-
2
-
-
33644846842
-
Genetic instability in human tumors
-
Raptis S, Bapat B. Genetic instability in human tumors. EXS 2006; 96: 303-320
-
(2006)
EXS
, vol.96
, pp. 303-320
-
-
Raptis, S.1
Bapat, B.2
-
3
-
-
84890313801
-
Chromosomal instability (CIN) what it is and why it is crucial to cancer evolution
-
(e-pub ahead of print 19 April 2013)
-
Heng HH, Bremer SW, Stevens JB, Horne SD, Liu G, Abdallah BY.et al.. Chromosomal instability (CIN): what it is and why it is crucial to cancer evolution. Cancer Metastasis Rev. (e-pub ahead of print 19 April 2013).
-
Cancer Metastasis Rev
-
-
Heng, H.H.1
Bremer, S.W.2
Stevens, J.B.3
Horne, S.D.4
Liu, G.5
Abdallah, B.Y.6
-
4
-
-
34547875773
-
Sirtuins: Critical regulators at the crossroads between cancer and aging
-
Saunders LR, Verdin E. Sirtuins: critical regulators at the crossroads between cancer and aging. Oncogene 2007; 26: 5489-5504
-
(2007)
Oncogene
, vol.26
, pp. 5489-5504
-
-
Saunders, L.R.1
Verdin, E.2
-
6
-
-
0018564390
-
A suppressor of mating-type locus mutations in Saccharomyces cerevisiae: Evidence for and identification of cryptic mating-type loci
-
Rine J, Strathern JN, Hicks JB, Herskowitz I. A suppressor of mating-type locus mutations in Saccharomyces cerevisiae: evidence for and identification of cryptic mating-type loci. Genetics 1979; 93: 877-901
-
(1979)
Genetics
, vol.93
, pp. 877-901
-
-
Rine, J.1
Strathern, J.N.2
Hicks, J.B.3
Herskowitz, I.4
-
7
-
-
84887491976
-
The diversity of histone versus nonhistone sirtuin substrates
-
e-pub ahead of print 9 April 2013; doi 10.1177 1947601913483767)
-
Martinez-Redondo P, Vaquero A. The diversity of histone versus nonhistone sirtuin substrates. Genes Cancer (e-pub ahead of print 9 April 2013; doi:10.1177 1947601913483767).
-
Genes Cancer
-
-
Martinez-Redondo, P.1
Vaquero, A.2
-
8
-
-
0033887456
-
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
-
Frye RA. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun 2000; 273: 793-798
-
(2000)
Biochem Biophys Res Commun
, vol.273
, pp. 793-798
-
-
Frye, R.A.1
-
10
-
-
81055122671
-
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase
-
Du J, Zhou Y, Su X, Yu JJ, Khan S, Jiang H.et al.. Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science 2011; 334: 806-809
-
(2011)
Science
, vol.334
, pp. 806-809
-
-
Du, J.1
Zhou, Y.2
Su, X.3
Yu, J.J.4
Khan, S.5
Jiang, H.6
-
11
-
-
84875881601
-
SIRT6 regulates TNFa secretion through hydrolysis of long-chain fatty acyl lysine
-
Jiang H, Khan S, Wang Y, Charron G, He B, Sebastian C.et al.. SIRT6 regulates TNFa secretion through hydrolysis of long-chain fatty acyl lysine. Nature 2013; 496: 110-113
-
(2013)
Nature
, vol.496
, pp. 110-113
-
-
Jiang, H.1
Khan, S.2
Wang, Y.3
Charron, G.4
He, B.5
Sebastian, C.6
-
12
-
-
70349138701
-
The conserved role of sirtuins in chromatin regulation
-
Vaquero A. The conserved role of sirtuins in chromatin regulation. Int J Dev Biol 2009; 53: 303-322
-
(2009)
Int J Dev Biol
, vol.53
, pp. 303-322
-
-
Vaquero, A.1
-
13
-
-
34547875013
-
NAD-dependent deacetylation of H4 lysine 16 by class III HDACs
-
Vaquero A, Sternglanz R, Reinberg D. NAD-dependent deacetylation of H4 lysine 16 by class III HDACs. Oncogene 2007; 26: 5505-5520
-
(2007)
Oncogene
, vol.26
, pp. 5505-5520
-
-
Vaquero, A.1
Sternglanz, R.2
Reinberg, D.3
-
14
-
-
80054782483
-
The dual role of sirtuins in cancer
-
Bosch-Presegue L, Vaquero A. The dual role of sirtuins in cancer. Genes Cancer 2011; 2: 648-662
-
(2011)
Genes Cancer
, vol.2
, pp. 648-662
-
-
Bosch-Presegue, L.1
Vaquero, A.2
-
15
-
-
53149137486
-
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
-
Wang RH, Sengupta K, Li C, Kim HS, Cao L, Xiao C.et al.. Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell 2008; 14: 312-323
-
(2008)
Cancer Cell
, vol.14
, pp. 312-323
-
-
Wang, R.H.1
Sengupta, K.2
Li, C.3
Kim, H.S.4
Cao, L.5
Xiao, C.6
-
16
-
-
80054769188
-
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity
-
Kim HS, Vassilopoulos A, Wang RH, Lahusen T, Xiao Z, Xu X.et al.. SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. Cancer Cell 2011; 20: 487-499
-
(2011)
Cancer Cell
, vol.20
, pp. 487-499
-
-
Kim, H.S.1
Vassilopoulos, A.2
Wang, R.H.3
Lahusen, T.4
Xiao, Z.5
Xu, X.6
-
17
-
-
84875309392
-
The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation
-
Serrano L, Martinez-Redondo P, Marazuela-Duque A, Vazquez BN, Dooley SJ, Voigt P.et al.. The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation. Genes Dev 2013; 27: 639-653
-
(2013)
Genes Dev
, vol.27
, pp. 639-653
-
-
Serrano, L.1
Martinez-Redondo, P.2
Marazuela-Duque, A.3
Vazquez, B.N.4
Dooley, S.J.5
Voigt, P.6
-
18
-
-
74049094817
-
SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress
-
Kim HS, Patel K, Muldoon-Jacobs K, Bisht KS, Aykin-Burns N, Pennington JD.et al.. SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell 2010; 17: 41-52
-
(2010)
Cancer Cell
, vol.17
, pp. 41-52
-
-
Kim, H.S.1
Patel, K.2
Muldoon-Jacobs, K.3
Bisht, K.S.4
Aykin-Burns, N.5
Pennington, J.D.6
-
19
-
-
84876359638
-
SIRT4 has tumorsuppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism
-
Jeong SM, Xiao C, Finley LW, Lahusen T, Souza AL, Pierce K.et al.. SIRT4 has tumorsuppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell 2013; 23: 450-463
-
(2013)
Cancer Cell
, vol.23
, pp. 450-463
-
-
Jeong, S.M.1
Xiao, C.2
Finley, L.W.3
Lahusen, T.4
Souza, A.L.5
Pierce, K.6
-
20
-
-
31044445366
-
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
-
Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L.et al.. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 2006; 124: 315-329
-
(2006)
Cell
, vol.124
, pp. 315-329
-
-
Mostoslavsky, R.1
Chua, K.F.2
Lombard, D.B.3
Pang, W.W.4
Fischer, M.R.5
Gellon, L.6
-
21
-
-
38349171766
-
SIRT6 in DNA repair, metabolism and ageing
-
Lombard DB, Schwer B, Alt FW, Mostoslavsky R. SIRT6 in DNA repair, metabolism and ageing. J Intern Med 2008; 263: 128-141
-
(2008)
J Intern Med
, vol.263
, pp. 128-141
-
-
Lombard, D.B.1
Schwer, B.2
Alt, F.W.3
Mostoslavsky, R.4
-
22
-
-
41349090663
-
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
-
Michishita E, McCord RA, Berber E, Kioi M, Padilla-Nash H, Damian M.et al.. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature 2008; 452: 492-496
-
(2008)
Nature
, vol.452
, pp. 492-496
-
-
Michishita, E.1
McCord, R.A.2
Berber, E.3
Kioi, M.4
Padilla-Nash, H.5
Damian, M.6
-
23
-
-
12344296753
-
Heterochromatin-many flavours, common themes
-
Craig JM. Heterochromatin-many flavours, common themes. Bioessays 2005; 27: 17-28
-
(2005)
Bioessays
, vol.27
, pp. 17-28
-
-
Craig, J.M.1
-
24
-
-
0035839136
-
Translating the histone code
-
Jenuwein T, Allis CD. Translating the histone code. Science 2001; 293: 1074-1080
-
(2001)
Science
, vol.293
, pp. 1074-1080
-
-
Jenuwein, T.1
Allis, C.D.2
-
25
-
-
0242348752
-
Histone lysine methylation: A signature for chromatin function
-
Sims 3rd RJ, Nishioka K, Reinberg D. Histone lysine methylation: a signature for chromatin function. Trends Genet 2003; 19: 629-639
-
(2003)
Trends Genet
, vol.19
, pp. 629-639
-
-
Sims III, R.J.1
Nishioka, K.2
Reinberg, D.3
-
26
-
-
0035913911
-
Negative control of p53 by Sir2alpha promotes cell survival under stress
-
Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A.et al.. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 2001; 107: 137-148
-
(2001)
Cell
, vol.107
, pp. 137-148
-
-
Luo, J.1
Nikolaev, A.Y.2
Imai, S.3
Chen, D.4
Su, F.5
Shiloh, A.6
-
27
-
-
0035913903
-
HSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
-
Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, Pandita TK.et al.. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 2001; 107: 149-159
-
(2001)
Cell
, vol.107
, pp. 149-159
-
-
Vaziri, H.1
Dessain, S.K.2
Ng Eaton, E.3
Imai, S.I.4
Frye, R.A.5
Pandita, T.K.6
-
28
-
-
0035868764
-
Acetylation of TAF(I) 68, a subunit of TIF-IB/ SL1, activates RNA polymerase i transcription
