Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiology

Biochimica et Biophysica Acta - General Subjects

Volumn 1840, Issue 8, 2014, Pages 2460-2470

  Nastase, Madalina V ^a   Iozzo, Renato V ^b   Schaefer, Liliana ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Biglycan; Cancer; Decorin; Extracellular matrix; TGF ; Toll like receptor

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BIGLYCAN; BRONCHODILATING AGENT; CONNECTIVE TISSUE GROWTH FACTOR; CORTICOSTEROID; DECORIN; FLUTICASONE; LUMICAN; PROTEOGLYCAN; SMALL LEUCINE RICH PROTEOGLYCAN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ACUTE LUNG INJURY; ADULT RESPIRATORY DISTRESS SYNDROME; AIRWAY REMODELING; ARTICLE; ASTHMA; BLEOMYCIN-INDUCED PULMONARY FIBROSIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; DIABETIC NEPHROPATHY; FIBROSING ALVEOLITIS; HUMAN; KIDNEY DISEASE; KIDNEY FIBROSIS; LUNG ADENOCARCINOMA; LUNG CANCER; LUNG DISEASE; LUNG FIBROSIS; LUNG INFECTION; LUNG METASTASIS; LUNG SQUAMOUS CELL CARCINOMA; LUPUS ERYTHEMATOSUS NEPHRITIS; NEPHRITIS; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS INFECTION; SEPSIS; TUMOR GROWTH; TUMOR VASCULARIZATION;

BIGLYCAN; CANCER; DECORIN; EXTRACELLULAR MATRIX; TGF-Β; TOLL-LIKE RECEPTOR;

ANIMALS; HUMANS; KIDNEY; KIDNEY DISEASES; LUNG; LUNG DISEASES; PROTEINS; PROTEOGLYCANS;

EID: 84903516732     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2014.01.035     Document Type: Article

References (195)

1. L. Schaefer, and R.V. Iozzo Biological functions of the small leucine-rich proteoglycans: from genetics to signal transduction J. Biol. Chem. 283 2008 21305 21309
2. A.M. Hocking, T. Shinomura, and D.J. McQuillan Leucine-rich repeat glycoproteins of the extracellular matrix Matrix Biol. 17 1998 1 19
3. H. Park, J. Huxley-Jones, R.P. Boot-Handford, P.N. Bishop, T.K. Attwood, and J. Bella LRRCE: a leucine-rich repeat cysteine capping motif unique to the chordate lineage BMC Genomics 9 2008 599
4. R.V. Iozzo, and L. Schaefer Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans FEBS J. 277 2010 3864 3875
5. D. Nikitovic, J. Aggelidakis, M.F. Young, R.V. Iozzo, N.K. Karamanos, and G.N. Tzanakakis The biology of small leucine-rich proteoglycans in bone pathophysiology J. Biol. Chem. 287 2012 33926 33933
6. S. Chen, and D.E. Birk The regulatory roles of small leucine-rich proteoglycans in extracellular matrix assembly FEBS J. 280 2013 2120 2137
7. R.V. Iozzo The biology of the small leucine-rich proteoglycans. Functional network of interactive proteins J. Biol. Chem. 274 1999 18843 18846
8. L. Schaefer, and R.M. Schaefer Proteoglycans: from structural compounds to signaling molecules Cell Tissue Res. 339 2010 237 246
9. L. Schaefer, and R.V. Iozzo Small leucine-rich proteoglycans, at the crossroad of cancer growth and inflammation Curr. Opin. Genet. Dev. 22 2012 56 57
10. K. Imai, A. Hiramatsu, D. Fukushima, M.D. Pierschbacher, and Y. Okada Degradation of decorin by matrix metalloproteinases: identification of the cleavage sites, kinetic analyses and transforming growth factor-beta1 release Biochem. J. 322 Pt 3 1997 809 814
11. W.A. Boivin, M. Shackleford, A. Vanden Hoek, H. Zhao, T.L. Hackett, D.A. Knight, and D.J. Granville Granzyme B cleaves decorin, biglycan and soluble betaglycan, releasing active transforming growth factor-beta1 PLoS ONE 7 2012 e33163
12. T.F. Heathfield, P. Onnerfjord, L. Dahlberg, and D. Heinegard Cleavage of fibromodulin in cartilage explants involves removal of the N-terminal tyrosine sulfate-rich region by proteolysis at a site that is sensitive to matrix metalloproteinase-13 J. Biol. Chem. 279 2004 6286 6295
13. L.I. Melching, W.D. Fisher, E.R. Lee, J.S. Mort, and P.J. Roughley The cleavage of biglycan by aggrecanases Osteoarthritis Cartilage 14 2006 1147 1154
14. R. Fleischmajer, L.W. Fisher, E.D. MacDonald, L. Jacobs Jr., J.S. Perlish, and J.D. Termine Decorin interacts with fibrillar collagen of embryonic and adult human skin J. Struct. Biol. 106 1991 82 90
15. L. Svensson, D. Heinegard, and A. Oldberg Decorin-binding sites for collagen type I are mainly located in leucine-rich repeats 4-5 J. Biol. Chem. 270 1995 20712 20716
16. T. Douglas, S. Heinemann, S. Bierbaum, D. Scharnweber, and H. Worch Fibrillogenesis of collagen types I II, and III with small leucine-rich proteoglycans decorin and biglycan Biomacromolecules 7 2006 2388 2393
17. C. Wiberg, E. Hedbom, A. Khairullina, S.R. Lamande, A. Oldberg, R. Timpl, M. Morgelin, and D. Heinegard Biglycan and decorin bind close to the N-terminal region of the collagen VI triple helix J. Biol. Chem. 276 2001 18947 18952
18. E. Schonherr, P. Witsch-Prehm, B. Harrach, H. Robenek, J. Rauterberg, and H. Kresse Interaction of biglycan with type I collagen J. Biol. Chem. 270 1995 2776 2783
19. L. Svensson, I. Narlid, and A. Oldberg Fibromodulin and lumican bind to the same region on collagen type I fibrils FEBS Lett. 470 2000 178 182
20. S. Kalamajski, A. Aspberg, K. Lindblom, D. Heinegard, and A. Oldberg Asporin competes with decorin for collagen binding, binds calcium and promotes osteoblast collagen mineralization Biochem. J. 423 2009 53 59
21. A. Markmann, H. Hausser, E. Schonherr, and H. Kresse Influence of decorin expression on transforming growth factor-beta-mediated collagen gel retraction and biglycan induction Matrix Biol. 19 2000 631 636
