Molecular and Cellular Mechanisms of Ischemia-Induced Neuronal Death

Stroke: Pathophysiology, Diagnosis, and Management

Volumn , Issue , 2004, Pages 829-854

  Zukin, R Suzanne ^a,b   Jover, Teresa ^b   Yokota, Hidenori ^c   Calderone, Agata ^d   Simionescu, Monica ^e   Lau, C Geoff ^b  

^a Department of Neuroscience ^*  (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c JICHI MEDICAL UNIVERSITY   (Japan)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

^e LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84903996211     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B0-44-306600-0/50049-3     Document Type: Chapter

References (298)

1. On-line Medical Dictionary Dept. of Medical Oncology, University of Newcastle. © 1997-2003. http://cancerweb.ncl.ac.uk/cgi-bin/omd?ischemia.
2. Petito CK, Feldmann E, Pulsinelli WA, et al. Delayed hippocampal damage in humans following cardiorespiratory arrest. Neurology 1987, 37:1281-1286.
3. Brillman J Central nervous system complications in coronary artery bypass graft surgery. Neurol Clin 1993, 11:475-495.
4. Roach GW, Kanchuger M, Mangano CM, et al. Adverse cerebral outcomes after coronary bypass surgery: Multicenter Study of Perioperative Ischemia Research Group and the Ischemia Research and Education Foundation Investigators. N Engl J Med 1996, 335:1857-1863.
5. Swain JA, Anderson RV, Siegman MG Low-flow cardiopulmonary bypass and cerebral protection: A summary of investigations. Ann Thorac Surg 1993, 56:1490-1492.
6. Schmidt-Kastner R, Freund TF Selective vulnerability of the hippocampus in brain ischemia. Neuroscience 1991, 40:599-636.
7. Crain BJ, Westerkam WD, Harrison AH, et al. Selective neuronal death after transient forebrain ischemia in the Mongolian gerbil: A silver impregnation study. Neuroscience 1988, 27:387-402.
8. Kirino T Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res 1982, 239:57-69.
9. Garcia JH, Yoshida Y, Chen H, et al. Progression from ischemic injury to infarct following middle cerebral artery occlusion in the rat. Am J Pathol 1993, 142:623-635.
10. Memezawa H, Smith ML, Siesjö BK Penumbral tissues salvaged by reperfusion following middle cerebral artery occlusion in rats. Stroke 1992, 23:552-559.
11. Small DL, Buchan AM Animal models. Br Med Bull 2000, 56:307-317.
12. Ginsberg MD, Busto R Rodent models of cerebral ischemia. Stroke 1989, 20:1627-1642.
13. Pulsinelli WA, Brierley JB A new model of bilateral hemispheric ischemia in the unanesthetized rat. Stroke 1979, 10:267-272.
14. Kitagawa K, Matsumoto M, Yang G, et al. Cerebral ischemia after bilateral carotid artery occlusion and intraluminal suture occlusion in mice: Evaluation of the patency of the posterior communicating artery. J Cereb Blood Flow Metab 1998, 18:570-579.
15. Oguro K, Jover T, Tanaka H, et al. Global ischemia-induced increases in the gap junctional proteins connexin 32 (Cx32) and Cx36 in hippocampus and enhanced vulnerability of Cx32 knock-out mice. J Neurosci 2001, 21:7534-7542.
16. Nemoto EM Monkey model of complete global ischemia. Stroke 1993, 24:328-329.
17. Torregrosa G, Barbera MD, Centeno JM, et al. Characterization of the cortical laser-Doppler flow and hippocampal degenerative patterns after global cerebral ischaemia in the goat. Pflugers Arch 1998, 435:662-669.
18. Pulsinelli WA, Duffy TE Regional energy balance in rat brain after transient forebrain ischemia. J Neurochem 1983, 40:1500-1503.
19. Schmidt-Kastner R, Freund TF Selective vulnerability of the hippocampus in brain ischemia. Neuroscience 1991, 40:599-636.
20. Pulsinelli WA, Brierley JB, Plum F Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann Neurol 1982, 11:491-498.
21. Kirino T, Sano K Fine structural nature of delayed neuronal death following ischemia in the gerbil hippocampus. Acta Neuropathol (Berl) 1984, 62:209-218.
22. Kirino T, Tamura A, Sano K Selective vulnerability of the hippocampus to ischemia: Reversible and irreversible types of ischemic cell damage. Prog Brain Res 1985, 63:39-58.
23. Kinouchi H, Sharp FR, Koistinaho J, et al. Induction of heat shock hsp70 mRNA and HSP70 kDa protein in neurons in the 'penumbra' following focal cerebral ischemia in the rat. Brain Res 1993, 619:334-338.
24. Pulsinelli WA, Levy DE, Duffy TE Regional cerebral blood flow and glucose metabolism following transient forebrain ischemia. Ann Neurol 1982, 11:499-502.
25. Raffin CN, Harrison M, Sick TJ, et al. EEG suppression and anoxic depolarization: influences on cerebral oxygenation during ischemia. J Cereb Blood Flow Metab 1991, 11:407-415.
26. Xu ZC, Pulsinelli WA Responses of CA1 pyramidal neurons in rat hippocampus to transient forebrain ischemia: An in vivo intracellular recording study. Neurosci Lett 1994, 171:187-191.
27. Smith ML, Auer RN, Siesjö BK The density and distribution of ischemic brain injury in the rat following 2-10 min of forebrain ischemia. Acta Neuropathol (Berl) 1984, 64:319-332.
28. Smith ML, Bendek G, Dahlgren N, et al. Models for studying long-term recovery following forebrain ischemia in the rat. 2: A 2-vessel occlusion model. Acta Neurol Scand 1984, 69:385-401.
29. Lipton P Ischemic cell death in brain neurons. Physiol Rev 1999, 79:1431-1568.
30. Kato H, Araki T, Kogure K, et al. Sequential cerebral blood flow changes in short-term cerebral ischemia in gerbils. Stroke 1990, 21:1346-1349.
31. Suzuki R, Yamaguchi T, Li CL, et al. The effects of 5-minute ischemia in Mongolian gerbils. II: Changes of spontaneous neuronal activity in cerebral cortex and CA1 sector of hippocampus. Acta Neuropathol (Berl) 1983, 60:217-222.
32. Schauwecker PE, Steward O Genetic determinants of susceptibility to excitotoxic cell death: Implications for gene targeting approaches. Proc Natl Acad Sci U S A 1997, 94:4103-4108.
33. DeGirolami U, Crowell RM, Marcoux FW Selective necrosis and total necrosis in focal cerebral ischemia: Neuropathologic observations on experimental middle cerebral artery occlusion in the macaque monkey. J Neuropathol Exp Neurol 1984, 43:57-71.