-
Muth V, Nadaud S, Grummt I, Voit R. Acetylation of TAF(I)68, a subunit of TIF-IB/ SL1, activates RNA polymerase I transcription. EMBO J 2001; 20: 1353-1362
-
(2001)
EMBO J
, vol.20
, pp. 1353-1362
-
-
Muth, V.1
Nadaud, S.2
Grummt, I.3
Voit, R.4
-
29
-
-
0043244921
-
Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state
-
Fulco M, Schiltz RL, Iezzi S, King MT, Zhao P, Kashiwaya Y.et al.. Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol Cell 2003; 12: 51-62
-
(2003)
Mol Cell
, vol.12
, pp. 51-62
-
-
Fulco, M.1
Schiltz, R.L.2
Iezzi, S.3
King, M.T.4
Zhao, P.5
Kashiwaya, Y.6
-
30
-
-
0242322010
-
Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression
-
Senawong T, Peterson VJ, Avram D, Shepherd DM, Frye RA, Minucci S.et al.. Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression. J Biol Chem 2003; 278: 43041-43050
-
(2003)
J Biol Chem
, vol.278
, pp. 43041-43050
-
-
Senawong, T.1
Peterson, V.J.2
Avram, D.3
Shepherd, D.M.4
Frye, R.A.5
Minucci, S.6
-
31
-
-
0037474507
-
Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1-And HEY2-mediated transcriptional repression
-
Takata T, Ishikawa F. Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1-And HEY2-mediated transcriptional repression. Biochem Biophys Res Commun 2003; 301: 250-257
-
(2003)
Biochem Biophys Res Commun
, vol.301
, pp. 250-257
-
-
Takata, T.1
Ishikawa, F.2
-
32
-
-
4944245398
-
Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin
-
Vaquero A, Scher M, Lee D, Erdjument-Bromage H, Tempst P, Reinberg D. Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol Cell 2004; 16: 93-105
-
(2004)
Mol Cell
, vol.16
, pp. 93-105
-
-
Vaquero, A.1
Scher, M.2
Lee, D.3
Erdjument-Bromage, H.4
Tempst, P.5
Reinberg, D.6
-
33
-
-
1942502862
-
Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3
-
Kuzmichev A, Jenuwein T, Tempst P, Reinberg D. Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3. Mol Cell 2004; 14: 183-193
-
(2004)
Mol Cell
, vol.14
, pp. 183-193
-
-
Kuzmichev, A.1
Jenuwein, T.2
Tempst, P.3
Reinberg, D.4
-
34
-
-
36248954501
-
SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation
-
Vaquero A, Scher M, Erdjument-Bromage H, Tempst P, Serrano L, Reinberg D. SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation. Nature 2007; 450: 440-444
-
(2007)
Nature
, vol.450
, pp. 440-444
-
-
Vaquero, A.1
Scher, M.2
Erdjument-Bromage, H.3
Tempst, P.4
Serrano, L.5
Reinberg, D.6
-
35
-
-
0042671307
-
Epigenetic silencing of RNA polymerase i transcription
-
Grummt I, Pikaard CS. Epigenetic silencing of RNA polymerase I transcription. Nat Rev Mol Cell Biol 2003; 4: 641-649
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 641-649
-
-
Grummt, I.1
Pikaard, C.S.2
-
37
-
-
43049169926
-
Epigenetic control of rDNA loci in response to intracellular energy status
-
Murayama A, Ohmori K, Fujimura A, Minami H, Yasuzawa-Tanaka K, Kuroda T.et al.. Epigenetic control of rDNA loci in response to intracellular energy status. Cell 2008; 133: 627-639
-
(2008)
Cell
, vol.133
, pp. 627-639
-
-
Murayama, A.1
Ohmori, K.2
Fujimura, A.3
Minami, H.4
Yasuzawa-Tanaka, K.5
Kuroda, T.6
-
38
-
-
0034677535
-
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
-
Imai S, Armstrong CM, Kaeberlein M, Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 2000; 403: 795-800
-
(2000)
Nature
, vol.403
, pp. 795-800
-
-
Imai, S.1
Armstrong, C.M.2
Kaeberlein, M.3
Guarente, L.4
-
39
-
-
33744466971
-
Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase i transcription
-
Ford E, Voit R, Liszt G, Magin C, Grummt I, Guarente L. Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Genes Dev 2006; 20: 1075-1080
-
(2006)
Genes Dev
, vol.20
, pp. 1075-1080
-
-
Ford, E.1
Voit, R.2
Liszt, G.3
Magin, C.4
Grummt, I.5
Guarente, L.6
-
40
-
-
64849107827
-
Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis
-
Grob A, Roussel P, Wright JE, McStay B, Hernandez-Verdun D, Sirri V. Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis. J Cell Sci 2009; 122: 489-498
-
(2009)
J Cell Sci
, vol.122
, pp. 489-498
-
-
Grob, A.1
Roussel, P.2
Wright, J.E.3
McStay, B.4
Hernandez-Verdun, D.5
Sirri, V.6
-
41
-
-
84863453769
-
SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation
-
Barber MF, Michishita-Kioi E, Xi Y, Tasselli L, Kioi M, Moqtaderi Z.et al.. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature 2012; 487: 114-118
-
(2012)
Nature
, vol.487
, pp. 114-118
-
-
Barber, M.F.1
Michishita-Kioi, E.2
Xi, Y.3
Tasselli, L.4
Kioi, M.5
Moqtaderi, Z.6
-
42
-
-
13844315463
-
Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation
-
Kuzmichev A, Margueron R, Vaquero A, Preissner TS, Scher M, Kirmizis A.et al.. Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation. Proc Natl Acad Sci USA 2005; 102: 1859-1864
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 1859-1864
-
-
Kuzmichev, A.1
Margueron, R.2
Vaquero, A.3
Preissner, T.S.4
Scher, M.5
Kirmizis, A.6
-
43
-
-
0037111831
-
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein
-
Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D. Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev 2002; 16: 2893-2905
-
(2002)
Genes Dev
, vol.16
, pp. 2893-2905
-
-
Kuzmichev, A.1
Nishioka, K.2
Erdjument-Bromage, H.3
Tempst, P.4
Reinberg, D.5
-
44
-
-
84856466661
-
The role of EZH2 in tumour progression
-
Chang CJ, Hung MC. The role of EZH2 in tumour progression. Br J Cancer 2012; 106: 243-247
-
(2012)
Br J Cancer
, vol.106
, pp. 243-247
-
-
Chang, C.J.1
Hung, M.C.2
-
45
-
-
79958037576
-
A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development
-
Mulligan P, Yang F, Di Stefano L, Ji JY, Ouyang J, Nishikawa JL.et al.. A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development. Mol Cell 2011; 42: 689-699
-
(2011)
Mol Cell
, vol.42
, pp. 689-699
-
-
Mulligan, P.1
Yang, F.2
Di Stefano, L.3
Ji, J.Y.4
Ouyang, J.5
Nishikawa, J.L.6
-
47
-
-
50849104230
-
Notch tumor suppressor function
-
Dotto GP. Notch tumor suppressor function. Oncogene 2008; 27: 5115-5123
-
(2008)
Oncogene
, vol.27
, pp. 5115-5123
-
-
Dotto, G.P.1
-
48
-
-
58149090925
-
SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span
-
Kawahara TL, Michishita E, Adler AS, Damian M, Berber E, Lin M.et al.. SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell 2009; 136: 62-74
-
(2009)
Cell
, vol.136
, pp. 62-74
-
-
Kawahara, T.L.1
Michishita, E.2
Adler, A.S.3
Damian, M.4
Berber, E.5
Lin, M.6
-
49
-
-
74549142287
-
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha
-
Zhong L, DUrso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD.et al.. The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell 2010; 140: 280-293
-
(2010)
Cell
, vol.140
, pp. 280-293
-
-
Zhong, L.1
Durso, A.2
Toiber, D.3
Sebastian, C.4
Henry, R.E.5
Vadysirisack, D.D.6
-
50
-
-
84870874690
-
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism
-
Sebastian C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L.et al.. The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell 2012; 151: 1185-1199
-
(2012)
Cell
, vol.151
, pp. 1185-1199
-
-
Sebastian, C.1
Zwaans, B.M.2
Silberman, D.M.3
Gymrek, M.4
Goren, A.5
Zhong, L.6
-
51
-
-
84869082071
-
Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin
-
Min L, Ji Y, Bakiri L, Qiu Z, Cen J, Chen X.et al.. Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin. Nat Cell Biol 2013; 14: 1203-1211
-
(2013)
Nat Cell Biol
, vol.14
, pp. 1203-1211
-
-
Min, L.1
Ji, Y.2
Bakiri, L.3
Qiu, Z.4
Cen, J.5
Chen, X.6
-
52
-
-
84871852995
-
SIRT3 functions in the nucleus in the control of stress-related gene expression
-
Iwahara T, Bonasio R, Narendra V, Reinberg D. SIRT3 functions in the nucleus in the control of stress-related gene expression. Mol Cell Biol 2012; 32: 5022-5034
-
(2012)
Mol Cell Biol
, vol.32
, pp. 5022-5034
-
-
Iwahara, T.1
Bonasio, R.2
Narendra, V.3
Reinberg, D.4
-
53
-
-
34247271282
-
SirT3 is a nuclear NAD-dependent histone deacetylase that translocates to the mitochondria upon cellular stress
