Cytosolic redistribution of cytochrome c after transient focal cerebral ischemia in rats

Journal of Cerebral Blood Flow and Metabolism

Volumn 18, Issue 11, 1998, Pages 1239-1247

  Fujimura, Miki ^a   Morita Fujimura, Yuiko ^a   Murakami, Kensuke ^a,b   Kawase, Makoto ^a   Chan, Pak H ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cytochrome c; Focal cerebral ischemia; Immunohistochemistry; Mitochondria; Western blot

Indexed keywords

CYTOCHROME C; DNA FRAGMENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; BRAIN MITOCHONDRION; CELLULAR DISTRIBUTION; CHROMATIN CONDENSATION; CONTROLLED STUDY; CYTOSOL; DNA STRAND BREAKAGE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; RAT;

EID: 0031737635     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199811000-00010     Document Type: Article

References (35)

1. Abe K, Aoki M, Kawagoe J, Yoshida T, Hattori A, Kogure K, Itoyama Y (1995) Ischemic delayed neuronal death. A mitochondrial hypothesis. Stroke 26:1478-1489
2. Almeida A, Allen KL, Bates TE, Clark JB (1995) Effect of reperfusion following cerebral ischemia on the activity of the mitochondrial respiratory chain in the gerbil brain. J Neurochem 65:1698-1703
3. Asahi M, Hoshimaru M, Uemura Y, Tokime T, Kojima M, Ohtsuka T, Matsuura N, Aoki T, Shibahara K, Kikuchi H (1997) Expression of interleukin-1β converting enzyme gene family and bcl-2 gene family in the rat brain following permanent occlusion of the middle cerebral artery. J Cereb Blood Flow Metab 17:11-18
4. Boyer PD, Chance B, Ernster L, Mitchell P, Racker E, Slater EC (1977) Oxidative phosphorylation and photophosphorylation. Annu Rev Biochem 46:955-1026
5. Chan PH (1996) Role of oxidants in ischemic brain damage. Stroke 27:1124-1129
6. Charriaut-Marlangue C, Ben-Ari Y (1995) A cautionary note on the use of the TUNEL stain to determine apoptosis. Neuroreport 7:61-64
7. Charriaut-Marlangue C, Margaill I, Represa A, Popovici T, Plotkine M, Ben-Ari Y (1996) Apoptosis and necrosis after reversible focal ischemia: an in situ DNA fragmentation analysis. J Cereb Blood Flow Metab 16:186-194
8. Chen J, Graham SH, Chan PH, Lan J, Zhou RL, Simon RP (1995) Bcl-2 is expressed in neurons that survive focal ischemia in the rat. Neuroreport 6:394-398
9. Choi DW (1996) Ischemia-induced neuronal apoptosis. Curr Opin Neurobiol 6:667-672
10. Chopp M, Li Y (1996) Apoptosis in focal cerebral ischemia. Acta Neurochir Suppl (Wien) 66:21-26
11. Du C, Hu R, Csernansky CA, Hsu CY, Choi DW (1996) Very delayed infarction after mild focal cerebral ischemia: a role for apoptosis? J Cereb Blood Flow Metab 16:195-201
12. Gillardon F, Lenz C, Waschke KF, Krajewski S, Reed JC, Zimmermann M, Kuschinsky W (1996) Altered expression of Bcl-2, Bcl-x, Bax, and c-Fos colocalizes with DNA fragmentation and ischemic cell damage following middle cerebral artery occlusion in rats. Brain Res Mol Brain Res 40:254-260
13. Kawase M, Carlson E, Murakami K, Chen SF, Epstein CJ, Chan PH (1997) Neuronal damage is reduced after transient global ischemia in CuZn-superoxide dismutase transgenic rats. Soc Neurosci Abstr 23:2186
14. Kharbanda S, Pandey P, Schofield L, Israels S, Roncinske R, Yoshida K, Bharti A, Yuan ZM, Saxena S, Weichselbaum R, Nalin C, Kufe D (1997) Role for Bcl-XL as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis. Proc Natl Acad Sci USA 94:6939-6942
