Ablation of PDK1 in pancreatic β cells induces diabetes as a result of loss of β cell mass

Nature Genetics

Volumn 38, Issue 5, 2006, Pages 589-593

  Hashimoto, Naoko ^a   Kido, Yoshiaki ^a   Uchida, Tohru ^a   Asahara, Shun Ichiro ^a   Shigeyama, Yutaka ^a   Matsuda, Tomokazu ^a   Takeda, Akihiko ^a   Tsuchihashi, Daisuke ^a   Nishizawa, Akihiko ^a   Ogawa, Wataru ^a   Fujimoto, Yoshito ^a   Okamura, Hitoshi ^a   Arden, Karen C ^b   Herrera, Pedro L ^c   Noda, Tetsuo ^d   Kasuga, Masato ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^d CANCER INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN SERINE THREONINE KINASE; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; GLUCOSE HOMEOSTASIS; HYPERGLYCEMIA; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; ISLETS OF LANGERHANS; MICE; MICE, KNOCKOUT; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 33646351055     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1774     Document Type: Article

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