22. E.J. Sanders, M.A. Walter, E. Parker, C. Aramburo, and S. Harvey Opticin binds retinal growth hormone in the embryonic vitreous Invest. Ophthalmol. Vis. Sci. 44 2003 5404 5409
23. M.C. Embree, T.M. Kilts, M. Ono, C.A. Inkson, F. Syed-Picard, M.A. Karsdal, A. Oldberg, Y. Bi, and M.F. Young Biglycan and fibromodulin have essential roles in regulating chondrogenesis and extracellular matrix turnover in temporomandibular joint osteoarthritis Am. J. Pathol. 176 2010 812 826
24. L. Schaefer, A. Babelova, E. Kiss, H.J. Hausser, M. Baliova, M. Krzyzankova, G. Marsche, M.F. Young, D. Mihalik, M. Gotte, E. Malle, R.M. Schaefer, and H.J. Grone The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages J. Clin. Invest. 115 2005 2223 2233
25. R. Merline, K. Moreth, J. Beckmann, M.V. Nastase, J. Zeng-Brouwers, J.G. Tralhao, P. Lemarchand, J. Pfeilschifter, R.M. Schaefer, R.V. Iozzo, and L. Schaefer Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21 Sci. Signal. 4 2011 ra75
26. S. Buraschi, T. Neill, A. Goyal, C. Poluzzi, J. Smythies, R.T. Owens, L. Schaefer, A. Torres, and R.V. Iozzo Decorin causes autophagy in endothelial cells via Peg3 Proc. Natl. Acad. Sci. U. S. A. 110 2013 E2582 E2591
27. R.V. Iozzo, D.K. Moscatello, D.J. McQuillan, and I. Eichstetter Decorin is a biological ligand for the epidermal growth factor receptor J. Biol. Chem. 274 1999 4489 4492
28. L. Schaefer, W. Tsalastra, A. Babelova, M. Baliova, J. Minnerup, L. Sorokin, H.J. Grone, D.P. Reinhardt, J. Pfeilschifter, R.V. Iozzo, and R.M. Schaefer Decorin-mediated regulation of fibrillin-1 in the kidney involves the insulin-like growth factor-I receptor and mammalian target of rapamycin Am. J. Pathol. 170 2007 301 315
29. M.F. D'Onofrio, S. Brezillon, T. Baranek, C. Perreau, P.J. Roughley, F.X. Maquart, and Y. Wegrowski Identification of beta1 integrin as mediator of melanoma cell adhesion to lumican Biochem. Biophys. Res. Commun. 365 2008 266 272
30. G. Guidetti, A. Bertoni, M. Viola, E. Tira, C. Balduini, and M. Torti The small proteoglycan decorin supports adhesion and activation of human platelets Blood 100 2002 1707 1714
31. L.R. Fiedler, E. Schonherr, R. Waddington, S. Niland, D.G. Seidler, D. Aeschlimann, and J.A. Eble Decorin regulates endothelial cell motility on collagen I through activation of insulin-like growth factor I receptor and modulation of alpha2beta1 integrin activity J. Biol. Chem. 283 2008 17406 17415
32. C. Zeltz, S. Brezillon, J. Kapyla, J.A. Eble, H. Bobichon, C. Terryn, C. Perreau, C.M. Franz, J. Heino, F.X. Maquart, and Y. Wegrowski Lumican inhibits cell migration through alpha2beta1 integrin Exp. Cell Res. 316 2010 2922 2931
33. J. Niewiarowska, S. Brezillon, I. Sacewicz-Hofman, R. Bednarek, F.X. Maquart, M. Malinowski, M. Wiktorska, Y. Wegrowski, and C.S. Cierniewski Lumican inhibits angiogenesis by interfering with alpha2beta1 receptor activity and downregulating MMP-14 expression Thromb. Res. 128 2011 452 457
34. E. Brandan, C. Retamal, C. Cabello-Verrugio, and M.P. Marzolo The low density lipoprotein receptor-related protein functions as an endocytic receptor for decorin J. Biol. Chem. 281 2006 31562 31571
35. A.D. Berendsen, L.W. Fisher, T.M. Kilts, R.T. Owens, P.G. Robey, J.S. Gutkind, and M.F. Young Modulation of canonical Wnt signaling by the extracellular matrix component biglycan Proc. Natl. Acad. Sci. U. S. A. 108 2011 17022 17027
36. S. Goldoni, A. Humphries, A. Nystrom, S. Sattar, R.T. Owens, D.J. McQuillan, K. Ireton, and R.V. Iozzo Decorin is a novel antagonistic ligand of the Met receptor J. Cell Biol. 185 2009 743 754
37. S. Buraschi, N. Pal, N. Tyler-Rubinstein, R.T. Owens, T. Neill, and R.V. Iozzo Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels J. Biol. Chem. 285 2010 42075 42085
38. K.G. Danielson, H. Baribault, D.F. Holmes, H. Graham, K.E. Kadler, and R.V. Iozzo Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility J. Cell Biol. 136 1997 729 743
39. C.C. Reed, and R.V. Iozzo The role of decorin in collagen fibrillogenesis and skin homeostasis Glycoconj. J. 19 2002 249 255
40. G. Zhang, S. Chen, S. Goldoni, B.W. Calder, H.C. Simpson, R.T. Owens, D.J. McQuillan, M.F. Young, R.V. Iozzo, and D.E. Birk Genetic evidence for the coordinated regulation of collagen fibrillogenesis in the cornea by decorin and biglycan J. Biol. Chem. 284 2009 8888 8897
41. E. Schonherr, C. Sunderkotter, L. Schaefer, S. Thanos, S. Grassel, A. Oldberg, R.V. Iozzo, M.F. Young, and H. Kresse Decorin deficiency leads to impaired angiogenesis in injured mouse cornea J. Vasc. Res. 41 2004 499 508
42. A. Fust, F. LeBellego, R.V. Iozzo, P.J. Roughley, and M.S. Ludwig Alterations in lung mechanics in decorin-deficient mice Am. J. Physiol. Lung Cell. Mol. Physiol. 288 2005 L159 L166
43. X. Bi, C. Tong, A. Dockendorff, L. Bancroft, L. Gallagher, G. Guzman, R.V. Iozzo, L.H. Augenlicht, and W. Yang Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation Carcinogenesis 29 2008 1435 1440
44. T. Xu, P. Bianco, L.W. Fisher, G. Longenecker, E. Smith, S. Goldstein, J. Bonadio, A. Boskey, A.M. Heegaard, B. Sommer, K. Satomura, P. Dominguez, C. Zhao, A.B. Kulkarni, P.G. Robey, and M.F. Young Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice Nat. Genet. 20 1998 78 82