15. Kim CN, Wang X, Huang Y, Ibrado AM, Liu L, Fang G, Bhalla K (1997) Overexpression of Bcl-XL inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis. Cancer Res 57:3115-3120
16. Kinouchi H, Epstein CJ, Mizui T, Carlson E, Chen SF, Chan PH (1991) Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase. Proc Natl Acad Sci USA 88:11158-11162
17. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD (1997) The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275:1132-1136
18. Kondo T, Reaume AG, Huang TT, Carlson E, Murakami K, Chen SF, Hoffman EK, Scott RW, Epstein CJ, Chan PH (1997) Reduction of CuZn-superoxide dismutase activity exacerbates neuronal cell injury and edema formation after transient focal cerebral ischemia. J Neurosci 17:4180-4189
19. Lee CP (1995) Biochemical studies of isolated mitochondria from normal and diseased tissues. Biochim Biophys Acta 1271:21-28
20. Li F, Srinvasan A, Wang Y, Armstrong RC, Tomaselli KJ, Fritz LC (1997) Cell-specific induction of apoptosis by microinjection of cytochrome c. J Biol Chem 272:30299-30305
21. Li Y, Chopp M, Jiang N, Yao F, Zaloga C (1995a) Temporal profile of in situ DNA fragmentation after transient middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 15:389-397
22. Li Y, Chopp M, Jiang N, Zaloga C (1995b) In situ detection of DNA fragmentation after focal cerebral ischemia in mice. Brain Res Mol Brain Res 28:164-168
23. Li Y, Chopp M, Jiang N, Zhang ZG, Zaloga C (1995c) Induction of DNA fragmentation after 10 to 120 minutes of focal cerebral ischemia in rats. Stroke 26:1252-1258
24. Li Y, Sharov VG, Jiang N, Zaloga C, Sabbah HN, Chopp M (1995d) Ultrastructural and light microscopic evidence of apoptosis after middle cerebral artery occlusion in the rat. Am J Pathol 146:1045-1051
25. Linnik MD, Zobrist RH, Hatfield MD (1993) Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats. Stroke 24:2002-2008
26. Liu X, Kim CN, Yang J, Jemmerson R, Wang X (1996) Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86:147-157
27. Martinou JC, Dubois-Dauphin M, Staple JK, Rodriguez I, Frankowski H, Missotten M, Albertini P, Talabot D, Catsicas S, Pietra C (1994) Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron 13:1017-1030
28. Murakami K, Kondo T, Chan PH (1997a) Reperfusion following focal cerebral ischemia alters distribution of neuronal cells with DNA fragmentation in mice. Brain Res 751:160-164
29. Murakami K, Kondo T, Epstein CJ, Chan PH (1997b) Overexpression of CuZn-superoxide dismutase reduces hippocampal injury after global ischemia in transgenic mice. Stroke 28:1797-1804
30. Murakami K, Kondo T, Kawase M, Li Y, Sato S, Chen SF, Chan PH (1998) Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency. J Neurosci 18:205-213
31. Piantadosi CA, Zhang J (1996) Mitochondrial generation of reactive oxygen species after brain ischemia in the rat. Stroke 27:327-331
32. Tominaga T, Kure S, Narisawa K, Yoshimoto T (1993) Endonuclease activation following focal ischemic injury in the rat brain. Brain Res 608:21-26
33. Vander Heiden MG, Chandel NS, Williamson EK, Schumacker PT, Thompson CB (1997) Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria. Cell 91:627-637
34. Yang G, Chan PH, Chen J, Carlson E, Chen SF, Weinstein P, Epstein CJ, Kamii H (1994) Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia. Stroke 25:165-170
35. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng T, Jones DP, Wang X (1997) Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275:1129-1132