Longevity and aging: Beneficial effects of exposure to mild stress

Biogerontology

Volumn 1, Issue 1, 2000, Pages 15-29

  Minois, Nadège ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Aging; Hsp; Longevity; Metabolism; Stress

Indexed keywords

AGING; ANIMAL; HUMAN; LONGEVITY; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; STRESS;

AGING; ANIMALS; HUMANS; LONGEVITY; STRESS;

EID: 0034575085     PISSN: 13895729     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1010085823990     Document Type: Review

References (134)

1. Allen RG and Sohal RS (1982) Life-lengthening effects of gamma-radiation on the adult housefly, Musca domestica. Mech Ageing Dev 20: 369-375
2. Aly KB, Pipkin JL, Hinson WG, Feuers RJ, Duffy PH, Lyn-Cook L, Hart RW et al. (1994) Chronic caloric restriction induces stress proteins in the hypothalamus of rats. Mech Ageing Dev 76: 11-23
3. Austad SN (1989) Life extension by dietary restriction in the bowl and doily spider, Frontinella pyramitela. Exp Gerontol 24: 83-92
4. Benjamin IJ and McMillan DR (1998) Stress (heat shock) proteins molecular chaperones in cardiovascular biology and disease. Circ Res 83: 117-132
5. Brar BK, Stephanou A, Wagstaff MJD, Coffin RS, Marber MS, Engelmann G, Latchman DS et al. (1999) Heat shock proteins delivered with a virus vector can protect cardiac cells against apoptosis as well as against thermal or hypoxic stress. J Mol Cell Cardiol 31: 135-146
6. Caratero A, Courtade M, Bonnet L, Planel H, Caratero C et al. (1998) Effect of a continuous gamma irradiation at very low dose on the life span of mice. Gerontoly 44: 272-276
7. Chapman T and Partridge L (1996) Female fitness in Drosophila melanogaster: an interaction between the effect of nutrition and of encounter rate with males. Proc R Soc London 263: 755-759
8. Chapman T, Hutchings J, Partridge L et al. (1993) No reduction in the cost of mating for Drosophila melanogaster females mating with spermless males. Proc R Soc London 253: 211-217
9. Chen CP and Walker VK (1993) Increase in cold-shock tolerance by selection of cold resistant lines in Drosophila melanogaster. Ecological Entomol 18: 184-190
10. Chippindale AK, Leroi AM, Kim SB, Rose MR et al. (1993) Phenotypic plasticity and selection in Drosophila life-history evolution. I. Nutrition and the cost of reproduction. J Evol Biol 6: 171-193
11. Chong KY, Lai CC, Lille S, Chang C, Su CY et al. (1998) Stable overexpression of the constitutive form of heat shock protein 70 confers oxidative protection. J Mol Cell Cardiol 30: 599-608
12. Couzin J. (1998) Low-calorie diets may slow monkey's aging. Science 282: 1018.
13. Curtsinger JW, Fukui HH, Resler AS, Kelly K, Khazaeli AA et al. (1998) Genetic analysis of extended life span in Drosophila melanogaster I. RAPD screen for genetic divergence between selected and control lines. Genetica 104: 21-32
14. Dahlgaard J, Loeschcke V, Michalak P, Justesen J et al. (1998) Induced thermotolerance and associated expression of the heat-shock protein Hsp70 in adult Drosophila melanogaster. Funct Ecol 12: 786-793
15. David J, Van Herrewege J, Fouillet P et al. (1971) Quantitative under-feeding of Drosophila: effects on adult longevity and fecundity. Exp Gerontol 6: 249-257
16. De Benedictis G, Carotenuto L, Carrieri G, De Luca M, Falcone E, Rose G, Cavalcanti S, Corsonello F, Feraco E, Baggio G, Bertolini S, Mari D, Mattace R, Yashin AI, Bonafè M, Franceschi C et al. (1998) Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2). Eur J Hum Gen 6: 534-541
17. Ehrenfried JA, Evers BM, Chu KU, Townsend CM, Thompson JC et al. (1996) Caloric restriction increases the expression of heat shock protein in the gut. Ann Surg 223: 592-599
18. Enesco HE, McTavish A, Garberi Ret al. (1990) Spontaneous activity level and life span in rotifers: lack of support for the rate of living theory. Gerontology 36: 256-261
19. Ewbank JJ, Barnes TM, Lakowski B, Lussier M, Bussey H, Hekimi S et al. (1997) Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1. Science 275: 980-983
20. Fanestil DD and Barrows CH (1965) Aging in the rotifer. J Gerontol 20: 462-469
21. Feder ME, Cartaño NV, Milos L, Krebs RA, Lindquist SL et al. (1996) effect of engineering hsp70 copy number on Hsp70 expression and tolerance of ecologically relevant heat shock in larvae and pupae of Drosophila melanogaster. J Exp Biol 199: 1837-1844
22. Fleming JE, Walton JK, Dubitski R, Bensch KG et al. (1988) Aging results in an unusual expression of Drosophila heat shock proteins. Proc Natl Acad Sci USA 85: 4099-4103
23. Force AG, Staples T, Soliman S, Arking R et al. (1995) Comparative biochemical and stress analysis of genetically selected Drosophila strains with different longevities. Dev Gen 17: 340-351