-
Scher MB, Vaquero A, Reinberg D. SirT3 is a nuclear NAD-dependent histone deacetylase that translocates to the mitochondria upon cellular stress. Genes Dev 2007; 21: 920-928
-
(2007)
Genes Dev
, vol.21
, pp. 920-928
-
-
Scher, M.B.1
Vaquero, A.2
Reinberg, D.3
-
54
-
-
17944380227
-
Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability
-
Peters AH, OCarroll D, Scherthan H, Mechtler K, Sauer S, Schofer C.et al.. Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. Cell 2001; 107: 323-337
-
(2001)
Cell
, vol.107
, pp. 323-337
-
-
Peters, A.H.1
Ocarroll, D.2
Scherthan, H.3
Mechtler, K.4
Sauer, S.5
Schofer, C.6
-
55
-
-
0347988045
-
Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases
-
Garcia-Cao M, OSullivan R, Peters AH, Jenuwein T, Blasco MA. Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases. Nat Genet 2004; 36: 94-99
-
(2004)
Nat Genet
, vol.36
, pp. 94-99
-
-
Garcia-Cao, M.1
Osullivan, R.2
Peters, A.H.3
Jenuwein, T.4
Blasco, M.A.5
-
56
-
-
79954467406
-
Stabilization of Suv39H1 by SirT1 is part of oxidative stress response and ensures genome protection
-
Bosch-Presegue L, Raurell-Vila H, Marazuela-Duque A, Kane-Goldsmith N, Valle A, Oliver J.et al.. Stabilization of Suv39H1 by SirT1 is part of oxidative stress response and ensures genome protection. Mol Cell 2011; 42: 210-223
-
(2011)
Mol Cell
, vol.42
, pp. 210-223
-
-
Bosch-Presegue, L.1
Raurell-Vila, H.2
Marazuela-Duque, A.3
Kane-Goldsmith, N.4
Valle, A.5
Oliver, J.6
-
57
-
-
0025279931
-
Telomeres shorten during ageing of human fibroblasts
-
Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 1990; 345: 458-460
-
(1990)
Nature
, vol.345
, pp. 458-460
-
-
Harley, C.B.1
Futcher, A.B.2
Greider, C.W.3
-
58
-
-
0022402513
-
Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
-
Greider CW, Blackburn EH. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 1985; 43: 405-413
-
(1985)
Cell
, vol.43
, pp. 405-413
-
-
Greider, C.W.1
Blackburn, E.H.2
-
59
-
-
0024325562
-
The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
-
Morin GB. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell 1989; 59: 521-529
-
(1989)
Cell
, vol.59
, pp. 521-529
-
-
Morin, G.B.1
-
60
-
-
0030931491
-
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
-
Blasco MA, Lee HW, Hande MP, Samper E, Lansdorp PM, DePinho RA.et al.. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 1997; 91: 25-34
-
(1997)
Cell
, vol.91
, pp. 25-34
-
-
Blasco, M.A.1
Lee, H.W.2
Hande, M.P.3
Samper, E.4
Lansdorp, P.M.5
Depinho, R.A.6
-
61
-
-
0032499210
-
Essential role of mouse telomerase in highly proliferative organs
-
Lee HW, Blasco MA, Gottlieb GJ, Horner 2nd JW, Greider CW, DePinho RA. Essential role of mouse telomerase in highly proliferative organs. Nature 1998; 392: 569-574
-
(1998)
Nature
, vol.392
, pp. 569-574
-
-
Lee, H.W.1
Blasco, M.A.2
Gottlieb, G.J.3
Horner II, J.W.4
Greider, C.W.5
Depinho, R.A.6
-
62
-
-
0030668722
-
Human telomerase contains evolutionarily conserved catalytic and structural subunits
-
Harrington L, Zhou W, McPhail T, Oulton R, Yeung DS, Mar V.et al.. Human telomerase contains evolutionarily conserved catalytic and structural subunits. Genes Dev 1997; 11: 3109-3115
-
(1997)
Genes Dev
, vol.11
, pp. 3109-3115
-
-
Harrington, L.1
Zhou, W.2
McPhail, T.3
Oulton, R.4
Yeung, D.S.5
Mar, V.6
-
63
-
-
0030745448
-
HEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization
-
Meyerson M, Counter CM, Eaton EN, Ellisen LW, Steiner P, Caddle SD.et al.. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 1997; 90: 785-795
-
(1997)
Cell
, vol.90
, pp. 785-795
-
-
Meyerson, M.1
Counter, C.M.2
Eaton, E.N.3
Ellisen, L.W.4
Steiner, P.5
Caddle, S.D.6
-
64
-
-
0030819894
-
Telomerase catalytic subunit homologs from fission yeast and human
-
Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Lingner J.et al.. Telomerase catalytic subunit homologs from fission yeast and human. Science 1997; 277: 955-959
-
(1997)
Science
, vol.277
, pp. 955-959
-
-
Nakamura, T.M.1
Morin, G.B.2
Chapman, K.B.3
Weinrich, S.L.4
Andrews, W.H.5
Lingner, J.6
-
65
-
-
0029096515
-
The RNA component of human telomerase
-
Feng J, Funk WD, Wang SS, Weinrich SL, Avilion AA, Chiu CP.et al.. The RNA component of human telomerase. Science 1995; 269: 1236-1241
-
(1995)
Science
, vol.269
, pp. 1236-1241
-
-
Feng, J.1
Funk, W.D.2
Wang, S.S.3
Weinrich, S.L.4
Avilion, A.A.5
Chiu, C.P.6
-
66
-
-
0031027618
-
Control of telomere length by the human telomeric protein TRF1
-
van Steensel B, de Lange T. Control of telomere length by the human telomeric protein TRF1. Nature 1997; 385: 740-743
-
(1997)
Nature
, vol.385
, pp. 740-743
-
-
Van Steensel, B.1
De Lange, T.2
-
67
-
-
0028004378
-
Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1
-
Moretti P, Freeman K, Coodly L, Shore D. Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1. Genes Dev 1994; 8: 2257-2269
-
(1994)
Genes Dev
, vol.8
, pp. 2257-2269
-
-
Moretti, P.1
Freeman, K.2
Coodly, L.3
Shore, D.4
-
68
-
-
0033539095
-
DNA damage triggers disruption of telomeric silencing and Mec1p-dependent relocation of Sir3p
-
McAinsh AD, Scott-Drew S, Murray JA, Jackson SP. DNA damage triggers disruption of telomeric silencing and Mec1p-dependent relocation of Sir3p. Curr Biol 1999; 9: 963-966
-
(1999)
Curr Biol
, vol.9
, pp. 963-966
-
-
McAinsh, A.D.1
Scott-Drew, S.2
Murray, J.A.3
Jackson, S.P.4
-
69
-
-
0033612189
-
MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks
-
Mills KD, Sinclair DA, Guarente L. MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks. Cell 1999; 97: 609-620
-
(1999)
Cell
, vol.97
, pp. 609-620
-
-
Mills, K.D.1
Sinclair, D.A.2
Guarente, L.3
-
70
-
-
41649094992
-
SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity
-
Narala SR, Allsopp RC, Wells TB, Zhang G, Prasad P, Coussens MJ.et al.. SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity. Mol Biol Cell 2008; 19: 1210-1219
-
(2008)
Mol Biol Cell
, vol.19
, pp. 1210-1219
-
-
Narala, S.R.1
Allsopp, R.C.2
Wells, T.B.3
Zhang, G.4
Prasad, P.5
Coussens, M.J.6
-
71
-
-
70349319371
-
Functional interplay between Parp-1 and SirT1 in genome integrity and chromatin-based processes
-
El Ramy R, Magroun N, Messadecq N, Gauthier LR, Boussin FD, Kolthur-Seetharam U.et al.. Functional interplay between Parp-1 and SirT1 in genome integrity and chromatin-based processes. Cell Mol Life Sci 2009; 66: 3219-3234
-
(2009)
Cell Mol Life Sci
, vol.66
, pp. 3219-3234
-
-
El Ramy, R.1
Magroun, N.2
Messadecq, N.3
Gauthier, L.R.4
Boussin, F.D.5
Kolthur-Seetharam, U.6
-
72
-
-
79958787784
-
Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth
-
Chen J, Zhang B, Wong N, Lo AW, To KF, Chan AW.et al.. Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth. Cancer Res 2012; 71: 4138-4149
-
(2012)
Cancer Res
, vol.71
, pp. 4138-4149
-
-
Chen, J.1
Zhang, B.2
Wong, N.3
Lo, A.W.4
To, K.F.5
Chan, A.W.6
-
73
-
-
67650677845
-
Resveratrol induces senescence-like growth inhibition of U-2 OS cells associated with the instability of telomeric DNA and upregulation of BRCA1
-
Rusin M, Zajkowicz A, Butkiewicz D. Resveratrol induces senescence-like growth inhibition of U-2 OS cells associated with the instability of telomeric DNA and upregulation of BRCA1. Mech Ageing Dev 2009; 130: 528-537
-
(2009)
Mech Ageing Dev
, vol.130
, pp. 528-537
-
-
Rusin, M.1
Zajkowicz, A.2
Butkiewicz, D.3
-
74
-
-
78650747994
-
SIRT1 contributes to telomere maintenance and augments global homologous recombination
-
Palacios JA, Herranz D, De Bonis ML, Velasco S, Serrano M, Blasco MA. SIRT1 contributes to telomere maintenance and augments global homologous recombination. J Cell Biol 2010; 191: 1299-1313
-
(2010)
J Cell Biol
, vol.191
, pp. 1299-1313
-
-
Palacios, J.A.1
Herranz, D.2
De Bonis, M.L.3
Velasco, S.4
Serrano, M.5
Blasco, M.A.6
-
75
-
-
79960005365
-
Limited role of Sirt1 in cancer protection by dietary restriction
-