45. L. Ameye, D. Aria, K. Jepsen, A. Oldberg, T. Xu, and M.F. Young Abnormal collagen fibrils in tendons of biglycan/fibromodulin-deficient mice lead to gait impairment, ectopic ossification, and osteoarthritis FASEB J. 16 2002 673 680
46. A. Corsi, T. Xu, X.D. Chen, A. Boyde, J. Liang, M. Mankani, B. Sommer, R.V. Iozzo, I. Eichstetter, P.G. Robey, P. Bianco, and M.F. Young Phenotypic effects of biglycan deficiency are linked to collagen fibril abnormalities, are synergized by decorin deficiency, and mimic Ehlers-Danlos-like changes in bone and other connective tissues J. Bone Miner. Res. 17 2002 1180 1189
47. Y. Bi, C.H. Stuelten, T. Kilts, S. Wadhwa, R.V. Iozzo, P.G. Robey, X.D. Chen, and M.F. Young Extracellular matrix proteoglycans control the fate of bone marrow stromal cells J. Biol. Chem. 280 2005 30481 30489
48. L. Ameye, and M.F. Young Mice deficient in small leucine-rich proteoglycans: novel in vivo models for osteoporosis, osteoarthritis Ehlers-Danlos syndrome, muscular dystrophy, and corneal diseases Glycobiology 12 2002 107R 116R
49. M. Goldberg, M. Ono, D. Septier, M. Bonnefoix, T.M. Kilts, Y. Bi, M. Embree, L. Ameye, and M.F. Young Fibromodulin-deficient mice reveal dual functions for fibromodulin in regulating dental tissue and alveolar bone formation Cells Tissues Organs 189 2009 198 202
50. Z. Zheng, C. Nguyen, X. Zhang, H. Khorasani, J.Z. Wang, J.N. Zara, F. Chu, W. Yin, S. Pang, A. Le, K. Ting, and C. Soo Delayed wound closure in fibromodulin-deficient mice is associated with increased TGF-beta3 signaling J. Invest. Dermatol. 131 2011 769 778
51. S. Chakravarti Functions of lumican and fibromodulin: lessons from knockout mice Glycoconj. J. 19 2002 287 293
52. C.Y. Liu, D.E. Birk, J.R. Hassell, B. Kane, and W.W. Kao Keratocan-deficient mice display alterations in corneal structure J. Biol. Chem. 278 2003 21672 21677
53. S. Nuka, W. Zhou, S.P. Henry, C.M. Gendron, J.B. Schultz, T. Shinomura, J. Johnson, Y. Wang, D.R. Keene, R. Ramirez-Solis, R.R. Behringer, M.F. Young, and M. Hook Phenotypic characterization of epiphycan-deficient and epiphycan/biglycan double-deficient mice Osteoarthritis Cartilage 18 2010 88 96
54. R. Merline, R.M. Schaefer, and L. Schaefer The matricellular functions of small leucine-rich proteoglycans (SLRPs) J. Cell Commun. Signal. 3 2009 323 335
55. S. Kalamajski, and A. Oldberg The role of small leucine-rich proteoglycans in collagen fibrillogenesis Matrix Biol. 29 2010 248 253
56. A.D. Theocharis, S.S. Skandalis, G.N. Tzanakakis, and N.K. Karamanos Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting FEBS J. 277 2010 3904 3923
57. L. Schaefer Small leucine-rich proteoglycans in kidney disease J. Am. Soc. Nephrol. 22 2011 1200 1207
58. K. Moreth, R.V. Iozzo, and L. Schaefer Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation Cell Cycle 11 2012 2084 2091
59. T. Neill, L. Schaefer, and R.V. Iozzo Decorin: a guardian from the matrix Am. J. Pathol. 181 2012 380 387
60. M.V. Nastase, M.F. Young, and L. Schaefer Biglycan: a multivalent proteoglycan providing structure and signals J. Histochem. Cytochem. 60 2012 963 975
61. H. Frey, N. Schroeder, T. Manon-Jensen, R.V. Iozzo, and L. Schaefer Biological interplay between proteoglycans and their innate immune receptors in inflammation FEBS J. 280 2013 2165 2179
62. D.J. Pierson Respiratory considerations in the patient with renal failure Respir Care 51 2006 413 422
63. H.Y. Lee, T.B. Stretton, and A.M. Barnes The lungs in renal failure Thorax 30 1975 46 53
64. J.L. Koyner, and P.T. Murray Mechanical ventilation and lung-kidney interactions Clin. J. Am. Soc. Nephrol. 3 2008 562 570
65. S.C. Yap, and H.T. Lee Acute kidney injury and extrarenal organ dysfunction: new concepts and experimental evidence Anesthesiology 116 2012 1139 1148
66. P. Boor, K. Sebekova, T. Ostendorf, and J. Floege Treatment targets in renal fibrosis Nephrol. Dial. Transplant. 22 2007 3391 3407
67. Y. Liu Renal fibrosis: new insights into the pathogenesis and therapeutics Kidney Int. 69 2006 213 217
68. J. Liang, S. Tian, J. Han, and P. Xiong Resveratrol as a therapeutic agent for renal fibrosis induced by unilateral ureteral obstruction, Ren Fail 2013
69. A. Ghayur, and P.J. Margetts Transforming growth factor-beta and the glomerular filtration barrier Kidney Res. Clin. Pract. 32 2013 3 10
70. M.E. Choi, Y. Ding, and S.I. Kim TGF-beta signaling via TAK1 pathway: role in kidney fibrosis Semin. Nephrol. 32 2012 244 252
71. Y. Yamaguchi, D.M. Mann, and E. Ruoslahti Negative regulation of transforming growth factor-beta by the proteoglycan decorin Nature 346 1990 281 284
72. W.A. Border, N.A. Noble, T. Yamamoto, J.R. Harper, Y. Yamaguchi, M.D. Pierschbacher, and E. Ruoslahti Natural inhibitor of transforming growth factor-beta protects against scarring in experimental kidney disease Nature 360 1992 361 364
73. E. Brandan, C. Cabello-Verrugio, and C. Vial Novel regulatory mechanisms for the proteoglycans decorin and biglycan during muscle formation and muscular dystrophy Matrix Biol. 27 2008 700 708
74. M. Kolb, P.J. Margetts, P.J. Sime, and J. Gauldie Proteoglycans decorin and biglycan differentially modulate TGF-beta-mediated fibrotic responses in the lung Am. J. Physiol. Lung Cell. Mol. Physiol. 280 2001 L1327 L1334
