Regulation of Nrf2, NF-κB, and AP-1 signaling pathways by chemopreventive agents

Antioxidants and Redox Signaling

Volumn 7, Issue 11-12, 2005, Pages 1648-1663

  Shen, Guoxiang ^a   Jeong, Woo Sik ^b   Hu, Rong ^a   Kong, Ah Ng Tony ^a  

^a RUTGERS UNIVERSITY   (United States)

^b Inje University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

3 INDOLEMETHANOL; ACETYLCYSTEINE; ANTIOXIDANT; ASCORBIC ACID; CAFFEIC ACID PHENETHYL ESTER; CAPSAICIN; CARNOSOL; CURCUMIN; DIALLYL TRISULFIDE; DNA; EPIGALLOCATECHIN GALLATE; GENISTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUPEOL; MITOGEN ACTIVATED PROTEIN KINASE; PHENETHYL ISOTHIOCYANATE; PROTEIN C JUN; QUERCETIN; RESVERATROL; SILIBININ; SILYMARIN; SULFORAPHANE; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NRF2;

CANCER INHIBITION; CHEMOPROPHYLAXIS; DISEASE COURSE; DISEASE MODEL; IN VITRO STUDY; MOLECULAR MECHANICS; NONHUMAN; PHYTOCHEMISTRY; POMEGRANATE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RED WINE; REVIEW; SIGNAL TRANSDUCTION; TUMOR PROMOTION;

ANIMALS; ANTINEOPLASTIC AGENTS; DRUG RESISTANCE, NEOPLASM; HUMANS; NF-E2-RELATED FACTOR 2; NF-KAPPA B; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1;

ANIMALIA; LYTHRACEAE;

EID: 28844501753     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2005.7.1648     Document Type: Review

References (140)

1. Adhami VM, Afaq F, and Ahmad N. Suppression of ultraviolet B exposure-mediated activation of NF-kappaB in normal human keratinocytes by resveratrol. Neoplasia 5: 74-82, 2003.
2. Afaq F, Ahmad N, and Mukhtar H. Suppression of UVB-induced phosphorylation of mitogen-activated protein kinases and nuclear factor kappa B by green tea polyphenol in SKH-1 hairless mice. Oncogene 22: 9254-9264, 2003.
3. Ahmad N, Gupta S, and Mukhtar H, Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor kappaB in cancer cells versus normal cells. Arch Biochem Biophys 376: 338-346, 2000.
4. Alam J, Stewart D, Touchard C, Boinapally S, Choi AM, and Cook JL. Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene. J Biol Chem 274: 26071-26078, 1999.
5. Angel P and Karin M. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta 1072: 129-157, 1991.
6. Angel P and Karin M. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta 1072: 129-157, 1991.
7. Aoki Y, Sato H, Nishimura N, Takahashi S, Itoh K, and Yamamoto M. Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust. Toxicol Appl Pharmacol 173: 154-160, 2001.
8. Baihwal VR and Baeuerle PA. Activate NF-kappa B or die? Curr Biol 7: R94-R96, 1997.
9. Balasubramanian S, Efimova T, and Eckert RL. Green tea polyphenol stimulates a Ras, MEKK1, MEK3, and p38 cascade to increase activator protein 1 factor-dependent involucrin gene expression in normal human keratinocytes. J Biol Chem 277: 1828-1836, 2002.
10. Balogun E, Hoque M, Gong P, Killeen E, Green CJ, Foresti R, Alam J, and Motterlini R. Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element. Biochem J 371: 887-895, 2003.
11. Banerjee S, Bueso-Ramos C, and Aggarwal BB, Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9. Cancer Res 62: 4945-954, 2002.
12. Bharti AC and Aggarwal BB. Nuclear factor-kappa B and cancer: its role in prevention and therapy. Biochem Pharmacol 64: 883-888, 2002.
13. Bloom DA and Jaiswal AK. Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element-mediated NAD(P)H:quinone oxidoreductase-1 gene expression. J Biol Chem 278: 44675-4682, 2003.
14. Bosland MC. Use of animal models in defining efficacy of chemoprevention agents against prostate cancer. Eur Urol 35: 459-63, 1999.
15. Bours V, Bentires-Alj M, Hellin AC, Viatour R Robe P, Delhalle S, Benoit V, and Merville MP. Nuclear factor-kappa B, cancer, and apoptosis. Biochem Pharmacol 60: 1085-1089, 2000.