Herranz D, Iglesias G, Munoz-Martin M, Serrano M. Limited role of Sirt1 in cancer protection by dietary restriction. Cell Cycle 2011; 10: 2215-2217
-
(2011)
Cell Cycle
, vol.10
, pp. 2215-2217
-
-
Herranz, D.1
Iglesias, G.2
Munoz-Martin, M.3
Serrano, M.4
-
76
-
-
69249221533
-
Cell cycledependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6
-
Michishita E, McCord RA, Boxer LD, Barber MF, Hong T, Gozani O.et al.. Cell cycledependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6. Cell Cycle 2009; 8: 2664-2666
-
(2009)
Cell Cycle
, vol.8
, pp. 2664-2666
-
-
Michishita, E.1
McCord, R.A.2
Boxer, L.D.3
Barber, M.F.4
Hong, T.5
Gozani, O.6
-
77
-
-
69249229772
-
The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability
-
Yang B, Zwaans BM, Eckersdorff M, Lombard DB. The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability. Cell Cycle 2009; 8: 2662-2663
-
(2009)
Cell Cycle
, vol.8
, pp. 2662-2663
-
-
Yang, B.1
Zwaans, B.M.2
Eckersdorff, M.3
Lombard, D.B.4
-
78
-
-
65549113750
-
CBP/p300-mediated acetylation of histone H3 on lysine 56
-
Das C, Lucia MS, Hansen KC, Tyler JK. CBP/p300-mediated acetylation of histone H3 on lysine 56. Nature 2009; 459: 113-117
-
(2009)
Nature
, vol.459
, pp. 113-117
-
-
Das, C.1
Lucia, M.S.2
Hansen, K.C.3
Tyler, J.K.4
-
79
-
-
80052399287
-
SIRT6 is required for maintenance of telomere position effect in human cells
-
Tennen RI, Bua DJ, Wright WE, Chua KF. SIRT6 is required for maintenance of telomere position effect in human cells. Nat Commun 2011; 2: 433
-
(2011)
Nat Commun
, vol.2
, pp. 433
-
-
Tennen, R.I.1
Bua, D.J.2
Wright, W.E.3
Chua, K.F.4
-
80
-
-
33751515840
-
Nuclear export modulates the cytoplasmic Sir2 homologue Hst2
-
Wilson JM, Le VQ, Zimmerman C, Marmorstein R, Pillus L. Nuclear export modulates the cytoplasmic Sir2 homologue Hst2. EMBO Rep 2006; 7: 1247-1251
-
(2006)
EMBO Rep
, vol.7
, pp. 1247-1251
-
-
Wilson, J.M.1
Le, V.Q.2
Zimmerman, C.3
Marmorstein, R.4
Pillus, L.5
-
81
-
-
39149122568
-
Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis
-
North BJ, Verdin E. Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis. PLoS One 2007; 2: e784
-
(2007)
PLoS One
, vol.2
-
-
North, B.J.1
Verdin, E.2
-
82
-
-
33646550204
-
SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis
-
Vaquero A, Scher MB, Lee DH, Sutton A, Cheng HL, Alt FW.et al.. SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev 2006; 20: 1256-1261
-
(2006)
Genes Dev
, vol.20
, pp. 1256-1261
-
-
Vaquero, A.1
Scher, M.B.2
Lee, D.H.3
Sutton, A.4
Cheng, H.L.5
Alt, F.W.6
-
83
-
-
0037066738
-
Conserved enzymatic production and biological effect of O-Acetyl-ADP-ribose by silent information regulator 2-like NAD-dependent deacetylases
-
Borra MT, ONeill FJ, Jackson MD, Marshall B, Verdin E, Foltz KR.et al.. Conserved enzymatic production and biological effect of O-Acetyl-ADP-ribose by silent information regulator 2-like NAD-dependent deacetylases. J Biol Chem 2002; 277: 12632-12641
-
(2002)
J Biol Chem
, vol.277
, pp. 12632-12641
-
-
Borra, M.T.1
Oneill, F.J.2
Jackson, M.D.3
Marshall, B.4
Verdin, E.5
Foltz, K.R.6
-
84
-
-
0037405043
-
Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle
-
Dryden SC, Nahhas FA, Nowak JE, Goustin AS, Tainsky MA. Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. Mol Cell Biol 2003; 23: 3173-3185
-
(2003)
Mol Cell Biol
, vol.23
, pp. 3173-3185
-
-
Dryden, S.C.1
Nahhas, F.A.2
Nowak, J.E.3
Goustin, A.S.4
Tainsky, M.A.5
-
85
-
-
3142548829
-
Human histone deacetylase SIRT2 interacts with the homeobox transcription factor HOXA10
-
Bae NS, Swanson MJ, Vassilev A, Howard BH. Human histone deacetylase SIRT2 interacts with the homeobox transcription factor HOXA10. J Biochem 2004; 135: 695-700
-
(2004)
J Biochem
, vol.135
, pp. 695-700
-
-
Bae, N.S.1
Swanson, M.J.2
Vassilev, A.3
Howard, B.H.4
-
86
-
-
8844248619
-
Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage
-
Sanders SL, Portoso M, Mata J, Bahler J, Allshire RC, Kouzarides T. Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage. Cell 2004; 119: 603-614
-
(2004)
Cell
, vol.119
, pp. 603-614
-
-
Sanders, S.L.1
Portoso, M.2
Mata, J.3
Bahler, J.4
Allshire, R.C.5
Kouzarides, T.6
-
87
-
-
2642542643
-
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin
-
Schotta G, Lachner M, Sarma K, Ebert A, Sengupta R, Reuter G.et al.. A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev 2004; 18: 1251-1262
-
(2004)
Genes Dev
, vol.18
, pp. 1251-1262
-
-
Schotta, G.1
Lachner, M.2
Sarma, K.3
Ebert, A.4
Sengupta, R.5
Reuter, G.6
-
88
-
-
48749102722
-
A chromatinwide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse
-
Schotta G, Sengupta R, Kubicek S, Malin S, Kauer M, Callen E.et al.. A chromatinwide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev 2008; 22: 2048-2061
-
(2008)
Genes Dev
, vol.22
, pp. 2048-2061
-
-
Schotta, G.1
Sengupta, R.2
Kubicek, S.3
Malin, S.4
Kauer, M.5
Callen, E.6
-
89
-
-
13844269327
-
PR-Set7-dependent methylation of histone H4 Lys 20 functions in repression of gene expression and is essential for mitosis
-
Karachentsev D, Sarma K, Reinberg D, Steward R. PR-Set7-dependent methylation of histone H4 Lys 20 functions in repression of gene expression and is essential for mitosis. Genes Dev 2005; 19: 431-435
-
(2005)
Genes Dev
, vol.19
, pp. 431-435
-
-
Karachentsev, D.1
Sarma, K.2
Reinberg, D.3
Steward, R.4
-
90
-
-
64749106929
-
Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development
-
Oda H, Okamoto I, Murphy N, Chu J, Price SM, Shen MM.et al.. Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development. Mol Cell Biol 2009; 29: 2278-2295
-
(2009)
Mol Cell Biol
, vol.29
, pp. 2278-2295
-
-
Oda, H.1
Okamoto, I.2
Murphy, N.3
Chu, J.4
Price, S.M.5
Shen, M.M.6
-
91
-
-
34547098165
-
Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation
-
North BJ, Verdin E. Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation. J Biol Chem 2007; 282: 19546-19555
-
(2007)
J Biol Chem
, vol.282
, pp. 19546-19555
-
-
North, B.J.1
Verdin, E.2
-
92
-
-
78349272437
-
Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression
-
Wu S, Wang W, Kong X, Congdon LM, Yokomori K, Kirschner MW.et al.. Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression. Genes Dev 2010; 24: 2531-2542
-
(2010)
Genes Dev
, vol.24
, pp. 2531-2542
-
-
Wu, S.1
Wang, W.2
Kong, X.3
Congdon, L.M.4
Yokomori, K.5
Kirschner, M.W.6
-
93
-
-
0141744707
-
Histone hyperacetylation in mitosis prevents sister chromatid separation and produces chromosome segregation defects
-
Cimini D, Mattiuzzo M, Torosantucci L, Degrassi F. Histone hyperacetylation in mitosis prevents sister chromatid separation and produces chromosome segregation defects. Mol Biol Cell 2003; 14: 3821-3833
-
(2003)
Mol Biol Cell
, vol.14
, pp. 3821-3833
-
-
Cimini, D.1
Mattiuzzo, M.2
Torosantucci, L.3
Degrassi, F.4
-
94
-
-
33646020705
-
Histone deacetylase activity is necessary for chromosome condensation during meiotic maturation in Xenopus laevis
-
Magnaghi-Jaulin L, Jaulin C. Histone deacetylase activity is necessary for chromosome condensation during meiotic maturation in Xenopus laevis. Chromosome Res 2006; 14: 319-332
-
(2006)
Chromosome Res
, vol.14
, pp. 319-332
-
-
Magnaghi-Jaulin, L.1
Jaulin, C.2
-
95
-
-
49349107518
-
Lysine acetylation: Codified crosstalk with other posttranslational modifications
-
Yang XJ, Seto E. Lysine acetylation: codified crosstalk with other posttranslational modifications. Mol Cell 2008; 31: 449-461
-
(2008)
Mol Cell
, vol.31
, pp. 449-461
-
-
Yang, X.J.1
Seto, E.2
-
96
-
-
33847053144
-
SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress
-
Inoue T, Hiratsuka M, Osaki M, Yamada H, Kishimoto I, Yamaguchi S.et al.. SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress. Oncogene 2007; 26: 945-957
-
(2007)
Oncogene
, vol.26
, pp. 945-957
-
-
Inoue, T.1
Hiratsuka, M.2
Osaki, M.3
Yamada, H.4
Kishimoto, I.5
Yamaguchi, S.6
-
97
-
-
34248151365
-
