PR-Set7-dependent methylation of histone H4 Lys 20 functions in repression of gene expression and is essential for mitosis

Genes and Development

Volumn 19, Issue 4, 2005, Pages 431-435

  Karachentsev, Dmitry ^a   Sarma, Kavitha ^b   Reinberg, Danny ^b   Steward, Ruth ^a  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Cell cycle and mitosis; Drosophila; Facultative and constitutive heterochromatin; Histone methylation; Transcriptional repression

Indexed keywords

HISTONE H4; METHYLTRANSFERASE; PR SET7 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; DNA CONTENT; DROSOPHILA; EUCHROMATIN; GENE INSERTION; GENE MUTATION; GENE SILENCING; HETEROCHROMATIN; LARVA; METHYLATION; MITOSIS; NONHUMAN; POSITION EFFECT VARIEGATION; PRIORITY JOURNAL; WESTERN BLOTTING; WILD TYPE;

ANIMALS; BLOTTING, WESTERN; DROSOPHILA; DROSOPHILA PROTEINS; GENE SILENCING; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; LYSINE; METHYLATION; MITOSIS;

EID: 13844269327     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1263005     Document Type: Article

References (21)

1. Ashburner, M. 1989. Drosophila - A laboratory handbook. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
2. Bate, M. and Arias, A.M. 1993. The development of Drosophila melanogaster, pp. 149-301. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
3. Cryderman, D.E., Cuaycong, M.H., Elgin, S.C., and Wallrath, L.L. 1998. Characterization of sequences associated with position-effect variegation at pericentric sites in Drosophila heterochromatin. Chromosoma 107: 277-285.
4. Cryderman, D.E., Morris, E.J., Biessmann, H., Elgin, S.C., and Wallrath, L.L. 1999. Silencing at Drosophila telomeres: Nuclear organization and chromatin structure play critical roles. EMBO J. 18: 3724-3735.
5. Fang, J., Feng, Q., Ketel, C.S., Wang, H., Cao, R., Xia, L., Erdjument-Bromage, H., Tempst, P., Simon, J.A., and Zhang, Y. 2002. Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase. Clin. Biol. 9: 1086-1099.
6. Jenuwein, T., Laible, G., Dorn, R., and Reuter, G. 1998. SET domain proteins modulate chromatin domains in eu- and heterochromatin. Cell Mol. Life Sci. 54: 80-93.
7. Julien, E. and Herr, W. 2004. A switch in mitotic Histone H4 lysine 20 methylation status is linked to M phase defects upon loss of HCF-1. Mol. Cell 18: 713-725.
8. Lis, J.T., Mason, P., Peng, J., Price, D.H., and Werner, J. 2000. P-TEF β kinase recruitment and function at heat shock loci. Genes & Dev. 1: 792-803.
9. Luger, K., Mader, A.W., Richmond, R.K., Sargent, D.F., and Richmond, T.J. 1997. Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature 18: 251-260.
10. Nishioka, K., Rice, J.C., Sarma, K., Erdjument-Bromage, H., Werner, J., Wang, Y., Chuikov, S., Valenzuela, P., Tempst, P., Steward, R., et al. 2002. PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Mol. Cell. 9: 1201-1213.
11. Rice, J.C. and Allis, C.D. 2001. Code of silence. Nature 15: 258-261.
12. Rice, J.C., Nishioka, K., Sarma, K., Steward, R., Reinberg, D., and Allis, C.D. 2002. Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes. Genes & Dev. 1: 2225-2230.
13. Sanders, S.L., Portoso, M., Mata, J., Bahler, J., Allshire, R.C., and Kouzarides, T. 2004. Methylation of histone H4 Lysine 20 controls recruitment of crb2 to sites of DNA damage. Cell 24: 603-614.
14. Schotta, G., Ebert, A., Krauss, V., Fischer, A., Hoffmann, J., Rea, S., Jenuwein, T., Dorn, R., and Reuter, G. 2002. Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing. EMBO J. 21: 1121-1131.
15. Schotta, G., Lachner, M., Sarma, K., Ebert, A., Sengupta, R., Reuter, G., Reinberg, D., and Jenuwein, T. 2004. A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes & Dev. 1: 1251-1262.
16. Spradling, A.C. 1986. P-element mediated transformation. In Drosophila: A practical approach (ed. D.B. Roberts), pp. 175-197. IRL Press, Oxford, UK.
17. Strahl, B.D. and Allis, C.D. 2000. The language of covalent histone modifications. Nature 403: 41-15.
18. Strahl, B.D., Ohba, R., Cook, R.G., and Allis, C.D. 1999. Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in Tetrahymena. Proc. Natl. Acad. Sci. 21: 14967-14972.
19. van Holde, K.E. 1988. Chromatin. In Molecular biology (ed. A. Rich), pp. 111-148. Springer, New York.
20. Whalen, A.M. and Steward, R. 1993. Dissociation of the dorsal-cactus complex and phosphorylation of the dorsal protein correlate with the nuclear localization of dorsal. J. Cell Biol. 123: 523-534.
21. Zhang, Y. and Reinberg, D. 2001. Transcription regulation by histone methylation: Interplay between different covalent modifications of the core histone tails. Genes &. Dev. 15: 2343-2360.