16. Sowie AG and O'Neill LA. Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase. J Immunol 165: 7180-7188, 2000.
17. Carrasco-Legleu CE, Marquez-Rosado L, Fattel-Fazenda S, Arce-Popoca E, Perez-Carreon JI, and Villa-Trevino S. Chemoprotective effect of caffeic acid phenethyl ester on promotion in a medium-term rat hepatocarcinogenesis assay. Int J Cancer 108: 488-492, 2004.
18. Chang L and Karin M. Mammalian MAP kinase signalling cascades. Nature 410: 37-40, 2001.
19. Chen C, Shen G, Hebbar V, Hu R, Owuor ED, and Kong AN. Epigallocatechin-3-gallate-induced stress signals in HT-29 human colon adenocarcinoma cells. Carcinogenesis 24: 1369-1378, 2003.
20. Chen W, Dong Z, Valcic S, Timmermann BN, and Bowden GT. Inhibition of ultraviolet B-induced c-fos gene expression and p38 mitogen-activated protein kinase activation by (-)-epigallocatechin gallate in a human keratinocyte cell line. Mol Carcinog 24: 79-84, 1999.
21. Chun KS, Keum YS, Han SS, Song YS, Kim SH, and Surh YJ. Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappaB activation. Carcinogenesis 24: 1515-1524, 2003.
22. Chung JY, Park JO, Phyu H, Dong Z, and Yang CS. Mechanisms of inhibition of the Ras-MAP kinase signaling pathway in 30.7b Ras 12 cells by tea polyphenols (-)-epigallocatechin-3-gallate and theaflavin-3,3'-digallate. FASEB J 15: 2022-2024, 2001.
23. Corpet DE and Pierre F. Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system. Cancer Epidemiol Biomarkers Prev 12: 391-400, 2003.
24. Cullinan SB and Diehl JA. PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress. J Biol Chem 279: 20108-20117, 2004.
25. Cullinan SB, Zhang D, Hannink M, Arvisais E, Kaufman RJ, and Diehl JA. Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol 23: 7198-7209, 2003.
26. Deng T and Karin M. JunB differs from c-Jun in its DNA-binding and dimerization domains, and represses c-Jun by formation of inactive heterodimers. Genes Dev 7: 479-490, 1993.
27. Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N, Katoh Y, Yamamoto M, and Talalay P. Direct evidence that sulfhydryl groups of Keapl are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci USA 99: 11908-11913, 2002.
28. Domann FE, Levy JP, Birrer MJ, and Bowden GT. Stable expression of a c-JUN deletion mutant in two malignant mouse epidermal cell lines blocks tumor formation in nude mice. Cell Growth Differ 5: 9-16, 1994.
29. Dong Z. Effects of food factors on signal transduction pathways. Biofactors 12: 17-28, 2000.
30. Dong Z, Birrer MJ, Watts RG, Matrisian LM, and Colburn NH. Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells. Proc Natl Acad Sci USA 91: 609-613, 1994.
31. Eferl R and Wagner EF. AP-1 : a double-edged sword in tumorigenesis. Nat Rev Cancer 3: 859-868, 2003.
32. Eferl R, Ricci R, Kenner L, Zenz R, David JP, Rath M, and Wagner EF. Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53. Cell 112: 181-192, 2003.
33. Enomoto A, Itoh K, Nagayoshi E, Haruta J, Kimura T, O'Connor T, Harada T, and Yamamoto M. High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. Toxicol Sci 59: 169-177, 2001.
34. Fahey JW, Haristoy X, Dolan PM, Kensler TW, Scholtus I, Stephenson KK, Talalay P, and Lozniewski A. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proc Natl Acad Sci USA 99: 7610-7615, 2002.
35. Frigo DE, Duong BN, Melnik LI, Schief LS, Collins-Burow BM, Pace DK, McLachlan JA, and Burow ME. Flavonoid phytochemicals regulate activator protein-1 signal transduction pathways in endometrial and kidney stable cell lines. J Nutr 132: 1848-1853, 2002.
36. Funakoshi-Tago M, Tago K, Sonoda Y, Tominaga S, and Kasahara T. TRAF6 and C-SRC induce synergistic AP-I activation via P13-kinase-AKT-JNK pathway. Eur J Biochem 270: 1257-1268, 2003.