24. Fowler K and Partridge L. (1989) A cost of mating in female fruit flies, Nature 338: 760-761
25. Frolkis VV (1982) Aging and Life-Prolonging Processes. Springer-Verlag, New-York.
26. Frolkis VV (1993) Stress-age syndrome. Mech Ageing Dev 69: 93-107
27. Giess MC and Planel H (1973) Influence de la radioprotection effectuée à différents stades sur la longévité de Drosophila melanogaster. CR Acad Sci Paris 276: 1029-1032
28. Gilad GM and Gilad VH (1995) Strain, stress, neurodegeneration and longevity. Mech Ageing Dev 78: 75-83
29. Goodman R and Blank M (1998) Magnetic field stress induces expression of hsp70. Cell Stress & Chaperones 3: 79-88
30. Goodrick CL (1980) Effects of long-term voluntary wheel exercise on male and female Wistar rats. Gerontology 26: 22-33
31. Goodrick CL, Ingram DK, Reynolds MA, Freeman JR, Cider NL et al. (1983) Differential effects of intermittent feeding and voluntary exercise on body weight and lifespan in rats. J Gerontol 38: 36-45
32. Gowda A, Yang C, Asimakis GK, Rastegar S, Motamedi M et al. (1998) Heat shock improves recovery and provides protection against global ischemia after hypothermic storage. Ann Thorac Surg 66: 1991-1997
33. Gray CC, Amrani M, Yacoub MH et al. (1999) Heat stress proteins and myocardial protection: experimental model or potential clinical tool? Intern J Biochem Cell Biol 31: 559-573
34. Han ES, Levin N, Bengani N, Roberts JL, Suh Y, Karelus K, Nelson JF et al. (1995) Hyperadrenocorticism and food restriction-induced life extension in the rat: evidence for divergent regulation of pituitary proopiomelanocortin RNA and adrenocorticotropic hormone biosynthesis. J Gerontol 50A: B288-B294
35. Heydari AR, You S, Takahashi R, Gutsmann A, Sarge KD, Richardson A et al. (1996) Effect of caloric restriction on the expression of heat shock protein 70 and the activation of heat shock transcription factor 1. Dev Gen 18: 114-124
36. Hoffmann AA and Parsons PA (1989) Selection for increased desiccation resistance in Drosophila melanogaster. additive genetic control and correlated responses for other stresses. Genetics 122: 837-845
37. Hoffmann AA and Parsons PA (1991) Evolutionary Genetics and Environmental Stress. Oxford University Press, Oxford
38. Holloszy JO (1993) Exercise increases average longevity of female rats despite increased food intake and no growth retardation. J Gerontol 48: B97-B100
39. Holloszy JO (1997) Mortality rate and longevity of food-restricted exercising male rats: a reevaluation. J Appl Physiol 82: 399-403
40. Holloszy JO and Smith EK (1986) Longevity of cold-exposed rats: a reevaluation of the 'rate of living theory'. J Appl Physiol 61: 1656-1660
41. Holloszy JO, Smith EK, Vining M, Adams S et al. (1985) Effect of voluntary exercise on longevity of rats. J Appl Physiol 59: 826-831
42. Isosaki M and Nakashima T (1998) Psychological stress induces heat shock protein 70 expression in rat aorta. Jpn J Pharmacol 76: 305-308
43. Johnson TE, Lithgow GJ, Murakami S et al. (1996) Hypothesis: interventions that increase the response to stress offer the potential for effective life prolongation and increased health. J Gerontol 51A: B392-B395
44. Khazaeli AA, Xiu L, Curtsinger JW et al. (1995) Stress experiments as a means of investigating age-specific mortality in Drosophila melanogaster. Exp Gerontol 30: 177-184
45. Khazaeli AA, Tatar M, Pletcher SD, Curtsinger JW et al. (1997) Heat-induced longevity extension in Drosophila. I. Heat treatment, mortality, and thermotolerance. J Gerontol 52A: B48-B52
