Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 52, 2010, Pages 22623-22628

  Ming, Mei ^a   Shea, Christopher R ^a   Guo, Xiumei ^b   Li, Xiaoling ^b   Soltani, Keyoumars ^a   Han, Weinong ^a   He, Yu Ying ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

AKT; PTEN; UVB

Indexed keywords

HISTONE DEACETYLASE; NUCLEOTIDE; PROTEIN KINASE B; SIRTUIN 1; XERODERMA PIGMENTOSUM GROUP C PROTEIN;

ARTICLE; DNA REPAIR; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXCISION REPAIR; GENOME; HIGH RISK BEHAVIOR; HUMAN; HUMAN CELL; HUMAN TISSUE; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SKIN TUMOR;

ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; CELL NUCLEUS; CELLS, CULTURED; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; EMBRYO, MAMMALIAN; EUROPEAN CONTINENTAL ANCESTRY GROUP; FIBROBLASTS; GENOME; HUMANS; IMMUNOHISTOCHEMISTRY; KERATINOCYTES; MICE; MICE, KNOCKOUT; PROTO-ONCOGENE PROTEINS C-AKT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIRTUIN 1; SKIN NEOPLASMS;

EID: 78651105018     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1010377108     Document Type: Article

References (69)

1. Niggli HJ, Röthlisberger R (1988) Cyclobutane-type pyrimidine photodimer formation and induction of ornithine decarboxylase in human skin fibroblasts after UV irradiation. J Invest Dermatol 91:579-584.
2. Vink AA, Berg RJ, de Gruijl FR, Roza L, Baan RA (1991) Induction, repair and accumulation of thymine dimers in the skin of UV-B-irradiated hairless mice. Carcinogenesis 12:861-864.
3. Cleaver JE (2005) Cancer in xeroderma pigmentosum and related disorders of DNA repair. Nat Rev Cancer 5:564-573.
4. Cleaver JE, Lam ET, Revet I (2009) Disorders of nucleotide excision repair: The genetic and molecular basis of heterogeneity. Nat Rev Genet 10:756-768.
5. Hoeijmakers JH (2001) Genome maintenance mechanisms for preventing cancer. Nature 411:366-374.
6. Volker M, et al. (2001) Sequential assembly of the nucleotide excision repair factors in vivo. Mol Cell 8:213-224.
7. Sugasawa K, et al. (1998) Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair. Mol Cell 2:223-232.
8. Riedl T, Hanaoka F, Egly JM (2003) The comings and goings of nucleotide excision repair factors on damaged DNA. EMBO J 22:5293-5303.
9. Haigis MC, Guarente LP (2006) Mammalian sirtuins - emerging roles in physiology, aging, and calorie restriction. Genes Dev 20:2913-2921.
10. Blander G, Guarente L (2004) The Sir2 family of protein deacetylases. Annu Rev Biochem 73:417-435.
11. Guarente L (2000) Sir2 links chromatin silencing, metabolism, and aging. Genes Dev 14:1021-1026.
12. Michan S, Sinclair D (2007) Sirtuins in mammals: Insights into their biological function. Biochem J 404:1-13.
13. Haigis MC, Sinclair DA (2010) Mammalian sirtuins: Biological insights and disease relevance. Annu Rev Pathol 5:253-295.
14. Brooks CL, Gu W (2009) How does SIRT1 affect metabolism, senescence and cancer? Nat Rev Cancer 9:123-128.
15. Deng CX (2009) SIRT1, is it a tumor promoter or tumor suppressor? Int J Biol Sci 5:147-152.
16. Lim CS (2006) SIRT1: Tumor promoter or tumor suppressor? Med Hypotheses 67:341-344.
17. Nayagam VM, et al. (2006) SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents. J Biomol Screen 11:959-967.
18. Zhang Y, et al. (2009) Deacetylation of cortactin by SIRT1 promotes cell migration. Oncogene 28:445-460.
19. Huffman DM, et al. (2007) SIRT1 is significantly elevated in mouse and human prostate cancer. Cancer Res 67:6612-6618.
20. Bradbury CA, et al. (2005) Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors. Leukemia 19:1751-1759.
21. Stünkel W, et al. (2007) Function of the SIRT1 protein deacetylase in cancer. Biotechnol J 2:1360-1368.
22. Hida Y, Kubo Y, Murao K, Arase S (2007) Strong expression of a longevity-related protein, SIRT1, in Bowen's disease. Arch Dermatol Res 299:103-106.
23. Wang RH, et al. (2008) Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell 14:312-323.
24. Sugasawa K, et al. (2005) UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex. Cell 121:387-400.
25. Sugasawa K (2006) UV-induced ubiquitylation of XPC complex, the UV-DDB-ubiquitin ligase complex, and DNA repair. J Mol Histol 37:189-202.
26. Lan F, Cacicedo JM, Ruderman N, Ido Y (2008) SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. J Biol Chem 283:27628-27635.
27. Cam H, et al. (2004) A common set of gene regulatory networks links metabolism and growth inhibition. Mol Cell 16:399-411.
28. Dominguez-Brauer C, Chen YJ, Brauer PM, Pimkina J, Raychaudhuri P (2009) ARF stimulates XPC to trigger nucleotide excision repair by regulating the repressor complex of E2F4. EMBO Rep 10:1036-1042.
29. Ikenoue T, Inoki K, Zhao B, Guan KL (2008) PTEN acetylation modulates its interaction with PDZ domain. Cancer Res 68:6908-6912.
30. Datta SR, Brunet A, Greenberg ME (1999) Cellular survival: A play in three Akts. Genes Dev 13:2905-2927.
31. Okumura K, et al. (2006) PCAF modulates PTEN activity. J Biol Chem 281:26562-26568.
32. Han W, Ming M, He TC, He YY (2010) Immunosuppressive cyclosporin A activates AKT in keratinocytes through PTEN suppression: Implications in skin carcinogenesis. J Biol Chem 285:11369-11377.
33. Tsukamoto Y, Kato J, Ikeda H (1997) Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae. Nature 388:900-903.
34. McAinsh AD, Scott-Drew S, Murray JA, Jackson SP (1999) DNA damage triggers disruption of telomeric silencing and Mec1p-dependent relocation of Sir3p. Curr Biol 9:963-966.
35. Mills KD, Sinclair DA, Guarente L (1999) MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks. Cell 97:609-620.
36. Oberdoerffer P, et al. (2008) SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell 135:907-918.
37. Jeong J, et al. (2007) SIRT1 promotes DNA repair activity and deacetylation of Ku70. Exp Mol Med 39:8-13.
38. Yuan Z, Zhang X, Sengupta N, Lane WS, Seto E (2007) SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol Cell 27:149-162.
39. Sugasawa K (2008) Xeroderma pigmentosum genes: Functions inside and outside DNA repair. Carcinogenesis 29:455-465.
40. Berg RJ, Ruven HJ, Sands AT, de Gruijl FR, Mullenders LH (1998) Defective global genome repair in XPC mice is associated with skin cancer susceptibility but not with sensitivity to UVB induced erythema and edema. J Invest Dermatol 110:405-409.
41. Cheo DL, et al. (2000) Ultraviolet B radiation-induced skin cancer in mice defective in the Xpc, Trp53, and Apex (HAP1) genes: Genotype-specific effects on cancer predisposition and pathology of tumors. Cancer Res 60:1580-1584.
42. Choudhary C, et al. (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 325:834-840.
43. Toyooka T, Ibuki Y (2009) Histone deacetylase inhibitor sodium butyrate enhances the cell killing effect of psoralen plus UVA by attenuating nucleotide excision repair. Cancer Res 69:3492-3500.