37. Haddad JJ. Antioxidant and prooxidant mechanisms in the regulation of redox(y)-sensitive transcription factors. Cell Signal 14: 879-897, 2002.
38. Han SS, Keum YS, Seo HJ, and Surh YJ. Curcumin suppresses activation of NF-kappaB and AP-1 induced by phorbol ester in cultured human promyelocytic leukemia cells. J Biochem Mol Biol 15: 337-342, 2002.
39. Hatta Y, Arima N, Machino T, Itoh T, Hashimoto S, Takeuchi J, Sawada U, Hayakawa S, Yamamoto T, and Horie T. Mutational analysis of IκBα in hematologic malignancies. Int J Mol Med 11: 239-242, 2003.
40. Hayes JD, Chanas SA, Henderson CJ, McMahon M, Sun C, Moffat GJ, Wolf CR, and Yamamoto M. The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin. Biochem Soc Trans 28: 33-41, 2000.
41. Heiss E, Herhaus C, Klimo K, Bartsch H, and Gerhauser C. Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms. J Biol Chem 276: 32008-32015, 2001.
42. Hergenhahn M, Soto U, Weninger A, Polack A, Hsu CH, Cheng AL, and Rosl F. The chemopreventive compound curcumin is an efficient inhibitor of Epstein-Barr virus BZLF1 transcription in Raji DR-LUC cells. Mol Carcinog 33: 137-145, 2002.
43. Hibi M, Lin A, Smeal T, Minden A, and Karin M. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev 7: 2135-2148, 1993.
44. Holmes-McNary M and Baldwin AS Jr. Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IkappaB kinase. Cancer Res 60: 3477-3483, 2000.
45. Hu R and Kong AN. Activation of MAP kinases, apoptosis and nutrigenomics of gene expression elicited by dietary cancer-prevention compounds. Nutrition 20: 83-88, 2004.
46. Huang HC, Nguyen T, and Pickett CB. Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2. Proc Natl Acad Sci USA 97: 12475-12480, 2000.
47. Huang HC, Nguyen T, and Pickett CB. Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription. J Biol Chem 277: 42769-42774, 2002.
48. Huang MT, Ho CT, Wang ZY, Ferraro T, Lou YR, Stauber K, Ma W, Georgiadis C, Laskin JD, and Conney AH. Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid. Cancer Res 54: 701-708, 1994.
49. Huang S, Pettaway CA, Uehara H, Bucana CD, and Fidler IJ. Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis. Oncogene 20: 4188-4197, 2001.
50. Huang TT, Kudo N, Yoshida M, and Miyamoto S. A nuclear export signal in the N-terminal regulatory domain of IkappaBalpha controls cytoplasmic localization of inactive NF-kappaB/IkappaBalpha complexes. Proc Natl Acad Sci USA 97: 1014-1019, 2000.
51. Ichiki K, Mitani N, Doki Y, Hara H, Misaki T, and Saiki I. Regulation of activator protein-1 activity in the mediastinal lymph node metastasis of lung cancer. Clin Exp Metastasis 18: 539-545, 2000.
52. Ishii T, Itoh K, Sato H, and Bannai S. Oxidative stress-inducible proteins in macrophages. Free Radic Res 31: 351-355, 1999.
53. Ishii T, Itoh K, Takahashi S, Sato H, Yanagawa T, Katoh Y, Bannai S, and Yamamoto M. Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem 275: 16023-16029, 2000.
54. Itoh K, Chiba T, Takahashi S, Ishii T, Igarashi K, Katoh Y, Oyake T, Hayashi N, Satoh K, Hatayama I, Yamamoto M, and Nabeshima Y An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun 236: 313-322, 1997.
55. Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, and Yamamoto M. Keapl represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev 13: 76-86, 1999.
56. Janssen-Heininger YM, Poynter ME, and Baeuerle PA. Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB. Free Radic Biol Med 28: 1317-1327, 2000.
57. Jeong WS, Kim IW, Hu R, and Kong AN. Modulation of AP-1 by natural chemopreventive compounds in human colon HT-29 cancer cell line. Pharm Res 21: 649-660, 2004.
58. Jeong WS, Kim IW, Hu R, and Kong AN. Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway. Pharm Res 21: 661-670, 2004.