34. Longa EZ, Weinstein PR, Carlson S, et al. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989, 20:84-91.
35. Nagasawa H, Kogure K Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion. Stroke 1989, 20:1037-1043.
36. Zhang RL, Chopp M, Chen H, et al. Temporal profile of ischemic tissue damage, neutrophil response, and vascular plugging following permanent and transient (2H) middle cerebral artery occlusion in the rat. J Neurol Sci 1994, 125:3-10.
37. McAuley MA Rodent models of focal ischemia. Cerebrovasc Brain Metab Rev 1995, 7:153-180.
38. Buchan AM, Xue D, Slivka A A new model of temporary focal neocortical ischemia in the rat. Stroke 1992, 23:273-279.
39. Kilic E, Hermann DM, Hossmann KA A reproducible model of thromboembolic stroke in mice. Neuroreport 1998, 9:2967-2970.
40. Markgraf CG, Kraydieh S, Prado R, et al. Comparative histopathologic consequences of photothrombotic occlusion of the distal middle cerebral artery in Sprague-Dawley and Wistar rats. Stroke 1993, 24:286-292.
41. Brint S, Jacewicz M, Kiessling M, et al. Focal brain ischemia in the rat: Methods for reproducible neocortical infarction using tandem occlusion of the distal middle cerebral and ipsilateral common carotid arteries. J Cereb Blood Flow Metab 1988, 8:474-485.
42. Chen ST, Hsu CY, Hogan EL, et al. A model of focal ischemic stroke in the rat: Reproducible extensive cortical infarction. Stroke 1986, 17:738-743.
43. Petito CK Early and late mechanisms of increased vascular permeability following experimental cerebral infarction. J Neuropathol Exp Neurol 1979, 38:222-234.
44. Rice JE, Vannucci RC, Brierley JB The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann Neurol 1981, 9:131-141.
45. Roohey T, Raju TN, Moustogiannis AN Animal models for the study of perinatal hypoxic-ischemic encephalopathy: A critical analysis. Early Hum Dev 1997, 47:115-146.
46. Salford LG, Plum F, Brierley JB Graded hypoxia-oligemia in rat brain. II: Neuropathological alterations and their implications. Arch Neurol 1973, 29:234-238.
47. Williams GD, Towfighi J, Smith MB Cerebral energy metabolism during hypoxia-ischemia correlates with brain damage: A 31P NMR study in unanesthetized immature rats. Neurosci Lett 1994, 170:31-34.
48. Dawson VL, Kizushi VM, Huang PL, et al. Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice. J Neurosci 1996, 16:2479-2487.
49. Goldberg MP, Choi DW Combined oxygen and glucose deprivation in cortical cell culture: Calcium-dependent and calcium-independent mechanisms of neuronal injury. J Neurosci 1993, 13:3510-3524.
50. Martin RL, Lloyd HG, Cowan AI The early events of oxygen and glucose deprivation: Setting the scene for neuronal death?. Trends Neurosci 1994, 17:251-257.
51. Gottron FJ, Ying HS, Choi DW Caspase inhibition selectively reduces the apoptotic component of oxygen-glucose deprivation-induced cortical neuronal cell death. Mol Cell Neurosci 1997, 9:159-169.
52. Pellegrini-Giampietro DE, Peruginelli F, Meli E, et al. Protection with metabotropic glutamate 1 receptor antagonists in models of ischemic neuronal death: Time-course and mechanisms. Neuropharmacology 1999, 38:1607-1619.
53. Strasser U, Fischer G Protection from neuronal damage induced by combined oxygen and glucose deprivation in organotypic hippocampal cultures by glutamate receptor antagonists. Brain Res 1995, 687:167-174.
54. Friedlander RM Apoptosis and caspases in neurodegenerative diseases. N Engl J Med 2003, 348:1365-1375.
55. Leist M, Jaattela M Four deaths and a funeral: From caspases to alternative mechanisms. Nat Rev Mol Cell Biol 2001, 2:589-598.
56. Choi DW Ischemia-induced neuronal apoptosis. Curr Opin Neurobiol 1996, 6:667-672.
57. Colbourne F, Sutherland GR, Auer RN Electron microscopic evidence against apoptosis as the mechanism of neuronal death in global ischemia. J Neurosci 1999, 19:4200-4210.
58. Banasiak KJ, Xia Y, Haddad GG Mechanisms underlying hypoxia-induced neuronal apoptosis. Prog Neurobiol 2000, 62:215-249.
59. Kalimo H, Garcia JH, Kamijyo Y, et al. The ultrastructure of "brain death." II: Electron microscopy of feline cortex after complete ischemia. Virchows Arch B Cell Pathol 1977, 25:207-220.
60. Kalimo H, Olsson Y, Paljarvi L, et al. Structural changes in brain tissue under hypoxic-ischemic conditions. J Cereb Blood Flow Metab 1982, 2(Suppl 1):S19-S22.
61. Kirino T, Sano K Selective vulnerability in the gerbil hippocampus following transient ischemia. Acta Neuropathol (Berl) 1984, 62:201-208.
62. Petito CK, Pulsinelli WA Sequential development of reversible and irreversible neuronal damage following cerebral ischemia. J Neuropathol Exp Neurol 1984, 43:141-153.
63. Brown AW, Brierley JB Anoxic-ischaemic cell change in rat brain light microscopic and fine-structural observations. J Neurol Sci 1972, 16:59-84.
64. Brown AW Structural abnormalities in neurones. J Clin Pathol Suppl (R Coll Pathol) 1977, 11:155-169.
65. Inamura K, Olsson Y, Siesjö BK Substantia nigra damage induced by ischemia in hyperglycemic rats: A light and electron microscopic study. Acta Neuropathol (Berl) 1987, 75:131-139.
66. Martin-Villalba A, Herr I, Jeremias I, et al. CD95 ligand (Fas L/APO-IL) and tumor necrosis factor-related apoptosis-inducing ligand mediate ischemia-induced apoptosis in neurons. J Neurosci 1999, 19:3809-3817.
67. Fujimura M, Morita-Fujimura Y, Murakami K, et al. Cytosolic redistribution of cytochrome c after transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab 1998, 18:1239-1247.
68. Namura S, Zhu J, Fink K, et al. Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia. J Neurosci 1998, 18:3659-3668.
69. Benveniste H, Drejer J, Schousboe A, et al. Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J Neurochem 1984, 43:1369-1374.
70. Cardell M, Koide T, Wieloch T Pyruvate dehydrogenase activity in the rat cerebral cortex following cerebral ischemia. J Cereb Blood Flow Metab 1989, 9:350-357.