44. Kim MS, Baek JH, Chakravarty D, Sidransky D, Carrier F (2005) Sensitization to UV-induced apoptosis by the histone deacetylase inhibitor trichostatin A (TSA). Exp Cell Res 306:94-102.
45. Despras E, et al. (2007) Long-term XPC silencing reduces DNA double-strand break repair. Cancer Res 67:2526-2534.
46. Cimprich KA, Cortez D (2008) ATR: An essential regulator of genome integrity. Nat Rev Mol Cell Biol 9:616-627.
47. Zhou BB, Elledge SJ (2000) The DNA damage response: Putting checkpoints in perspective. Nature 408:433-439.
48. Luo J, et al. (2004) Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci USA 101:2259-2264.
49. Tang Y, Zhao W, Chen Y, Zhao Y, Gu W (2008) Acetylation is indispensable for p53 activation. Cell 133:612-626.
50. Lain S, et al. (2008) Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell 13:454-463.
51. Guo X, Williams JG, Schug TT, Li X (2010) DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. J Biol Chem 285:13223-13232.
52. Lehman TA, et al. (1993) p53 mutations in human immortalized epithelial cell lines. Carcinogenesis 14:833-839.
53. Datto MB, et al. (1995) Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc Natl Acad Sci USA 92:5545-5549.
54. Smith ML, et al. (2000) p53-mediated DNA repair responses to UV radiation: Studies of mouse cells lacking p53, p21, and/or gadd45 genes. Mol Cell Biol 20:3705-3714.
55. Zhu Q, Wani MA, El-Mahdy M, Wani AA (2000) Decreased DNA repair efficiency by loss or disruption of p53 function preferentially affects removal of cyclobutane pyrimidine dimers from non-transcribed strand and slow repair sites in transcribed strand. J Biol Chem 275:11492-11497.
56. Ferguson BE, Oh DH (2005) Proficient global nucleotide excision repair in human keratinocytes but not in fibroblasts deficient in p53. Cancer Res 65:8723-8729.
57. Jonason AS, et al. (1996) Frequent clones of p53-mutated keratinocytes in normal human skin. Proc Natl Acad Sci USA 93:14025-14029.
58. Di Cristofano A, Pandolfi PP (2000) The multiple roles of PTEN in tumor suppression. Cell 100:387-390.
59. Wong S, Weber JD (2007) Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1. Biochem J 407:451-460.
60. Weinberg RA (1995) The retinoblastoma protein and cell cycle control. Cell 81:323-330.
61. Mittnacht S (1998) Control of pRB phosphorylation. Curr Opin Genet Dev 8:21-27.
62. Kabra N, et al. (2009) SirT1 is an inhibitor of proliferation and tumor formation in colon cancer. J Biol Chem 284:18210-18217.
63. Jung-Hynes B, Nihal M, Zhong W, Ahmad N (2009) Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition? J Biol Chem 284:3823-3832.
64. Marín MS, et al. (2004) Poly (AT) polymorphism in intron 11 of the XPC DNA repair gene enhances the risk of lung cancer. Cancer Epidemiol Biomarkers Prev 13:1788-1793.
65. Hollander MC, et al. (2005) Deletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis. Proc Natl Acad Sci USA 102:13200-13205.
66. Lee GY, et al. (2005) XPC polymorphisms and lung cancer risk. Int J Cancer 115:807-813.
67. Hu Z, et al. (2005) DNA repair gene XPC genotypes/haplotypes and risk of lung cancer in a Chinese population. Int J Cancer 115:478-483. (Pubitemid 40663754)
68. Zhu Y, et al. (2007) Genotypes, haplotypes and diplotypes of XPC and risk of bladder cancer. Carcinogenesis 28:698-703.
69. Nakagawa A, et al. (1998) Three-dimensional visualization of ultraviolet-induced DNA damage and its repair in human cell nuclei. J Invest Dermatol 110:143-148.