The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation
-
Inoue T, Hiratsuka M, Osaki M, Oshimura M. The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation. Cell Cycle 2007; 6: 1011-1018
-
(2007)
Cell Cycle
, vol.6
, pp. 1011-1018
-
-
Inoue, T.1
Hiratsuka, M.2
Osaki, M.3
Oshimura, M.4
-
98
-
-
0037291214
-
The human Sir2 ortholog, SIRT2, is an NAD-dependent tubulin deacetylase
-
North BJ, Marshall BL, Borra MT, Denu JM, Verdin E. The human Sir2 ortholog, SIRT2, is an NAD-dependent tubulin deacetylase. Mol Cell 2003; 11: 437-444
-
(2003)
Mol Cell
, vol.11
, pp. 437-444
-
-
North, B.J.1
Marshall, B.L.2
Borra, M.T.3
Denu, J.M.4
Verdin, E.5
-
99
-
-
33748331132
-
Progressive loss of SIRT1 with cell cycle withdrawal
-
Sasaki T, Maier B, Bartke A, Scrable H. Progressive loss of SIRT1 with cell cycle withdrawal. Aging Cell 2006; 5: 413-422
-
(2006)
Aging Cell
, vol.5
, pp. 413-422
-
-
Sasaki, T.1
Maier, B.2
Bartke, A.3
Scrable, H.4
-
100
-
-
79960466223
-
Human SIRT1 associates with mitotic chromatin and contributes to chromosomal condensation
-
Fatoba ST, Okorokov AL. Human SIRT1 associates with mitotic chromatin and contributes to chromosomal condensation. Cell Cycle 2011; 10: 2317-2322
-
(2011)
Cell Cycle
, vol.10
, pp. 2317-2322
-
-
Fatoba, S.T.1
Okorokov, A.L.2
-
101
-
-
35748949600
-
Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1
-
Wong S, Weber JD. Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1. Biochem J 2007; 407: 451-460
-
(2007)
Biochem J
, vol.407
, pp. 451-460
-
-
Wong, S.1
Weber, J.D.2
-
102
-
-
0037079677
-
Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases
-
Vaute O, Nicolas E, Vandel L, Trouche D. Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases. Nucleic Acids Res 2002; 30: 475-481
-
(2002)
Nucleic Acids Res
, vol.30
, pp. 475-481
-
-
Vaute, O.1
Nicolas, E.2
Vandel, L.3
Trouche, D.4
-
103
-
-
33748200050
-
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage
-
Wang C, Chen L, Hou X, Li Z, Kabra N, Ma Y.et al.. Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol 2006; 8: 1025-1031
-
(2006)
Nat Cell Biol
, vol.8
, pp. 1025-1031
-
-
Wang, C.1
Chen, L.2
Hou, X.3
Li, Z.4
Kabra, N.5
Ma, Y.6
-
104
-
-
44449141876
-
SIRT1 negatively regulates HDAC1-dependent transcriptional repression by the RBP1 family of proteins
-
Binda O, Nassif C, Branton PE. SIRT1 negatively regulates HDAC1-dependent transcriptional repression by the RBP1 family of proteins. Oncogene 2008; 27: 3384-3392
-
(2008)
Oncogene
, vol.27
, pp. 3384-3392
-
-
Binda, O.1
Nassif, C.2
Branton, P.E.3
-
105
-
-
0037093346
-
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
-
Langley E, Pearson M, Faretta M, Bauer UM, Frye RA, Minucci S.et al.. Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J 2002; 21: 2383-2396
-
(2002)
EMBO J
, vol.21
, pp. 2383-2396
-
-
Langley, E.1
Pearson, M.2
Faretta, M.3
Bauer, U.M.4
Frye, R.A.5
Minucci, S.6
-
106
-
-
15944365507
-
Role of NAD-dependent deacetylases SIRT1 and SIRT2 in radiation and cisplatin-induced cell death in vertebrate cells
-
Matsushita N, Takami Y, Kimura M, Tachiiri S, Ishiai M, Nakayama T.et al.. Role of NAD-dependent deacetylases SIRT1 and SIRT2 in radiation and cisplatin-induced cell death in vertebrate cells. Genes Cells 2005; 10: 321-332
-
(2005)
Genes Cells
, vol.10
, pp. 321-332
-
-
Matsushita, N.1
Takami, Y.2
Kimura, M.3
Tachiiri, S.4
Ishiai, M.5
Nakayama, T.6
-
107
-
-
78650638268
-
SIRT2 downregulation in HeLa can induce p53 accumulation via p38 MAPK activationdependent p300 decrease, eventually leading to apoptosis
-
Li Y, Matsumori H, Nakayama Y, Osaki M, Kojima H, Kurimasa A.et al.. SIRT2 downregulation in HeLa can induce p53 accumulation via p38 MAPK activationdependent p300 decrease, eventually leading to apoptosis. Genes Cells 2011; 16: 34-45
-
(2011)
Genes Cells
, vol.16
, pp. 34-45
-
-
Li, Y.1
Matsumori, H.2
Nakayama, Y.3
Osaki, M.4
Kojima, H.5
Kurimasa, A.6
-
108
-
-
27844497945
-
FOXO transcription factors at the interface between longevity and tumor suppression
-
Greer EL, Brunet A. FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 2005; 24: 7410-7425
-
(2005)
Oncogene
, vol.24
, pp. 7410-7425
-
-
Greer, E.L.1
Brunet, A.2
-
109
-
-
17644379936
-
FOXO transcription factors in cell-cycle regulation and the response to oxidative stress
-
Furukawa-Hibi Y, Kobayashi Y, Chen C, Motoyama N. FOXO transcription factors in cell-cycle regulation and the response to oxidative stress. Antioxid Redox Signal 2005; 7: 752-760
-
(2005)
Antioxid Redox Signal
, vol.7
, pp. 752-760
-
-
Furukawa-Hibi, Y.1
Kobayashi, Y.2
Chen, C.3
Motoyama, N.4
-
110
-
-
4644324186
-
NF-kappaB functions as a tumour promoter in inflammation-Associated cancer
-
Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S.et al.. NF-kappaB functions as a tumour promoter in inflammation-Associated cancer. Nature 2004; 431: 461-466
-
(2004)
Nature
, vol.431
, pp. 461-466
-
-
Pikarsky, E.1
Porat, R.M.2
Stein, I.3
Abramovitch, R.4
Amit, S.5
Kasem, S.6
-
111
-
-
79951482450
-
Genomic instability and cancer: An introduction
-
Shen Z. Genomic instability and cancer: an introduction. J Mol Cell Biol 2011; 3: 1-3
-
(2011)
J Mol Cell Biol
, vol.3
, pp. 1-3
-
-
Shen, Z.1
-
112
-
-
27244435939
-
Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress
-
Chua KF, Mostoslavsky R, Lombard DB, Pang WW, Saito S, Franco S.et al.. Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. Cell Metab 2005; 2: 67-76
-
(2005)
Cell Metab
, vol.2
, pp. 67-76
-
-
Chua, K.F.1
Mostoslavsky, R.2
Lombard, D.B.3
Pang, W.W.4
Saito, S.5
Franco, S.6
-
113
-
-
36849002444
-
SIRT3 is pro-Apoptotic and participates in distinct basal apoptotic pathways
-
Allison SJ, Milner J. SIRT3 is pro-Apoptotic and participates in distinct basal apoptotic pathways. Cell Cycle 2007; 6: 2669-2677
-
(2007)
Cell Cycle
, vol.6
, pp. 2669-2677
-
-
Allison, S.J.1
Milner, J.2
-
114
-
-
34447626095
-
SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
-
Wang F, Nguyen M, Qin FX, Tong Q. SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell 2007; 6: 505-514
-
(2007)
Aging Cell
, vol.6
, pp. 505-514
-
-
Wang, F.1
Nguyen, M.2
Qin, F.X.3
Tong, Q.4
-
115
-
-
39749087530
-
SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization
-
Han MK, Song EK, Guo Y, Ou X, Mantel C, Broxmeyer HE. SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization. Cell Stem Cell 2008; 2: 241-251
-
(2008)
Cell Stem Cell
, vol.2
, pp. 241-251
-
-
Han, M.K.1
Song, E.K.2
Guo, Y.3
Ou, X.4
Mantel, C.5
Broxmeyer, H.E.6
-
116
-
-
84865793242
-
AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells
-
Lee CW, Wong LL, Tse EY, Liu HF, Leong VY, Lee JM.et al.. AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells. Cancer Res 2012; 72: 4394-4404
-
(2012)
Cancer Res
, vol.72
, pp. 4394-4404
-
-
Lee, C.W.1
Wong, L.L.2
Tse, E.Y.3
Liu, H.F.4
Leong, V.Y.5
Lee, J.M.6
-
117
-
-
79952235291
-
Dynamics of DNA damage response proteins at DNA breaks: A focus on protein modifications
-
Polo SE, Jackson SP. Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev 2011; 25: 409-433
-
(2011)
Genes Dev
, vol.25
, pp. 409-433
-
-
Polo, S.E.1
Jackson, S.P.2
-
118
-
-
77955501963
-
SIRT1 regulates UV-induced DNA repair through deacetylating XPA
-
Fan W, Luo J. SIRT1 regulates UV-induced DNA repair through deacetylating XPA. Mol Cell 2010; 39: 247-258
-
(2010)
Mol Cell
, vol.39
, pp. 247-258
-
-
Fan, W.1
Luo, J.2
-
119
-
-
78651105018
-
Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C
-
Ming M, Shea CR, Guo X, Li X, Soltani K, Han W.et al.. Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C. Proc Natl Acad Sci USA 2010; 107: 22623-22628
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 22623-22628
-
-
Ming, M.1
Shea, C.R.2
Guo, X.3
Li, X.4
Soltani, K.5
Han, W.6
-
120
-
-
37549016377
-
A functional link between SIRT1 deacetylase and NBS1 in DNA damage response
-
Yuan Z, Seto E. A functional link between SIRT1 deacetylase and NBS1 in DNA damage response. Cell Cycle 2007; 6: 2869-2871