71. Tominaga T, Kure S, Narisawa K, et al. Endonuclease activation following focal ischemic injury in the rat brain. Brain Res 1993, 608:21-26.
72. McLaughlin B, Hartnett KA, Erhardt JA, et al. Caspase-3 activation is essential for neuroprotection in preconditioning. Proc Natl Acad Sci USA 2003, 100(2):715-720.
73. Garnier P, Ying W, Swanson RA Ischemic preconditioning by caspase cleavage of poly(ADP-ribose) polymerase-1. J Neurosci 2003, 23(22):7967-7973.
74. Chen J, Nagayama T, Jin K, et al. Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia. J Neurosci 1998, 18:4914-4928.
75. Chen J, Nagayama T, Jin K, et al. Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia. J Neurosci 1998, 18:4914-4928.
76. Nicholson DW, Thornberry NA Caspases: Killer proteases. Trends Biochem Sci 1997, 22:299-306.
77. Cohen GM Caspases: The executioners of apoptosis. Biochem J 1997, 326:1-16.
78. Kroemer G, Reed JC Mitochondrial control of cell death. Nat Med 2000, 6:513-519.
79. Burgering BM, Kops GJ Cell cycle and death control: Long live Forkheads. Trends Biochem Sci 2002, 27:352-360.
80. Cryns V, Yuan J Proteases to die for. Genes Dev 1998, 12:1551-1570.
81. Jin K, Graham SH, Nagayama T, et al. Altered expression of the neuropeptide-processing enzyme carboxypeptidase E in the rat brain after global ischemia. J Cereb Blood Flow Metab 2001, 21:1422-1429.
82. Bagum MA, Miyamoto O, Toyoshima T, et al. The contribution of low affinity NGF receptor (p75NGFR) to delayed neuronal death after ischemia in the gerbil hippocampus. Acta Med Okayama 2001, 55:19-24.
83. Jover T, Tanaka H, Calderone A, et al. Estrogen protects against global ischemia-induced neuronal death and prevents activation of apoptotic signaling cascades in the hippocampal CA1. J Neurosci 2002, 22:2115-2124.
84. Lee TH, Abe K, Kogure K, et al. Expressions of nerve growth factor and p75 low affinity receptor after transient forebrain ischemia in gerbil hippocampal CA1 neurons. J Neurosci Res 1995, 41:684-695.
85. Krajewski S, Krajewska M, Ellerby LM, et al. Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia. Proc Natl Acad Sci U S A 1999, 96:5752-5757.
86. MacManus JP, Buchan AM, Hill IE, et al. Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain. Neurosci Lett 1993, 164:89-92.
87. Ouyang YB, Tan Y, Comb M, et al. Survival- and death-promoting events after transient cerebral ischemia: Phosphorylation of Akt, release of cytochrome C and activation of caspase-like proteases. J Cereb Blood Flow Metab 1999, 19:1126-1135.
88. Deveraux QL, Reed JC IAP family proteins-suppressors of apoptosis. Genes Dev 1999, 13:239-252.
89. Salvesen GS, Duckett CS IAP proteins: Blocking the road to death's door. Nat Rev Mol Cell Biol 2002, 3:401-410.
90. Salvesen GS, Duckett CS IAP proteins: Blocking the road to death's door. Nat Rev Mol Cell Biol 2002, 3:401-410.
91. Weissman AM Themes and variations on ubiquitylation. Nat Rev Mol Cell Biol 2001, 2:169-178.
92. Shi Y A structural view of mitochondria-mediated apoptosis. Nat Struct Biol 2001, 8:394-401.
93. Hengartner MO The biochemistry of apoptosis. Nature 2000, 407:770-776.
94. Xue D, Horvitz HR Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor. Nature 1997, 390:305-308.
95. Shimazaki K, Ishida A, Kawai N Increase in bcl-2 oncoprotein and the tolerance to ischemia-induced neuronal death in the gerbil hippocampus. Neuroscience Research 1994, 20:95-99.
96. D'Amours D, Desnoyers S, D'Silva I, et al. Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. Biochem J 1999, 342:249-268.
97. Folbergrova J, Memezawa H, Smith ML, et al. Focal and perifocal changes in tissue energy state during middle cerebral artery occlusion in normo- and hyperglycemic rats. J Cereb Blood Flow Metab 1992, 12:25-33.
98. Folbergrova J, Zhao Q, Katsura K, et al. N-tert-butyl-alphaphenylnitrone improves recovery of brain energy state in rats following transient focal ischemia. Proc Natl Acad Sci U S A 1995, 92:5057-5061.
99. Szabo C, Dawson VL Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion. Trends Pharmacol Sci 1998, 19:287-298.
100. Eliasson MJ, Sampei K, Mandir AS, et al. Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nat Med 1997, 3:1089-1095.
101. Endres M, Wang ZQ, Namura S, et al. Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase. J Cereb Blood Flow Metab 1997, 17:1143-1151.
102. Pieper AA, Walles T, Wei G, et al. Myocardial postischemic injury is reduced by polyADPripose polymerase-1 gene disruption. Mol Med 2000, 6:271-282.
103. Mandir AS, Poitras MF, Berliner AR, et al. NMDA but not non-NMDA excitotoxicity is mediated by poly(ADP-ribose) polymerase. J Neurosci 2000, 20:8005-8011.
104. Zhang J, Dawson VL, Dawson TM, et al. Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity. Science 1994, 263:687-689.
105. Chiarugi A, Moskowitz MA Cell biology: PARP-1: A perpetrator of apoptotic cell death?. Science 2002, 297:200-201.
106. Yu SW, Wang H, Poitras MF, et al. Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science 2002, 297:259-263.
107. Choi DW Calcium-mediated neurotoxicity: Relationship to specific channel types and role in ischemic damage. Trends Neurosci 1988, 11:465-469.
108. Lucas DR, Newhouse JP The toxic effect of sodium L-glutamate on the inner layers of the retina. Arch Ophthalmol 1957, 58:193-201.
109. Olney JW, Ho OL Brain damage in infant mice following oral intake of glutamate, aspartate or cysteine. Nature 1970, 227:609-611.
110. Kass IS, Lipton P Mechanisms involved in irreversible anoxic damage to the in vitro rat hippocampal slice. J Physiol 1982, 332:459-472.
111. Rothman SM Synaptic activity mediates death of hypoxic neurons. Science 1983, 220:536-537.
112. Rothman SM The neurotoxicity of excitatory amino acids is produced by passive chloride influx. J Neurosci 1985, 5:1483-1489.