75. C. Alan, H. Kocoglu, R. Altintas, B. Alici, and A. Resit Ersay Protective effect of decorin on acute ischaemia-reperfusion injury in the rat kidney Arch. Med. Sci. 7 2011 211 216
76. A. Al Haj Zen, G. Caligiuri, J. Sainz, M. Lemitre, C. Demerens, and A. Lafont Decorin overexpression reduces atherosclerosis development in apolipoprotein E-deficient mice Atherosclerosis 187 2006 31 39
77. T.A. Jarvinen Design of target-seeking antifibrotic compounds Methods Enzymol. 509 2012 243 261
78. P. Bianco, L.W. Fisher, M.F. Young, J.D. Termine, and P.G. Robey Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues J. Histochem. Cytochem. 38 1990 1549 1563
79. L. Schaefer, H. Hausser, M. Altenburger, J. Ugorcakova, C. August, L.W. Fisher, R.M. Schaefer, and H. Kresse Decorin, biglycan and their endocytosis receptor in rat renal cortex Kidney Int. 54 1998 1529 1541
80. M.B. Stokes, K.L. Hudkins, V. Zaharia, S. Taneda, and C.E. Alpers Up-regulation of extracellular matrix proteoglycans and collagen type I in human crescentic glomerulonephritis Kidney Int. 59 2001 532 542
81. A. Mogyorosi, and F.N. Ziyadeh What is the role of decorin in diabetic kidney disease? Nephrol. Dial. Transplant. 14 1999 1078 1081
82. K. Suzuki, R. Wang, H. Kubota, H. Shibuya, J. Saegusa, and T. Sato Kinetics of biglycan, decorin and thrombospondin-1 in mercuric chloride-induced renal tubulointerstitial fibrosis Exp. Mol. Pathol. 79 2005 68 73
83. L. Schaefer, K. Macakova, I. Raslik, M. Micegova, H.J. Grone, E. Schonherr, H. Robenek, F.G. Echtermeyer, S. Grassel, P. Bruckner, R.M. Schaefer, R.V. Iozzo, and H. Kresse Absence of decorin adversely influences tubulointerstitial fibrosis of the obstructed kidney by enhanced apoptosis and increased inflammatory reaction Am. J. Pathol. 160 2002 1181 1191
84. K.J. Williams, G. Qiu, H.K. Usui, S.R. Dunn, P. McCue, E. Bottinger, R.V. Iozzo, and K. Sharma Decorin deficiency enhances progressive nephropathy in diabetic mice Am. J. Pathol. 171 2007 1441 1450
85. R. Merline, S. Lazaroski, A. Babelova, W. Tsalastra-Greul, J. Pfeilschifter, K.D. Schluter, A. Gunther, R.V. Iozzo, R.M. Schaefer, and L. Schaefer Decorin deficiency in diabetic mice: aggravation of nephropathy due to overexpression of profibrotic factors, enhanced apoptosis and mononuclear cell infiltration J. Physiol. Pharmacol. 60 Suppl. 4 2009 5 13
86. J.Y. Sun, Y. Sun, H.J. Wu, H.X. Zhang, Z.H. Zhao, Q. Chen, and Z.G. Zhang Transgene therapy for rat anti-Thy1.1 glomerulonephritis via mesangial cell vector with a polyethylenimine/decorin nanocomplex Nanoscale research letters 7 2012 451
87. A. Hildebrand, M. Romaris, L.M. Rasmussen, D. Heinegard, D.R. Twardzik, W.A. Border, and E. Ruoslahti Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta Biochem. J. 302 Pt 2 1994 527 534
88. R. Droguett, C. Cabello-Verrugio, C. Riquelme, and E. Brandan Extracellular proteoglycans modify TGF-beta bio-availability attenuating its signaling during skeletal muscle differentiation Matrix Biol. 25 2006 332 341
89. L. Schaefer, D. Mihalik, A. Babelova, M. Krzyzankova, H.J. Grone, R.V. Iozzo, M.F. Young, D.G. Seidler, G. Lin, D.P. Reinhardt, and R.M. Schaefer Regulation of fibrillin-1 by biglycan and decorin is important for tissue preservation in the kidney during pressure-induced injury Am. J. Pathol. 165 2004 383 396
90. D.R. Brigstock Connective tissue growth factor (CCN2, CTGF) and organ fibrosis: lessons from transgenic animals J. Cell Commun. Signal. 4 2010 1 4
91. C.M. Tran, I.M. Shapiro, and M.V. Risbud Molecular regulation of CCN2 in the intervertebral disc: lessons learned from other connective tissues Matrix Biol. 32 2013 298 306
92. L.L. Falke, A. Dendooven, J.W. Leeuwis, T.Q. Nguyen, R.J. van Geest, D.M. van der Giezen, R. Broekhuizen, K. Lyons, R. Stoop, H. Kemperman, R. Schlingemann, J.A. Joles, and R. Goldschmeding Hemizygous deletion of CTGF/CCN2 does not suffice to prevent fibrosis of the severely injured kidney Matrix Biol. 31 2012 421 431
93. A. Leask, S.K. Parapuram, X. Shi-Wen, and D.J. Abraham Connective tissue growth factor (CTGF, CCN2) gene regulation: a potent clinical bio-marker of fibroproliferative disease? J. Cell Commun. Signal. 3 2009 89 94
94. C. Vial, J. Gutierrez, C. Santander, D. Cabrera, and E. Brandan Decorin interacts with connective tissue growth factor (CTGF)/CCN2 by LRR12 inhibiting its biological activity J. Biol. Chem. 286 2011 24242 24252
95. Y. Ito, J. Aten, R.J. Bende, B.S. Oemar, T.J. Rabelink, J.J. Weening, and R. Goldschmeding Expression of connective tissue growth factor in human renal fibrosis Kidney Int. 53 1998 853 861
96. L. Schaefer, I. Raslik, H.J. Grone, E. Schonherr, K. Macakova, J. Ugorcakova, S. Budny, R.M. Schaefer, and H. Kresse Small proteoglycans in human diabetic nephropathy: discrepancy between glomerular expression and protein accumulation of decorin, biglycan, lumican, and fibromodulin FASEB J. 15 2001 559 561
97. M.M. Mozes, E.P. Bottinger, T.A. Jacot, and J.B. Kopp Renal expression of fibrotic matrix proteins and of transforming growth factor-beta (TGF-beta) isoforms in TGF-beta transgenic mice J. Am. Soc. Nephrol. 10 1999 271 280
98. W.A. Border, S. Okuda, L.R. Languino, and E. Ruoslahti Transforming growth factor-beta regulates production of proteoglycans by mesangial cells Kidney Int. 37 1990 689 695