-
(2007)
Cell Cycle
, vol.6
, pp. 2869-2871
-
-
Yuan, Z.1
Seto, E.2
-
121
-
-
34250897968
-
SIRT1 regulates the function of the Nijmegen breakage syndrome protein
-
Yuan Z, Zhang X, Sengupta N, Lane WS, Seto E. SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol Cell 2007; 27: 149-162
-
(2007)
Mol Cell
, vol.27
, pp. 149-162
-
-
Yuan, Z.1
Zhang, X.2
Sengupta, N.3
Lane, W.S.4
Seto, E.5
-
122
-
-
0034576494
-
The many substrates and functions of ATM
-
Kastan MB, Lim DS. The many substrates and functions of ATM. Nat Rev Mol Cell Biol 2000; 1: 179-186
-
(2000)
Nat Rev Mol Cell Biol
, vol.1
, pp. 179-186
-
-
Kastan, M.B.1
Lim, D.S.2
-
123
-
-
0034611728
-
ATM phosphorylates p95/ nbs1 in an S-phase checkpoint pathway
-
Lim DS, Kim ST, Xu B, Maser RS, Lin J, Petrini JH.et al.. ATM phosphorylates p95/ nbs1 in an S-phase checkpoint pathway. Nature 2000; 404: 613-617
-
(2000)
Nature
, vol.404
, pp. 613-617
-
-
Lim, D.S.1
Kim, S.T.2
Xu, B.3
Maser, R.S.4
Lin, J.5
Petrini, J.H.6
-
124
-
-
56749156405
-
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging
-
Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK.et al.. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell 2008; 135: 907-918
-
(2008)
Cell
, vol.135
, pp. 907-918
-
-
Oberdoerffer, P.1
Michan, S.2
McVay, M.3
Mostoslavsky, R.4
Vann, J.5
Park, S.K.6
-
125
-
-
84864020743
-
SIRT1 negatively regulates the activities, functions, and protein levels of hMOF and TIP60
-
Peng L, Ling H, Yuan Z, Fang B, Bloom G, Fukasawa K.et al.. SIRT1 negatively regulates the activities, functions, and protein levels of hMOF and TIP60. Mol Cell Biol 2012; 32: 2823-2836
-
(2012)
Mol Cell Biol
, vol.32
, pp. 2823-2836
-
-
Peng, L.1
Ling, H.2
Yuan, Z.3
Fang, B.4
Bloom, G.5
Fukasawa, K.6
-
126
-
-
37549014206
-
The mammalian ortholog of Drosophila MOF that acetylates histone H4 lysine 16 is essential for embryogenesis and oncogenesis
-
Gupta A, Guerin-Peyrou TG, Sharma GG, Park C, Agarwal M, Ganju RK.et al.. The mammalian ortholog of Drosophila MOF that acetylates histone H4 lysine 16 is essential for embryogenesis and oncogenesis. Mol Cell Biol 2008; 28: 397-409
-
(2008)
Mol Cell Biol
, vol.28
, pp. 397-409
-
-
Gupta, A.1
Guerin-Peyrou, T.G.2
Sharma, G.G.3
Park, C.4
Agarwal, M.5
Ganju, R.K.6
-
127
-
-
34547913733
-
Males absent on the first (MOF): From flies to humans
-
Rea S, Xouri G, Akhtar A. Males absent on the first (MOF): from flies to humans. Oncogene 2007; 26: 5385-5394
-
(2007)
Oncogene
, vol.26
, pp. 5385-5394
-
-
Rea, S.1
Xouri, G.2
Akhtar, A.3
-
128
-
-
0034682736
-
Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis
-
Ikura T, Ogryzko VV, Grigoriev M, Groisman R, Wang J, Horikoshi M.et al.. Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. Cell 2000; 102: 463-473
-
(2000)
Cell
, vol.102
, pp. 463-473
-
-
Ikura, T.1
Ogryzko, V.V.2
Grigoriev, M.3
Groisman, R.4
Wang, J.5
Horikoshi, M.6
-
129
-
-
24944516931
-
A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM
-
Sun Y, Jiang X, Chen S, Fernandes N, Price BD. A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. Proc Natl Acad Sci USA 2005; 102: 13182-13187
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 13182-13187
-
-
Sun, Y.1
Jiang, X.2
Chen, S.3
Fernandes, N.4
Price, B.D.5
-
130
-
-
70449518412
-
Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60
-
Sun Y, Jiang X, Xu Y, Ayrapetov MK, Moreau LA, Whetstine JR.et al.. Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60. Nat Cell Biol 2009; 11: 1376-1382
-
(2009)
Nat Cell Biol
, vol.11
, pp. 1376-1382
-
-
Sun, Y.1
Jiang, X.2
Xu, Y.3
Ayrapetov, M.K.4
Moreau, L.A.5
Whetstine, J.R.6
-
131
-
-
37349090772
-
Expression and localization of Werner syndrome protein is modulated by SIRT1 and PML
-
Vaitiekunaite R, Butkiewicz D, Krzesniak M, Przybylek M, Gryc A, Snietura M.et al.. Expression and localization of Werner syndrome protein is modulated by SIRT1 and PML. Mech Ageing Dev 2007; 128: 650-661
-
(2007)
Mech Ageing Dev
, vol.128
, pp. 650-661
-
-
Vaitiekunaite, R.1
Butkiewicz, D.2
Krzesniak, M.3
Przybylek, M.4
Gryc, A.5
Snietura, M.6
-
132
-
-
46749109938
-
Sirtuin-mediated deacetylation pathway stabilizes Werner syndrome protein
-
Kahyo T, Mostoslavsky R, Goto M, Setou M. Sirtuin-mediated deacetylation pathway stabilizes Werner syndrome protein. FEBS Lett 2008; 582: 2479-2483
-
(2008)
FEBS Lett
, vol.582
, pp. 2479-2483
-
-
Kahyo, T.1
Mostoslavsky, R.2
Goto, M.3
Setou, M.4
-
133
-
-
43149118368
-
Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation
-
Li K, Casta A, Wang R, Lozada E, Fan W, Kane S.et al.. Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation. J Biol Chem 2008; 283: 7590-7598
-
(2008)
J Biol Chem
, vol.283
, pp. 7590-7598
-
-
Li, K.1
Casta, A.2
Wang, R.3
Lozada, E.4
Fan, W.5
Kane, S.6
-
134
-
-
66249144685
-
Identification and characterization of proteins interacting with SIRT1 and SIRT3: Implications in the anti-Aging and metabolic effects of sirtuins
-
Law IK, Liu L, Xu A, Lam KS, Vanhoutte PM, Che CM.et al.. Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-Aging and metabolic effects of sirtuins. Proteomics 2009; 9: 2444-2456
-
(2009)
Proteomics
, vol.9
, pp. 2444-2456
-
-
Law, I.K.1
Liu, L.2
Xu, A.3
Lam, K.S.4
Vanhoutte, P.M.5
Che, C.M.6
-
135
-
-
77949653651
-
Role of SIRT1 in homologous recombination
-
Uhl M, Csernok A, Aydin S, Kreienberg R, Wiesmuller L, Gatz SA. Role of SIRT1 in homologous recombination. DNA Repair (Amst) 2010; 9: 383-393
-
(2010)
DNA Repair (Amst)
, vol.9
, pp. 383-393
-
-
Uhl, M.1
Csernok, A.2
Aydin, S.3
Kreienberg, R.4
Wiesmuller, L.5
Gatz, S.A.6
-
136
-
-
33847647624
-
SIRT1 promotes DNA repair activity and deacetylation of Ku70
-
Jeong J, Juhn K, Lee H, Kim SH, Min BH, Lee KM.et al.. SIRT1 promotes DNA repair activity and deacetylation of Ku70. Exp Mol Med 2007; 39: 8-13
-
(2007)
Exp Mol Med
, vol.39
, pp. 8-13
-
-
Jeong, J.1
Juhn, K.2
Lee, H.3
Kim, S.H.4
Min, B.H.5
Lee, K.M.6
-
137
-
-
0037385609
-
Ku70 suppresses the apoptotic translocation of Bax to mitochondria
-
Sawada M, Sun W, Hayes P, Leskov K, Boothman DA, Matsuyama S. Ku70 suppresses the apoptotic translocation of Bax to mitochondria. Nat Cell Biol 2003; 5: 320-329
-
(2003)
Nat Cell Biol
, vol.5
, pp. 320-329
-
-
Sawada, M.1
Sun, W.2
Hayes, P.3
Leskov, K.4
Boothman, D.A.5
Matsuyama, S.6
-
138
-
-
3142740860
-
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
-
Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B.et al.. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 2004; 305: 390-392
-
(2004)
Science
, vol.305
, pp. 390-392
-
-
Cohen, H.Y.1
Miller, C.2
Bitterman, K.J.3
Wall, N.R.4
Hekking, B.5
Kessler, B.6
-
139
-
-
84863981612
-
Emerging roles of SIRT6 on telomere maintenance, DNA repair, metabolism and mammalian aging
-
Jia G, Su L, Singhal S, Liu X. Emerging roles of SIRT6 on telomere maintenance, DNA repair, metabolism and mammalian aging. Mol Cell Biochem 2012; 364: 345-350
-
(2012)
Mol Cell Biochem
, vol.364
, pp. 345-350
-
-
Jia, G.1
Su, L.2
Singhal, S.3
Liu, X.4
-
140
-
-
79959363092
-
SIRT6 promotes DNA repair under stress by activating PARP1
-
Mao Z, Hine C, Tian X, Van Meter M, Au M, Vaidya A.et al.. SIRT6 promotes DNA repair under stress by activating PARP1. Science 2011; 332: 1443-1446
-
(2011)
Science
, vol.332
, pp. 1443-1446
-
-
Mao, Z.1
Hine, C.2
Tian, X.3
Van Meter, M.4
Au, M.5
Vaidya, A.6
-
141
-
-
84863974838
-
Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence
-
Mao Z, Tian X, Van Meter M, Ke Z, Gorbunova V, Seluanov A. Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence. Proc Natl Acad Sci USA 2012; 109: 11800-11805
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 11800-11805
-
-
Mao, Z.1
Tian, X.2
Van Meter, M.3
Ke, Z.4
Gorbunova, V.5
Seluanov, A.6
-
142
-
-
33749260519
-
Nuclear ADP-ribosylation reactions in mammalian cells: Where are we today and where are we going?