113. Simon RP, Swan JH, Griffiths T, et al. Blockade of N-methyl- d-aspartate receptors may protect against ischemic damage in the brain. Science 1984, 226:850-852.
114. Choi DW Calcium-mediated neurotoxicity: Relationship to specific channel types and role in ischemic damage. Trends Neurosci 1988, 11:465-469.
115. Tsubokawa H, Oguro K, Masuzawa T, et al. Ca(2+)-dependent non-NMDA receptor-mediated synaptic currents in ischemic CA1 hippocampal neurons. J Neurophysiol 1994, 71:1190-1196.
116. Tsubokawa H, Oguro K, Robinson HP, et al. Intracellular inositol 1,3,4,5-tetrakisphosphate enhances the calcium current in hippocampal CA1 neurones of the gerbil after ischaemia. J Physiol (Lond) 1996, 497:67-78.
117. Oguro K, Nakamura M, Masuzawa T Histochemical study of Ca(2+)-ATPase activity in ischemic CA1 pyramidal neurons in the gerbil hippocampus. Acta Neuropathol (Berl) 1995, 90:448-453.
118. Choi DW Calcium: Still center-stage in hypoxic-ischemic neuronal death. Trends Neurosci 1995, 18:58-60.
119. Meldrum B, Garthwaite J Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Pharmacol Sci 1990, 11:379-387.
120. Baker AJ, Zornow MH, Scheller MS, et al. Changes in extracellular concentrations of glutamate, aspartate, glycine, dopamine, serotonin, and dopamine metabolites after transient global ischemia in the rabbit brain. J Neurochem 1991, 57:1370-1379.
121. Mitani A, Kataoka K Critical levels of extracellular glutamate mediating gerbil hippocampal delayed neuronal death during hypothermia: Brain microdialysis study. Neuroscience 1991, 42:661-670.
122. Lee JM, Zipfel GJ, Choi DW The changing landscape of ischaemic brain injury mechanisms. Nature 1999, 399:A7-A14.
123. Hardingham GE, Fukunaga Y, Bading H Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat Neurosci 2002, 5:405-414.
124. Lonze BE, Riccio A, Cohen S, et al. Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB. Neuron 2002, 34:371-385.
125. Hardingham GE, Bading H The yin and yang of NMDA receptor signalling. Trends Neurosci 2003, 26:81-89.
126. Lonze BE, Ginty DD Function and regulation of CREB family transcription factors in the nervous system. Neuron 2002, 35:605-623.
127. Riccio A, Ginty DD What a privilege to reside at the synapse: NMDA receptor signaling to CREB. Nat Neurosci 2002, 5:389-390.
128. Yu SP, Canzoniero LM, Choi DW Ion homeostasis and apoptosis. Curr Opin Cell Biol 2001, 13:405-411.
129. Hollmann M, Hartley M, Heinemann S Ca2+ permeability of KA-AMPA-gated glutamate receptor channels depends on subunit composition. Science 1991, 252:851-853.
130. Verdoorn TA, Burnashev N, Monyer H, et al. Structural determinants of ion flow through recombinant glutamate receptor channels. Science 1991, 252:1715-1718.
131. Borges K, Dingledine R AMPA receptors: Molecular and functional diversity. Prog Brain Res 1998, 116:153-170.
132. Friedman LK, Pellegrini-Giampietro DE, Sperber EF, et al. Kainate-induced status epilepticus alters glutamate and GABAA receptor gene expression in adult rat hippocampus: An in situ hybridization study. J Neurosci 1994, 14:2697-2707.
133. Prince HK, Conn PJ, Blackstone CD, et al. Down-regulation of AMPA receptor subunit GluR2 in amygdaloid kindling. J Neurochem 1995, 64:462-465.
134. Tanaka H, Grooms SY, Bennett MV, et al. The AMPAR subunit GluR2: Still front and center-stage. Brain Res 2000, 886:190-207.
135. Pulsinelli W, Sarokin A, Buchan A Antagonism of the NMDA and non-NMDA receptors in global versus focal brain ischemia. Prog Brain Res 1993, 96:125-135.
136. Sheardown MJ The pharmacology of AMPA receptors and their antagonists. Stroke 1993, 24:I146-I147.
137. Nurse S, Corbett D Neuroprotection after several days of mild, drug-induced hypothermia. J Cereb Blood Flow Metab 1996, 16:474-480.
138. Noh K, Yokota H, Castillo PE, et al; GluR2-lacking, calciumpermeable AMPA receptors in ischemia-induced delayed neuronal death in hippocampal CA1. Society for Neuroscience Abstract, 2002, Program No. 539.4.
139. Weiss JH, Sensi SL Ca2+-Zn2+ permeable AMPA or kainate receptors: Possible key factors in selective neurodegeneration. Trends Neurosci 2000, 23:365-371.
140. Gorter JA, Petrozzino JJ, Aronica EM, et al. Global ischemia induces downregulation of Glur2 mRNA and increases AMPA receptor-mediated Ca2+ influx in hippocampal CA1 neurons of gerbil. J Neurosci 1997, 17:6179-6188.
141. Oguro K, Oguro N, Kojima T, et al. Knockdown of AMPA receptor GluR2 expression causes delayed neurodegeneration and increases damage by sublethal ischemia in hippocampal CA1 and CA3 neurons. J Neurosci 1999, 19:9218-9227.
142. Ying HS, Weishaupt JH, Grabb M, et al. Sublethal oxygen-glucose deprivation alters hippocampal neuronal AMPA receptor expression and vulnerability to kainate-induced death. J Neurosci 1997, 17:9536-9544.
143. O'Neill MJ, Bogaert L, Hicks CA, et al. LY377770, a novel iGlu5 kainate receptor antagonist with neuroprotective effects in global and focal cerebral ischaemia. Neuropharmacology 2000, 39:1575-1588.
144. Furukawa K, Fu W, Li Y, et al. The actin-severing protein gelsolin modulates calcium channel and NMDA receptor activities and vulnerability to excitotoxicity in hippocampal neurons. J Neurosci 1997, 17:8178-8186.
145. Chen ZL, Strickland S Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin. Cell 1997, 91:917-925.
146. Choi DW Cerebral hypoxia: Some new approaches and unanswered questions. J Neurosci 1990, 10:2493-2501.
147. Rothman SM, Olney JW Glutamate and the pathophysiology of hypoxic-ischemic brain damage. Ann Neurol 1986, 19:105-111.
148. Siesjö BK, Bengtsson F Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: A unifying hypothesis. J Cereb Blood Flow Metab 1989, 9:127-140.
149. Tsubokawa H, Oguro K, Robinson HP, et al. Abnormal Ca2+ homeostasis before cell death revealed by whole cell recording of ischemic CA1 hippocampal neurons. Neuroscience 1992, 49:807-817.
