinositol 3-kinase/AKT and ERK pathways
-
Wu CC, Hsu MC, Hsieh CW et al. (2006) Upregulation of heme oxygenase-1 by epigallocatechin-3-gallate via the phosphatidylinositol 3-kinase/AKT and ERK pathways. Life Sci 78:2889-2897.
-
(2006)
Life Sci
, vol.78
, pp. 2889-2897
-
-
Wu, C.C.1
Hsu, M.C.2
Hsieh, C.W.3
-
153
-
-
0025965278
-
Cooperative binding of Drosophila heat shock factor to arrays of a conserved 5 bp unit
-
Xiao H, Perisic O, Lis JT (1991) Cooperative binding of Drosophila heat shock factor to arrays of a conserved 5 bp unit. Cell 64:585-593.
-
(1991)
Cell
, vol.64
, pp. 585-593
-
-
Xiao, H.1
Perisic, O.2
Lis, J.T.3
-
154
-
-
0033229880
-
HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice
-
Xiao X, Zuo X, Davis AA et al. (1999) HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice. EMBO J 18:5943-5952.
-
(1999)
EMBO J
, vol.18
, pp. 5943-5952
-
-
Xiao, X.1
Zuo, X.2
Davis, A.A.3
-
155
-
-
0242580049
-
Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress
-
Zhang DD, Hannink M (2003) Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Mol Cell Biol 23:8137-8151.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 8137-8151
-
-
Zhang, D.D.1
Hannink, M.2
-
156
-
-
33845442925
-
Mechanistic studies of the Nrf2-Keap1 signaling pathway
-
Zhang DD (2006) Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metab Rev 38:769-789.
-
(2006)
Drug Metab Rev
, vol.38
, pp. 769-789
-
-
Zhang, D.D.1
-
157
-
-
0032555685
-
Repression of heat shock factor HSF1 activation by HSP90 (HSP90-complex) that forms a stress sensitive complex with HSF1
-
Zou J, Guo Y, Guettouche T et al. (1998) Repression of heat shock factor HSF1 activation by HSP90 (HSP90-complex) that forms a stress sensitive complex with HSF1. Cell 94:471-480.
-
(1998)
Cell
, vol.94
, pp. 471-480
-
-
Zou, J.1
Guo, Y.2
Guettouche, T.3
|