Sirtuin-mediated deacetylation pathway stabilizes Werner syndrome protein

FEBS Letters

Volumn 582, Issue 17, 2008, Pages 2479-2483

  Kahyo, Tomoaki ^a   Mostoslavsky, Raul ^b   Goto, Makoto ^c   Setou, Mitsutoshi ^a,d  

^a Mitsubishi Kagaku Institute of Life Sciences   (Japan)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Division of Anti Ageing and Longevity Sciences   (Japan)

^d HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Caloric restriction; Longevity; SIRT; Werner syndrome

Indexed keywords

SIRTUIN; SIRTUIN 1; WERNER SYNDROME PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALORIC RESTRICTION; CELL CULTURE; CELL STRAIN HEK293; CONTROLLED STUDY; DEACETYLATION; DNA REPAIR; ENZYME ACTIVITY; HUMAN; HUMAN CELL; NONHUMAN; PREMATURE AGING; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN STABILITY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ACETYLATION; ANIMALS; CALORIC RESTRICTION; ENZYME INHIBITORS; ENZYME STABILITY; EXODEOXYRIBONUCLEASES; HUMANS; LIVER; MICE; MICE, MUTANT STRAINS; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; RECQ HELICASES; SIRTUINS;

MAMMALIA; MUS; RATTUS;

EID: 46749109938     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2008.06.031     Document Type: Article

References (29)

1. Kahyo T., Nishida T., and Yasuda H. Involvement of PIAS1 in the sumoylation of tumor suppressor p53. Mol. Cell 8 (2001) 713-718
2. Yao I., et al. SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release. Cell 130 (2007) 943-957
3. Ikegami K., Mukai M., Tsuchida J., Heier R.L., Macgregor G.R., and Setou M. TTLL7 is a mammalian beta-tubulin polyglutamylase required for growth of MAP2-positive neurites. J. Biol. Chem. 281 (2006) 30707-30716
4. Ikegami K., et al. Loss of alpha-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function. Proc. Natl. Acad. Sci. USA 104 (2007) 3213-3218
5. Inoue E., et al. SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release. Neuron 50 (2006) 261-275
6. Imai S., Armstrong C.M., Kaeberlein M., and Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403 (2000) 795-800
7. Grubisha O., Smith B.C., and Denu J.M. Small molecule regulation of Sir2 protein deacetylases. FEBS J. 272 (2005) 4607-4616
8. Howitz K.T., et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425 (2003) 191-196
9. Wood J.G., Rogina B., Lavu S., Howitz K., Helfand S.L., Tatar M., and Sinclair D. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430 (2004) 686-689
10. Frye R.A. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochem. Biophys. Res. Commun. 260 (1999) 273-279
11. Luo J., Nikolaev A.Y., Imai S., Chen D., Su F., Shiloh A., Guarente L., and Gu W. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107 (2001) 137-148
12. Vaziri H., Dessain S.K., Ng Eaton E., Imai S.I., Frye R.A., Pandita T.K., Guarente L., and Weinberg R.A. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107 (2001) 149-159
13. Cheng H.L., et al. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc. Natl. Acad. Sci. USA 100 (2003) 10794-10799
14. McBurney M.W., Yang X., Jardine K., Hixon M., Boekelheide K., Webb J.R., Lansdorp P.M., and Lemieux M. The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol. Cell. Biol. 23 (2003) 38-54
15. Lombard D.B., Chua K.F., Mostoslavsky R., Franco S., Gostissa M., and Alt F.W. DNA repair, genome stability, and aging. Cell 120 (2005) 497-512
16. Martin G.M., and Oshima J. Lessons from human progeroid syndromes. Nature 408 (2000) 263-266
17. Goto M. Hierarchical deterioration of body systems in Werner's syndrome: implications for normal ageing. Mech. Ageing Dev. 98 (1997) 239-254
18. Weindruch R. The retardation of aging by caloric restriction: studies in rodents and primates. Toxicol. Pathol. 24 (1996) 742-745
19. Guarente L., and Kenyon C. Genetic pathways that regulate ageing in model organisms. Nature 408 (2000) 255-262
20. Guarente L., and Picard F. Calorie restriction-the SIR2 connection. Cell 120 (2005) 473-482
21. Lipman J.M., Turturro A., and Hart R.W. The influence of dietary restriction on DNA repair in rodents: a preliminary study. Mech. Ageing Dev. 48 (1989) 135-143
22. Li K., et al. Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation. J. Biol. Chem. 283 (2008) 7590-7598
23. Cohen H.Y., et al. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305 (2004) 390-392
24. Opresko P.L., Cheng W.H., von Kobbe C., Harrigan J.A., and Bohr V.A. Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process. Carcinogenesis 24 (2003) 791-802
25. Grozinger C.M., Chao E.D., Blackwell H.E., Moazed D., and Schreiber S.L. Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J. Biol. Chem. 276 (2001) 38837-38843
26. Yoshida M., Kijima M., Akita M., and Beppu T. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J. Biol. Chem. 265 (1990) 17174-17179
27. Varshavsky A. Regulated protein degradation. Trends Biochem. Sci. 30 (2005) 283-286
28. Mostoslavsky R., et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 124 (2006) 315-329
29. Kanfi Y., et al. Regulation of SIRT6 protein levels by nutrient availability. FEBS Lett. 582 (2008) 543-548