150. Takei N, Endo Y Ca2+ ionophore-induced apoptosis on cultured embryonic rat cortical neurons. Brain Res 1994, 652:65-70.
151. Johnson EM, Koike T, Franklin J A "calcium set-point hypothesis" of neuronal dependence on neurotrophic factor. Exp Neurol 1992, 115:163-166.
152. Juin P, Pelletier M, Oliver L, et al. Induction of a caspase-3-like activity by calcium in normal cytosolic extracts triggers nuclear apoptosis in a cell-free system. J Biol Chem 1998, 273:17559-17564.
153. Gaido ML, Cidlowski JA Identification, purification, and characterization of a calcium-dependent endonuclease (NUC18) from apoptotic rat thymocytes. NUC18 is not histone H2B. J Biol Chem 1991, 266:18580-18585.
154. Choi DW, Koh JY Zinc and brain injury. Annu Rev Neurosci 1998, 21:347-375.
155. Palmiter RD, Cole TB, Quaife CJ, et al. ZnT-3, a putative transporter of zinc into synaptic vesicles. Proc Natl Acad Sci U S A 1996, 93:14934-14939.
156. Assaf SY, Chung SH Release of endogenous Zn2+ from brain tissue during activity. Nature 1984, 308:734-736.
157. Howell GA, Welch MG, Frederickson CJ Stimulation-induced uptake and release of zinc in hippocampal slices. Nature 1984, 308:736-738.
158. Li Y, Hough CJ, Frederickson CJ, et al. Induction of mossy fiber >Ca3 long-term potentiation requires translocation of synaptically released Zn2+. J Neurosci 2001, 21:8015-8025.
159. Aniksztejn L, Charton G, Ben Ari Y Selective release of endogenous zinc from the hippocampal mossy fibers in situ. Brain Res 1987, 404:58-64.
160. Sloviter RS A selective loss of hippocampal mossy fiber Timm stain accompanies granule cell seizure activity induced by perforant path stimulation. Brain Res 1985, 330:150-153.
161. Yanamoto H, Nagata I, Sakata M, et al. Infarct tolerance induced by intra-cerebral infusion of recombinant brain-derived neurotrophic factor. Brain Res 2000, 859:240-248.
162. Weiss JH, Hartley DM, Koh JY, et al. AMPA receptor activation potentiates zinc neurotoxicity. Neuron 1993, 10:43-49.
163. Koh JY, Suh SW, Gwag BJ, et al. The role of zinc in selective neuronal death after transient global cerebral ischemia. Science 1996, 272:1013-1016.
164. Grooms SY, Opitz T, Bennett MV, et al. Status epilepticus decreases glutamate receptor 2 mRNA and protein expression in hippocampal pyramidal cells before neuronal death. Proc Natl Acad Sci U S A 2000, 97:3631-3636.
165. Koh JY, Choi DW Zinc alters excitatory amino acid neurotoxicity on cortical neurons. J Neurosci 1988, 8:2164-2171.
166. Weiss JH, Turetsky D, Wilke G, et al. AMPA/kainate receptor-mediated damage to NADPH-diaphorase-containing neurons is Ca2+ dependent. Neurosci Lett 1994, 167:93-96.
167. Harris RJ, Symon L, Branston NM, et al. Changes in extracellular calcium activity in cerebral ischaemia. J Cereb Blood Flow Metab 1981, 1:203-209.
168. Gido G, Kristian T, Siesjö BK Extracellular potassium in a neocortical core area after transient focal ischemia. Stroke 1997, 28:206-210.
169. Nedergaard M, Hansen AJ Characterization of cortical depolarizations evoked in focal cerebral ischemia. J Cereb Blood Flow Metab 1993, 13:568-574.
170. Nicotera P, Leist M, Fava E, et al. Energy requirement for caspase activation and neuronal cell death. Brain Pathol 2000, 10:276-282.
171. Harris RJ, Symon L Extracellular pH, potassium, and calcium activities in progressive ischaemia of rat cortex. J Cereb Blood Flow Metab 1984, 4:178-186.
172. Hengartner MO The biochemistry of apoptosis. Nature 2000, 407:770-776.
173. Wang HG, Pathan N, Ethell IM, et al. Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD. Science 1999, 284:339-343.
174. Baranano DE, Ferris CD, Snyder SH Atypical neural messengers. Trends Neurosci 2001, 24:99-106.
175. Bredt DS, Ferris CD, Snyder SH Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase: Identification of flavin and calmodulin binding sites. J Biol Chem 1992, 267:10976-10981.
176. Garthwaite J Glutamate, nitric oxide and cell-cell signalling in the nervous system. Trends Neurosci 1991, 14:60-67.
177. Kumura E, Yoshimine T, Iwatsuki KI, et al. Generation of nitric oxide and superoxide during reperfusion after focal cerebral ischemia in rats. Am J Physiol 1996, 270:C748-C752.
178. Liu PK, Grossman RG, Hsu CY, et al. Ischemic injury and faulty gene transcripts in the brain. Trends Neurosci 2001, 24:581-588.
179. Bolanos JP, Heales SJ, Land JM, et al. Effect of peroxynitrite on the mitochondrial respiratory chain: Differential susceptibility of neurones and astrocytes in primary culture. J Neurochem 1995, 64:1965-1972.
180. Liu PK, Arora T Transcripts of damaged genes in the brain during cerebral oxidative stress. J Neurosci Res 2002, 70:713-720.
181. Love S Oxidative stress in brain ischemia. Brain Pathol 1999, 9:119-131.
182. Chan PH Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab 2001, 21:2-14.
183. Aronowski J, Strong R, Grotta JC Citicoline for treatment of experimental focal ischemia: histologic and behavioral outcome. Neurol Res 1996, 18:570-574.
184. Aguilar HI, Botla R, Arora AS, et al. Induction of the mitochondrial permeability transition by protease activity in rats: A mechanism of hepatocyte necrosis. Gastroenterology 1996, 110:558-566.
185. Sensi SL, Yin HZ, Carriedo SG, et al. Preferential Zn2+ influx through Ca2+-permeable AMPA/kainate channels triggers prolonged mitochondrial superoxide production. Proc Natl Acad Sci U S A 1999, 96:2414-2419.
186. Zolotarjova N, Ho C, Mellgren RL, et al. Different sensitivities of native and oxidized forms of Na+/K(+)-ATPase to intracellular proteinases. Biochim Biophys Acta 1994, 1192:125-131.
187. Liu PK Ischemia-reperfusion-related repair deficit after oxidative stress: Implications of faulty transcripts in neuronal sensitivity after brain injury. J Biomed Sci 2003, 10:4-13.