-
Hassa PO, Haenni SS, Elser M, Hottiger MO. Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going? Microbiol Mol Biol Rev 2006; 70: 789-829
-
(2006)
Microbiol Mol Biol Rev
, vol.70
, pp. 789-829
-
-
Hassa, P.O.1
Haenni, S.S.2
Elser, M.3
Hottiger, M.O.4
-
143
-
-
0034575578
-
Poly(ADP-ribosyl)ation: A posttranslational protein modification linked with genome protection and mammalian longevity
-
Burkle A. Poly(ADP-ribosyl)ation: a posttranslational protein modification linked with genome protection and mammalian longevity. Biogerontology 2000; 1: 41-46
-
(2000)
Biogerontology
, vol.1
, pp. 41-46
-
-
Burkle, A.1
-
144
-
-
33645288259
-
Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells
-
Hochegger H, Dejsuphong D, Fukushima T, Morrison C, Sonoda E, Schreiber V.et al.. Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells. EMBO J 2006; 25: 1305-1314
-
(2006)
EMBO J
, vol.25
, pp. 1305-1314
-
-
Hochegger, H.1
Dejsuphong, D.2
Fukushima, T.3
Morrison, C.4
Sonoda, E.5
Schreiber, V.6
-
146
-
-
0032518339
-
DNA repair: PARP-Another guardian angel?
-
Jeggo PA. DNA repair: PARP-Another guardian angel? Curr Biol 1998; 8: R49-R51
-
(1998)
Curr Biol
, vol.8
-
-
Jeggo, P.A.1
-
147
-
-
0032842477
-
Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability
-
dAdda di Fagagna F, Hande MP, Tong WM, Lansdorp PM, Wang ZQ, Jackson SP. Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability. Nat Genet 1999; 23: 76-80
-
(1999)
Nat Genet
, vol.23
, pp. 76-80
-
-
Dadda Di Fagagna, F.1
Hande, M.P.2
Tong, W.M.3
Lansdorp, P.M.4
Wang, Z.Q.5
Jackson, S.P.6
-
148
-
-
77956550868
-
Human SIRT6 promotes DNA end resection through CtIP deacetylation
-
Kaidi A, Weinert BT, Choudhary C, Jackson SP. Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science 2010; 329: 1348-1353
-
(2010)
Science
, vol.329
, pp. 1348-1353
-
-
Kaidi, A.1
Weinert, B.T.2
Choudhary, C.3
Jackson, S.P.4
-
149
-
-
66049150672
-
SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair
-
McCord RA, Michishita E, Hong T, Berber E, Boxer LD, Kusumoto R.et al.. SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair. Aging (Albany, NY) 2009; 1: 109-121
-
(2009)
Aging (Albany, NY)
, vol.1
, pp. 109-121
-
-
McCord, R.A.1
Michishita, E.2
Hong, T.3
Berber, E.4
Boxer, L.D.5
Kusumoto, R.6
-
150
-
-
66749102871
-
Histone H3-K56 acetylation is important for genomic stability in mammals
-
Yuan J, Pu M, Zhang Z, Lou Z. Histone H3-K56 acetylation is important for genomic stability in mammals. Cell Cycle 2009; 8: 1747-1753
-
(2009)
Cell Cycle
, vol.8
, pp. 1747-1753
-
-
Yuan, J.1
Pu, M.2
Zhang, Z.3
Lou, Z.4
-
151
-
-
33745520486
-
The sirtuins hst3 and Hst4p preserve genome integrity by controlling histone h3 lysine 56 deacetylation
-
Celic I, Masumoto H, Griffith WP, Meluh P, Cotter RJ, Boeke JD.et al.. The sirtuins hst3 and Hst4p preserve genome integrity by controlling histone h3 lysine 56 deacetylation. Curr Biol 2006; 16: 1280-1289
-
(2006)
Curr Biol
, vol.16
, pp. 1280-1289
-
-
Celic, I.1
Masumoto, H.2
Griffith, W.P.3
Meluh, P.4
Cotter, R.J.5
Boeke, J.D.6
-
152
-
-
53549105529
-
SIRT3 is a stressresponsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70
-
Sundaresan NR, Samant SA, Pillai VB, Rajamohan SB, Gupta MP. SIRT3 is a stressresponsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70. Mol Cell Biol 2008; 28: 6384-6401
-
(2008)
Mol Cell Biol
, vol.28
, pp. 6384-6401
-
-
Sundaresan, N.R.1
Samant, S.A.2
Pillai, V.B.3
Rajamohan, S.B.4
Gupta, M.P.5
-
153
-
-
33744465025
-
Mitochondria damage checkpoint, aging, and cancer
-
Singh KK. Mitochondria damage checkpoint, aging, and cancer. Ann NY Acad Sci 2006; 1067: 182-190
-
(2006)
Ann NY Acad Sci
, vol.1067
, pp. 182-190
-
-
Singh, K.K.1
-
154
-
-
52649107626
-
Cancer cell metabolism: Warburg and beyond
-
Hsu PP, Sabatini DM. Cancer cell metabolism: Warburg and beyond. Cell 2008; 134: 703-707
-
(2008)
Cell
, vol.134
, pp. 703-707
-
-
Hsu, P.P.1
Sabatini, D.M.2
-
155
-
-
59849084800
-
Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation
-
Aykin-Burns N, Ahmad IM, Zhu Y, Oberley LW, Spitz DR. Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation. Biochem J 2009; 418: 29-37
-
(2009)
Biochem J
, vol.418
, pp. 29-37
-
-
Aykin-Burns, N.1
Ahmad, I.M.2
Zhu, Y.3
Oberley, L.W.4
Spitz, D.R.5
-
156
-
-
37549002891
-
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
-
Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R.et al.. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol 2007; 27: 8807-8814
-
(2007)
Mol Cell Biol
, vol.27
, pp. 8807-8814
-
-
Lombard, D.B.1
Alt, F.W.2
Cheng, H.L.3
Bunkenborg, J.4
Streeper, R.S.5
Mostoslavsky, R.6
-
157
-
-
0037108799
-
SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria
-
Onyango P, Celic I, McCaffery JM, Boeke JD, Feinberg AP. SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. Proc Natl Acad Sci USA 2002; 99: 13653-13658
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 13653-13658
-
-
Onyango, P.1
Celic, I.2
McCaffery, J.M.3
Boeke, J.D.4
Feinberg, A.P.5
-
158
-
-
0037135972
-
The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase
-
Schwer B, North BJ, Frye RA, Ott M, Verdin E. The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol 2002; 158: 647-657
-
(2002)
J Cell Biol
, vol.158
, pp. 647-657
-
-
Schwer, B.1
North, B.J.2
Frye, R.A.3
Ott, M.4
Verdin, E.5
-
159
-
-
0024402834
-
An assay for superoxide dismutase activity in mammalian tissue homogenates
-
Spitz DR, Oberley LW. An assay for superoxide dismutase activity in mammalian tissue homogenates. Anal Biochem 1989; 179: 8-18
-
(1989)
Anal Biochem
, vol.179
, pp. 8-18
-
-
Spitz, D.R.1
Oberley, L.W.2
-
160
-
-
78650248160
-
Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress
-
Tao R, Coleman MC, Pennington JD, Ozden O, Park SH, Jiang H.et al.. Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. Mol Cell 2010; 40: 893-904
-
(2010)
Mol Cell
, vol.40
, pp. 893-904
-
-
Tao, R.1
Coleman, M.C.2
Pennington, J.D.3
Ozden, O.4
Park, S.H.5
Jiang, H.6
-
161
-
-
78651468722
-
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction
-
Someya S, Yu W, Hallows WC, Xu J, Vann JM, Leeuwenburgh C.et al.. Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell 2010; 143: 802-812
-
(2010)
Cell
, vol.143
, pp. 802-812
-
-
Someya, S.1
Yu, W.2
Hallows, W.C.3
Xu, J.4
Vann, J.M.5
Leeuwenburgh, C.6
-
162
-
-
0037207475
-
The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis
-
McBurney MW, Yang X, Jardine K, Hixon M, Boekelheide K, Webb JR.et al.. The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol 2003; 23: 38-54
-
(2003)
Mol Cell Biol
, vol.23
, pp. 38-54
-
-
McBurney, M.W.1
Yang, X.2
Jardine, K.3
Hixon, M.4
Boekelheide, K.5
Webb, J.R.6
-
163
-
-
45549098657
-
SirT1 regulates energy metabolism and response to caloric restriction in mice
-
Boily G, Seifert EL, Bevilacqua L, He XH, Sabourin G, Estey C.et al.. SirT1 regulates energy metabolism and response to caloric restriction in mice. PLoS One 2008; 3: e1759