99. M.B. Stokes, S. Holler, Y. Cui, K.L. Hudkins, F. Eitner, A. Fogo, and C.E. Alpers Expression of decorin, biglycan, and collagen type I in human renal fibrosing disease Kidney Int. 57 2000 487 498
100. W.P. Pulskens, E. Rampanelli, G.J. Teske, L.M. Butter, N. Claessen, I.K. Luirink, T. van der Poll, S. Florquin, and J.C. Leemans TLR4 promotes fibrosis but attenuates tubular damage in progressive renal injury J. Am. Soc. Nephrol. 21 2010 1299 1308
101. J.C. Leemans, L.M. Butter, W.P. Pulskens, G.J. Teske, N. Claessen, T. van der Poll, and S. Florquin The role of Toll-like receptor 2 in inflammation and fibrosis during progressive renal injury PLoS ONE 4 2009 e5704
102. V. Friden, E. Oveland, O. Tenstad, K. Ebefors, J. Nystrom, U.A. Nilsson, and B. Haraldsson The glomerular endothelial cell coat is essential for glomerular filtration Kidney Int. 79 2011 1322 1330
103. A. Krishnan, X. Li, W.Y. Kao, K. Viker, K. Butters, H. Masuoka, B. Knudsen, G. Gores, and M. Charlton Lumican, an extracellular matrix proteoglycan, is a novel requisite for hepatic fibrosis Lab. Invest. 92 2012 1712 1725
104. E. Mormone, Y. Lu, X. Ge, M.I. Fiel, and N. Nieto Fibromodulin, an oxidative stress-sensitive proteoglycan, regulates the fibrogenic response to liver injury in mice Gastroenterology 142 2012 612 621 (e615)
105. K. Baghy, K. Dezso, V. Laszlo, A. Fullar, B. Peterfia, S. Paku, P. Nagy, Z. Schaff, R.V. Iozzo, and I. Kovalszky Ablation of the decorin gene enhances experimental hepatic fibrosis and impairs hepatic healing in mice Lab. Invest. 91 2011 439 451
106. A. Babelova, K. Moreth, W. Tsalastra-Greul, J. Zeng-Brouwers, O. Eickelberg, M.F. Young, P. Bruckner, J. Pfeilschifter, R.M. Schaefer, H.J. Grone, and L. Schaefer Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors J. Biol. Chem. 284 2009 24035 24048
107. K. Moreth, R. Brodbeck, A. Babelova, N. Gretz, T. Spieker, J. Zeng-Brouwers, J. Pfeilschifter, M.F. Young, R.M. Schaefer, and L. Schaefer The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis J. Clin. Invest. 120 2010 4251 4272
108. Z.V. Popovic, S. Wang, M. Papatriantafyllou, Z. Kaya, S. Porubsky, M. Meisner, M. Bonrouhi, S. Burgdorf, M.F. Young, L. Schaefer, and H.J. Grone The proteoglycan biglycan enhances antigen-specific T cell activation potentially via MyD88 and TRIF pathways and triggers autoimmune perimyocarditis J. Immunol. 187 2011 6217 6226
109. V. Skuginna, M. Lech, R. Allam, M. Ryu, S. Clauss, H.E. Susanti, C. Rommele, C. Garlanda, A. Mantovani, and H.J. Anders Toll-like receptor signaling and SIGIRR in renal fibrosis upon unilateral ureteral obstruction PLoS ONE 6 2011 e19204
110. H. Wu, G. Chen, K.R. Wyburn, J. Yin, P. Bertolino, J.M. Eris, S.I. Alexander, A.F. Sharland, and S.J. Chadban TLR4 activation mediates kidney ischemia/reperfusion injury J. Clin. Invest. 117 2007 2847 2859
111. S. Wang, C. Schmaderer, E. Kiss, C. Schmidt, M. Bonrouhi, S. Porubsky, N. Gretz, L. Schaefer, C.J. Kirschning, Z.V. Popovic, and H.J. Grone Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88- and TRIF-dependent signaling Dis. Model. Mech. 3 2010 92 103
112. E. Kiss, Z.V. Popovic, J. Bedke, J. Adams, M. Bonrouhi, A. Babelova, C. Schmidt, F. Edenhofer, I. Zschiedrich, S. Domhan, A. Abdollahi, L. Schafer, N. Gretz, S. Porubsky, and H.J. Grone Peroxisome proliferator-activated receptor (PPAR)gamma can inhibit chronic renal allograft damage Am. J. Pathol. 176 2010 2150 2162
113. J. Zeng-Brouwers, J. Beckmann, M.V. Nastase, R.V. Iozzo, and L. Schaefer De novo expression of circulating biglycan evokes an innate inflammatory tissue response via MyD88/TRIF pathways Matrix Biol. 2013 10.1016/j.matbio.2013.12.003
114. A.K. Lim, and G.H. Tesch Inflammation in diabetic nephropathy Mediat. Inflamm. 2012 2012 146154
115. J. Thompson, P. Wilson, K. Brandewie, D. Taneja, L. Schaefer, B. Mitchell, and L.R. Tannock Renal accumulation of biglycan and lipid retention accelerates diabetic nephropathy Am. J. Pathol. 179 2011 1179 1187
116. L.R. Tannock Proteoglycans can mediate renal lipoprotein retention Diabetologia 49 2006 1115 1116
117. Y. Zhang, R. Hu, H. Wu, W. Jiang, Y. Sun, Y. Wang, Y. Song, T. Jin, H. Zhang, X. Mao, Z. Zhao, and Z. Zhang OTUB1 overexpression in mesangial cells is a novel regulator in the pathogenesis of glomerulonephritis through the decrease of DCN level PLoS ONE 7 2012 e29654
118. K. Ebefors, A. Granqvist, M. Ingelsten, J. Molne, B. Haraldsson, and J. Nystrom Role of glomerular proteoglycans in IgA nephropathy PLoS ONE 6 2011 e18575
119. F. Sallustio, V. Costantino, S.N. Cox, A. Loverre, C. Divella, M. Rizzi, and F.P. Schena Human renal stem/progenitor cells repair tubular epithelial cell injury through TLR2-driven inhibin-A and microvesicle-shuttled decorin Kidney Int. 83 2013 392 403
120. Y.M. Kim, Y.S. Kim, S.G. Jeon, and Y.K. Kim Immunopathogenesis of allergic asthma: more than the th2 hypothesis Allergy Asthma Immunol. Res. 5 2013 189 196
121. L. Pini, Q. Hamid, J. Shannon, L. Lemelin, R. Olivenstein, P. Ernst, C. Lemiere, J.G. Martin, and M.S. Ludwig Differences in proteoglycan deposition in the airways of moderate and severe asthmatics Eur. Respir. J. 29 2007 71 77
122. C.L. Marchica, V. Pinelli, M. Borges, J. Zummer, V. Narayanan, R.V. Iozzo, and M.S. Ludwig A role for decorin in a murine model of allergen-induced asthma Am. J. Physiol. Lung Cell. Mol. Physiol. 300 2011 L863 L873
123. J. Huang, R. Olivenstein, R. Taha, Q. Hamid, and M. Ludwig Enhanced proteoglycan deposition in the airway wall of atopic asthmatics Am. J. Respir. Crit. Care Med. 160 1999 725 729
124. J. de Kluijver, J.A. Schrumpf, C.E. Evertse, J.K. Sont, P.J. Roughley, K.F. Rabe, P.S. Hiemstra, T. Mauad, and P.J. Sterk Bronchial matrix and inflammation respond to inhaled steroids despite ongoing allergen exposure in asthma Clin. Exp. Allergy 35 2005 1361 1369
125. C.R. Roberts Is asthma a fibrotic disease? Chest 107 1995 111S 117S
126. M. de Medeiros Matsushita, L.F. da Silva, M.A. dos Santos, S. Fernezlian, J.A. Schrumpf, P. Roughley, P.S. Hiemstra, P.H. Saldiva, T. Mauad, and M. Dolhnikoff Airway proteoglycans are differentially altered in fatal asthma J. Pathol. 207 2005 102 110
127. G. Westergren-Thorsson, J. Chakir, M.J. Lafreniere-Allard, L.P. Boulet, and G.M. Tremblay Correlation between airway responsiveness and proteoglycan production by bronchial fibroblasts from normal and asthmatic subjects Int. J. Biochem. Cell Biol. 34 2002 1256 1267
128. M.S. Ludwig, N. Ftouhi-Paquin, W. Huang, N. Page, J. Chakir, and Q. Hamid Mechanical strain enhances proteoglycan message in fibroblasts from asthmatic subjects Clin. Exp. Allergy 34 2004 926 930
129. K. Nihlberg, A. Andersson-Sjoland, E. Tufvesson, J.S. Erjefalt, L. Bjermer, and G. Westergren-Thorsson Altered matrix production in the distal airways of individuals with asthma Thorax 65 2010 670 676
130. L. Pini, C. Torregiani, J.G. Martin, Q. Hamid, and M.S. Ludwig Airway remodeling in allergen-challenged Brown Norway rats: distribution of proteoglycans Am. J. Physiol. Lung Cell. Mol. Physiol. 290 2006 L1052 L1058
131. A.E. Redington, W.R. Roche, S.T. Holgate, and P.H. Howarth Co-localization of immunoreactive transforming growth factor-beta 1 and decorin in bronchial biopsies from asthmatic and normal subjects J. Pathol. 186 1998 410 415
132. A.E. Redington, and P.H. Howarth Airway wall remodelling in asthma Thorax 52 1997 310 312
133. J.Y. Cho Recent advances in mechanisms and treatments of airway remodeling in asthma: a message from the bench side to the clinic Korean J. Intern. Med. 26 2011 367 383
134. J.L. Black, J.K. Burgess, and P.R. Johnson Airway smooth muscle - its relationship to the extracellular matrix Respir. Physiol. Neurobiol. 137 2003 339 346
135. B.B. Araujo, M. Dolhnikoff, L.F. Silva, J. Elliot, J.H. Lindeman, D.S. Ferreira, A. Mulder, H.A. Gomes, S.M. Fernezlian, A. James, and T. Mauad Extracellular matrix components and regulators in the airway smooth muscle in asthma Eur. Respir. J. 32 2008 61 69
136. C.Y. Yick, D.S. Ferreira, R. Annoni, J.H. von der Thusen, P.W. Kunst, E.H. Bel, R. Lutter, T. Mauad, and P.J. Sterk Extracellular matrix in airway smooth muscle is associated with dynamics of airway function in asthma Allergy 67 2012 552 559
137. B.E. McParland, P.T. Macklem, and P.D. Pare Airway wall remodeling: friend or foe? J. Appl. Physiol. 95 2003 426 434
138. S.E. Bottoms, J.E. Howell, A.K. Reinhardt, I.C. Evans, and R.J. McAnulty Tgf-Beta isoform specific regulation of airway inflammation and remodelling in a murine model of asthma PLoS ONE 5 2010 e9674
139. J.A. Elias Airway remodeling in asthma. Unanswered questions Am. J. Respir. Crit. Care Med. 161 2000 S168 S171
140. D.J. Tschumperlin, and J.M. Drazen Mechanical stimuli to airway remodeling Am. J. Respir. Crit. Care Med. 164 2001 S90 S94
141. S.M. Pasternyk, M.L. D'Antoni, N. Venkatesan, S. Siddiqui, J.G. Martin, and M.S. Ludwig Differential effects of extracellular matrix and mechanical strain on airway smooth muscle cells from ovalbumin- vs. saline-challenged Brown Norway rats Respir. Physiol. Neurobiol. 181 2012 36 43
142. B.M. Varisco The pharmacology of acute lung injury in sepsis Adv. Pharmacol. Sci. 2011 2011 254619
143. H. Shao, S. Lee, S. Gae-Scott, C. Nakata, S. Chen, A.R. Hamad, and S. Chakravarti Extracellular matrix lumican promotes bacterial phagocytosis, and Lum -/- mice show increased Pseudomonas aeruginosa lung infection severity J. Biol. Chem. 287 2012 35860 35872
144. H. Shao, S.G. Scott, C. Nakata, A.R. Hamad, and S. Chakravarti Extracellular matrix protein lumican promotes clearance and resolution of Pseudomonas aeruginosa keratitis in a mouse model PLoS ONE 8 2013 e54765
145. W.A. Wuyts, C. Agostini, K.M. Antoniou, D. Bouros, R.C. Chambers, V. Cottin, J.J. Egan, B.N. Lambrecht, R. Lories, H. Parfrey, A. Prasse, C. Robalo-Cordeiro, E. Verbeken, J.A. Verschakelen, A.U. Wells, and G.M. Verleden The pathogenesis of pulmonary fibrosis: a moving target Eur. Respir. J. 41 2013 1207 1218
146. M.A. Mouratis, and V. Aidinis Modeling pulmonary fibrosis with bleomycin Curr. Opin. Pulm. Med. 17 2011 355 361
147. N. Venkatesan, T. Ebihara, P.J. Roughley, and M.S. Ludwig Alterations in large and small proteoglycans in bleomycin-induced pulmonary fibrosis in rats Am. J. Respir. Crit. Care Med. 161 2000 2066 2073
148. G. Westergren-Thorsson, J. Hernnas, B. Sarnstrand, A. Oldberg, D. Heinegard, and A. Malmstrom Altered expression of small proteoglycans, collagen, and transforming growth factor-beta 1 in developing bleomycin-induced pulmonary fibrosis in rats J. Clin. Invest. 92 1993 632 637
149. S.N. Giri, D.M. Hyde, R.K. Braun, W. Gaarde, J.R. Harper, and M.D. Pierschbacher Antifibrotic effect of decorin in a bleomycin hamster model of lung fibrosis Biochem. Pharmacol. 54 1997 1205 1216
150. M. Kolb, P.J. Margetts, T. Galt, P.J. Sime, Z. Xing, M. Schmidt, and J. Gauldie Transient transgene expression of decorin in the lung reduces the fibrotic response to bleomycin Am. J. Respir. Crit. Care Med. 163 2001 770 777
151. M. Shimizukawa, M. Ebina, K. Narumi, T. Kikuchi, H. Munakata, and T. Nukiwa Intratracheal gene transfer of decorin reduces subpleural fibroproliferation induced by bleomycin Am. J. Physiol. Lung Cell. Mol. Physiol. 284 2003 L526 L532
152. N. Rovina, A. Koutsoukou, and N.G. Koulouris Inflammation and immune response in COPD: where do we stand? Mediat. Inflamm. 2013 2013 413735
153. O. Hallgren, K. Nihlberg, M. Dahlback, L. Bjermer, L.T. Eriksson, J.S. Erjefalt, C.G. Lofdahl, and G. Westergren-Thorsson Altered fibroblast proteoglycan production in COPD Respir. Res. 11 2010 55
154. J.F. van Straaten, W. Coers, J.A. Noordhoek, S. Huitema, J.T. Flipsen, H.F. Kauffman, W. Timens, and D.S. Postma Proteoglycan changes in the extracellular matrix of lung tissue from patients with pulmonary emphysema Mod. Pathol. 12 1999 697 705
155. J.A. Noordhoek, D.S. Postma, L.L. Chong, L. Menkema, H.F. Kauffman, W. Timens, J.F. van Straaten, and Y.M. van der Geld Different modulation of decorin production by lung fibroblasts from patients with mild and severe emphysema COPD 2 2005 17 25
156. C.C. van Diemen, D.S. Postma, J.M. Vonk, M. Bruinenberg, I.M. Nolte, and H.M. Boezen Decorin and TGF-beta1 polymorphisms and development of COPD in a general population Respir. Res. 7 2006 89
157. C.A. Brandsma, H.A. Kerstjens, W.H. van Geffen, M. Geerlings, D.S. Postma, M.N. Hylkema, and W. Timens Differential switching to IgG and IgA in active smoking COPD patients and healthy controls Eur. Respir. J. 40 2012 313 321
158. E.R. Sutherland, and R.M. Cherniack Management of chronic obstructive pulmonary disease N. Engl. J. Med. 350 2004 2689 2697
159. C.A. Brandsma, W. Timens, M.R. Jonker, B. Rutgers, J.A. Noordhoek, and D.S. Postma Differential effects of fluticasone on extracellular matrix production by airway and parenchymal fibroblasts in severe COPD Am. J. Physiol. Lung Cell. Mol. Physiol. 2013
160. L.I. Kunz, J. Strebus, S.E. Budulac, T.S. Lapperre, P.J. Sterk, D.S. Postma, T. Mauad, W. Timens, P.S. Hiemstra, and G.S. Group Inhaled steroids modulate extracellular matrix composition in bronchial biopsies of COPD patients: a randomized, controlled trial PLoS ONE 8 2013 e63430
161. A.K. Larsson-Callerfelt, O. Hallgren, A. Andersson-Sjoland, L. Thiman, J. Bjorklund, J. Kron, K. Nihlberg, L. Bjermer, C.G. Lofdahl, and G. Westergren-Thorsson Defective alterations in the collagen network to prostacyclin in COPD lung fibroblasts Respir. Res. 14 2013 21
162. R.V. Iozzo, and R.D. Sanderson Proteoglycans in cancer biology, tumour microenvironment and angiogenesis J. Cell. Mol. Med. 15 2011 1013 1031
163. S. Goldoni, and R.V. Iozzo Tumor microenvironment: modulation by decorin and related molecules harboring leucine-rich tandem motifs Int. J. Cancer 123 2008 2473 2479
164. D.D. Sofeu Feugaing, M. Gotte, and M. Viola More than matrix: the multifaceted role of decorin in cancer Eur. J. Cell Biol. 92 2013 1 11
165. J.X. Zhu, S. Goldoni, G. Bix, R.T. Owens, D.J. McQuillan, C.C. Reed, and R.V. Iozzo Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis J. Biol. Chem. 280 2005 32468 32479
166. G. Csordas, M. Santra, C.C. Reed, I. Eichstetter, D.J. McQuillan, D. Gross, M.A. Nugent, G. Hajnoczky, and R.V. Iozzo Sustained down-regulation of the epidermal growth factor receptor by decorin. A mechanism for controlling tumor growth in vivo J. Biol. Chem. 275 2000 32879 32887
167. D.G. Seidler, S. Goldoni, C. Agnew, C. Cardi, M.L. Thakur, R.T. Owens, D.J. McQuillan, and R.V. Iozzo Decorin protein core inhibits in vivo cancer growth and metabolism by hindering epidermal growth factor receptor function and triggering apoptosis via caspase-3 activation J. Biol. Chem. 281 2006 26408 26418
168. P. Jung, A. Menssen, D. Mayr, and H. Hermeking AP4 encodes a c-MYC-inducible repressor of p21 Proc. Natl. Acad. Sci. U. S. A. 105 2008 15046 15051
169. E. Gherardi, W. Birchmeier, C. Birchmeier, and G. Vande Woude Targeting MET in cancer: rationale and progress Nat. Rev. Cancer 12 2012 89 103
170. E. Schonherr, B. Levkau, L. Schaefer, H. Kresse, and K. Walsh Decorin-mediated signal transduction in endothelial cells. Involvement of Akt/protein kinase B in up-regulation of p21(WAF1/CIP1) but not p27(KIP1) J. Biol. Chem. 276 2001 40687 40692
171. D.S. Grant, C. Yenisey, R.W. Rose, M. Tootell, M. Santra, and R.V. Iozzo Decorin suppresses tumor cell-mediated angiogenesis Oncogene 21 2002 4765 4777
172. T. Neill, H. Painter, S. Buraschi, R.T. Owens, M.P. Lisanti, L. Schaefer, and R.V. Iozzo Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3 J. Biol. Chem. 287 2012 5492 5506
173. T. Neill, H.R. Jones, Z. Crane-Smith, R.T. Owens, L. Schaefer, and R.V. Iozzo Decorin induces rapid secretion of thrombospondin-1 in basal breast carcinoma cells via inhibition of Ras homolog gene family, member A/Rho-associated coiled-coil containing protein kinase 1 FEBS J. 280 2013 2353 2368
174. A. Goyal, T. Neill, R.T. Owens, L. Schaefer, and R.V. Iozzo Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells Matrix Biol. 2014 (in press)
175. R.V. Iozzo, S. Buraschi, M. Genua, S.Q. Xu, C.C. Solomides, S.C. Peiper, L.G. Gomella, R.C. Owens, and A. Morrione Decorin antagonizes IGF receptor I (IGF-IR) function by interfering with IGF-IR activity and attenuating downstream signaling J. Biol. Chem. 286 2011 34712 34721
176. D. Metalli, F. Lovat, F. Tripodi, M. Genua, S.Q. Xu, M. Spinelli, L. Alberghina, M. Vanoni, R. Baffa, L.G. Gomella, R.V. Iozzo, and A. Morrione The insulin-like growth factor receptor I promotes motility and invasion of bladder cancer cells through Akt- and mitogen-activated protein kinase-dependent activation of paxillin Am. J. Pathol. 176 2010 2997 3006
177. C. Soria-Valles, A. Gutierrez-Fernandez, M. Guiu, B. Mari, A. Fueyo, R.R. Gomis, and C. Lopez-Otin The anti-metastatic activity of collagenase-2 in breast cancer cells is mediated by a signaling pathway involving decorin and miR-21 Oncogene 2013
178. S. Asakura, H. Kato, S. Fujino, T. Konishi, N. Tezuka, and A. Mori Role of transforming growth factor-beta1 and decorin in development of central fibrosis in pulmonary adenocarcinoma Hum. Pathol. 30 1999 195 198
179. A.L. McDoniels-Silvers, C.F. Nimri, G.D. Stoner, R.A. Lubet, and M. You Differential gene expression in human lung adenocarcinomas and squamous cell carcinomas Clin. Cancer Res. 8 2002 1127 1138
180. K. Shintani, A. Matsumine, K. Kusuzaki, J. Morikawa, T. Matsubara, T. Wakabayashi, K. Araki, H. Satonaka, H. Wakabayashi, T. Iino, and A. Uchida Decorin suppresses lung metastases of murine osteosarcoma Oncol. Rep. 19 2008 1533 1539
181. Y. Liu, W. Li, X. Li, Y. Tai, Q. Lu, N. Yang, and J. Jiang Expression and significance of biglycan in endometrial cancer Arch. Gynecol. Obstet. 2013 (http://dx.doi.org/10.1007/s00404-013-3017-3)
182. G. Aprile, C. Avellini, M. Reni, M. Mazzer, L. Foltran, D. Rossi, S. Cereda, E. Iaiza, G. Fasola, and A. Piga Biglycan expression and clinical outcome in patients with pancreatic adenocarcinoma Tumour Biol. 34 2013 131 137
183. B. Wang, G.X. Li, S.G. Zhang, Q. Wang, Y.G. Wen, H.M. Tang, C.Z. Zhou, A.Y. Xing, J.W. Fan, D.W. Yan, G.Q. Qiu, Z.H. Yu, and Z.H. Peng Biglycan expression correlates with aggressiveness and poor prognosis of gastric cancer Exp. Biol. Med. 236 2011 1247 1253
184. X. Gu, Y. Ma, J. Xiao, H. Zheng, C. Song, Y. Gong, and X. Xing Up-regulated biglycan expression correlates with the malignancy in human colorectal cancers Clin. Exp. Med. 12 2012 195 199
185. F. Modolo, M.T. Biz, M.T. Martins, S.O. Machado de Sousa, and N.S. de Araujo Expression of extracellular matrix proteins in adenomatoid odontogenic tumor J. Oral Pathol. Med. 39 2010 230 235
186. S. Pan, L. Cheng, J.T. White, W. Lu, A.G. Utleg, X. Yan, N.D. Urban, C.W. Drescher, L. Hood, and B. Lin Quantitative proteomics analysis integrated with microarray data reveals that extracellular matrix proteins, catenins, and p53 binding protein 1 are important for chemotherapy response in ovarian cancers OMICS 13 2009 345 354
187. C.K. Weber, G. Sommer, P. Michl, H. Fensterer, M. Weimer, F. Gansauge, G. Leder, G. Adler, and T.M. Gress Biglycan is overexpressed in pancreatic cancer and induces G1-arrest in pancreatic cancer cell lines Gastroenterology 121 2001 657 667
188. C.V. Recktenwald, S. Leisz, A. Steven, K. Mimura, A. Muller, J. Wulfanger, R. Kiessling, and B. Seliger HER-2/neu-mediated down-regulation of biglycan associated with altered growth properties J. Biol. Chem. 287 2012 24320 24329
189. K. Yamamoto, N. Ohga, Y. Hida, N. Maishi, T. Kawamoto, K. Kitayama, K. Akiyama, T. Osawa, M. Kondoh, K. Matsuda, Y. Onodera, M. Fujie, K. Kaga, S. Hirano, N. Shinohara, M. Shindoh, and K. Hida Biglycan is a specific marker and an autocrine angiogenic factor of tumour endothelial cells Br. J. Cancer 106 2012 1214 1223
190. Y. Li, T. Aoki, Y. Mori, M. Ahmad, H. Miyamori, T. Takino, and H. Sato Cleavage of lumican by membrane-type matrix metalloproteinase-1 abrogates this proteoglycan-mediated suppression of tumor cell colony formation in soft agar Cancer Res. 64 2004 7058 7064
191. N. Vij, L. Roberts, S. Joyce, and S. Chakravarti Lumican suppresses cell proliferation and aids Fas-Fas ligand mediated apoptosis: implications in the cornea Exp. Eye Res. 78 2004 957 971
192. B. Sharma, M.D. Ramus, C.T. Kirkwood, E.E. Sperry, P.H. Chu, W.W. Kao, and A.R. Albig Lumican Exhibits Anti-Angiogenic Activity in a Context Specific Manner Cancer Microenviron. 6 2013 263 271
193. T. Okano, T. Kondo, T. Kakisaka, K. Fujii, M. Yamada, H. Kato, T. Nishimura, A. Gemma, S. Kudoh, and S. Hirohashi Plasma proteomics of lung cancer by a linkage of multi-dimensional liquid chromatography and two-dimensional difference gel electrophoresis Proteomics 6 2006 3938 3948
194. Y. Matsuda, T. Yamamoto, M. Kudo, K. Kawahara, M. Kawamoto, Y. Nakajima, K. Koizumi, N. Nakazawa, T. Ishiwata, and Z. Naito Expression and roles of lumican in lung adenocarcinoma and squamous cell carcinoma Int. J. Oncol. 33 2008 1177 1185
195. S. Brezillon, C. Zeltz, L. Schneider, C. Terryn, B. Vuillermoz, L. Ramont, C. Perrau, M. Pluot, M.D. Diebold, A. Radwanska, M. Malicka- Blaszkiewicz, F.X. Maquart, and Y. Wegrowski Lumican inhibits B16F1 melanoma cell lung metastasis J. Physiol. Pharmacol. 60 Suppl. 4 2009 15 22