188. Back T, Zhao W, Ginsberg MD Three-dimensional image analysis of brain glucose metabolism-blood flow uncoupling and its electrophysiological correlates in the acute ischemic penumbra following middle cerebral artery occlusion. J Cereb Blood Flow Metab 1995, 15:566-577.
189. Back T, Ginsberg MD, Dietrich WD, et al. Induction of spreading depression in the ischemic hemisphere following experimental middle cerebral artery occlusion: Effect on infarct morphology. J Cereb Blood Flow Metab 1996, 16:202-213.
190. Baker CJ, Fiore AJ, Frazzini VI, et al. Intraischemic hypothermia decreases the release of glutamate in the cores of permanent focal cerebral infarcts. Neurosurgery 1995, 36:994-1001.
191. Baimbridge KG, Celio MR, Rogers JH Calcium-binding proteins in the nervous system. Trends Neurosci 1992, 15:303-308.
192. Ashkenazi A, Dixit VM Death receptors: Signaling and modulation. Science 1998, 281:1305-1308.
193. Sheng M, Greenberg ME The regulation and function of c-fos and other immediate early genes in the nervous system. Neuron 1990, 4:477-485.
194. Sasaki M, Gonzalez-Zulueta M, Huang H, et al. Dynamic regulation of neuronal NO synthase transcription by calcium influx through a CREB family transcription factor-dependent mechanism. Proc Natl Acad Sci U S A 2000, 97:8617-8622.
195. Tao X, Finkbeiner S, Arnold DB, et al. Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron 1998, 20:709-726.
196. Kornhauser JM, Cowan CW, Shaywitz AJ, et al. CREB transcriptional activity in neurons is regulated by multiple, calcium-specific phosphorylation events. Neuron 2002, 34:221-233.
197. Mattson MP, Camandola S NF-kappaB in neuronal plasticity and neurodegenerative disorders. J Clin Invest 2001, 107:247-254.
198. Schneider A, Martin-Villalba A, Weih F, et al. NF-kappaB is activated and promotes cell death in focal cerebral ischemia. Nat Med 1999, 5:554-559.
199. Brunet A, Datta SR, Greenberg ME Transcription-dependent and-independent control of neuronal survival by the PI2K-Akt signaling pathway. Curr Opin Neurobiol 2001, 11:297-305.
200. Datta SR, Brunet A, Greenberg ME Cellular survival: A play in three Akts. Genes Dev 1999, 13:2905-2927.
201. Kaplan DR, Miller FD Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol 2000, 10:381-391.
202. Brunet A, Datta SR, Greenberg ME Transcription-dependent and-independent control of neuronal survival by the PI3K-Akt signaling pathway. Curr Opin Neurobiol 2001, 11:297-305.
203. Chong JA, Tapia-Ramirez J, Kim S, et al. REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell 1995, 80:949-957.
204. Schoenherr CJ, Paquette AJ, Anderson DJ Identification of potential target genes for the neuron-restrictive silencer factor. Proc Natl Acad Sci U S A 1996, 93:9881-9886.
205. Schoenherr CJ, Anderson DJ Silencing is golden: Negative regulation in the control of neuronal gene transcription. Curr Opin Neurobiol 1995, 5:566-571.
206. Roopra A, Sharling L, Wood IC, et al. Transcriptional repression by neuron-restrictive silencer factor is mediated via the Sin3-histone deacetylase complex. Mol Cell Biol 2000, 20:2147-2157.
207. Chen ZF, Paquette AJ, Anderson DJ NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis [see comments]. Nat Genet 1998, 20:136-142.
208. Ballas N, Battaglioli E, Atouf F, et al. Regulation of neuronal traits by a novel transcriptional complex. Neuron 2001, 31:353-365.
209. Bahn S, Mimmack M, Ryan M, et al. Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: A gene expression study. Lancet 2002, 359:310-315.
210. Okazaki T, Wang Masliah E, et al. SCG10, a neuron-specific growth-associated protein in Alzheimer's disease. Neurobiol Aging 1995, 16:883-894.
211. Lawinger P, Venugopal R, Guo ZS, et al. The neuronal repressor REST/NRSF is an essential regulator in medulloblastoma cells. Nat Med 2000, 6:826-831.
212. Calderone A, Jover T, Noh KM, et al. Ischemic insults derepress the gene silencer REST in neurons destined to die. J Neurosci 2003, 23:2112-2121.
213. Iadecola C Bright and dark sides of nitric oxide in ischemic brain injury. Trends Neurosci 1997, 20:132-139.
214. Dirnagl U, Iadecola C, Moskowitz MA Pathobiology of ischaemic stroke: An integrated view. Trends Neurosci 1999, 22:391-397.
215. Ishibashi N, Prokopenko O, Reuhl KR, et al. Inflammatory response and glutathione peroxidase in a model of stroke. J Immunol 2002, 168:1926-1933.
216. Stevens SL, Bao J, Hollis J, et al. The use of flow cytometry to evaluate temporal changes in inflammatory cells following focal cerebral ischemia in mice. Brain Res 2002, 932:110-119.
217. Sharp FR, Massa SM, Swanson RA Heat-shock protein protection. Trends Neurosci 1999, 22:97-99.
218. Kiessling M, Stumm G, Xie Y, et al. Differential transcription and translation of immediate early genes in the gerbil hippocampus after transient global ischemia. J Cereb Blood Flow Metab 1993, 13:914-924.
219. Dragunow M, Beilharz E, Sirimanne E, et al. Immediate-early gene protein expression in neurons undergoing delayed death, but not necrosis, following hypoxic-ischaemic injury to the young rat brain. Brain Res Mol Brain Res 1994, 25:19-33.
220. Parsell DA, Lindquist S The function of heat-shock proteins in stress tolerance: Degradation and reactivation of damaged proteins. Annu Rev Genet 1993, 27:437-496.
221. Beere HM Stressed to death: Regulation of apoptotic signaling pathways by the heat shock proteins. Sci STKE 2001, 93:RE1.
222. Papadopoulos M, Sun X, Cao J, et al. Over-expression of HSP-70 protects astrocytes from combined oxygen-glucose deprivation. Neuroreport 1996, 7:429-432.
223. Plumier J, Kruejer A, Currie R, et al. Transgenic mice expressing the human inducible HSP70 have hippocampal neurons resistant to ischemic injury. Cell Stress Chaperones 1997, 2:162-167.
224. Wagstaff M, Collaco-Moraes Y, Smith J, et al. Protection of neuronal cells from apoptosis by HSP27 delivered with a herpes simplex virus-based vector. J Biol Chem 1999, 274:5069.