-
(2008)
PLoS One
, vol.3
-
-
Boily, G.1
Seifert, E.L.2
Bevilacqua, L.3
He, X.H.4
Sabourin, G.5
Estey, C.6
-
164
-
-
33244486764
-
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells
-
Bordone L, Motta MC, Picard F, Robinson A, Jhala US, Apfeld J.et al.. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol 2006; 4: e31
-
(2006)
PLoS Biol
, vol.4
-
-
Bordone, L.1
Motta, M.C.2
Picard, F.3
Robinson, A.4
Jhala, U.S.5
Apfeld, J.6
-
165
-
-
0141814680
-
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
-
Cheng HL, Mostoslavsky R, Saito S, Manis JP, Gu Y, Patel P.et al.. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci USA 2003; 100: 10794-10799
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 10794-10799
-
-
Cheng, H.L.1
Mostoslavsky, R.2
Saito, S.3
Manis, J.P.4
Gu, Y.5
Patel, P.6
-
166
-
-
84865555215
-
Dilated cardiomyopathy and mitochondrial dysfunction in Sirt1-deficient mice: A role for Sirt1-Mef2 in adult heart
-
Planavila A, Dominguez E, Navarro M, Vinciguerra M, Iglesias R, Giralt M.et al.. Dilated cardiomyopathy and mitochondrial dysfunction in Sirt1-deficient mice: a role for Sirt1-Mef2 in adult heart. J Mol Cell Cardiol 2012; 53: 521-531
-
(2012)
J Mol Cell Cardiol
, vol.53
, pp. 521-531
-
-
Planavila, A.1
Dominguez, E.2
Navarro, M.3
Vinciguerra, M.4
Iglesias, R.5
Giralt, M.6
-
167
-
-
78751506082
-
SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse
-
Ou X, Chae HD, Wang RH, Shelley WC, Cooper S, Taylor T.et al.. SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse. Blood 2011; 117: 440-450
-
(2011)
Blood
, vol.117
, pp. 440-450
-
-
Ou, X.1
Chae, H.D.2
Wang, R.H.3
Shelley, W.C.4
Cooper, S.5
Taylor, T.6
-
168
-
-
77950806433
-
SIRT3 regulates mitochondrial fatty-Acid oxidation by reversible enzyme deacetylation
-
Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB.et al.. SIRT3 regulates mitochondrial fatty-Acid oxidation by reversible enzyme deacetylation. Nature 2010; 464: 121-125
-
(2010)
Nature
, vol.464
, pp. 121-125
-
-
Hirschey, M.D.1
Shimazu, T.2
Goetzman, E.3
Jing, E.4
Schwer, B.5
Lombard, D.B.6
-
169
-
-
78649509214
-
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production
-
Shimazu T, Hirschey MD, Hua L, Dittenhafer-Reed KE, Schwer B, Lombard DB.et al.. SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab 2010; 12: 654-661
-
(2010)
Cell Metab
, vol.12
, pp. 654-661
-
-
Shimazu, T.1
Hirschey, M.D.2
Hua, L.3
Dittenhafer-Reed, K.E.4
Schwer, B.5
Lombard, D.B.6
-
170
-
-
80052291180
-
Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production
-
Jing E, Emanuelli B, Hirschey MD, Boucher J, Lee KY, Lombard D.et al.. Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. Proc Natl Acad Sci USA 2011; 108: 14608-14613
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 14608-14613
-
-
Jing, E.1
Emanuelli, B.2
Hirschey, M.D.3
Boucher, J.4
Lee, K.Y.5
Lombard, D.6
-
171
-
-
78649521247
-
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
-
Qiu X, Brown K, Hirschey MD, Verdin E, Chen D. Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab 2010; 12: 662-667
-
(2010)
Cell Metab
, vol.12
, pp. 662-667
-
-
Qiu, X.1
Brown, K.2
Hirschey, M.D.3
Verdin, E.4
Chen, D.5
-
172
-
-
70349208608
-
Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3adependent antioxidant defense mechanisms in mice
-
Sundaresan NR, Gupta M, Kim G, Rajamohan SB, Isbatan A, Gupta MP. Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3adependent antioxidant defense mechanisms in mice. J Clin Invest 2009; 119: 2758-2771
-
(2009)
J Clin Invest
, vol.119
, pp. 2758-2771
-
-
Sundaresan, N.R.1
Gupta, M.2
Kim, G.3
Rajamohan, S.B.4
Isbatan, A.5
Gupta, M.P.6
-
173
-
-
82455212901
-
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome
-
Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B.et al.. SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell 2011; 44: 177-190
-
(2011)
Mol Cell
, vol.44
, pp. 177-190
-
-
Hirschey, M.D.1
Shimazu, T.2
Jing, E.3
Grueter, C.A.4
Collins, A.M.5
Aouizerat, B.6
-
174
-
-
55749084738
-
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
-
Ahn BH, Kim HS, Song S, Lee IH, Liu J, Vassilopoulos A.et al.. A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc Natl Acad Sci USA 2008; 105: 14447-14452
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 14447-14452
-
-
Ahn, B.H.1
Kim, H.S.2
Song, S.3
Lee, I.H.4
Liu, J.5
Vassilopoulos, A.6
-
175
-
-
78651468707
-
Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction
-
Hallows WC, Yu W, Smith BC, Devries MK, Ellinger JJ, Someya S.et al.. Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction. Mol Cell 2011; 41: 139-149
-
(2011)
Mol Cell
, vol.41
, pp. 139-149
-
-
Hallows, W.C.1
Yu, W.2
Smith, B.C.3
Devries, M.K.4
Ellinger, J.J.5
Someya, S.6
-
176
-
-
77952940043
-
Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle
-
Palacios OM, Carmona JJ, Michan S, Chen KY, Manabe Y, Ward 3rd JL.et al.. Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle. Aging (Albany, NY) 2009; 1: 771-783
-
(2009)
Aging (Albany, NY)
, vol.1
, pp. 771-783
-
-
Palacios, O.M.1
Carmona, J.J.2
Michan, S.3
Chen, K.Y.4
Manabe, Y.5
Ward III, J.L.6
-
177
-
-
77951235122
-
NAD-dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10
-
Yang Y, Cimen H, Han MJ, Shi T, Deng JH, Koc H.et al.. NAD-dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10. J Biol Chem 2009; 285: 7417-7429
-
(2009)
J Biol Chem
, vol.285
, pp. 7417-7429
-
-
Yang, Y.1
Cimen, H.2
Han, M.J.3
Shi, T.4
Deng, J.H.5
Koc, H.6
-
178
-
-
33748316536
-
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells
-
Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ.et al.. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell 2006; 126: 941-954
-
(2006)
Cell
, vol.126
, pp. 941-954
-
-
Haigis, M.C.1
Mostoslavsky, R.2
Haigis, K.M.3
Fahie, K.4
Christodoulou, D.C.5
Murphy, A.J.6
-
179
-
-
65249087389
-
SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle
-
Nakagawa T, Lomb DJ, Haigis MC, Guarente L. SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell 2009; 137: 560-570
-
(2009)
Cell
, vol.137
, pp. 560-570
-
-
Nakagawa, T.1
Lomb, D.J.2
Haigis, M.C.3
Guarente, L.4
-
180
-
-
83055173304
-
The first identification of lysine malonylation substrates and its regulatory enzyme
-
M111.012658
-
Peng C, Lu Z, Xie Z, Cheng Z, Chen Y, Tan M.et al.. The first identification of lysine malonylation substrates and its regulatory enzyme. Mol Cell Proteomics 2011; 10: M111.012658
-
(2011)
Mol Cell Proteomics
, vol.10
-
-
Peng, C.1
Lu, Z.2
Xie, Z.3
Cheng, Z.4
Chen, Y.5
Tan, M.6
-
181
-
-
41449083867
-
Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice
-
Vakhrusheva O, Smolka C, Gajawada P, Kostin S, Boettger T, Kubin T.et al.. Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circ Res 2008; 102: 703-710.
-
(2008)
Circ Res
, vol.102
, pp. 703-710
-
-
Vakhrusheva, O.1
Smolka, C.2
Gajawada, P.3
Kostin, S.4
Boettger, T.5
Kubin, T.6
|