59. Jochum W, Passegue E, and Wagner EF. AP-1 in mouse development and tumorigenesis. Oncogene 20: 2401-2412, 2001.
60. Johnson C, Van Antwerp D, and Hope TJ. An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of IkappaBalpha. EMBO J 18: 6682-6693, 1999.
61. Kang G, Kong PJ, Yuh YJ, Lim SY, Yim SV, Chun W, and Kim SS. Curcumin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression by inhibiting activator protein 1 and nuclear factor kappab bindings in BV2 microglial cells. J Pharmacol Sci 94: 325-328, 2004.
62. Kang JS, Jeon YJ, Kim HM, Han SH, and Yang KH. Inhibition of inducible nitric-oxide synthase expression by silymarin in lipopolysaccharide-stimulated macrophages. J Pharmacol Exp Ther 302: 138-144, 2002.
63. Kang KW, Lee SJ, Park JW, and Kim SG. Phosphatidylinositol 3-kinase regulates nuclear translocation of NF-E2-related factor 2 through actin rearrangement in response to oxidative stress. Mol Pharmacol 62: 1001-1010, 2002.
64. Kang KW, Park EY, and Kim SG. Activation of CCAAT/enhancer-binding protein beta by 2′-amino-3′-methoxyflavone (PD98059) leads to the induction of glutathione S-transferase A2. Carcinogenesis 24: 475-482, 2003.
65. Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem 270: 16483-16486, 1995.
66. Karin M and Ben-Neriah Y. Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu Rev Immunol 18: 621-663, 2000.
67. Katiyar SK and Mukhtar H. Tea consumption and cancer. World Rev Nutr Diet 79: 154-184, 1996.
68. Katoh Y, Itoh K, Yoshida E, Miyagishi M, Fukamizu A, and Yamamoto M. Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription. Genes Cells 6: 857-868, 2001.
69. Kensler TW, Curphey TJ, Maxiutenko Y, and Roebuck BD. Chemoprotection by organosulfur inducers of phase 2 enzymes: dithiolethiones and dithiins. Drug Metab Drug Interact 17: 3-22, 2000.
70. Kim DW, Sovak MA, Zanieski G, Nonet G, Romieu-Mourez R, Lau AW, Hafer LJ, Yaswen P, Stampfer M, Rogers AE, Russo J, and Sonenshein GE. Activation of NF-kappaB/Rel occurs early during neoplastic transformation of mammary cells. Carcinogenesis 21: 871-879, 2000.
71. Kim SG, Cho MK, Choi SH, Kim HJ, Kwak MK, and Kim ND. Molecular basis for hepatic detoxifying enzyme induction by 2-(allylthio)pyrazine in rats in comparison with oltipraz: effects on prooxidant production and DNA degradation. Drug Metab Dispos 27: 667-673, 1999.
72. Kobayashi M, Itoh K, Suzuki T, Osanai H, Nishikawa K, Katoh Y, Takagi Y, and Yamamoto M. Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system. Genes Cells 1: 807-820, 2002.
73. Kong AN, Owuor E, Yu R, Hebbar V, Chen C, Hu R, and Mandlekar S. Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE). Drug Metab Rev 33: 255-271,2001.
74. Kurata S and Nakajima H. Transcriptional activation of the heme oxygenase gene by TPA in mouse M1 cells during their differentiation to macrophage. Exp Cell Res 191: 89-94, 1990.
75. Kwak MK, Egner PA, Dolan PM, Ramos-Gomez M, Groopman JD, Itoh K, Yamamoto M, and Kensler TW. Role of phase 2 enzyme induction in chemoprotection by dithiolethiones. Mutat Res 480-481: 305-315, 2001.
76. Kwak MK, Itoh K, Yamamoto M, and Kensler TW. Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter. Mol Cell Biol 22: 2883-2892, 2002.
77. Kwak MK, Wakabayashi N, Itoh K, Motohashi H, Yamamoto M, and Kensler TW. Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival. J Biol Chem 278: 8135-8145, 2003.
78. Lagarrigue S, Chaumontet C, Heberden C, Martel P, and Gaillard-Sanchez I. Suppression of oncogene-induced transformation by quercetin and retinoic acid in rat liver epithelial cells. Cell Mol Biol Res 41: 551-560, 1995.
79. Lee H, Kim YO, Kim H, Kim SY, Noh HS, Kang SS, Cho GJ, Choi WS, and Suk K. Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia. FASEB J 17: 1943-1944, 2003.