225. Yenari MA, Fink SL, Sun G, et al. Gene therapy with HSP72 is neuroprotective in rat models of stroke and epilepsy. Ann Neurol 1998, 44:584-591.
226. Kinouchi H, Sharp FR, Koistinaho J, et al. Induction of heat shock HSP70 mRNA and HSP70 kDa protein in neurons in the "penumbra" following focal cerebral ischemia in the rat. Brain Res 1993, 619:334-338.
227. Li Y, Chopp M, Zhang ZG, et al. Neuronal survival is associated with 72-kDa heat shock protein expression after transient middle cerebral artery occlusion in the rat. J Neurol Sci 1993, 120:187-194.
228. Bruey JM, Ducasse C, Bonniaud P, et al. Hsp27 negatively regulates cell death by interacting with cytochrome c. Nat Cell Biol 2000, 2:645-652.
229. Pandey P, Saleh A, Nakazawa A, et al. Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90. EMBO J 2000, 19:4310-4322.
230. Saleh A, Srinivasula SM, Balkir L, et al. Negative regulation of the Apaf-1 apoptosome by HSP70. Nat Cell Biol 2000, 2:476-483.
231. Rajdev S, Hara K, Kokubo Y, et al. Mice overexpressing rat heat shock protein 70 are protected against cerebral infarction. Ann Neurol 2000, 47:782-791.
232. Lee S-H, Kim M, Yoon B-W, et al. Targeted HSP70.1 disruption increases infarction volume after focal cerebral ischemia in mice. Stroke 2001, 32:2905-2912.
233. Hoehn B, Ringer TM, Xu L, et al. Overexpression of HSP72 after induction of experimental stroke protects neurons from ischemic damage. J Cereb Blood Flow Metab 2001, 11:1303-1309.
234. James MF, Smith JM, Boniface SJ, et al. Cortical spreading depression and migraine: New insights from imaging?. Trends Neurosci 2001, 24:266-271.
235. Theis M, Jauch R, Zhuo L, et al. Accelerated hippocampal spreading depression and enhanced locomotory activity in mice with astrocyte-directed inactivation of connexin43. J Neurosci 2003, 23:766-776.
236. Crowder RJ, Freeman RS Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons. J Neurosci 1998, 18:2933-2943.
237. Kuruvilla R, Ye H, Ginty DD Spatially and functionally distinct roles of the PI3-K effector pathway during NGF signaling in sympathetic neurons. Neuron 2000, 27:499-512.
238. Philpott KL, McCarthy MJ, Klippel A, et al. Activated phosphatidylinositol 3-kinase and Akt kinase promote survival of superior cervical neurons. J Cell Biol 1997, 139:809-815.
239. Rosenmund C, Westbrook GL Calcium-induced actin depolymerization reduces NMDA channel activity. Neuron 1993, 10:805-814.
240. Yao R, Cooper GM Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 1995, 267:2003-2006.
241. Yuan J, Yankner BA Apoptosis in the nervous system. Nature 2000, 407:802-809.
242. Pearson G, Robinson F, Beers GT, et al. Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions. Endocr Rev 2001, 22:153-183.
243. Bonni A, Brunet A, West AE, et al. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and-independent mechanisms. Science 1999, 286:1358-1362.
244. Nandagopal K, Dawson TM, Dawson VL Critical role for nitric oxide signaling in cardiac and neuronal ischemic preconditioning and tolerance. J Pharmacol Exp Ther 2001, 297:474-478.
245. McBain CJ, Fisahn A Interneurons unbound. Nat Rev Neurosci 2001, 2:11-23.
246. Galarreta M, Hestrin S Electrical synapses between GABA-releasing interneurons. Nat Rev Neurosci 2001, 2:425-433.
247. Bennett MV, Barrio LC, Bargiello TA, et al. Gap junctions: New tools, new answers, new questions. Neuron 1991, 6:305-320.
248. Bruzzone R, White TW, Paul DL Connections with connexins: The molecular basis of direct intercellular signaling. Eur J Biochem 1996, 238:1-27.
249. Dermietzel R, Spray DC From neuro-glue ('Nervenkitt') to glia: A prologue. Glia 1998, 24:1-7.
250. Goodenough DA, Goliger JA, Paul DL Connexins, connexons, and intercellular communication. Annu Rev Biochem 1996, 65:475-502.
251. Kunzelmann P, Blumcke I, Traub O, et al. Coexpression of connexin45 and -32 in oligodendrocytes of rat brain. J Neurocytol 1997, 26:17-22.
252. Li J, Hertzberg EL, Nagy JI Connexin32 in oligodendrocytes and association with myelinated fibers in mouse and rat brain. J Comp Neurol 1997, 379:571-591.
253. Rash JE, Staines WA, Yasumura T, et al. Immunogold evidence that neuronal gap junctions in adult rat brain and spinal cord contain connexin-36 but not connexin-32 or connexin-43. Proc Natl Acad Sci U S A 2000, 97:7573-7578.
254. Sohl G, Degen J, Teubner B, et al. The murine gap junction gene connexin36 is highly expressed in mouse retina and regulated during brain development. FEBS Lett 1998, 428:27-31.
255. Gibson JR, Beierlein M, Connors BW Two networks of electrically coupled inhibitory neurons in neocortex. Nature 1999, 402:75-79.
256. Venance L, Rozov A, Blatow M, et al. Connexin expression in electrically coupled postnatal rat brain neurons. Proc Natl Acad Sci U S A 2000, 97:10260-10265.
257. Oguro K, Jover T, Tanaka H Global ischemia-induced increases in the gap junctional proteins connexin 3 (Cx32) and Cx36 in hippocampus and enhanced vulnerability of Cx32 knock out mice. J Neurosci 2001, 21(19):7534-7542.
258. Sutor B, Schmolke C, Teubner B, et al. TI-myelination defects and neuronal hyperexcitability in the neocortex of connexin 32-deficient mice. Cereb Cortex 2000, 10:684-697.
259. Haydon PG Neuroglial networks: Neurons and glia talk to each other. Curr Biol 2000, 10:R712-R714.
260. Haydon PG GLIA: Listening and talking to the synapse. Nat Rev Neurosci 2001, 2:185-193.
261. Lin B, Ginsberg MD, Busto R Hyperglycemic exacerbation of neuronal damage following forebrain ischemia: Microglial, astrocytic and endothelial alterations. Acta Neuropathol (Berl) 1998, 96:610-620.
262. Rawanduzy A, Hansen A, Hansen TW, et al. Effective reduction of infarct volume by gap junction blockade in a rodent model of stroke. J Neurosurg 1997, 87:916-920.
