Inhaled Steroids Modulate Extracellular Matrix Composition in Bronchial Biopsies of COPD Patients: A Randomized, Controlled Trial

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Kunz, Lisette I Z ^a   Strebus, Jolanda ^a   Budulac, Simona E ^b   Lapperre, Therese S ^a   Sterk, Peter J ^c   Postma, Dirkje S ^b   Mauad, Thais ^d   Timens, Wim ^b   Hiemstra, Pieter S ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 3; CORTICOSTEROID DERIVATIVE; DECORIN; FLUTICASONE; FLUTICASONE PLUS SALMETEROL; FLUTICASONE PROPIONATE; GLUCOCORTICOID; PLACEBO; UNCLASSIFIED DRUG; VERSICAN;

ADULT; AGED; AIRWAY REMODELING; ARTICLE; BRONCHUS BIOPSY; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE SEVERITY; DRUG EFFICACY; ELASTIC FIBER; EXTRACELLULAR MATRIX; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; LONG TERM CARE; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; RANDOMIZED CONTROLLED TRIAL; SMOKING;

ADMINISTRATION, INHALATION; ADULT; ANDROSTADIENES; BIOPSY; BRONCHI; COLLAGEN TYPE I; EXTRACELLULAR MATRIX; EXTRACELLULAR MATRIX PROTEINS; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PLACEBOS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKING; STEROIDS;

EID: 84877147602     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063430     Document Type: Article

References (35)

1. Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, et al. (2007) Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 176: 532-555.
2. Hogg JC, Timens W, (2009) The pathology of chronic obstructive pulmonary disease. Annu Rev Pathol 4: 435-459.
3. Gosselink JV, Hayashi S, Elliott WM, Xing L, Chan B, et al. (2010) Differential Expression of Tissue Repair Genes in the Pathogenesis of Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 181: 1329-1335.
4. Fernandes DJ, Bonacci JV, Stewart AG, (2006) Extracellular matrix, integrins, and mesenchymal cell function in the airways. Curr Drug Targets 7: 567-577.
5. Suki B, Bates JHT, (2008) Extracellular matrix mechanics in lung parenchymal diseases. Respir Physiol Neurobiol 163: 33-43.
6. Black PN, Ching PST, Beaumont B, Ranasinghe S, Taylor G, et al. (2008) Changes in elastic fibres in the small airways and alveoli in COPD. Eur Respir J 31: 998-1004.
7. Chrzanowski P, Keller S, Cerreta J, Mandl I, Turino GM, (1980) Elastin content of normal and emphysematous lung parenchyma. Am J Med 69: 351-359.
8. Merrilees M, Ching P, Beaumont B, Hinek A, Wight T, et al. (2008) Changes in elastin, elastin binding protein and versican in alveoli in chronic obstructive pulmonary disease. Resp Res 9: 41.
9. Hallgren O, Nihlberg K, Dahlback M, Bjermer L, Eriksson L, et al. (2010) Altered fibroblast proteoglycan production in COPD. Resp Res 11: 55.
10. van Straaten JF, Coers W, Noordhoek JA, Huitema S, Flipsen JT, et al. (1999) Proteoglycan changes in the extracellular matrix of lung tissue from patients with pulmonary emphysema. Mod Pathol 12: 697-705.
11. Annoni R, Lanças T, Tanigawa RY, de Medeiros Matsushita M, de Morais Fernezlian S, et al. (2012) Extracellular matrix composition in chronic obstructive pulmonary disease. Eur Respir J 40(6): 1362-1373.
12. Wang H, Liu X, Umino T, Kohyama T, Zhu YK, et al. (2003) Effect of cigarette smoke on fibroblast-mediated gel contraction is dependent on cell density. Am J Physiol Lung Cell Mol Physiol 284: L205-L213.
13. Takizawa H, Tanaka M, Takami K, Ohtoshi T, Satoh M, et al. (2001) Increased Expression of Transforming Growth Factor-{beta}1 in Small Airway Epithelium from Tobacco Smokers and Patients with Chronic Obstructive Pulmonary Disease (COPD). Am J Respir Crit Care Med 163: 1476-1483.
14. Wright JL, Postma DS, Kerstjens HA, Timens W, Whittaker P, et al. (2007) Airway remodeling in the smoke exposed guinea pig model. Inhal Toxicol 19: 915-923.
15. Deslee G, Woods JC, Moore CM, Liu L, Conradi SH, et al. (2009) Elastin expression in very severe human COPD. Eur Respir J 34: 324-331.
16. Zandvoort A, Postma DS, Jonker MR, Noordhoek JA, Vos JT, et al. (2008) Smad gene expression in pulmonary fibroblasts: indications for defective ECM repair in COPD. Respir Res 9: 83.
17. Lapperre TS, Snoeck-Stroband JB, Gosman MM, Jansen DF, van Schadewijk A, et al. (2009) Effect of fluticasone with and without salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease: a randomized trial. Ann Intern Med 151: 517-527.
18. Godfrey RW, Lorimer S, Majumdar S, Adelroth E, Johnston PW, et al. (1995) Airway and lung elastic fibre is not reduced in asthma nor in asthmatics following corticosteroid treatment. Eur Respir J 8: 922-927.
19. Todorova L, Gurcan E, Miller-Larsson A, Westergren-Thorsson G, (2006) Lung Fibroblast Proteoglycan Production Induced by Serum Is Inhibited by Budesonide and Formoterol. Am J Respir Cell Mol Biol 34: 92-100.
20. Quanjer PH, Tammeling GJ, Cotes JE, Pedersen OF, Peslin R et al. (1993) Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J Suppl 16: 5-40.
21. Sterk PJ, Fabbri LM, Quanjer PH, Cockcroft DW, O'Byrne PM et al. (1993) Airway responsiveness. Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J Suppl 16: 53-83.
22. Lapperre TS, Postma DS, Gosman MME, Snoeck-Stroband JB, ten Hacken NHT, et al. (2006) Relation between duration of smoking cessation and bronchial inflammation in COPD. Thorax 61: 115-121.
23. Budulac S, Postma DS, Hiemstra PS, Kunz LIZ, Siedlinski M, et al. (2010) Multidrug resistance-associated protein-1 (MRP1) genetic variants, MRP1 protein levels and severity of COPD. Respir Res 11: 60.
24. Hsia CCW, Hyde DM, Ochs M, Weibel ER, on behalf of the ATS/ERS Joint Task Force on the Quantitative Assessment of Lung Structure, (2010) An Official Research Policy Statement of the American Thoracic Society/European Respiratory Society: Standards for Quantitative Assessment of Lung Structure. Am J Respir Crit Care Med 181: 394-418.
25. Jeffery PK, Holgate S, Wenzel S, (2003) Methods for the assessment of endobronchial biopsies in clinical research: Application to studies of pathogenesis and the effects of treatment. Am J Respir Crit Care Med 168: 1S-17.
26. Staining manual elastic tissue fibers. Available: http://library.med.utah.edu/WebPath/HISTHTML/MANUALS/WEIGERTS.PDF. Accessed 2011 Jan 7.
27. Kunz LIZ, Lapperre TS, Snoeck-Stroband JB, Budulac S, Timens W, et al. (2011) Smoking status and anti-inflammatory macrophages in bronchoalveolar lavage and induced sputum in COPD. Respir Res 12: 34.
28. Rufino R, Madi K, Souza HS, Costa CH, Saito EH, et al. (2007) Quantitative assessment of elastic fibers in chronic obstructive pulmonary disease. J Bras Pneumol 33: 502-509.
29. Krimmer DI, Burgess JK, Wooi TK, Black JL, Oliver BG (2011) Matrix Proteins from Smoke Exposed Fibroblasts are Pro-proliferative. Am J Respir Cell Mol Biol 2010-0426OC.
30. Ning W, Li CJ, Kaminski N, Feghali-Bostwick CA, Alber SM, et al. (2004) Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A 101: 14895-14900.
31. Gao S, Chen K, Zhao Y, Rich CB, Chen L, et al. (2005) Transcriptional and Posttranscriptional Inhibition of Lysyl Oxidase Expression by Cigarette Smoke Condensate in Cultured Rat Fetal Lung Fibroblasts. Toxicol Sci 87: 197-203.
32. Churg A, Zhou S, Preobrazhenska O, Tai H, Wang R, et al. (2009) Expression of Profibrotic Mediators in Small Airways versus Parenchyma after Cigarette Smoke Exposure. Am J Respir Cell Mol Biol 40: 268-276.
33. Brusselle GG, Joos GF, Bracke KR, (2010) New insights into the immunology of chronic obstructive pulmonary disease. Lancet 378: 1015-1026.
34. Kelly EA, Jarjour NN, (2003) Role of matrix metalloproteinases in asthma. Curr Opin Pulm Med 9: 28-33.
35. Russell REK, Culpitt SV, DeMatos C, Donnelly L, Smith M, et al. (2002) Release and Activity of Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 by Alveolar Macrophages from Patients with Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol 26: 602-609.