46. Kirkwood TBL (1993) The disposable soma theory: evidence and implications. Neth J Zool 43: 359-363
47. Klass MR (1977) Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span. Mech Ageing Dev 6: 413-429
48. Krebs RA and Loeschcke V (1994) Effects of exposure to short-term heat stress on fitness components in Drosophila melanogaster. J Evol Biol 7: 39-49
49. Krebs RA and Feder ME (1997a) Deleterious consequences of Hsp70 overexpression in Drosophila melanogaster larvae. Cell Stress & Chaperones 2: 60-71
50. Krebs RA and Feder ME (1997b) Natural variation in the expression of the heat-shock protein HSP70 in a population of Drosophila melanogaster and its correlation with tolerance of ecologically relevant thermal stress. Evolution 51: 173-179
51. Kregel KC and Moseley PL (1996) Differential effects of exercise and heat stress on liver hsp70 accumulation with aging. J Appl Physiol 80: 547-551
52. Lakowski B and Hekimi S (1996) Determination of life-span in Caenorhabditis elegans by four cloch genes. Science 272: 1010-1013
53. Lakowski B and Hekimi S (1998) The genetics of caloric restriction in Caenorhabditis elegans. Proc Natl Acad Sci USA 95: 13091-13096
54. Lamb MJ (1964) The effects of radiation on the longevity of female Drosophila subobscura. J Ins Physiol 10: 487-497
55. Lamb MJ and McDonald RP (1973) Heat tolerance changes with age in normal and irradiated Drosophila melanogaster. Exp Gerontol 8: 207-217
56. Larsen PL, Albert PS, Riddle DL et al. (1995) Genes that regulate development and longevity in Caenorhabditis elegans. Genetics 139: 1567-1583
57. Le Bourg E (1987) The rate of living theory. Spontaneous locomotor activity, aging and longevity in Drosophila melanogaster. Exp Gerontol 22: 359-369
58. Le Bourg E and Médioni J (1991) Food restriction and longevity in Drosophila melanogaster. Age Nutr 2: 90-94
59. Le Bourg E and Minois N (1996) Failure to confirm increased longevity in Drosophila melanogaster submitted to a food restriction procedure. J Gerontol 51A: B280-B283
60. Le Bourg E and Minois N (1997) Increased longevity and resistance to heat shock in Drosophila melanogaster flies exposed to hypergravity. CR Acad Sci Paris 320: 215-221
61. Le Bourg E and Minois N (1999) A mild stress, hypergravity exposure, postpones behavioral aging in Drosophila melanogaster. Exp Gerontol 34: 157-172
62. Le Bourg E, Lints FA, Fresquet N, Bullens P et al. (1993) Hypergravity, aging and longevity in Drosophila melanogaster. Comp Biochem Physiol 105A: 389-396
63. Lin YJ, Seroude L, Benzer S et al. (1998) Extended life-span and stress resistance in the Drosophila mutant methuselah. Science 282: 943-946
64. Lints FA, Bullens P, Le Bourg E et al. (1993) Hypergravity and aging in Drosophila melanogaster 7: new longevity data. Exp Gerontol 28: 611-615
65. Lithgow GJ and Kirkwood TBL (1996) Mechanisms and evolution of aging. Science 273: 80
66. Lithgow GJ, White TM, Hinerfeld DA, Johnson TE et al. (1994) Thermotolerance of a long-lived mutant of Caenorhabditis elegans. J Gerontol 49: B270-B276
67. Lithgow GJ, White TM, Melov S, Johnson TE et al. (1995) Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress. Proc Natl Acad Sci USA 92: 7540-7544
68. Liu AYC, Lee YK, Manalo D, Huang LE et al. (1996) Attenuated heat shock transcriptional response in aging: molecular mechanism and implication in the biology of aging. In: Feige U, Morimoto RI, Yahara I, Polla B et al. (eds) Stress-Inducible Cellular Responses, pp 39-408. Birkhäuser Verlag, Basel
69. Luckinbill LS (1998) Selection for longevity confers resistance to low-temperature stress in Drosophila melanogaster. J Gerontol 53A: B147-B153