80. Lee JM, Hanson JM, Chu WA, and Johnson JA. Phosphatidylinositol 3-kinase, not extracellular signal-regulated kinase, regulates activation of the antioxidant-responsive element in IMR-32 human neuroblastoma cells. J Biol Chem 276: 20011-20016, 2001.
81. Li J, Ma C, Huang Y, Luo J, and Huang C. Differential requirement of EGF receptor and its tyrosine kinase for AP-1 transactivation induced by EGF and TPA. Oncogene 22: 211-219, 2003.
82. Lo AH, Liang YC, Lin-Shiau SY, Ho CT, and Lin JK. Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappaB in mouse macrophages. Carcinogenesis 23: 983-991, 2002.
83. Manna SK, Mukhopadhyay A, and Aggarwal BB. Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. J Immunol 164: 6509-6519, 2000.
84. Marini MG, Chan K, Casula L, Kan YW, Cao A, and Moi P. hMAF, a small human transcription factor that heterodimerizes specifically with Nrfl and Nrf2. J Biol Chem 111: 16490-16497, 1997.
85. Moon SK, Cho GO, Jung SY, Gal SW, KwonTK, Lee YC, Madamanchi NR, and Kim CH. Quercetin exerts multiple inhibitory effects on vascular smooth muscle cells: role of ERK1/2, cell-cycle regulation, and matrix metalloproteinase-9. Biochem Biophys Res Commun 301: 1069-1078, 2003.
86. Morimitsu Y, Nakagawa Y, Hayashi K, Fujii H, Kumagai T, Nakamura Y, Osawa T, Horio F, Itoh K, Iida K, Yamamoto M, and Uchida K. A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway. J Biol Chem 277: 3456-3463, 2002.
87. Moscat J, Diaz-Meco MT, and Rennert P. NF-kappaB activation by protein kinase C isoforms and B-cell function. EMBO Rep 4: 31-36, 2003.
88. Mukhopadhyay A, Bueso-Ramos C, Chatterjee D, Pantazis P, and Aggarwal BB. Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines. Oncogene 20: 7597-7609, 2001.
89. Muller JM, Ziegler-Heitbrock HW, and Baeuerle PA. Nuclear factor kappa B, a mediator of lipopolysaccharide effects. Immunobiology 187: 233-256, 1993.
90. Nakamura K, Yasunaga Y, Segawa T, Ko D, Moul JW, Srivastava S, and Rhim JS. Curcumin down-regulates AR gene expression and activation in prostate cancer cell lines. Int J Oncol 21: 825-830, 2002.
91. Nguyen T, Huang HC, and Pickett CB. Transcriptional regulation of the antioxidant response element. Activation by Nrf2 and repression by MafK. J Biol Chem 275 : 15466-15473, 2000.
92. Nguyen T, Sherratt PJ, Huang HC, Yang CS, and Pickett CB. Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome. J Biol Chem 278: 4536-4541, 2003.
93. Nomura M, Ma W, Chen N, Bode AM, and Dong Z. Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced NF-kappaB activation by tea polyphenols, (-)-epigallocatechin gallate and theaflavins. Carcinogenesis 21: 1885-1890, 2000.
94. Osborn L, Kunkel S, and Nabel GJ. Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B. Proc Natl Acad Sci USA 86: 2336-2340, 1989.
95. Paolini M, Perocco P, Canistro D, Valgimigli L, Pedulli GF, Iori R, Croce CD, Cantelli-Forti G, Legator MS, and Abdel-Rahman SZ. Induction of cytochrome P450, generation of oxidative stress and in vitro cell-transforming and DNA-damaging activities by glucoraphanin, the bio-precursor of the chemopreventive agent sulforaphane found in broccoli. Carcinogenesis 25: 61-67, 2004.
96. Passegue E, Jochum W, Schorpp-Kistner M, Mohle-Steinlein U, and Wagner EF. Chronic myeloid leukemia with increased granulocyte progenitors in mice lacking junB expression in the myeloid lineage. Cell 104: 21-32, 2001.
97. Patten EJ and DeLong MJ. Temporal effects of the detoxification enzyme inducer, benzyl isothiocyanate: activation of c-Jun N-terminal kinase prior to the transcription factors AP-1 and NFkappaB. Biochem Biophys Res Commun 257:149-15 5, 1999.
98. Pfarr CM, Mechta F, Spyrou G, Lallemand D, Carillo S, and Yaniv M. Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras. Cell 76: 747-760, 1994.
99. Prestera T, Holtzclaw WD, Zhang Y, and Talalay P. Chemical and molecular regulation of enzymes that detoxify carcinogens. Proc Natl Acad Sci U S A 90: 2965-2969, 1993.
100. Ramos-Gomez M, Kwak MK, Dolan PM, Itoh K, Yamamoto M, Talalay P, and Kensler TW Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci U S A 98: 3410-3415, 2001.
101. Reddy BS. Studies with the azoxymethane-rat preclinical model for assessing colon tumor development and chemoprevention. Environ Mol Mittagen 44: 26-35, 2004.
102. Saleem M, Afaq F, Adhami VM, and Mukhtar H. Lupeol modulates NF-kappaB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice. Oncogene 23: 5203-5214, 2004.
103. Schonthal A, Herrlich P, Rahmsdorf HJ, and Ponta H. Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters. Cell 54: 325-334, 1988.
104. Schubert SY, Neeman I, and Resnick N. A novel mechanism for the inhibition of NF-kappaB activation in vascular endothelial cells by natural antioxidants. FASEB J 16: 1931-1933, 2002.
105. Schulze-Osthoff K, Ferrari D, Riehemann K, and Wesselborg S. Regulation of NF-kappa B activation by MAP kinase cascades. Immunobiology 198: 35-49, 1997.
106. Schwartz SA, Hernandez A, and Mark Evers B. The role of NF-kappaB/IkappaB proteins in cancer: implications for novel treatment strategies. Surg Oncol 8: 143-153, 1999.
107. Shaulian E and Karin M. AP-1 in cell proliferation and survival. Oncogene 20: 2390-2400, 2001.
108. Shaulian E and Karin M. AP-1 as a regulator of cell life and death. Nat Cell Biol 4: E131-E136, 2002.
109. Shen G, Hebbar V, Nair S, Xu C, Li W, Lin W, Keum YS, Han J, Gallo MA, and Kong AN. Regulation of Nrf2 transactivation domain activity: the differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein. J Biol Chem 279: 23052-23060, 2004.
110. Shi CS and Kehrl JH. PYK2 links G(q)alpha and G(13)alpha signaling to NF-kappa B activation. J Biol Chem 276: 31845-31850, 2001.
111. Shi X, Ye J, Leonard SS, Ding M, Vallyathan V, Castranova V, Rojanasakul Y, and Dong Z. Antioxidant properties of (-)-epicatechin-3-gallate and its inhibition of Cr(VI)-induced DNA damage and Cr(IV)- or TPA-stimulated NF-kappaB activation. MoI Cell Biochem 206: 125-132, 2000.
112. Shishodia S, Potdar P, Gairola CG, and Aggarwal BB. Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1. Carcinogenesis 24: 1269-1279, 2003.
113. Singh S, Natarajan K, and Aggarwal BB. Capsaicin (8-methyl-N-vanillyl-6- nonenamide) is a potent inhibitor of nuclear transcription factor-kappa B activation by diverse agents. J Immunol 157: 4412-4420, 1996.
114. Singletary KW and Nelshoppen JM. Inhibition of 7,12-dimethylbenz[a] anthracene (DMBA)-induced mammary tumorigenesis and of in vivo formation of mammary DMBA-DNA adducts by rosemary extract. Cancer Lett 60: 169-175, 1991.
115. Sovak MA, Bellas RE, Kim DW, Zanieski GJ, Rogers AE, Traish AM, and Sonenshein GE. Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer. J Clin invest 100: 2952-2960, 1997.
116. Suk K, Lee H, Kang SS, Cho GJ, and Choi WS. Flavonoid baicalein attenuates activation-induced cell death of brain microglia. J Pharmacol Exp Ther 305: 638-645, 2003.
117. Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 3: 768-780, 2003.
118. Surh Y-J, Kim SG, Liem A, Lee JW, and Miller JA. Inhibitory effects of isopropyl-2-(1,3-dithietane-2-ylidene)-2-[N-(4-methylthiazol-2-yl)carbamoyl] -acetate (YH439) on benzo[a]pyrene-induced skin carcinogenesis and micronucleated reticulocyte formation in mice. Mutat Res 423: 149-153, 1999.
