Mitochondria damage checkpoint, aging, and cancer

Annals of the New York Academy of Sciences

Volumn 1067, Issue 1, 2006, Pages 182-190

  Singh, Keshav K ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

Apoptosis; Cell mutation; Cell senescence; Mitochondria; Tumorigenesis

Indexed keywords

CELL NUCLEUS DNA; REACTIVE OXYGEN METABOLITE;

AGING; APOPTOSIS; CARCINOGENESIS; CELL AGING; CELL CYCLE ARREST; CELL DAMAGE; CELL DESTRUCTION; CONFERENCE PAPER; GENE MUTATION; HUMAN; MITOCHONDRIA DAMAGE CHECKPOINT; MITOCHONDRIAL GENETICS; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; TISSUE DEGENERATION;

EID: 33744465025     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1354.022     Document Type: Conference Paper

References (32)

1. Singh, K.K. Ed. 1998. Mitochondrial DNA Mutations in Aging, Disease, and Cancer. Springer, New York.
2. Modica-Napolitano, J. & K.K. Singh. 2002. Mitochondria as targets for detection and treatment of cancer. Expert Reviews in Molecular, Medicine. http://www-ermm.cbcu.cam.ac.uk/02004453h.htm.
3. Modica-Napolitano, J. & K.K. Singh. 2004. Mitochondrial dysfunction in cancer. Mitochondrion 4: 755 762.
4. Rasmussen, A.K., A. Chatterjee, L.J. Rasmussen, et al. 2003. Mitochondria-mediated nuclear mutator phenotype in Saccharomyces cerevisiae. Nucleic Acids Res. 31: 3909 3917.
5. Delsite, R.L., L.J. Rasmussen, A.K. Rasmussen, et al. 2003. Mitochondrial impairment is accompanied by impaired oxidative DNA repair in the nucleus. Mutagenesis 18: 497 503.
6. Singh, K.K., M. Kulaweic, I. Still, et al. 2005. Inter-genomic cross talk between mitochondria and the nucleus plays an important role in tumorigenesis. Gene 354: 140 146.
7. Singh, K.K. 2004. Mitochondrial dysfunction is a common phenotype in aging and cancer. Ann N.Y. Acad. Sci. 1019: 260 264.
8. Richter, C., J.W. Park & B.N. Ames. 1988. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc. Natl. Acad. Sci. USA 85: 6465 6467.
9. Suganuma, N., T. Kitagawa, A. Nawa, et al. 1993. Human ovarian aging and mitochondrial DNA deletion. Horm. Res. 39 Suppl 1 16 21.
10. Kitagawa, T., N. Suganuma, A. Nawa, et al. 1993. Rapid accumulation of deleted mitochondrial deoxyribonucleic acid in postmenopausal ovaries. Biol. Reprod. 49: 730 736.
11. Wei, Y.H. & H.C. Lee. 2002. Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging. Exp. Biol. Med. 227: 671 682.
12. Trifunovic, A., A. Wredenberg, M. Falkenberg, et al. 2004. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429: 417 423.
13. Kujoth, G.C., A. Hiona, T.D. Pugh, et al. 2005. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 309: 481 484.
14. Harman, D. 1972. The biologic clock: the mitochondria¿ J. Am. Geriatr. Soc. 20: 145 147.
15. Chinnery, P.F., D.C. Samuels, J. Elson, et al. 2002. Accumulation of mitochondrial DNA mutations in ageing, cancer, and mitochondrial disease: is there a common mechanism¿ Lancet 360: 1323 1325.
16. Copeland, W.C., J.T. Wachsman, F.M. Johnson, et al. 2002. Mitochondrial DNA alterations in cancer. Cancer Invest. 20: 557 569.
17. Carew, J.S. & P. Huang. 2002. Mitochondrial defects in cancer. Mol. Cancer 1: 9.
18. Lee, H.C., P.H. Yin, J.C. Lin, et al. 2005. Mitochondrial, genome instability and mtDNA, depletion in human cancers. Ann. N.Y. Acad. Sci. 1042: 109 122.
19. Wu, C.W., P.H. Yin, W.Y. Hung, et al. 2005. Mitochondrial DNA mutations and mitochondrial DNA depletion in gastric cancer. Genes Chrom. Cancer 44: 19 28.
20. Hayflick, L. & P.S. Moorhead. 1961. The serial cultivation of human diploid cell strains. Exp. Cell Res. 25: 585 621.
21. Campisi, J. 2005. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120: 513 522.
22. Park, S.Y., I. Chang, S.W. Kang, et al. 2004. Resistance of mitochondrial DNA depleted cells against cell death: role of mitochondrial superoxide dismutase. J. Biol. Chem. 279: 7512 7520.
23. Park, S.Y., B. Choi, H. Cheon, et al. 2004. Cellular aging of mitochondrial DNA-depleted cells. Biochem. Biophys. Res. Commun. 325: 1399 1405.
24. Singh, K.K. 2004. Mitochondria damage checkpoint in apoptosis and genome stability. FEMS Yeast Res. 2: 127 132.
25. Sweet, S. & G. Singh. 1995. Accumulation of human promyelocytic leukemic (HL-60) cells at two energetic cell cycle checkpoints. Cancer Res. 55: 5164 5167.
26. Singh, K.K., A.K. Rasmussen & L.J. Rasmussen. 2004. Genome wide analysis of signal transducers and regulators of mitochondrial dysfunction in Saccharomyces cerevisiae. Ann. N.Y. Acad. Sci. 1011: 284 298.
27. Dimri, G.P. 2005. What has senescence got to do with cancer¿ Cancer Cell 7: 505 512.
28. Sharpless, N.E. & R.A. DePinho. 2005. Cancer: crime and punishment. Nature 436: 636 637.
29. Collado, M., J. Gil, A. Efeyan, et al. 2005. Tumour biology: senescence in premalignant tumours. Nature 436: 642.
30. Michaloglou, C., L.C. Vredeveld, M.S. Soengas, et al. 2005. BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 436: 720 724.
31. Chen, Z., L.C. Trotman, D. Shaffer, et al. 2005. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 436: 725 730.
32. Desouki, M.M., M. Kulawiec, S. Bansal, et al. 2005. Crosstalk, between mitochondria and superoxide generating NADPH oxidase in breast and ovarian tumors. Cancer Biol. Ther. 4: 1367 1373.