70. Lundenberg T, Kohler R, Bucinskaite V, Eriksson SV et al. (1998) Physical exercise increases survival after an experimental myocardial infarction in rats. Cardiology 90: 28-31
71. Martínez DE (1996) Rejuvenation of the disposable soma: repeated injury extends lifespan in an asexual annelid. Exp Gerontol 31: 699-704
72. Masoro EJ (1995) Dietary restriction. Exp Gerontol 30: 291-298
73. Masoro EJ (1996) The biological mechanism of aging: is it still an enigma? Age 19: 141-145
74. Matz JM, Lavoi KP, Moen RJ, Blake MJ et al. (1996) Cold-induced heat shock protein expression in rat aorta and brown adipose tissue. Physiol Behav 60: 1369-1374
75. McCarter RJ, Shimokawa I, Ikeno Y, Higami Y, Hubbard GB, Yu BP, McMahan CA et al. (1997) Physical activity as a factor in the action of dietary restriction on aging: effects in Fischer 344 rats. Aging Clin Exp Res 9: 73-79
76. McCay CM, Crowell MF, Maynard LA et al. (1935) The effect of retarded growth upon the length of life and upon the ultimate body size. J Nutr 10: 63-79
77. Milakofsky L, Harris N, Vogel WH et al. (1996) Effect of repeated stress on a number of plasma amino acids and related compounds in young and old rats. Physiol Behav 60: 969-971
78. Minois N and Le Bourg E (1999) Resistance to stress as a function of age in Drosophila melanogaster living in hypergravity. Mech Ageing Dev 109: 53-64
79. Minois N, Guinaudy MJ, Payre F, Le Bourg E et al. (1999) HSP70 induction may explain the long-lasting resistance to heat of Drosophila melanogaster having lived in hypergravity. Mech Ageing Dev 109: 65-77
80. Mlekusch W, Tillian M, Lamprecht M, Oettl K, Krainz H, Reibnegger G et al. (1998) The life-shortening effect of reduced physical activity is abolished by a fat rich diet. Mech Ageing Dev 105: 61-73
81. Mlekusch W, Tillian H, Lamprecht M, Trutnovsky H, Horejsi R, Reibnegger G et al. (1996) The effect of reduced physical activity on longevity of mice. Mech Ageing Dev 88: 159-168
82. Moore SA, Lopez A, Richardson A, Pahlavani MA et al. (1998) Effect of age and dietary restriction on expression of heat shock protein 70 in rat alveolar macrophages. Mech Ageing Dev 104: 59-73
83. Morimoto RI and Santoro MG (1998) Stress-inducible responses and heat shock proteins: new pharmacologic targets for cytoprotection. Nature Biotech 16: 833-838
84. Murakami S and Johnson TE (1996) A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans. Genetics 143: 1207-1218
85. Murakami S and Johnson TE (1998) Life extension and stress resistance in Caenorhabditis elegans modulated by the tkr-1 gene. Curr Biol 8: 1091-1094
86. Nishizawa J, Nakai A, Matsuda K, Komeda M, Ban T, Nagata K et al. (1999) Reactive oxygen species play an important role in the activation of heat shock factor 1 in ischemic-reperfused heart. Circulation 99: 934-941
87. Nuzhdin SV, Pasyukova EG, Dilda CL, Zeng ZB, Mackay TFC et al. (1997) Sex-specific quantitative trait loci affecting longevity in Drosophila melanogaster. Proc Natl Acad Sci USA 94: 9734-9739
88. Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA, Ruvkun G et al. (1997) The fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389: 994-999
89. Oh HJ, Chen X, Subjeck JR et al. (1997) HspllO protects heat-denatured proteins and confers cellular thermoresistance. J Biol Chem 272: 31636-31640
90. Ordy JM, Samorajski T, Zeman W, Curtis HJ et al. (1967) Interaction effects of environmental stress and deuteron irradiation of the brain on mortality and longevity of C57BL/10 mice. Proc Soc Exp Biol Med 126: 184-190
