NMDA but not non-NMDA excitotoxicity is mediated by poly(ADP-ribose) polymerase

Journal of Neuroscience

Volumn 20, Issue 21, 2000, Pages 8005-8011

  Mandir, A S ^a   Poitras, M F ^a   Berliner, A R ^a   Herring, W J ^a   Guastella, D B ^a   Feldman, A ^a   Poirier, G G ^a   Wang, Z Q ^a   Dawson, T M ^a   Dawson, V L ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AMPA; Excitotoxicity; Nitric oxide; NMDA; NOS; Parkinsonism; PARP; Poly(ADP ribose); Sindbis virus

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

ANIMAL CELL; ARTICLE; BRAIN ISCHEMIA; CELL DEATH; DNA REPAIR; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NEUROTRANSMITTER RELEASE; NONHUMAN; PARKINSONISM; PRIORITY JOURNAL; SINDBIS VIRUS; STEREOTAXIS;

EID: 0034329823     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-21-08005.2000     Document Type: Article

References (71)

1. Immunodot blot method for the detection of poly (ADP-ribose) synthesized in vitro and in vivo
2. Immunological determination and size characterization of poly(ADP-ribose) synthesized in vitro and in vivo
3. Mechanisms of reduced striatal NMDA excitotoxicity in type I nitric oxide synthase knock-out mice
4. Pathological implications of nitric oxide, superoxide and peroxynitrite formation
5. Poly(ADP-ribose) in the cellular response to DNA damage
6. Ontogenetic differences in energy metabolism and inhibition of protein synthesis in hippocampal slices during in vitro ischemia and 24 h of recovery
7. Cloning and characterization of postsynaptic density 93, a nitric oxide synthase interacting protein
8. NMDA antagonists partially protect against MPTP induced neurotoxicity in mice
9. Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin
10. Implication of glutamate in the expression of inducible nitric oxide synthase after oxygen and glucose deprivation in rat forebrain slices
11. Glutamate neurotoxicity and diseases of the nervous system
12. Global cerebral ischemia activates nuclear factor-kappa B prior to evidence of DNA fragmentation
13. Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions
14. Nitric oxide as a mediator of neurotoxicity
15. Nitric oxide neurotoxicity
16. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures
17. Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures
18. Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase deficient mice
19. Structure and function of poly(ADP-ribose) polymerase
20. GRIP: A synaptic PDZ domain-containing protein that interacts with AMPA receptors
21. Genetic determinants of Sindbis virus neuroinvasiveness
22. Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia
23. Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase
24. Activation of nuclear factor-kappaB in the rat brain after transient focal ischemia
25. Manganese superoxide dismutase protects nNOS neurons from NMDA and nitric oxide-mediated neurotoxicity
26. A review of alphavirus replication in neurons
27. A neuron-specific gene transfer by a recombinant defective Sindbis virus
28. Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion
29. Targeted disruption of the neuronal nitric oxide synthase gene
30. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase
31. Bright and dark sides of nitric oxide in ischemic brain injury
32. Basis of neurovirulence in Sindbis virus encephalomyelitis of mice
33. Neuroprotective effects of the strychnine-insensitive glycine site NMDA antagonist (R)-HA-966 in an experimental model of Parkinson's disease
34. The competitive NMDA antagonist CPP protects substantia nigra neurons from MPTP-induced degeneration in primates
35. Molecular and biochemical features of poly(ADP-ribose) metabolism
36. Apoptosis, excitotoxicity, and neuropathology
37. Alphavirus-induced apoptosis in mouse brains correlates with neurovirulence
38. Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease
39. Excitatory amino acids as a final common pathway for neurologic disorders
40. Inhibition of poly(ADP-ribose) polymerase: Reduction of ischemic injury and attenuation of N-methyl-D-aspartate-induced neurotransmitter dysregulation
41. Alphaviruses as tools in neurobiology and gene therapy
42. Secondary mechanisms in neuronal trauma
43. Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism
44. Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes
45. Excitatory amino acid neurotoxicity and neurodegenerative disease
46. NMDA and non-NMDA receptor-stimulated IkappaB-alpha degradation: Differential effects of the caspase-3 inhibitor DEVD.CHO, ethanol and free radical scavenger OPC-14117
47. Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice
48. Excitotoxicity: An overview
49. Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes
50. Nitric oxide toxicity in islet cells involves poly(ADP-ribose) polymerase activation and concomitant NAD+ depletion
51. Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein
52. NF-kappaB is activated and promotes cell death in focal cerebral ischemia
53. Role of nitric oxide in neurodegenerative diseases
54. Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo
55. Peroxynitrite production and activation of poly (adenosine diphosphate-ribose) synthetase in spinal cord injury
56. Complete inhibition of poly(ADP-ribose) polymerase activity prevents the recovery of C3H10T1/2 cells from oxidative stress
57. Poly(ADP-ribose) polymerase inhibitors preserve nicotinamide adenine dinucleotide and adenosine 5'-triphosphate pools in DNA-damaged cells: Mechanism of stimulation of unscheduled DNA synthesis
58. Neuroprotective effects of poly (ADP-ribose) polymerase inhibitors in transient focal cerebral ischemia of rats
59. Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion
60. Partial protective effect of MK-801 on MPTP-induced reduction of striatal dopamine in mice
61. The effect of reperfusion on neuroprotection using an inhibitor of poly(ADP-ribose) polymerase
62. Post-treatment with an inhibitor of poly(ADP-ribose) polymerase attenuates cerebral damage in focal ischemia
63. Early postischemic dantrolene-induced amelioration of poly(ADP-ribose) polymerase-related bioenergetic failure in neonatal rat brain slices
64. Enhanced poly(ADP-ribosyl)ation after focal ischemia in rat brain
65. Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists
66. PARP is important for genomic stability but dispensable in apoptosis
67. NMDAR1 glutamate receptor subunit isoforms in neostriatal, neocortical, and hippocampal nitric oxide synthase neurons
68. Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury
69. Poly(ADP-ribose) synthetase activation: An early indicator of neurotoxic DNA damage
70. Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity