The BRCT domain of PARP-1 is required for immunoglobulin gene conversion

PLoS Biology

Volumn 8, Issue 7, 2010, Pages

  Paddock, Marcia N ^a,b   Buelow, Ben D ^a,b   Takeda, Shunichi ^c   Scharenberg, Andrew M ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b SEATTLE CHILDREN S RESEARCH INSTITUTE   (United States)

^c KYOTO UNIVERSITY FACULTY OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTIDINE DEAMINASE; DNA; IMMUNOGLOBULIN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; MESYLIC ACID METHYL ESTER; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; AICDA (ACTIVATION INDUCED CYTIDINE DEAMINASE); AICDA (ACTIVATION-INDUCED CYTIDINE DEAMINASE); HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID; MUTANT PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; TRICHOSTATIN A;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; EXCISION REPAIR; GENE CONVERSION; GENETIC ENGINEERING; GENETIC VARIABILITY; MUTAGENICITY; NONHUMAN; PROTEIN DOMAIN; SEQUENCE ANALYSIS; SOMATIC MUTATION; ANIMAL; BIOLOGICAL MODEL; CELL SURVIVAL; CHEMISTRY; CHICKEN; DOUBLE STRANDED DNA BREAK; DRUG EFFECT; ENZYME ACTIVATION; GENE INACTIVATION; GENETIC RECOMBINATION; GENETICS; HUMAN; IMMUNOGLOBULIN GENE; METABOLISM; MUTATION; PROTEIN TERTIARY STRUCTURE; SOMATIC HYPERMUTATION;

ANIMALS; CELL SURVIVAL; CHICKENS; CYTIDINE DEAMINASE; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; ENZYME ACTIVATION; GENE CONVERSION; GENE KNOCKOUT TECHNIQUES; GENES, IMMUNOGLOBULIN; HISTONE DEACETYLASE INHIBITORS; HUMANS; HYDROXAMIC ACIDS; MODELS, BIOLOGICAL; MUTANT PROTEINS; MUTATION; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN STRUCTURE, TERTIARY; RECOMBINATION, GENETIC; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN;

EID: 77955037815     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1000428     Document Type: Article

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