91. Oyama J. (1982) Metabolic effects of hypergravity on experimental animals. In: Miquel J and Economos AC (eds) Space Gerontology, Vol 2248, pp 37-51. NASA Conference Publication
92. Paffenbarger RS, Hyde RT, Hsieh CC, Wing AL et al. (1986) Physical activity, other life-style patterns, cardiovascular disease and longevity. Acta Med Scand 711: 85-91
93. Paffenbarger RS, Kampert JB, Lee IM, Hyde RT, Leung RW, Wing AL et al. (1994) Changes in physical activity and other lifeway patterns influencing longevity. Med Sci Sports Exerc 26: 857-865
94. Parkes TL, Elia AJ, Dickinson D, Hilliker AJ, Phillips JP, Boulianne GL et al. (1998) Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons. Nature Gen 19: 171-174
95. Pearl R (1928) The Rate of Living. Knopf, London
96. Plumier JCL, Krueger AM, Currie RW, Kontoyiannis D, Kollias G, Pagoulatos GN et al. (1997) Transgenic mice expressing the human inducible hsp70 have hippocampal neurons resistant to ischemic injury. Cell Stress & Chaperones 2: 162-167
97. Przepiorka D and Srivastava PK (1998) Heat shock protein-peptide complexes as immunotherapy for human cancer. Mol Med Today 4: 478-484
98. Rao DV, Watson K, Jones GL et al. (1999) Age-related attenuation in the expression of the major heat shock proteins in human peripheral lymphocytes. Mech Ageing Dev 107: 105-118
99. Resler AS, Kelly K, Kantor G, Khazaeli AA, Tatar M, Curtsinger JW et al. (1998) Genetic analysis of extended life span in Drosophila melanogaster II. Replication of the backcross test and molecular characterization of the N14 locus. Genetica 104: 33-39
100. Reveillaud I, Niedzwiecki A, Bensch KG, Fleming JE et al. (1991) Expression of bovine superoxide dismutase in Drosophila melanogaster augments resistance to oxidative stress. Mol Cell Biol 11: 632-640
101. Sacher GA (1963) Effects of X-rays on the survival of Drosophila imagoes. Physiol Zool 36: 295-311
102. Sacher GA (1977) Life table prolongation and life prolongation. In: Finch CE and Hayflick L (eds) Handbook of the Biology of Aging, pp 582-638. Van Nostrand Reinhold Company, New York
103. Sanchez Y and Lindquist SL (1990) Hsp104 required for induced thermotolerance. Science 248: 1112-1115
104. Selye H (1970) Stress and aging. J Am Genat Soc 28: 669-680
105. Service PM, Hutchinson EW, MacKinley MD, Rose MR et al. (1985) Resistance to environmental stress in Drosophila melanogaster selected for postponed senescence. Physiol Zool 58: 380-389
106. Shama S, Lai CY, Antoniazzi JM, Jiang JC, Jazwinski SM et al. (1998) Heat stress-induced life span extension in yeast. Exp Cell Res 245: 379-388
107. Shook DR, Brooks A and Johnson TE (1996) Mapping quantitative trait loci affecting life history traits in the nematode Caenorhabditis elegans. Genetics 142: 801-817
108. Shpund S and Gershon D (1997) Alterations in the chaperone activity of HSP70 in aging organisms. Arch Gerontol Geriat 24: 125-131
109. Smith-Sonneborn J and Barbee SA (1998) Exercise-induced stress response as an adaptive tolerance strategy. Environ Health Perspect 106 (Suppl 1): 325-330
110. Sohal RS (1986) The rate of living theory: a contemporary interpretation. In: Collatz KG and Sohal RS (eds) Insect Aging, pp 23-44. Springer-Verlag Berlin
111. Sohal RS and Buchan PB (1981) Relationship between physical activity and life span in the adult housefly, Musca domestica. Exp Gerontol 16: 157-162
112. Stearns SC (1992) Trade-offs. In: The Evolution of Life-Histories, pp 72-90. Oxford University Press, Oxford
