Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases

Nature Genetics

Volumn 36, Issue 1, 2004, Pages 94-99

  García Cao, Marta ^a   O'Sullivan, Roderick ^b   Peters, Antoine H F M ^b   Jenuwein, Thomas ^b   Blasco, María A ^a  

^a Hospital Infantil Universitario Niño Jesús   (Spain)

^b RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE METHYLTRANSFERASE; METHYLTRANSFERASE; PROTEIN; PROTEIN CBX1; PROTEIN CBX3; PROTEIN CBX5; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHROMOSOME SIZE; EMBRYO; EPIGENETICS; GENE CONTROL; HETEROCHROMATIN; IMMUNOPRECIPITATION; MAMMAL CELL; METHYLATION; MOUSE; MOUSE STRAIN; NONHUMAN; NUCLEOTIDE REPEAT; PRIORITY JOURNAL; TELOMERE;

ANIMALS; HISTONE-LYSINE N-METHYLTRANSFERASE; METHYLATION; METHYLTRANSFERASES; MICE; MICE, MUTANT STRAINS; MODELS, GENETIC; REPRESSOR PROTEINS; TELOMERE;

ANIMALIA; DROSOPHILA MELANOGASTER; EUKARYOTA; MAMMALIA; MELANOGASTER;

EID: 0347988045     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1278     Document Type: Article

References (30)

1. Blackburn, E.H. Switching and signaling at the telomere. Cell 106, 661-673 (2001).
2. Chan, S.W.-L. & Blackburn, E.H. New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin. Oncogene 21, 553-563 (2002).
3. De Lange, T. Protection of mammalian telomeres. Oncogene 21, 532-540 (2002).
4. Cenci, G., Siriaco, G., Raffa, G.D., Kellum, R. & Gatti, M. The Drosophila HOAP protein is required for telomere capping. Nat. Cell. Biol. 1, 82-84 (2003).
5. Fanti, L., Giovinazzo, G., Berloco, M. & Pimpinelli, S. The heterochromatin protein 1 prevents telomere fusions in Drosophila. Mol. Cell 2, 527-538 (1998).
6. Dubrana, K., Perrod, S. & Gasser, S.M. Turning telomeres off and on. Curr. Opin. Cell Biol. 13, 281-289 (2001).
7. Peters, A.H. et al. Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. Cell 107, 323-337 (2001).
8. Jenuwein, T. & Allis, C.D. Translating the histone code. Science 293, 1074-1080 (2001).
9. Lachner, M., O'Carrol, D., Rea, S., Mechtler, K. & Jenuwein, T. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 410, 116-120 (2001).
10. Blasco, M.A. et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91, 25-34 (1997).
11. Hande, P.M., Samper, E., Lansdorp, P. & Blasco, M.A. Telomere length dynamics in cultured cells from normal and telomerase null mice. J. Cell Biol. 144, 589-601 (1999).
12. Samper, E., Goytisolo, F, Slijepcevic, P., van Buul, P. & Blasco, M.A. Mammalian Ku86 prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang. EMBO Rep. 1, 244-252 (2000).
13. van Steensel, B., Smogorzewska, A. & de Lange, T. TRF2 protects human telomeres from end-to-end fusions. Cell 92, 401-413 (1998).
14. -/- mice with short telomeres. EMBO Rep. 2, 800-807 (2001).
15. Hemann, M.T., Strong, M.A., Hao, L.Y. & Greider, C.W. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 107, 67-77 (2001).
16. Peters, A.H. et al. Partitioning and plasticity of repressive histone methylation states in mammalian chromatin. Mol. Cell (in the press).
17. Loayza, D. & De Lange, T. POT1 as a terminal transducer of TRF1 telomere length control. Nature 424, 1013-1018 (2003).
18. Espejel, S. et al. Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres. EMBO J. 21, 2207-2219 (2002).
19. Jenuwein, T. Re-SET-ting heterochromatin by histone methyltransferases. Trends Cell Biol. 11, 266-273 (2001).
20. Shiels, P.G. et al. Analysis of telomere lengths in cloned sheep. Nature 399, 316-317 (1999).
21. Lanza, R.P. et al. Extension of cell life-span and telomere length in animals cloned from senescent somatic cells. Science 288, 665-669 (2000).
22. Baur, J.A., Zou, Y., Shay, J.W. & Wright, W.E. Telomere position effect in human cells. Science 292, 2075-2077 (2001).
23. Koering, C.E. et al. Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity. EMBO Rep. 3, 1055-1061 (2002).
24. Ng, H.H. et al. Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association. Genes Dev. 16, 1518-1527 (2002).
25. Lehnertz, B. et al. Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr. Biol. 13, 1192-1200 (2003).
26. O'Carroll, D. et al. Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression. Mol. Cell Biol. 20, 9423-9433 (2000).
27. McIlrath, J. et al. Telomere length abnormalities in mammalian radiosensitive cells. Cancer Res. 61, 912-915 (2001).
28. Herrera, E. et al. Disease states associated with telomerase deficiency appear earlier in mice with short telomeres. EMBO J. 18, 2950-2960 (1999).
29. Espejel, S. et al Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres. EMBO J. 21, 2207-2219 (2002).
30. Perez-Burgos, L. et al. Generation and characterization of methyl-lysine histone antibodies. Methods Enzymol. (in the press).