263. Warner DS, Ludwig PS, Pearlstein R, et al. Halothane reduces focal ischemic injury in the rat when brain temperature is controlled. Anesthesiology 1995, 82:1237-1245.
264. Saito R, Graf R, Hubel K, et al. Reduction of infarct volume by halothane: Effect on cerebral blood flow or perifocal spreading depression-like depolarizations. J Cereb Blood Flow Metab 1997, 17:857-864.
265. Eckenstein FP Fibroblast growth factors in the nervous system. J Neurobiol 1994, 25:1467-1480.
266. Kitagawa K, Matsumoto M, Kuwabara K, et al. 'Ischemic tolerance' phenomenon detected in various brain regions. Brain Res 1991, 561:203-211.
267. Liu Y, Kato H, Nakata N, et al. Protection of rat hippocampus against ischemic neuronal damage by pretreatment with sublethal ischemia. Brain Res 1992, 586:121-124.
268. Nishi S, Taki W, Uemura Y, et al. Ischemic tolerance due to the induction of HSP70 in a rat ischemic recirculation model. Brain Res 1993, 615:281-288.
269. Simon RP, Niiro M, Gwinn R Prior ischemic stress protects against experimental stroke. Neurosci Lett 1993, 163:135-137.
270. Wu C, Zhan RZ, Qi S, et al. A forebrain ischemic preconditioning model established in C57Black/Crj6 mice. J Neurosci Methods 2001, 107:101-106.
271. Kirino T Ischemic tolerance. J Cereb Blood Flow Metab 2002, 22:1283-1296.
272. Chow AK, Thompson CS, Hogan MJ, et al. Cortical spreading depression transiently activates MAP kinases. Brain Res Mol Brain Res 2002, 99:75-81.
273. Obrenovitch TP, Urenjak J, Wang M Nitric oxide formation during cortical spreading depression is critical for rapid subsequent recovery of ionic homeostasis. J Cereb Blood Flow Metab 2002, 22:680-688.
274. Behl C Oestrogen as a neuroprotective hormone. Nat Rev Neurosci 2002, 3:433-442.
275. McEwen B, Akama K, Alves S, et al. Tracking the estrogen receptor in neurons: Implications for estrogen-induced synapse formation. Proc Natl Acad Sci U S A 2001, 98:7093-7100.
276. Hurn PD, Macrae IM Estrogen as a neuroprotectant in stroke. J Cereb Blood Flow Metab 2000, 20:631-652.
277. Culmsee C, Vedder H, Ravati A, et al. Neuroprotection by estrogens in a mouse model of focal cerebral ischemia and in cultured neurons: Evidence for a receptor-independent antioxidative mechanism. J Cereb Blood Flow Metab 1999, 19:1263-1269.
278. Dubal DB, Kashon ML, Pettigrew LC, et al. Estradiol protects against ischemic injury. J Cereb Blood Flow Metab 1998, 18:1253-1258.
279. Dubal DB, Zhu H, Yu J, et al. Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury. Proc Natl Acad Sci U S A 2001, 98:1952-1957.
280. Dubal DB, Wise PM Neuroprotective effects of estradiol in middle-aged female rats. Endocrinology 2001, 142:43-48.
281. Rusa R, Alkayed NJ, Crain BJ, et al. 17beta-estradiol reduces stroke injury in estrogen-deficient female animals. Stroke 1999, 30:1665-1670.
282. Toung TJ, Traystman RJ, Hurn PD Estrogen-mediated neuroprotection after experimental stroke in male rats. Stroke 1998, 29:1666-1670.
283. Dubal DB, Zhu H, Yu J, et al. Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury. Proc Natl Acad Sci U S A 2001, 98:1952-1957.
284. Dubal DB, Shughrue PJ, Wilson ME, et al. Estradiol modulates bcl-2 in cerebral ischemia: A potential role for estrogen receptors. J Neurosci 1999, 19:6385-6393.
285. Chen J, Adachi N, Liu K, et al. The effects of 17beta-estradiol on ischemia-induced neuronal damage in the gerbil hippocampus. Neuroscience 1998, 87:817-822.
286. Sudo S, Wen TC, Desaki J, et al. Beta-estradiol protects hippocampal CA1 neurons against transient forebrain ischemia in gerbil. Neurosci Res 1997, 29:345-354.
287. Kondo Y, Suzuki K, Sakuma Y Estrogen alleviates cognitive dysfunction following transient brain ischemia in ovariectomized gerbils. Neurosci Lett 1997, 238:45-48.
288. McKenna NJ, O'Malley BW Combinatorial control of gene expression by nuclear receptors and coregulators. Cell 2002, 108:465-474.
289. Nilsson S, Makela S, Treuter E, et al. Mechanisms of estrogen action. Physiol Rev 2001, 81:1535-1565.
290. Kelly MJ, Levin ER Rapid actions of plasma membrane estrogen receptors. Trends Endocrinol Metab 2001, 12:152-156.
291. Harms C, Lautenschlager M, Bergk A, et al. Differential mechanisms of neuroprotection by 17beta-estradiol in apoptotic versus necrotic neurodegeneration. J Neurosci 2001, 21:2600-2609.
292. Honda K, Sawada H, Kihara T, et al. Phosphatidylinositol 3-kinase mediates neuroprotection by estrogen in cultured cortical neurons. J Neurosci Res 2000, 60:321-327.
293. Mendez P, Azcoitia I, Garcia-Segura LM Estrogen receptor alpha forms estrogen-dependent multimolecular complexes with insulin-like growth factor receptor and phosphatidylinositol 3-kinase in the adult rat brain. Brain Res Mol Brain Res 2003, 112:170-176.
294. Canzoniero LM, Turetsky DM, Choi DW Measurement of intracellular free zinc concentrations accompanying zinc-induced neuronal death. J Neurosci 1999, 19:RC31.
295. Colbourne F, Sutherland G, Corbett D Postischemic hypothermia: A critical appraisal with implications for clinical treatment. Mol Neurobiol 1997, 14:171-201.
296. Colbourne F, Li H, Buchan AM Indefatigable CA1 sector neuroprotection with mild hypothermia induced 6 hours after severe forebrain ischemia in rats. J Cereb Blood Flow Metab 1999, 19:742-749.
297. Sonn J, Granot E, Etziony R, et al. Effect of hypothermia on brain multi-parametric activities in normoxic and partially ischemic rats. Comp Biochem Physiol A Mol Integr Physiol 2002, 132:239-246.
298. Kimura T, Sako K, Tanaka K, et al. Effect of mild hypothermia on energy state recovery following transient forebrain ischemia in the gerbil. Exp Brain Res 2002, 145:83-90.