113. Su CY, Chong KY, Chen JX, Ryter S, Khardori R, Lai CC et al. (1999) A physiologically relevant hyperthermia selectively activates constitutive hsp70 in H9c2 cardiac myoblasts and confers oxidative protection. J Mol Cell Cardiol 31: 845-855
114. Su CY, Chong KY, Owen OE, Dillmann WH, Chang C, Lai CC et al. (1998) Constitutive and inducible hsp70s are involved in oxidative resistance evoked by heat shock or ethanol. J Mol Cell Cardiol 30: 587-598
115. Sun J and Tower J (1999) FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol 19: 216-228
116. Talan MI and Ingram DK (1986) Effects of voluntary and forced exercise on thermoregulation and survival in aged C57BL/6J mice. Mech Ageing Dev 36: 269-279
117. Tamura K, Miyashita M, Iwahashi H et al. (1998) Stress tolerance of pressure-shocked Saccharomyces cerevisiae. Biotech Lett 20: 1167-1169
118. Tatar M and Promislow DEL (1997) Fitness costs of female reproduction. Evolution 51: 1323-1326
119. Tatar M, Khazaeli AA, Curtsinger JW et al. (1997) Chaperoning extended life. Nature 390: 30
120. Theodorakis NG, Drujan D, De Maio A et al. (1999) Thermotolerant cells show an attenuated expression of Hsp70 after heat shock. J Biol Chem 274: 12081-12086
121. Van de Klundert FAJM, Van den Ijssel PRLA, Stege GJJ, De Jong WW et al. (1999) Rat hsp20 confers thermoresistance in a clonal survival assay, but fails to protect coexpressed luciferase in Chinese hamster ovary cells. Biochem Biophys Res Comm 254: 164-168
122. Vanflateren JR and De Vreese A (1995) The gerontogenes age-1 and daf-2 determine metabolic rate potential in aging Caenorhabditis elegans. FASEB J 9: 1355-1361
123. Verdery RB and Walford RL (1998) Changes in plasma lipids and lipoproteins in humans during a 2-year period of dietary restriction in biosphere 2. Arch Intern Med 158: 900-906
124. Verdone-Smith C and Enesco HE (1982) The effect of temperature and of dietary restriction on lifespan and reproduction in the rotifer Asplanchna brightwelli. Exp Gerontol 17: 255-262
125. Villeneuve PJ, Momson HI, Craig CL, Schaubel DE et al. (1998) Physical activity, physical fitness, and risk of dying. Epidemiology 9: 626-631
126. Walford RL, Weber L, Panov S et al. (1995) Caloric restriction and aging as viewed from biosphere 2. Receptor 5: 29-33
127. Wannamethee SG, Shaper AG, Walker M, Ebrahim S et al. (1998) Lifestyle and 15-year survival free of heart attack, stroke, and diabetes in middle-aged British men. Arch Intern Med 158: 2433-2440
128. Welte MA, Tetrault JM, Dellavalle RP, Lindquist SL et al. (1993) A new method for manipulating transgenes: engineering heat tolerance in a complex, multicellular organism. Curr Biol 3: 842-853
129. Wong A, Boutis P, Hekimi S et al. (1995) Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing. Genetics 139: 1247-1259
130. Wong HR, Menendez IY, Ryan MA, Denenberg AG, Wispe JR et al. (1998) Increased expression of heat shock protein-70 protects A549 cells against hyperoxia. Am J Physiol 275: L836-L841
131. Woodhead AD (1985) Feral fishes. Interdiscipl Topics Gerontol 21: 22-50
132. Yahav S and Hurwitz S (1996) Induction of thermotolerance in male broiler chickens by temperature conditioning at an early age. Poultry Sci 75: 402-406
133. Yang Y and Wilson DL (1999) Characterization of a life-extending mutation in age-2, a new aging gene in Caenorhabditis elegans. J Gerontol 54A: B137-B142
134. Yenari MA, Fink SL, Sun HH, Chang LK, Patel MK, Kunis DM, Onley D, Ho DY, Sapolsky RM, Steinberg GK et al. (1998) Gene therapy with HSP72 is neuroprotective in rat models of stroke and epilepsy. Ann Neurol 44: 584-591