119. Surh YJ, Han SS, Keum YS, Seo HJ, and Lee SS. Inhibitory effects of curcumin and capsaicin on phorbol ester-induced activation of eukaryotic transcription factors, NF-kappaB and AP-1. Biofactors 12: 107-112, 2000.
120. Thimmulappa RK, Mai KH, Srisuma S, Kensler TW, Yamamoto M, and Biswal S. Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res 62:5196-5203, 2002.
121. Tominaga S and Kuroishi T. An ecological study on diet/nutrition and cancer in Japan. Int J Cancer 10 (Suppl): 2-6, 1997.
122. Vayalil PK, Elmets CA, and Katiyar SK. Treatment of green tea polyphenols in hydrophilic cream prevents UVB-induced oxidation of lipids and proteins, depletion of antioxidant enzymes and phosphorylation of MAPK proteins in SKH-I hairless mouse skin. Carcinogenesis 24: 927-936, 2003.
123. Vermeulen L, De Wilde G, Notebaert S, Vanden Berghe W and Haegeman G. Regulation of the transcriptional activity of the nuclear factor-kappaB p65 subunit. Biochem Pharmacol 64: 963-970, 2002.
124. Wadsworth TL, McDonald TL, and Koop DR. Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced signaling pathways involved in the release of tumor necrosis factor-alpha. Biochem Pharmacol 62: 963-974, 2001.
125. Wakabayashi N, Dinkova-Kostova AT, Holtzclaw WD, Kang MI, Kobayashi A, Yamamoto M, Kensler TW, and Talalay P. Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers. Proc Natl Acad Sci USA 101: 2040-2045, 2004.
126. Wang W, Abbruzzese JL, Evans DB, Larry L, Cleary KR, and Chiao PJ. The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin Cancer Res 5: 119-127, 1999.
127. Wang ZQ, Grigoriadis AE, Mohle-Steinlein U, and Wagner EF. A novel target cell for c-fos-induced oncogenesis: development of chondrogenic tumours in embryonic stem cell chimeras. EMBO J 10: 2437-2450, 1991.
128. Whitmarsh AJ and Davis RJ. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J Mol Med 74: 589-607, 1996.
129. Wild AC, Moinova HR, and Mulcahy RT. Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nfr2. J Biol Chem 274: 33627-33636, 1999.
130. Woo JH, Lim JH, Kim YH, Suh SI, Min do S, Chang JS, Lee YH, Park JW, and Kwon TK. Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC delta signal transduction. Oncogene 23: 1845-1853, 2004.
131. Yang CS and Wang ZY. Tea and cancer. J Natl Cancer Inst 85: 1038-1049, 1993.
132. Yang CX, Kuroishi T, Huang XE, Inoue M, and Tajima K. Correlation between food consumption and colorectal cancer: an ecological analysis in Japan. Asian Pac J Cancer Prev 3: 77-83, 2002.
133. 2 production in transformed and non-transformed human bronchial cell lines: possible mechanisms of cell growth inhibition and apoptosis induction. Carcinogenesis 21: 2035-2039, 2000.
134. Young MR, Li JJ, Rincon M, Flavell RA, Sathyanarayana BK, Hunziker R, and Colburn N. Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion. Proc Natl Acad Sci USA 96: 9827-9832, 1999.
135. Yu R, Chen C, Mo YY, Hebbar V, Owuor ED, Tan TH, and Kong AN. Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism. J Biol Chem 275: 39907-39913, 2000.
136. Yu R, Hebbar V, Kim DW, Mandlekar S, Pezzuto JM, and Kong AN. Resveratrol inhibits phorbol ester and UV-induced activator protein 1 activation by interfering with mitogen-activated protein kinase pathways. Mol Pharmacol 60: 217-224, 2001.
137. Zhang DD and Hannink M. Distinct cysteine residues in Keap1 are required for Reap1-dependent ubiquitination of Nfr2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Mol Cell Biol 23: 8137-8151, 2003.
138. Zhong H, Voll RE, and Ghosh S. Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol Cell 1: 661-671, 1998.
139. Zhu M and Fahl WE. Functional characterization of transcription regulators that interact with the electrophile response element. Biochem Biophys Res Commun 289: 212-219, 2001.
140. Zipper LM and Mulcahy RT. Erk activation is required for Nrf2 nuclear localization during pyrrolidine dithiocarbamate induction of glutamate cysteine ligase modulatory gene expression in HepG2 cells. Toxicol Sci 73: 124-134, 2003.